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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The role of hyperthermia on abdominal tissue concentrations of cisplatin during and after intraperitoneal chemotherapy - insights from a porcine model.

Harlev C, Bue M, Petersen EK et al. · 2025 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Epithelial ovarian cancer remains a leading cause of mortality among gynecological malignancies, with a high incidence of peritoneal carcinomatosis at diagnosis. Hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a…

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Negative / Null Result ReportOpen accessMedicine

Scheduled telephone support in internet-delivered cognitive behavioral therapy for depression: randomized controlled trials of two populations.

Pihlaja S, Lipsanen J, Ritola V et al. · 2026 · Frontiers in psychology

Among patients receiving internet-delivered cognitive behavioral therapy (iCBT) for depression in routine clinical practice, 101 patients were randomized to either iCBT as usual or to iCBT with add-on scheduled telephone support (STS).…

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Negative / Null Result ReportMedicine

Concentration, Antibacterial Effect, and Safety of Combining Intra-articular Epsilon-Aminocaproic Acid and Vancomycin in Primary Total Knee Arthroplasty: A Randomized Study.

Zhang Y, Wei J, Su C et al. · 2025 · The Journal of arthroplasty

Background In this study, we aimed to investigate the intra-articular concentration, antibacterial effect, and safety of a combination of vancomycin and epsilon-aminocaproic acid (EACA) in primary total knee arthroplasty (TKA). Methods…

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Negative / Null Result ReportMedicine

Effect of Individualised Homeopathic Medicine as Adjunct to Fluticasone Furoate for Allergic Rhinitis: A Prospective, Randomised, Open-Label, Controlled Trial.

Dixit AK, Sahoo AK, Sidam S et al. · 2025 · Homeopathy : the journal of the Faculty of Homeopathy

Allergic rhinitis (AR) impairs quality of life, with intranasal corticosteroids like fluticasone furoate as standard of care (SOC). Individualised homeopathic medicines (IHMs) are increasingly used as adjuncts, but robust evidence is…

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Negative / Null Result ReportMedicine

Effects of OXXYSLAB Probiotic Supplementation on Blood Oxygenation and Hypoxic Symptoms in Healthy Individuals: A Controlled Normobaric Hypoxia Trial.

Marzola M, Marazzato M, Nutini R et al. · 2026 · High altitude medicine & biology

Marzola, Manuel, Massimiliano Marazzato, Roberto Nutini, Adriano Di Marzio, Francesca Baroli, Manuel Paolucci, Matteo De Angelis, Joanna Giuliano, Ambra Menichelli, Guglielmo Sferrati, Carmen Santangelo, Danilo Bondi, Gerardo Bosco, and…

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Negative / Null Result ReportMedicine

Metabolic interoceptive rewards shape affect, but not action.

Fleming H, Whines A, Whelehan P et al. · 2026 · Biological psychology

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

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Negative / Null Result ReportMedicine

Intranasal prime-boost immunization with trivalent influenza virus neuraminidase proteins and conserved HCA2 sequences fused to a circularly permuted E. coli heat-labile enterotoxin B subunit.

Hung HC, Jheng KW, Cheng HY et al. · 2026 · Vaccine

To develop a mucosal influenza vaccine, we used trivalent recombinant neuraminidase (NA) proteins in combination with a circularly permuted TT mutant of the E. coli heat-labile enterotoxin B subunit, LTB(TT), as a mucosal adjuvant.…

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Negative / Null Result ReportMedicine

Burn severity modifies the impact of salvage logging on post-wildfire natural regeneration of Douglas-fir in interior British Columbia

McAulay J, Querejeta JI, Eskelson BNI et al. · 2025 · Forest Ecology and Management.

1.Exacerbated by climate change, wildfires in British Columbia, Canada, have increased in extent and severity, impacting forests, including commercially valuable species like interior Douglas-fir (Pseudotsuga menziesii var. glauca).…

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Negative / Null Result ReportMedicine

Saccharomyces cerevisiae postbiotics supplementation from gestation to weaning: Impacts on performance and immunity in pigs under low-biosecurity conditions.

Bui TH, Le DP, Ho TD et al. · 2026 · Veterinary journal (London, England : 1997)

This study investigated the effects of Saccharomyces cerevisiae fermentation-derived postbiotics (SCFP) on reproductive performance and immunity of sows and their offspring from gestation to weaning in a low biosecurity, small-scale pig…

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Negative / Null Result ReportMedicine

Exploring mechanisms underlying the beneficial effect of whey protein isolate on the biocompatibility of the thermally obtained curdlan-based hydrogel

Klimek K, Kierys A, Matwijczuk A et al. · 2025 · Carbohydrate Polymers.

This work aimed to compare the biomedical potential of thermally obtained hydrogels consisting of curdlan and a curdlan–whey protein isolate mixture. The purpose of this paper was also to investigate and explain the mechanisms responsible…

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Negative / Null Result ReportMedicine

Standard- versus high-dose tigecycline in pneumonia due to carbapenem-resistant Acinetobacter baumannii: A propensity score-matched retrospective study.

Özgen-Top Ö, Aysert-Yildiz P, Tekin-Taş Z et al. · 2026 · Infectious diseases now

Objectives This study aimed to compare the effectiveness and safety of standard-dose and high-dose tigecycline in pneumonia caused by carbapenem-resistant Acinetobacter baumannii (CRAB). Methods This retrospective, propensity score-matched…

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Negative / Null Result ReportMedicine

Evaluation of pharmacy unit inspection utilizing a mobile application with smart glasses.

Abdel-Kerem A, Wei W, Calzado A et al. · 2025 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose This study aimed to evaluate the impact of integrating smart glasses with a pharmacy compliance mobile application on the efficiency of completing medication unit inspections. The goal was to compare traditional inspection methods…

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Negative / Null Result ReportMedicine

Assessing the Impact of Visualizations of Quantitative and Qualitative Risk Information on the Comprehension of Hypothetical Risk-Based Breast Cancer Screening Results.

van Strien-Knippenberg IS, Timmermans DRM, Weber M et al. · 2025 · Health communication

This study aimed to assess whether, in the context of communicating risk-based breast cancer screening results, visualizations of risk information consisting of an icon array depicting quantified breast cancer risk and simplified drawings…

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Negative / Null Result ReportMedicine

Effect of copper and iron on the oxidation of vegetable oil during aging

Randhawa S, Mukherjee T · 2025 · Journal of Food Composition and Analysis.

The research paper investigates how elemental copper and iron, affect the aging process of canola, coconut, groundnut, rice bran, soybean, and sunflower oils. Samples analysed biannually over two years indicate that the addition of copper,…

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Negative / Null Result ReportMedicine

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

Borges CC, Alves da Silva W, de Sá Filho AS et al. · 2026 · International journal of sport nutrition and exercise metabolism

This study aimed to evaluate the effects of short-term oral L-arginine (ARG) supplementation on vascular parameters, nitric oxide (NO) concentration, and muscular performance during upper limb resistance exercise in healthy young men. A…

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Negative / Null Result ReportOpen accessMedicine

Biomechanical evaluation of patch augmentation in a rotator cuff repair model using a porcine flexor digitorum profundus tendon: influence of knot tying and time-zero stability.

Rhee SM, Cho CH, Kim M et al. · 2025 · Clinics in shoulder and elbow

Background This study evaluates the biomechanical effects of acellular dermal matrix (ADM) patch augmentation in a rotator cuff repair model and determines the effect of medial knot tying on time-zero stability. Methods A biomechanical…

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Negative / Null Result ReportMedicine

A Simplified and Data-Driven Lung Ultrasound Approach for Predicting Surfactant Need in Preterm Infants: A Pilot Study Using Machine Learning and Rule-Based Models.

Meau-Petit V, Mottez C, Bhojnagarwala B et al. · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Objectives Six-region lung ultrasound (LUS) scores show good predictive value for predicting surfactant need in preterm infants but rely on a fixed threshold, which may lead to misclassification near the cut-off and lack data-driven…

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Negative / Null Result ReportOpen accessMedicine

Correlation between systemic blood pressure and free flap perfusion: A photoplethysmography study.

Sahu SA, Mishra JK, De M et al. · 2026 · GMS Interdisciplinary plastic and reconstructive surgery DGPW

Background Microvascular tissue transfer is the method of choice for oncological and trauma reconstruction. Successful free tissue transfer requires technical expertise and management of patients and surgery related factors. However,…

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Negative / Null Result ReportMedicine

Does Hypnosis Aid Memory Retrieval?: A Review of Steven Jay Lynn's Research.

Krackow E, Rashed J, Thompson I · 2025 · The International journal of clinical and experimental hypnosis

Steven Jay Lynn was one of the most prolific clinical psychologists who made major contributions to the scientific literature in numerous areas, including in the area of hypnosis and memory. We review this work, limited to studies…

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