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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Multi-strain probiotic reduces gastrointestinal side effects in women with elevated HOMA-IR index treated with metformin: a 12-week randomised controlled trial.

Ratajczak M, Bilska A, Musialik K et al. · 2026 · Frontiers in endocrinology

Background Metformin is widely used as a first-line therapy for type 2 diabetes and increasingly prescribed off-label in women with elevated HOMA-IR indices, including those at risk of metabolic disorders. However, its clinical use is…

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Negative / Null Result ReportMedicine

Mesenchymal Stem Cell Therapy Fails to Improve Fat Graft Retention: Cryopreserved and Cultured Syngeneic and Allogeneic Mesenchymal Stem Cells in a Rat Model.

Alstrup T, Pedersen JO, Kjær EM et al. · 2025 · Plastic and reconstructive surgery

Background Fat grafting is a gentle technique used to correct soft-tissue defects, but it is challenged by low graft survival rates. To enhance retention, mesenchymal stromal cells (MSCs) have been explored. Autologous MSC therapy has…

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Negative / Null Result ReportOpen accessMedicine

Evidence that SmTetX is not a tetracycline resistance determinant.

Beech MJ, Trush MM, Toma EC et al. · 2026 · Microbiology spectrum

SmTetX, a flavin-dependent monooxygenase from the opportunistic pathogen Stenotrophomonas maltophilia , is structurally related to the tetracycline-degrading Tet(X) resistance enzymes, though displays substantial divergence in active site…

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Negative / Null Result ReportOpen accessMedicine

Non-visualization of the fetal gallbladder with ultrasound in the second trimester in a Chinese cohort: prognosis and clinical consultation.

Ding H, Wang Y, He F et al. · 2026 · BMC pregnancy and childbirth

BACKGROUND: To investigate the prenatal characteristics and clinical outcomes of fetuses with non-visualization of the fetal gallbladder (NVFGB) with ultrasound during the second trimester and to promote prenatal consultations based on…

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Negative / Null Result ReportOpen accessMedicine

Acute beetroot juice ingestion fails to improve sprint performance and neuromuscular function in trained male sprinters: a randomized, double-blind, placebo-controlled study.

López-Samanes Á, Moreno-Pérez D, Aguilar-Navarro M et al. · 2026 · Journal of the International Society of Sports Nutrition

Introduction The aim of this study was to evaluate the acute effect of beetroot juice ingestion on sprint performance and neuromuscular properties of male trained sprinters. Methods Twelve male sprinters (24.3 ± 4.8 years) participated in…

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Negative / Null Result ReportMedicine

Criteria for knee flexion range of motion and quadriceps strength to ascend and descend stairs 1 year after bilateral total knee arthroplasty: A cross-sectional study.

Nanjo K, Ikeda T, Kaneyama R et al. · 2025 · Journal of back and musculoskeletal rehabilitation

BackgroundStair ascent/descent pose significant challenges after total knee arthroplasty (TKA); however, the exact knee flexion range of motion (ROM) and quadriceps strength requirements remain unclear.ObjectiveTo establish criteria for…

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Negative / Null Result ReportMedicine

Local Recurrence and Survival Outcomes after Portal Vein/Superior Mesenteric Vein Separation without Resection Preceding Neoadjuvant Therapy for Pancreatic Ductal Adenocarcinoma.

Inoue K, Mizuma M, Motoi F et al. · 2025 · Pancreas

Objectives In patients with pancreatic ductal adenocarcinoma (PDAC) and portal vein/superior mesenteric vein (PV/SMV) contact, we can often separate the tumor from the PV/SMV and avoid PV/SMV resection (VR) owing to the favorable efficacy…

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Negative / Null Result ReportOpen accessMedicine

Quercetin Enhances Gastric Nitric Oxide Formation and Potentiates the Antihypertensive Effects of Oral Nitrite Administration.

Silva-Cunha M, Conde-Tella SO, Rebelo MA et al. · 2026 · Basic & clinical pharmacology & toxicology

Oral nitrite supplementation enhances nitric oxide (NO) bioavailability and lowers blood pressure. Quercetin may facilitate the reduction of nitrite to NO. However, the combined effects of nitrite and Quercetin on gastric NO formation and…

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Negative / Null Result ReportOpen accessMedicine

Dafadine Does Not Promote Dauer Development in Pristionchus pacificus .

Carstensen HR, Hong RL · 2025 · microPublication biology

In response to unfavorable conditions, nematodes develop into the stress-resistant dauer larvae. Under favorable conditions, many nematodes are known to synthesize dafachronic acids (DAs) that bind to the conserved nuclear hormone receptor…

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Negative / Null Result ReportMedicine

Exploring mechanisms underlying the beneficial effect of whey protein isolate on the biocompatibility of the thermally obtained curdlan-based hydrogel.

Klimek K, Kierys A, Matwijczuk A et al. · 2025 · Carbohydrate polymers

This work aimed to compare the biomedical potential of thermally obtained hydrogels consisting of curdlan and a curdlan-whey protein isolate mixture. The purpose of this paper was also to investigate and explain the mechanisms responsible…

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Negative / Null Result ReportMedicine

Investigating the role of ketogenic diet and high-dose vitamin C in modulating doxorubicin toxicity in a murine breast cancer model.

Al-Jada DN, Takruri HR, Talib WH et al. · 2025 · Biochemical and biophysical research communications

In this study, we investigated the effectiveness of combining the ketogenic diet (KD) with high-dose vitamin C (VitC) as adjuvant nutritional therapy to mitigate doxorubicin (DOX) toxicity, with a focus on cardiotoxicity, while enhancing…

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Negative / Null Result ReportOpen accessMedicine

Myeloid Cell Targeting Strategies Show Limited Durable Activity in the Breast Cancer Tumor Microenvironment and Do Not Enhance the Activity of Thermally Ablative Focused Ultrasound.

Van Wagoner CM, Kitelinger LE, DeWitt MR et al. · 2026 · Cells

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BrCa), owing to its lack of targetable receptors and resistance to chemical and molecularly targeted therapeutic approaches. While chemotherapy and…

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Negative / Null Result ReportMedicine

Irradiation with Ultraviolet-C Light-Emitting Diodes: Evaluation of the potential and limitations in controlling the spread of mobile genetic elements.

Duering H, Westerhoff T, Kipp F et al. · 2025 · Environment international

Background Recent reports of multispecies outbreaks show that, in addition to multidrug-resistant bacteria, the accumulation and spread of antibiotic resistance-conferring genes (ARGs) in clinical settings is a growing concern.…

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Negative / Null Result ReportOpen accessMedicine

Rapamycin reduces peritendinous fibrosis but has a limited effect on intratendinous healing in a rodent Achilles tendon injury model.

Marr N, Zamboulis DE, Beaumont RE et al. · 2026 · Scientific reports

Tendon injuries are common, affecting both athletes and the general population. Healing is often poor, with deposition of fibrotic, disorganised scar-like tissue leading to continued pain, dysfunction and reinjury. The pathogeneses of many…

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Negative / Null Result ReportOpen accessMedicine

Multimodal approach to intraventricular hemorrhage using echocardiography, near-infrared spectroscopy, and electrical cardiometry in preterm infants.

Hibner AM, Tong K, Liu L et al. · 2026 · Journal of perinatology : official journal of the California Perinatal Association

Objective To investigate single versus combination hemodynamic parameters on intraventricular hemorrhage (IVH) or mortality in preterm infants. Study design Data from 482 infants under 32 weeks gestational age were analyzed, including…

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Negative / Null Result ReportOpen accessMedicine

Effects of Inhaled Corticosteroids and Long-Acting β2-Agonists on Efferocytosis and Inflammatory Cell Survival: An In Vitro Study Relevant to COPD and Lung Cancer.

Redwan B, Biancosino C, Fischer S et al. · 2026 · International journal of molecular sciences

Efferocytosis-the tightly regulated clearance of apoptotic cells by phagocytes-maintains tissue homeostasis and is impaired in chronic obstructive pulmonary disease (COPD), where it contributes to persistent inflammation and increases the…

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Negative / Null Result ReportMedicine

Medetomidine Administration at the Subcutaneous GV20 Acupoint Compared with the Intramuscular Route in Guinea Pigs (Cavia porcellus): Sedation Score, Onset, and Duration of Action.

Esjaita EI, Fuensalida SE, Giansanti NH et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Recent research in both humans and animals has explored alternative routes for drug administration, such as pharmacopuncture, a technique involving the subcutaneous administration of low drug doses at acupuncture points. Among these…

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Negative / Null Result ReportMedicine

The added value of artificial intelligence using Quantib Prostate for the detection of prostate cancer at multiparametric magnetic resonance imaging.

Russo T, Quarta L, Pellegrino F et al. · 2025 · La Radiologia medica

Purpose Artificial intelligence (AI) has been proposed to assist radiologists in reporting multiparametric magnetic resonance imaging (mpMRI) of the prostate. We evaluate the diagnostic performance of radiologists with different levels of…

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