11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Zhang Y, Pan J, Hou J et al. · 2025 · Medicine
Rationale Asthenozoospermia (AZS), a leading cause of male infertility, frequently results from genetic defects that disrupt flagellar assembly. Mutations in the DNAH11 gene can cause abnormal dynein arm structures, leading to AZS and…
View details →Masri A, Tully TN, Como K et al. · 2025 · Journal of avian medicine and surgery
Euthanasia is a common veterinary medical procedure performed on terminally ill backyard chickens ( Gallus gallus domesticus ). To reduce stress for these animals, it is important to develop a euthanasia protocol that provides a rapid and…
View details →Lee JH, Hwang K, Jeong WK · 2026 · Clinics in orthopedic surgery
Background Arthroscopic rotator cuff repair is widely performed; yet tendon healing failure still occurs in some cases and remains a challenge. To address this issue, several studies have investigated intraoperative injection or patch…
View details →Cuadrado C, Breedlove C, Toro H · 2025 · Avian diseases
Vaccination with a recombinant Newcastle disease virus (NDV) LaSota (LS) strain expressing Arkansas (Ark) -type infectious bronchitis virus (IBV) spike ectodomain (Se) protein and granulocyte-macrophage colony-stimulating factor (GMCSF)…
View details →Daudi S, Zampelis V, Belfrage O et al. · 2025 · The bone & joint journal
Aims Short, uncemented hip stems might provide a favourable alternative in total hip arthroplasty (THA) by preserving proximal bone mass through reduced strain-adaptive remodelling. We evaluated and compared the migration and…
View details →Gates RS, McCoy K, Stewart J et al. · 2026 · Surgery
Background Timely diagnosis and treatment of primary hyperparathyroidism requires a high index of suspicion and collaboration across specialties. The diagnosis often is overlooked. This study aimed to determine whether the introduction of…
View details →Busanello A, Koller OG, Menezes VM et al. · 2025 · The British journal of nutrition
The objective of this study was to evaluate the impact of incorporating group-based nutritional education into usual care on adherence to nutritional counselling among outpatients with type 2 diabetes (T2DM). This parallel-group,…
View details →Williams KG, Constantine EP, Whitney KE et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose To determine whether patients undergoing arthroscopic partial meniscectomy (APM) with synovitis treated by synovectomy exhibit similar outcomes to those without synovitis after 24-month follow-up. Methods A total of 181 patients…
View details →Lopresti AL, Smith SJ · 2025 · Clinical drug investigation
Background and objectives Bacopa monnieri is a plant used in Ayurvedic medicine with traditional uses for memory and cognitive function. The objective of this study was to examine the effects of supplementation with a Bacopa monnieri…
View details →Timmermans J, Van Goethem B, Stock E et al. · 2026 · Veterinary surgery : VS
Objective To evaluate the soft palate thickness in brachycephalic dogs 3 months after performing folded flap palatoplasty (FFP) or standard staphylectomy (STS). Study design Prospective, observational study. Animals Twenty client-owned…
View details →Foddai M, Carter CG, Wood AT et al. · 2025 · Comparative Biochemistry and Physiology, Part A
Sustained aerobic training is suggested to enhance cardiac performance and growth in farmed salmonids, but its effects under suboptimum elevated temperatures remain unclear. This study examined whether continuous training at different…
View details →Pulikova EP, Kotsarev VI, Demin KA et al. · 2025 · Journal of environmental management
Polycyclic aromatic hydrocarbons (PAHs) are one of the most widespread organic pollutants. The methods to restore the natural environments contaminated with these substances include bioremediation based on PAH-degrading microorganisms. In…
View details →Blomberg M, Schaper R, Bonabi A et al. · 2025 · Behaviour research and therapy
Background Effective treatments for anorexia nervosa (AN) are available, yet many patients do not respond to treatment or experience relapse. Cognitive bias modification aims to ameliorate cognitive biases that are assumed to contribute to…
View details →Lorigan P, Medina TM, Nyakas M et al. · 2026 · European journal of cancer (Oxford, England : 1990)
Purpose Immune checkpoint inhibitor (ICI) combinations have improved outcomes in patients with advanced melanoma; however, long term survival remains poor. The addition of therapeutic cancer vaccines to ICI combinations represents a…
View details →Steen L, Javed H, Contorno E et al. · 2025 · Transplantation proceedings
Objective The cornerstone of immunosuppression for transplantation is tacrolimus. One of the most reliable routes for administering tacrolimus in porcine models is intramuscular injection. However, the pharmacokinetics of intramuscular…
View details →Simon S, Shanmugalingam T, Neu T et al. · 2025 · European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Active efflux transporters can play a substantial role in the drug disposition of their substrates in the human body. Efflux transporters like P-glycoprotein (P-gp), multidrug resistance associated protein 1 (MRP1) and breast cancer…
View details →DE Souza GC, Araujo Filho HB, DE Oliveira CZ et al. · 2025 · Arquivos de gastroenterologia
Background Chemotherapy-induced diarrhea is a common and distressing side effect experienced by patients undergoing cancer treatment, particularly those with gastrointestinal cancer. It can lead to significant health complications,…
View details →López-Campos Ó, Chabot B, Attema HR et al. · 2025 · Meat Science.
The effect of localized low voltage electrical stimulation (LVES, 45 V) on meat quality and palatability of the longissimus thoracis et lumborum (LTL) and semitendinosus (ST) was evaluated in this study. There were stimulation method ×…
View details →Modica V, Glávits R, Clewell A et al. · 2025 · International journal of toxicology
Anaerostipes caccae CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple…
View details →Miravalles C, Kane R, Rossier AT et al. · 2026 · Journal of affective disorders
Background Current treatments for depressive episodes in bipolar disorder are often limited by partial efficacy or delayed therapeutic response. Intravenous scopolamine, a pan-muscarinic antagonist, has shown rapid antidepressant effects…
View details →Grote A, Genther-Schroeder O, Wilson BK et al. · 2025 · Applied Animal Science
Our objective was to determine the effect of plane of nutrition through 92 d of age on subsequent finishing performance, feed efficiency, and carcass characteristics in beef × dairy crossbred steers. Beef × dairy crossbred steers (n = 109)…
View details →Gündüz N, Duran M, Erdal AI et al. · 2026 · The Journal of craniofacial surgery
Facial fractures are a significant aspect of pediatric trauma cases. The impact of intermaxillary fixation (IMF) using screws on dental development, particularly in pediatric patients undergoing primary and mixed dentition, remains a…
View details →Baek CH, Lim C, Kim JG et al. · 2025 · The bone & joint journal
Aims This study aimed to compare clinical outcomes according to the location of transferred graft retear in arthroscopy-assisted lower trapezius tendon transfer (aLTT) for posterosuperior irreparable rotator cuff tears (PSIRCTs). Methods…
View details →Pirracchio R, Fong N, Legrand M · 2025 · Intensive care medicine
Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arterial pressure targets (65-70 mmHg vs 80-85 mmHg) in septic shock and…
View details →Łukasik AJ, Podlasin RB · 2025 · Przeglad epidemiologiczny
Rabies is a zoonotic viral infection caused by an RNA virus from the Rhabdoviridae family, a Lyssavirus species with the highest mortality rate among all infectious diseases. Post-exposure propylahis (PEP) should be applied as soon as…
View details →Long Y, Wang W, Liu J et al. · 2025 · The Journal of laryngology and otology
Objective To compare the sound localisation abilities of bimodal cochlear implant and bilateral cochlear implant users. Methods A horizontal sound source discrimination task was conducted with 44 and 20 bimodal and bilateral cochlear…
View details →Alsalem Z, Alothemeen M, Alshehri D et al. · 2026 · Journal of medicine and life
This study aimed to evaluate the effect of a glaze coating on the surface roughness and color stability of 3D-printed temporary crown resin materials before and after simulated toothbrushing. Nano-filled ceramic resin specimens were…
View details →Stokes MA, Lai T, Reiter L et al. · 2025 · International journal of antimicrobial agents
Objective To describe the impact of a real-world, vancomycin dosing bundle ('the bundle'), on vancomycin-associated nephrotoxicity (VAN) rates in critically ill children in a single paediatric intensive care unit (PICU). Methods A…
View details →Choo JM, Kang WX, Le Leu R et al. · 2025 · Journal of nephrology
Background Disruption of the gut microbiota in kidney transplant recipients has been linked to an increased risk of post-transplant infections and gastrointestinal symptoms, including diarrhoea. Dietary supplementation with resistant…
View details →Andueza D, Martin-Rosset W · 2025 · Animal : an international journal of animal bioscience
The nutritive value of forage for horses is closely dependent on the digestibility of organic matter (OMD), which is typically measured in vivo. Researchers have developed a variety of prediction methods to estimate the digestibility value…
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