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Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Moderate intermittent hypoxic conditioning to enhance cerebrovascular function in the elderly: a randomized controlled trial.

Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…

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Negative / Null Result ReportMedicine

Comparative Analysis of Four Risk Stratification Models to Identify Patients with Acute Pulmonary Embolism at Risk of Short-term Mortality.

Bonsu KO, Young SW, Lee T et al. · 2025 · Seminars in thrombosis and hemostasis

Acute pulmonary embolism (PE) is potentially life-threatening, with up to 15% risk of death. We compared four risk stratification models to identify outpatients at risk of mortality up to 90 days post acute PE. A retrospective cohort study…

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Negative / Null Result ReportMedicine

Revisiting NaOH Addition during the Amination of Cellulose Nanocrystals.

Clouse DE, Collins EG, Khodakovskaya MV et al. · 2025 · Biomacromolecules

There is growing recognition that both cellulose nanocrystal (CNC) source and production scheme affect their physicochemical properties and dispersion behavior. However, how these differences affect CNC surface chemistry modification has…

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Negative / Null Result ReportMedicine

Open- source computed tomography (CT)-based sarcopenia assessment in women with suspicious adnexal masses: a feasibility and reproducibility study.

Badran PM, Stecca CM, de Souza de Castro JT et al. · 2025 · Clinical radiology

Aim Ovarian cancer is the most lethal gynecologic malignancy, with prognosis linked to stage at diagnosis. Ultrasonography is the first-line tool for adnexal mass evaluation, while computed tomography (CT) supports staging and surgical…

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Negative / Null Result ReportMedicine

Effects of Zinc oxide nanoparticles on llama sperm cryopreservation.

di Fonzo AR, Bertuzzi ML, Amusquibar MV et al. · 2025 · Animal reproduction science

Zinc oxide nanoparticles (ZnO-NPs) have been reported to enhance sperm cryopreservation in several species, but their effect on frozen llama semen remains unexplored. This study aims to evaluate the effect of ZnO-NPs on sperm parameters in…

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Negative / Null Result ReportOpen accessMedicine

Performance of the Self-Controlled Case Series With Active Comparators for Drug Safety Signal Detection Using Merative MarketScan Research Databases.

Coste A, Wong AYS, Haguinet F et al. · 2025 · Pharmacoepidemiology and drug safety

Background Despite testing of epidemiological methods in US Claims databases for signal detection, such data sources have not become a routine capability. The Self Controlled Case Series (SCCS) is one of the most promising methods for drug…

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Negative / Null Result ReportMedicine

Effects of passive information dissemination on human papillomavirus vaccination attitudes and knowledge among pharmacy visitors: A cluster randomized controlled trial.

Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA

Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…

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Negative / Null Result ReportOpen accessMedicine

Subacromial bursa augmentation in arthroscopic rotator cuff repair: Clinical and doppler ultrasound assessment-A preliminary study.

Freislederer F, Dimitriu M, Endell D et al. · 2026 · Journal of experimental orthopaedics

Purpose To determine whether augmentation with the subacromial bursa influences postoperative tendon healing, particularly regarding morphology and vascularity, after arthroscopic rotator cuff repair. Methods In this prospective…

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Negative / Null Result ReportMedicine

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots Without Altering the Performance of Two Root Herbivores, Diabrotica virgifera and Diabrotica balteata.

Verdecia-Mogena AM, Himmighofen PA, Mateo P et al. · 2025 · Plant, cell & environment

Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…

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Negative / Null Result ReportOpen accessMedicine

The Impact on Audience Engagement of Coordinating a Public Health Campaign on Antimicrobial Resistance Through a Network of Health Content Creators: Longitudinal Observational Study.

Chen F, Cooper J, Acharya A et al. · 2026 · JMIR public health and surveillance

Background Antimicrobial resistance (AMR) is a significant global health threat. Several public health campaigns aimed to raise AMR awareness and inspire related behavioral changes have been delivered in a time-specific, coordinated…

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Negative / Null Result ReportMedicine

The Acute Effects of Caffeine and Normobaric Hypoxia on Cardiorespiratory Exercise Responses in Healthy Adults: A Randomized Controlled Trial.

Narang BJ, Štritof A, Debevec T · 2025 · International journal of sport nutrition and exercise metabolism

The ergogenic effects of caffeine for endurance performance at sea level are well established. However, whether caffeine enhances exercise capacity or modulates cardiorespiratory responses in hypoxia remains unclear. Twenty-nine healthy,…

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Negative / Null Result ReportMedicine

PcrV in an intranasal adjuvanted tobacco mosaic virus conjugate vaccine mediates protection from Pseudomonas aeruginosa via an early Th1/Th17 skewed localized and systemic immune response.

Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine

Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…

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Negative / Null Result ReportMedicine

Preimplantation genetic testing for aneuploidy mosaicism reporting lacks clinical predictive value for live birth in a multisite, double-blinded study with independent validation.

Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology

Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…

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Negative / Null Result ReportMedicine

Perceptual, Thermoregulatory, and Performance Effects of Menthol Gel Application in Trained Triathletes Exercising in Hot Conditions.

Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance

Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…

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Negative / Null Result ReportMedicine

Reduction of Enteric Pathogens in Bottled Water Using Residual Ozone.

Schwaner WR, Kumar S, Thippareddi H · 2025 · Journal of food protection

Ozone is an effective and safe disinfectant used globally in the bottled water industry. Ozone infusion at a high level helps maintain a residual level (0.1-0.4 mg/L) at the time of bottling, thus can ensure 4 log microbial reductions.…

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Negative / Null Result ReportOpen accessMedicine

Evaluating Dermal Bioactivity of Metal Additive Manufacturing Powders Using Human <i>In Vitro</i> and <i>Ex Vivo</i> Skin Models.

Persson A, Łyczyńska Z, Shahata M et al. · 2026 · Chemical research in toxicology

Metal additive manufacturing (AM) relies on alloy feedstock powders that may come into contact with the workers' skin during handling, yet skin-relevant data on metal release and biological reactivity remain limited. Here, we assessed the…

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Negative / Null Result ReportMedicine

Design and optimization of an automatic deep learning-based cerebral reperfusion scoring (TICI) using thrombus localization.

Folcher A, Piters J, Wallach D et al. · 2025 · Journal of neuroradiology = Journal de neuroradiologie

Background The Thrombolysis in Cerebral Infarction (TICI) scale is widely used to assess angiographic outcomes of mechanical thrombectomy despite significant variability. Our objective was to create and optimize an artificial intelligence…

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Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic reactivity during…

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Negative / Null Result ReportOpen accessMedicine

Trained immunity agonists given to neonatal mice fail to protect against leptospiral infection in adulthood and may cause adverse effects.

Fernandez M, Vernel-Pauillac F, Pezier T et al. · 2026 · Innate immunity

Background and ObjectivesTrained immunity (TI) refers to a non-specific, long-lasting protective immune response that occurs following initial stimulation of the immune system and thought to be largely mediated by functional reprogramming…

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Negative / Null Result ReportMedicine

Will a co-created program enhance implementation of injury prevention training in youth handball in Sweden? A cluster-randomized controlled trial.

Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport

Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…

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Negative / Null Result ReportMedicine

The metal-organic framework MIL-100(Fe) and ferric citrate as potential counteracting biomaterials against osteoarthritis-induced articular inflammation and fibrosis.

Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…

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Negative / Null Result ReportMedicine

Added value of a balloon-based mucosal exposure device in computer-aided detection-assisted colonoscopy: a randomized controlled trial (COMBAT study).

Rocchetto S, Rondonotti E, Alicante S et al. · 2025 · Endoscopy

Both computer-aided detection (CADe) systems and mucosal exposure devices can enhance adenoma detection during colonoscopy. This research investigates whether combining a CADe system with a balloon-based mucosal exposure device increases…

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Negative / Null Result ReportMedicine

The role of social and emotional experience in representing abstract words.

Goriachun D, Strijkers K, Gala N et al. · 2025 · Journal of experimental psychology. General

words challenge embodied cognition theories due to their lack of direct connections to the sensory and bodily world. To address this, some theories propose that abstract words are represented through emotional and social information. We…

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Negative / Null Result ReportMedicine

PcrV in an intranasal adjuvanted tobacco mosaic virus conjugate vaccine mediates protection from Pseudomonas aeruginosa via an early Th1/Th17 skewed localized and systemic immune response.

Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine

Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…

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Negative / Null Result ReportMedicine

Cost does not prevent pigeons from investing in the future.

Cowie S, Davison M · 2025 · Behavioural processes

One of the simplest forms of behavior, operant behavior, appears fundamentally prospective, implying potential similarity to 'sophisticated' prospective behaviors like planning in terms of underlying mechanisms. But differences between…

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