11,283 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Thomas G. Brott, George Howard, Gary S. Roubin et al. · 2016 · New England Journal of Medicine
BACKGROUND: In the Carotid Revascularization Endarterectomy versus Stenting Trial, we found no significant difference between the stenting group and the endarterectomy group with respect to the primary composite end point of stroke,…
View details →Marco Valgimigli, Gianluca Campo, Monia Monti et al. · 2012 · Circulation
BACKGROUND: The optimal duration of dual-antiplatelet therapy and the risk-benefit ratio for long-term dual-antiplatelet therapy after coronary stenting remain poorly defined. We evaluated the impact of up to 6 versus 24 months of…
View details →Xiuchan Guo, Cheryl A. Winkler, Ji Li et al. · 2014 · BioMed Research International
UNLABELLED: Genetic factors, as well as environmental factors, play a role in development of nasopharyngeal carcinoma (NPC). A number of single nucleotide polymorphisms (SNPs) have been reported to be associated with NPC. To confirm these genetic associations with NPC, two independent case-control studies from Southern China comprising 1166 NPC cases and 2340 controls were conducted. Seven SNPs in ITGA9 at 3p21.3 and 9 SNPs within the 6p21.3 HLA region were genotyped. To explore the potential clinical application of these genetic markers in NPC, we further evaluate the predictive/diagnostic ro
View details →Bart L. Scott, Marcelo C. Pasquini, Brent R. Logan et al. · 2017 · Journal of Clinical Oncology
Purpose The optimal regimen intensity before allogeneic hematopoietic cell transplantation (HCT) is unknown. We hypothesized that lower treatment-related mortality (TRM) with reduced-intensity conditioning (RIC) would result in improved…
View details →Duncan Young, Sarah E Lamb, Sanjoy Shah et al. · 2013 · New England Journal of Medicine
BACKGROUND: Patients with the acute respiratory distress syndrome (ARDS) require mechanical ventilation to maintain arterial oxygenation, but this treatment may produce secondary lung injury. High-frequency oscillatory ventilation (HFOV)…
View details →Nereo Segnan, Paola Armaroli, L Bonelli et al. · 2011 · JNCI Journal of the National Cancer Institute
BACKGROUND: A single flexible sigmoidoscopy at around the age of 60 years has been proposed as an effective strategy for colorectal cancer (CRC) screening. METHODS: We conducted a randomized controlled trial to evaluate the effect of…
View details →Aneesh B. Singhal · 2011 · Archives of Neurology
OBJECTIVES: To compare the clinical, laboratory, and imaging features of patients with reversible cerebral vasoconstriction syndromes evaluated at 2 academic centers, compare subgroups, and investigate treatment effects. DESIGN:…
View details →Francis Kim, Graham Nichol, Charles Maynard et al. · 2013 · JAMA
IMPORTANCE: Hospital cooling improves outcome after cardiac arrest, but prehospital cooling immediately after return of spontaneous circulation may result in better outcomes. OBJECTIVE: To determine whether prehospital cooling improves…
View details →Leonard L. Gunderson, Kathryn Winter, Jaffer A. Ajani et al. · 2012 · Journal of Clinical Oncology
PURPOSE: On initial publication of GI Intergroup Radiation Therapy Oncology Group (RTOG) 98-11 [A Phase III Randomized Study of 5-Fluorouracil (5-FU), Mitomycin, and Radiotherapy Versus 5-Fluorouracil, Cisplatin and Radiotherapy in…
View details →Andrew X. Zhu, Olivier Rosmorduc, T.R. Jeffry Evans et al. · 2014 · Journal of Clinical Oncology
PURPOSE: To compare the clinical outcomes of sorafenib plus either erlotinib or placebo in patients with advanced hepatocellular carcinoma (HCC) in a multicenter, multinational, randomized, phase III trial. PATIENTS AND METHODS: Patients…
View details →Kentaro Suzuki, Yuji Matsumaru, Masataka Takeuchi et al. · 2021 · JAMA
IMPORTANCE: Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy in patients with acute large vessel occlusion stroke is unclear. OBJECTIVE: To examine whether mechanical thrombectomy alone is noninferior…
View details →Mark A. Socinski, Makoto Nishio, Robert M. Jotte et al. · 2021 · Journal of Thoracic Oncology
INTRODUCTION: We report the final overall survival (OS) analyses of atezolizumab-carboplatin-paclitaxel (ACP [experimental arm]) and OS data with approximately 39.8 months of median follow-up with…
View details →Obbina Abani, Ali Abbas, Fatima Abbas et al. · 2021 · The Lancet
BACKGROUND: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. METHODS: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care al
View details →The ICU-ROX Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group · 2019 · New England Journal of Medicine
BACKGROUND: ) and have a high arterial oxygen tension. The conservative use of oxygen may reduce oxygen exposure, diminish lung and systemic oxidative injury, and thereby increase the number of ventilator-free days (days alive and free…
View details →Michael Lim, Michael Weller, Ahmed Idbaïh et al. · 2022 · Neuro-Oncology
BACKGROUND: Nearly all patients with newly diagnosed glioblastoma experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ). The purpose of the phase III randomized CheckMate 548 study was to evaluate RT + TMZ…
View details →Horng H. Chen, Kevin J. Anstrom, Michael M. Givertz et al. · 2013 · JAMA
IMPORTANCE: Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously…
View details →US Preventive Services Task Force, Susan J. Curry, Alex H. Krist et al. · 2019 · JAMA
Importance: Perinatal depression, which is the occurrence of a depressive disorder during pregnancy or following childbirth, affects as many as 1 in 7 women and is one of the most common complications of pregnancy and the postpartum…
View details →Joshua D. Harris, Jefferson C. Brand, Mark P. Cote et al. · 2017 · Arthroscopy The Journal of Arthroscopic and Related Surgery
Patient-reported outcomes (PROs) are increasingly being used in today's rapidly evolving health care environment. The value of care provision emphasizes the highest quality of care at the lowest cost. Quality is in the eye of the beholder,…
View details →T-K Clarke, Mark J. Adams, Gail Davies et al. · 2017 · Molecular Psychiatry
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5% of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for example, ALDH2 and ADH1B , are strongly associated with alcohol consumption but have limited impact in European populations where they are found at low frequency. We performed a genome-wide association study (GWAS) of self-reported alcohol consumption in 112 117 individuals in the UK Biobank (UKB) sample of white British individuals. We report significant genome-wide associations at 14 loci. These include single-nuc
View details →John P. Clancy, Steven M. Rowe, Frank J. Accurso et al. · 2011 · Thorax
BACKGROUND: VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, has been shown to increase the cell surface density of functional F508del-CFTR in vitro. METHODS: A randomised, double-blind, placebo-controlled…
View details →Markus Waldén, I. Atroshi, Henrik Magnusson et al. · 2012 · BMJ
OBJECTIVE: To evaluate the effectiveness of neuromuscular training in reducing the rate of acute knee injury in adolescent female football players. DESIGN: Stratified cluster randomised controlled trial with clubs as the unit of…
View details →J. Michael Wells, George R. Washko, MeiLan K. Han et al. · 2012 · New England Journal of Medicine
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss of lung function and death. Identification of patients at risk for these events, particularly those requiring hospitalization,…
View details →Eva Haglind, Stefan Carlsson, Johan Stranne et al. · 2015 · European Urology
BACKGROUND: Robot-assisted laparoscopic radical prostatectomy (RALP) has become widely used without high-grade evidence of superiority regarding long-term clinical outcomes compared with open retropubic radical prostatectomy (RRP), the…
View details →Tiffany N. Castillo, Michael A. Pouliot, Hyeon Joo Kim et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: Clinical studies claim that platelet-rich plasma (PRP) shortens recovery times because of its high concentration of growth factors that may enhance the tissue repair process. Most of these studies obtained PRP using different…
View details →Roberto Castricini, Umile Giuseppe Longo, Massimo De Benedetto et al. · 2010 · The American Journal of Sports Medicine
BACKGROUND: After reinsertion on the humerus, the rotator cuff has limited ability to heal. Growth factor augmentation has been proposed to enhance healing in such procedure. PURPOSE: This study was conducted to assess the efficacy and…
View details →Abdulaziz N. Alagaili, Thomas Briese, Nischay Mishra et al. · 2014 · mBio
The Middle East respiratory syndrome (MERS) is proposed to be a zoonotic disease; however, the reservoir and mechanism for transmission of the causative agent, the MERS coronavirus, are unknown. Dromedary camels have been implicated through reports that some victims have been exposed to camels, camels in areas where the disease has emerged have antibodies to the virus, and viral sequences have been recovered from camels in association with outbreaks of the disease among humans. Nonetheless, whether camels mediate transmission to humans is unresolved. Here we provide evidence from a geographic
View details →Karen Kelly, Nasser K. Altorki, Wilfried Eberhardt et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitors have proven efficacy in advanced non-small-cell lung cancer (NSCLC). We hypothesized that erlotinib would be efficacious in the adjuvant setting. PATIENTS AND…
View details →Jodie M Dodd, Deborah Turnbull, Andrew J McPhee et al. · 2014 · BMJ
OBJECTIVE: To determine the effect of antenatal dietary and lifestyle interventions on health outcomes in overweight and obese pregnant women. DESIGN: Multicentre randomised trial. We utilised a central telephone randomisation server, with…
View details →Maria Grazia Bongiorni, Charles Kennergren, Christian Butter et al. · 2017 · European Heart Journal
AIMS: The European Lead Extraction ConTRolled Registry (ELECTRa), is a prospective registry of consecutive transvenous lead extraction (TLE) procedures conducted by the European Heart Rhythm Association (EHRA) in order to identify the…
View details →Neil A. Smart, Mark Waldron, Hashbullah Ismail et al. · 2015 · International Journal of Evidence-Based Healthcare
INTRODUCTION: Several established tools are available to assess study quality and reporting of randomized controlled trials; however, these tools were designed with clinical intervention trials in mind. In exercise training intervention…
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