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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Variability in adolescent reception of parental support: Testing the domain-matching hypothesis.

Altinoz ZS, Erath SA, Pettit GS et al. · 2024 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

The present study investigated matches and mismatches between adolescent and parent socialization domains (i.e., protection, guidance) as related to adolescent reception of parental support during a laboratory-based social evaluation…

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Negative / Null Result ReportMedicine

Effects of polyphenol-rich extracts and compounds on methane and ammonia emissions from pig slurry during 28-day incubation

Vazifehkhoran AH, Pedersen J, Guldberg LB et al. · 2024 · Biosystems engineering.

Animal manure in livestock production facilities is a major source of methane (CH₄) and ammonia (NH₃) emissions from agriculture. In this study, we investigated different polyphenol-rich extracts and chemicals including commercial chestnut…

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Negative / Null Result ReportOpen accessMedicine

Acute Effects of Commercial Yerba Mate Products on Cardiometabolic Responses during Submaximal Cycling: Brewed to Perform?

Zaki S, Berkachy R, Zein Eddine R et al. · 2026 · Current developments in nutrition

Background Yerba mate ( Ilex paraguariensis ) is an herb native to South America known for its caffeine and polyphenol content, with suggested benefits for fat oxidation and energy metabolism. However, few studies have evaluated its brewed…

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Negative / Null Result ReportOpen accessMedicine

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.

Mazzini G, Tuerlings M, van der Stap V et al. · 2026 · Cartilage

BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on…

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Negative / Null Result ReportMedicine

Acute metformin intake on exercise performance in healthy participants during functional fitness training.

Pinheiro AH, Silva LG, Bastos-Silva VJ · 2025 · The Journal of sports medicine and physical fitness

Background The study aimed to assess whether prior intake of metformin enhances performance in the FRAN workout, a popular Functional Fitness Training protocol. Methods Fourteen men (mean±SD: 24.2±3.5 years; height: 173.3±7.8 cm; weight:…

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Negative / Null Result ReportMedicine

Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model.

Pereira M, Brandão Ostermann RA, de Fáveri W et al. · 2025 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Aspirin has significant antineoplastic effects on the colon, whereas the outcomes of Vitamin C and D supplementation have been inconsistent. This study addressed the isolated and combined effects of vitamins C and D with aspirin on…

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Negative / Null Result ReportMedicine

Roles of spermary-specific carboxylesterases in Nilaparvata lugens reproduction: Opposite between insecticide-induced upregulation and resistance-associated overexpression.

Zhang H, Yang B, Xu X et al. · 2025 · International journal of biological macromolecules

Seminal fluid proteins (SFPs) in insect males are critical for reproduction, being transported into female ovary. In Nilaparvata lugens, a significant rice pest, seven spermary-specific carboxylesterases (CarEs) were found abundantly in…

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Negative / Null Result ReportMedicine

The role of loading-induced convection versus diffusion on the transport of small molecules into the intervertebral disc.

Salzer E, Gorgin Karaji Z, van Doeselaar M et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose Limited nutrient transport is hypothesized to be involved in intervertebral disc (IVD) degeneration. It is widely recognized that the dominant mode of transport of small molecules such as glucose is via diffusion, rather than…

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Negative / Null Result ReportOpen accessMedicine

Transcranial Direct Current Stimulation Does Not Enhance Perceptual Learning of Chinese Character Reading in Adults With Macular Degeneration.

Lyu A, Mungalsingh MA, Silva AE et al. · 2026 · Investigative ophthalmology & visual science

Purpose Macular degeneration impairs central vision, compelling patients to use their peripheral vision for reading, which is difficult due to reduced spatial resolution and crowding. Although perceptual learning improves reading,…

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Negative / Null Result ReportMedicine

Biological soil amendments can support survival of pathogenic and non-pathogenic Escherichia coli in soils and sporadic transfer to Romaine lettuce.

Xiong ZR, Gabriel E, Gutierrez A et al. · 2025 · International journal of food microbiology

Biological soil amendments (BSAs) are essential agricultural inputs that provide critical nutrients in organic leafy green production. Heat-treated poultry pellets (HTPP) and seabird guano (SBG), which have been treated to reduce microbial…

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Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses.

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Background Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic…

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Negative / Null Result ReportOpen accessMedicine

Topical betulinic acid for treatment of equine melanoma and sarcoid.

Moreno C, Mudge M, Horne R et al. · 2026 · Frontiers in veterinary science

Introduction Betulinic acid, a natural pentacyclic triterpenoid, has demonstrated anti-inflammatory and anti-tumor properties in vitro, including activity against equine melanoma and sarcoid. However, there is limited in vivo evidence…

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Negative / Null Result ReportMedicine

Cryoprotective effects of cholesterol-loaded cyclodextrin and iodixanol on ram sperm: assessment of post-thaw quality and in vitro fertilization outcomes.

Arıcı R, Eser A, Yağcıoğlu S et al. · 2026 · BMC veterinary research

Background This study aimed to investigate the effects of cholesterol-loaded cyclodextrin (CLC) and iodixanol, added individually or in combination to a ram semen extender, on post-thaw sperm quality, in vitro fertilization outcomes, and…

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Negative / Null Result ReportOpen accessMedicine

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

Stanfield B, Leroux B, Kaeberlein M et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults…

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Negative / Null Result ReportMedicine

Comparisons of the amylolytic enzymes and malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar developed in Japan) and Kitanohoshi (currently used cultivar for beer production).

Saburi W, Mori H · 2024 · Bioscience, biotechnology, and biochemistry

Starch degradation in malted barley produces yeast-fermentable sugars. In this study, we compared the amylolytic enzymes and composition of the malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar established in…

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Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study.

Ghazzagh A, Naderi A, Agha-Alinejad H et al. · 2025 · International journal of sport nutrition and exercise metabolism

Taurine (TAU) has been shown to improve time to exhaustion (TTE) and fat oxidation during exercise; however, no studies have examined the effect of acute TAU supplementation on maximal fat oxidation (MFO) and related intensity to MFO…

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Negative / Null Result ReportMedicine

Evaluating the Effectiveness of Assisted Oocyte Activation in ICSI: Pairwise Meta-Analyses and Systematic Evidence Evaluation.

Fawzy M, Elsuity MA, Magdi Y et al. · 2025 · BJOG : an international journal of obstetrics and gynaecology

Background Artificial oocyte activation (AOA) is used to improve fertilisation rates in intracytoplasmic sperm injection (ICSI) cycles. Objectives To assess the effectiveness of AOA on fertilisation, embryo development, and clinical…

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