e-ISSN: Pending
WASTE Journal

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Antibacterial resin infiltrants containing DMAHDM and NACP: Effects on antibacterial activity, cytotoxicity, and remineralization potential - an in vitro study.

Souza AF, Fraga MAA, Correr AB et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials

Objectives To evaluate the effects of incorporating the antibacterial monomer dimethylaminohexadecyl methacrylate (DMAHDM; 2.5% and 5% wt%) and amorphous calcium phosphate nanoparticles (NACP; 2 wt%) on the antibacterial activity,…

View details →
Negative / Null Result ReportMedicine

The relationship between fall risk, trochanteric soft tissue thickness, and hip fracture risk in older adults.

Johannesdottir F, Aspelund T, Mahar S et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Current fracture risk assessment does not directly include fall probability, despite the fact that most hip fractures resulting from falls. Additionally, the role of trochanteric soft tissue thickness (TST) in hip fracture risk remains…

View details →
Negative / Null Result ReportMedicine

Preharvest application of Meyerozyma guilliermondii LMA-Cp01 biofungicide combined with sodium benzoate for eco-friendly management of anthracnose disease on mango fruit.

López-Cruz R, Ragazzo-Sánchez JA, Calderón-Santoyo M · 2026 · Archives of microbiology

In this study, mango fruit trees cv. Kent (Mangifera indica L.) grown in Nayarit, Mexico, during the 2024 and 2025 seasons were preharvest-treated with four applications of microencapsulated Meyerozyma guilliermondii LMA-Cp01 (0.4 g L⁻¹),…

View details →
Negative / Null Result ReportMedicine

Protective effects of hydrogen-rich water against acute lead-induced hepatic, renal, and testicular toxicity in rats.

Kharazmi K, Saroughi M, Khoshniat MT et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

Lead exposure is linked to various adverse effects on human health, including toxicity to multiple organs such as the kidneys, liver, and reproductive system. Lead induces its toxic effects through complex pathways, including mitochondrial…

View details →
Negative / Null Result ReportMedicine

No Effect of a Single Session of Anodal Transcranial Direct Current Stimulation on Exercise-Induced Hypoalgesia in Knee Osteoarthritis: A Randomized Cross-Over Trial.

Toomey D, Lewis G, Rashid U et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society

Background Exercise induces short-term pain relief (exercise-induced hypoalgesia, EIH), but this response is often blunted in people with knee osteoarthritis (OA). Transcranial direct current stimulation (tDCS) has been proposed as a…

View details →
Negative / Null Result ReportMedicine

Therapeutic and Prophylactic Effects of the Surfactant Protein D Mimetic CGSPS18 Against Schistosoma mansoni in Biomphalaria alexandrina and Mice.

El-Karim RMG, Ali REM, Habib MR et al. · 2026 · Acta parasitologica

Bachground Schistosomiasis remains difficult to control due to persistent transmission via freshwater snails and reliance on praziquantel (PZQ) as the primary treatment. Novel adjunctive strategies targeting multiple stages of the parasite…

View details →
Negative / Null Result ReportMedicine

Can transcranial Direct Current Stimulation enhance the efficacy of a rehabilitative intervention for the treatment of Freezing of Gait in Parkinson's disease? A double-blind, randomized controlled study.

Madrid J, Batzianouli E, Rutz D et al. · 2026 · Journal of Parkinson's disease

BackgroundFreezing of gait (FOG) in Parkinson's disease (PD) is a major cause of disability and falls and often responds incompletely to conventional therapy. Rehabilitative interventions including cognitive strategies and sensory cueing…

View details →
Negative / Null Result ReportMedicine

A Combinatorial Strategy for Peripheral Nerve Repair Utilizing 3D-Printed Collagen Nerve Guidance Conduits and Photobiomodulation Therapy: A Pilot Study in a Rat Sciatic Nerve Transection Model.

Fellin CR, Steiner RC, Buchen JT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery

Background Nerve guidance conduits (NGCs) are a clinically approved option for peripheral nerve repair but remain ineffective compared with autograft "gold standard" treatment options. A combinatorial approach to conduit-based peripheral…

View details →
Negative / Null Result ReportMedicine

Full-fat meal, defatted meal, oil and chitin from black soldier fly in low and high soybean-based diets on growth performance and nutrient retention of rainbow trout

Riesenbach IC, Tsomik G, Chiasson M et al. · 2026 · Aquaculture.

Insects, such as black soldier flies (BSF), have garnered attention in the aquaculture industry as a sustainable protein and lipid alternative to fishmeal and fish oil. However, research is lacking on which components of BSF improve fish…

View details →
Negative / Null Result ReportMedicine

Respiratory Biofeedback Training as an Adjunct Intervention in Pulmonary Rehabilitation for Late-Stage COPD: A Pilot Trial.

Lagravinese G, Castellana G, Genco M et al. · 2026 · Applied psychophysiology and biofeedback

Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and psychological…

View details →
Negative / Null Result ReportMedicine

Evaluating the utility of ICG-based NIR imaging for small intestine neuroendocrine tumors: Challenges and the need for tumor-specific tracers.

Dalmeijer SWR, Zweedijk BE, Boldewijn DF et al. · 2026 · Surgical oncology

Purpose Accurate intraoperative localization of small intestinal neuroendocrine tumors (SI-NETs) remains a surgical challenge, with standard staging protocols frequently missing small primary or metastatic lesions. ICG has shown utility in…

View details →
Negative / Null Result ReportMedicine

Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo.

Broadley D, Le Riche A, Yu Y et al. · 2026 · International journal of molecular sciences

Androgen receptor (AR) signaling plays a key role in male pattern baldness. We investigated whether targeting Dickkopf 1 ( DKK1 ) and Secreted frizzled-related protein 1 ( SFRP1 ), two AR-regulated genes, offers a novel therapeutic…

View details →
Negative / Null Result ReportMedicine

The role of hyperthermia on abdominal tissue concentrations of cisplatin during and after intraperitoneal chemotherapy - insights from a porcine model.

Harlev C, Bue M, Petersen EK et al. · 2025 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Background Epithelial ovarian cancer remains a leading cause of mortality among gynecological malignancies, with a high incidence of peritoneal carcinomatosis at diagnosis. Hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a…

View details →
Negative / Null Result ReportOpen accessMedicine

Scheduled telephone support in internet-delivered cognitive behavioral therapy for depression: randomized controlled trials of two populations.

Pihlaja S, Lipsanen J, Ritola V et al. · 2026 · Frontiers in psychology

Among patients receiving internet-delivered cognitive behavioral therapy (iCBT) for depression in routine clinical practice, 101 patients were randomized to either iCBT as usual or to iCBT with add-on scheduled telephone support (STS).…

View details →
Negative / Null Result ReportMedicine

Concentration, Antibacterial Effect, and Safety of Combining Intra-articular Epsilon-Aminocaproic Acid and Vancomycin in Primary Total Knee Arthroplasty: A Randomized Study.

Zhang Y, Wei J, Su C et al. · 2025 · The Journal of arthroplasty

Background In this study, we aimed to investigate the intra-articular concentration, antibacterial effect, and safety of a combination of vancomycin and epsilon-aminocaproic acid (EACA) in primary total knee arthroplasty (TKA). Methods…

View details →
Negative / Null Result ReportMedicine

Effect of Individualised Homeopathic Medicine as Adjunct to Fluticasone Furoate for Allergic Rhinitis: A Prospective, Randomised, Open-Label, Controlled Trial.

Dixit AK, Sahoo AK, Sidam S et al. · 2025 · Homeopathy : the journal of the Faculty of Homeopathy

Allergic rhinitis (AR) impairs quality of life, with intranasal corticosteroids like fluticasone furoate as standard of care (SOC). Individualised homeopathic medicines (IHMs) are increasingly used as adjuncts, but robust evidence is…

View details →
Negative / Null Result ReportMedicine

Effects of OXXYSLAB Probiotic Supplementation on Blood Oxygenation and Hypoxic Symptoms in Healthy Individuals: A Controlled Normobaric Hypoxia Trial.

Marzola M, Marazzato M, Nutini R et al. · 2026 · High altitude medicine & biology

Marzola, Manuel, Massimiliano Marazzato, Roberto Nutini, Adriano Di Marzio, Francesca Baroli, Manuel Paolucci, Matteo De Angelis, Joanna Giuliano, Ambra Menichelli, Guglielmo Sferrati, Carmen Santangelo, Danilo Bondi, Gerardo Bosco, and…

View details →
Negative / Null Result ReportMedicine

Metabolic interoceptive rewards shape affect, but not action.

Fleming H, Whines A, Whelehan P et al. · 2026 · Biological psychology

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

View details →
Negative / Null Result ReportMedicine

Intranasal prime-boost immunization with trivalent influenza virus neuraminidase proteins and conserved HCA2 sequences fused to a circularly permuted E. coli heat-labile enterotoxin B subunit.

Hung HC, Jheng KW, Cheng HY et al. · 2026 · Vaccine

To develop a mucosal influenza vaccine, we used trivalent recombinant neuraminidase (NA) proteins in combination with a circularly permuted TT mutant of the E. coli heat-labile enterotoxin B subunit, LTB(TT), as a mucosal adjuvant.…

View details →
Negative / Null Result ReportMedicine

Burn severity modifies the impact of salvage logging on post-wildfire natural regeneration of Douglas-fir in interior British Columbia

McAulay J, Querejeta JI, Eskelson BNI et al. · 2025 · Forest Ecology and Management.

1.Exacerbated by climate change, wildfires in British Columbia, Canada, have increased in extent and severity, impacting forests, including commercially valuable species like interior Douglas-fir (Pseudotsuga menziesii var. glauca).…

View details →