11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mayer S, Wegehaupt FJ, Hamza B · 2026 · BMC oral health
Objectives This in-vitro study compared the protective effects of a 5000-ppm fluoride dentifrice with an anti-erosive 1450-ppm formulation containing stannous chloride and chitosan under erosive, abrasive, and erosive/abrasive conditions.…
View details →Yang Y, Lan C, Jiang Z · 2026 · Tissue engineering and regenerative medicine
Background This study evaluates the impact of Bacillus subtilis dual-strain enteric-coated capsules combined with vonoprazan-amoxicillin (VA) therapy on Helicobacter pylori (Hp) eradication rates, gastrointestinal symptoms, adverse events…
View details →Pinheiro-Machado E, Kuiper T, Huurman RH et al. · 2026 · Journal of biomedical materials research. Part B, Applied biomaterials
Polymer scaffolds are a promising platform for the transplantation of insulin-producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood…
View details →Ten Berg S, Beske RP, Grand J et al. · 2026 · European heart journal. Acute cardiovascular care
Background Noradrenaline is frequently used to increase mean arterial pressure (MAP) in patients with cardiogenic shock caused by infarction-related out-of-hospital cardiac arrest (OHCA-AMICS). This Blood pressure and Oxygenation-Targets…
View details →Dong M, Niimi T, Maturana AD · 2026 · Journal of cellular physiology
Intracellular calcium (Ca 2+ ) signaling controls myoblast proliferation, fusion, and myofiber formation. In myoblasts, Transient Receptor Potential Canonical (TRPC) channels, with TRPC1 as a predominant isoform, mediate store-operated…
View details →Wongwachira C, Suwajanakorn D, Kongwattananon W et al. · 2026 · Eye (London, England)
Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2 C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who…
View details →Morales Ruiz S, Wang Z, Miura T et al. · 2026 · Virology
We constructed two novel LC16-derived vaccinia viruses as candidate mpox vaccines to clarify the contribution of B5 to vaccine-induced protection. LC16m8Δ2 is a B5R-null mutant derived from LC16mO that contains no artificial sequences.…
View details →Sinha P, Chatterjee P, Kathiresan P et al. · 2026 · Journal of the American Geriatrics Society
Objective To evaluate the efficacy of adjunct probiotic supplementation (Lactobacillus helveticus and Bifidobacterium longum) alongside standard care compared to placebo in older adults with moderate unipolar depression. Methods A…
View details →Pontet Y, Aguirrezábal P, Pintos J et al. · 2026 · Journal of clinical gastroenterology
Background In adults, the diagnosis of celiac disease (CeD) relies on the presence of disease-specific antibodies and the confirmation of duodenal atrophy. This study aimed to develop a diagnostic model to predict duodenal atrophy in…
View details →Tanabe H, Watanabe D, Agawa M et al. · 2026 · Biochemical and biophysical research communications
Objectives Intestinal fibrosis is a severe complication of Crohn's disease (CD). While ADAMDEC1 has been identified as a marker for specific fibroblast subsets, its functional role in fibrogenesis remains unclear. This study aimed to…
View details →Souza AF, Fraga MAA, Correr AB et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials
Objectives To evaluate the effects of incorporating the antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM; 2.5% and 5% wt%) and amorphous calcium phosphate nanoparticles (NACP; 2 wt%) on the antibacterial activity,…
View details →Johannesdottir F, Aspelund T, Mahar S et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Current fracture risk assessment does not directly include fall probability, despite the fact that most hip fractures resulting from falls. Additionally, the role of trochanteric soft tissue thickness (TST) in hip fracture risk remains…
View details →López-Cruz R, Ragazzo-Sánchez JA, Calderón-Santoyo M · 2026 · Archives of microbiology
In this study, mango fruit trees cv. Kent (Mangifera indica L.) grown in Nayarit, Mexico, during the 2024 and 2025 seasons were preharvest-treated with four applications of microencapsulated Meyerozyma guilliermondii LMA-Cp01 (0.4 g L⁻¹),…
View details →Kharazmi K, Saroughi M, Khoshniat MT et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology
Lead exposure is linked to various adverse effects on human health, including toxicity to multiple organs such as the kidneys, liver, and reproductive system. Lead induces its toxic effects through complex pathways, including mitochondrial…
View details →Carboni F, Bechi N, Proietti D et al. · 2026 · Carbohydrate polymers
Glycoconjugate vaccines are effective against bacterial infections. Key characteristics for optimal immunogenicity are the carbohydrate-to-protein ratio and consequent glycosylation density. Directing the conjugation to specific sites is…
View details →Toomey D, Lewis G, Rashid U et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society
Background Exercise induces short-term pain relief (exercise-induced hypoalgesia, EIH), but this response is often blunted in people with knee osteoarthritis (OA). Transcranial direct current stimulation (tDCS) has been proposed as a…
View details →El-Karim RMG, Ali REM, Habib MR et al. · 2026 · Acta parasitologica
Bachground Schistosomiasis remains difficult to control due to persistent transmission via freshwater snails and reliance on praziquantel (PZQ) as the primary treatment. Novel adjunctive strategies targeting multiple stages of the parasite…
View details →Madrid J, Batzianouli E, Rutz D et al. · 2026 · Journal of Parkinson's disease
BackgroundFreezing of gait (FOG) in Parkinson's disease (PD) is a major cause of disability and falls and often responds incompletely to conventional therapy. Rehabilitative interventions including cognitive strategies and sensory cueing…
View details →Fellin CR, Steiner RC, Buchen JT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery
Background Nerve guidance conduits (NGCs) are a clinically approved option for peripheral nerve repair but remain ineffective compared with autograft "gold standard" treatment options. A combinatorial approach to conduit-based peripheral…
View details →Oncul S, Lee H, Singh S et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
B cells constitute ∼15% to 20% of tumor-infiltrating lymphocytes in melanoma. Their presence in the tumor microenvironment correlates with improved survival and enhanced response to immune checkpoint blockade therapy. Yet, the functional…
View details →Bergen MA, Kim J, Piana LE et al. · 2026 · The Journal of hand surgery
Purpose To evaluate the biomechanical performance of the modified Brunelli scapholunate interosseous ligament (SLIL) reconstruction with and without suture augmentation, using a cadaveric model under cyclic loading conditions. Methods…
View details →Riesenbach IC, Tsomik G, Chiasson M et al. · 2026 · Aquaculture.
Insects, such as black soldier flies (BSF), have garnered attention in the aquaculture industry as a sustainable protein and lipid alternative to fishmeal and fish oil. However, research is lacking on which components of BSF improve fish…
View details →Nakajima K, Ishida Y, Miura D et al. · 2026 · Odontology
This study investigated the effects of air abrasion with different abrasive particles on the surface roughness and bond strength of resin-based luting agents to enamel and dentin, including dentin surfaces treated with immediate dentin…
View details →Lagravinese G, Castellana G, Genco M et al. · 2026 · Applied psychophysiology and biofeedback
Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and psychological…
View details →Oboite FO, Spencer S · 2025 · Forest Ecology and Management.
Salvage logging is widely used after wildfires to recover economic value and facilitate regeneration, yet its effects on post-fire recovery remain uncertain. The 2003 McLure fire in southern interior British Columbia burned a landscape…
View details →Dalmeijer SWR, Zweedijk BE, Boldewijn DF et al. · 2026 · Surgical oncology
Purpose Accurate intraoperative localization of small intestinal neuroendocrine tumors (SI-NETs) remains a surgical challenge, with standard staging protocols frequently missing small primary or metastatic lesions. ICG has shown utility in…
View details →Broadley D, Le Riche A, Yu Y et al. · 2026 · International journal of molecular sciences
Androgen receptor (AR) signaling plays a key role in male pattern baldness. We investigated whether targeting Dickkopf 1 ( DKK1 ) and Secreted frizzled-related protein 1 ( SFRP1 ), two AR-regulated genes, offers a novel therapeutic…
View details →Essang S, Iyer A, Durantini AM et al. · 2026 · Photochemistry and photobiology
Singlet oxygen ( 1 O 2 ) is a reactive species that plays a role in environmental and biological surface chemistry; however, the mechanisms of the association of airborne 1 O 2 at the air/surface interface are poorly known. Here, we help…
View details →Pister ML, Brost KN, Campbell JM et al. · 2025 · Journal of dairy science
Feeding plasma protein has been shown to have health benefits and help ameliorate stress in preweaning calves, aiding their ability to handle the challenges of weaning and initial social interactions. We hypothesized that feeding plasma…
View details →Bertret V, Latimier RLG, Monbet V · 2025 · Water research
This study compares various modeling approaches to predict ammonium concentration in wastewater treatment plants (WWTPs), with a focus on integrating data assimilation techniques. It explores white-box, grey-box, and black-box models,…
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