11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Dao GM, Shaw CS, Betik AC et al. · 2025 · Diabetes
Despite stimulating glucagon secretion, the mechanisms by which protein ingestion lowers glucose excursions remain unclear. We investigated this using the triple stable isotope glucose tracer technique to measure postprandial glucose…
View details →Bowers AN, Tonon CC, Yeo S et al. · 2025 · Archives of oral biology
Objectives Charcoal-containing dentifrices are increasingly popular for their whitening claims, but data on antimicrobial effects are limited. This study compared the antibacterial efficacy of charcoal dentifrices versus non-charcoal…
View details →Sajjad M, Ghorbaninejad P, Bitarafan V et al. · 2026 · The Journal of nutrition
Background The amino acids, L-leucine (Leu) and L-isoleucine (Ile), and the bitter substance, quinine, reduce postprandial glucose, stimulate insulin, and/or slow gastric emptying. Whether combining these stimuli can enhance these effects…
View details →Lima Neta PP, Leal PPMS, Passos VHAA et al. · 2025 · Anais da Academia Brasileira de Ciencias
Leishmaniasis is a group of diseases caused by protozoa of the genus Leishmania . Current treatments exhibit high toxicity, high costs, and parasite resistance. Consequently, the search for new drugs is of utmost importance, and drug…
View details →Chou AK, Chiu CC, Chen YW et al. · 2025 · Fundamental & clinical pharmacology
The aim of this study was to examine the effects of intrathecal lidocaine combined with guanfacine or dexmedetomidine on nociceptive and motor blockade, in comparison to clonidine. Using a rat model of intrathecal injection, we evaluated…
View details →Mohapatra S, Rath S, Kapoor AG et al. · 2026 · American journal of ophthalmology
Purpose To evaluate whether 0.04% mitomycin C (MMC) application at the ostium enhances the outcome of non-endoscopic endonasal dacryocystorhinostomy (NEED) in individuals with primary acquired nasolacrimal duct obstruction (PANDO). Design…
View details →Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and Biophysical Research Communications
In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…
View details →Harvin S, Guetterman TC, Hirko KA et al. · 2026 · Contemporary clinical trials
This study developed and evaluated strategies to optimize recruitment and retention to a mobile health-supported dietary intervention trial, the MyBestGI Study. This included instituting a Personal Technology Assistant and enhancing the…
View details →Firoozeh N, Park SY, Basavalingu D et al. · 2026 · Abdominal radiology (New York)
Objective To assess the diagnostic value of the delayed excretory phase in computed tomography urography (CTU) for detecting renal and urinary tract abnormalities and its impact on readers' confidence in patients with hematuria, given…
View details →Payette F, Kulp JC, Graves A et al. · 2025 · American journal of veterinary research
Objective To measure and compare CSF cytokine concentrations among horses with equine neuroaxonal dystrophy (eNAD)/equine degenerative myeloencephalopathy (EDM), horses with cervical vertebral stenotic myelopathy (CVSM), and control horses…
View details →Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology
Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…
View details →Bonsu KO, Young SW, Lee T et al. · 2025 · Seminars in thrombosis and hemostasis
Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study…
View details →Clouse DE, Collins EG, Khodakovskaya MV et al. · 2025 · Biomacromolecules
There is growing recognition that both cellulose nanocrystal (CNC) source and production scheme affect their physicochemical properties and dispersion behavior. However, how these differences affect CNC surface chemistry modification has…
View details →Badran PM, Stecca CM, de Souza de Castro JT et al. · 2025 · Clinical radiology
Aim Ovarian cancer is the most lethal gynecologic malignancy, with prognosis linked to stage at diagnosis. Ultrasonography is the first-line tool for adnexal mass evaluation, while computed tomography (CT) supports staging and surgical…
View details →di Fonzo AR, Bertuzzi ML, Amusquibar MV et al. · 2025 · Animal reproduction science
Zinc oxide nanoparticles (ZnO-NPs) have been reported to enhance sperm cryopreservation in several species, but their effect on frozen llama semen remains unexplored. This study aims to evaluate the effect of ZnO-NPs on sperm parameters in…
View details →Coste A, Wong AYS, Haguinet F et al. · 2025 · Pharmacoepidemiology and drug safety
Background Despite testing of epidemiological methods in US Claims databases for signal detection, such data sources have not become a routine capability. The Self Controlled Case Series (SCCS) is one of the most promising methods for drug…
View details →Pereyra EV, Kravetz S, Lucero J et al. · 2025 · Limnologica
Freshwater ecosystems face significant threats worldwide, particularly from land use changes that impact biodiversity and ecosystem functions in rivers and streams. Essential elements such as carbon, nitrogen, and phosphorus play crucial…
View details →Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA
Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…
View details →Freislederer F, Dimitriu M, Endell D et al. · 2026 · Journal of experimental orthopaedics
Purpose To determine whether augmentation with the subacromial bursa influences postoperative tendon healing, particularly regarding morphology and vascularity, after arthroscopic rotator cuff repair. Methods In this prospective…
View details →Verdecia-Mogena AM, Himmighofen PA, Mateo P et al. · 2025 · Plant, cell & environment
Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…
View details →Chen F, Cooper J, Acharya A et al. · 2026 · JMIR public health and surveillance
Background Antimicrobial resistance (AMR) is a significant global health threat. Several public health campaigns aimed to raise AMR awareness and inspire related behavioral changes have been delivered in a time-specific, coordinated…
View details →Narang BJ, Štritof A, Debevec T · 2025 · International journal of sport nutrition and exercise metabolism
The ergogenic effects of caffeine for endurance performance at sea level are well established. However, whether caffeine enhances exercise capacity or modulates cardiorespiratory responses in hypoxia remains unclear. Twenty-nine healthy,…
View details →Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine
Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…
View details →Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology
Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…
View details →Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance
Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…
View details →Schwaner WR, Kumar S, Thippareddi H · 2025 · Journal of food protection
Ozone is an effective and safe disinfectant used globally in the bottled water industry. Ozone infusion at a high level helps maintain a residual level (0.1-0.4 mg/L) at the time of bottling, thus can ensure 4 log microbial reductions.…
View details →Persson A, Łyczyńska Z, Shahata M et al. · 2026 · Chemical research in toxicology
Metal additive manufacturing (AM) relies on alloy feedstock powders that may come into contact with the workers' skin during handling, yet skin-relevant data on metal release and biological reactivity remain limited. Here, we assessed the…
View details →Normand-Gravier T, Solsona R, Arnould F et al. · 2025 · Journal of thermal biology
The use of kaumatherapy (i.e. heat exposure like sauna-bathing) as passive intervention has become of growing interest to promote skeletal muscle adaptations such as strength gains and preservation of muscle mass. Importantly, the effects…
View details →Román S, Vázquez E, Román M et al. · 2025 · Marine environmental research
Shellfish beds are key estuarine habitats coinhabited by commercial species and ecosystem engineers such as the seagrass Zostera noltei. Organisms inhabiting the intertidal areas of these beds are threatened by marine and atmospheric…
View details →Folcher A, Piters J, Wallach D et al. · 2025 · Journal of neuroradiology = Journal de neuroradiologie
Background The Thrombolysis in Cerebral Infarction (TICI) scale is widely used to assess angiographic outcomes of mechanical thrombectomy despite significant variability. Our objective was to create and optimize an artificial intelligence…
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