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Browse the failure-mode index

11,417 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Impaired Goal-Directed Planning in Transdiagnostic Compulsivity Is Explained by Uncertainty About Learned Task Structure.

Sookud S, Martin I, Gillan CM et al. · 2026 · Biological psychiatry. Cognitive neuroscience and neuroimaging

Background Diminished use of goal-directed (model-based) decision making is a hallmark of transdiagnostic compulsivity, promoting an overreliance on inflexible and habitual behaviors. However, the origin of this impairment remains unclear.…

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Negative / Null Result ReportMedicine

Predictors and Outcomes Associated with Clinically Significant Improvements in Anxiety and Depression Symptoms Following Cardiac Rehabilitation.

Hernández L, Williamson TM, Campbell T et al. · 2025 · The Canadian journal of cardiology

Background Cardiac rehabilitation (CR) participation improves depressive and anxious symptoms post-coronary catheterization, yet it is unclear to what extent improvements are clinically significant. This study characterized the proportion…

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Negative / Null Result ReportMedicine

Water deficit induced by polyethylene glycol leads to the depletion of phenolic compounds but did not alter lignification in roots of Scots pine (Pinus sylvestris).

Ivanov YV, Kartashov AV, Ivanova AI et al. · 2026 · Functional plant biology : FPB

Global climate change is accompanied by an increase in the frequency and severity of droughts, which negatively impact plant growth. One of the protective mechanisms that allows plants to withstand the negative drought effects is the…

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Negative / Null Result ReportMedicine

Comparative effects of inactivation and dopamine receptor agents in the dorsolateral and dorsomedial striatum on performance of action sequences in rats.

Turner KM, Svegborn A, Robbins TW · 2026 · Psychopharmacology

Rationale Recent research on habits and skills has produced a wave of new theories regarding the shift in control from medial to lateral regions of the dorsal striatum, and how these regions are implicated in the selected and executed of…

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Negative / Null Result ReportMedicine

Saccharomyces cerevisiae and Bacillus subtilis show modest, node-dependent effects on insulin sensitivity in periparturient cows.

Pirbornatan A, Chalmeh A, Pourjafar M et al. · 2026 · Veterinary journal (London, England : 1997)

Periparturient immunometabolic adaptations yield small, node-dependent shifts in endotoxin proxies and insulin-sensitivity indices. Direct-fed microbials (DFM) are mechanistically plausible but often produce modest metabolic readouts. Test…

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Negative / Null Result ReportMedicine

Toxicological Assessment of Petroleum Product WAFs in Crassostrea gigas: Evidence for Sub-chronic Tolerance and Rapid PAC Depuration.

Hura A, Green T, Kennedy C · 2026 · Archives of environmental contamination and toxicology

With increasing petroleum transport through coastal waters of the northeastern Pacific, understanding the ecological hazards of these mixtures is essential, yet the sublethal impacts on benthic filter feeders remain poorly characterized.…

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Negative / Null Result ReportMedicine

Reduced electroencephalogram power and no change in peak alpha frequency in individuals with chronic migraine: a cross-sectional investigation.

Wong R, Robertson R, Meylakh N et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Objectives Electroencephalographic (EEG) studies suggest chronic migraine (CM) is associated with increased global power, especially in somatosensory cortex. Furthermore, recent studies suggest chronic pain is associated with a reduced…

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Negative / Null Result ReportMedicine

The Effects of 31-Day Exogenous Ketone Consumption on Running Performance, Cognitive Function, Metabolism, Body Composition, Hemodynamics, and Mood in Recreational Runners: A Randomized-Control Trial.

Prins PJ, Buga A, Storoschuk K et al. · 2026 · Journal of the American Nutrition Association

Background Exogenous ketone supplementation acutely elevates circulating beta-hydroxybutyrate ( R -BHB), but the impact of chronic repeated dosing on exercise performance, cognition, mood, and cardiometabolic health remains unclear.…

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Negative / Null Result ReportMedicine

Characterizing non-hallucinogenic psychedelics beyond the head twitch response: phenotypic fingerprinting of lisuride and LSD.

King JL, Effinger DP, Basquez-Pfeifer C et al. · 2026 · Translational psychiatry

The head-twitch response (HTR) is widely used as a preclinical assay for the hallucinogenic potential of compounds, with its utility based on 5HT 2A R activation. Here, we examine how the polypharmacological agonists lisuride and lysergic…

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Negative / Null Result ReportMedicine

Single-dose intravenous α2-agonists do not acutely alter anti-inflammatory bioactive protein profiles but reduce interleukin-8 in equine autologous protein solution and platelet-rich plasma.

Brown KA, Max LNF, Struble SE et al. · 2026 · American journal of veterinary research

Objective Determine the acute effects of xylazine and detomidine on concentrations of selected growth factors, cytokines, and α2-macroglobulin (A2M) in platelet-rich plasma (PRP) and autologous protein solution (APS) and the long-term…

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Negative / Null Result ReportMedicine

Acute and post-acute neurobehavioral responses to lysergic acid diethylamide in healthy subjects: a randomized controlled study.

Calder AE, Diehl VJ, Lietz MP et al. · 2026 · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Preclinical studies suggest that lysergic acid diethylamide (LSD) may induce lasting changes in brain function and learning ability, but evidence in humans is uncertain. Motor learning, in particular, has clinical relevance but has not…

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Negative / Null Result ReportMedicine

Goal orientation is a key determinant of healthy dietary behaviour change in European adults receiving personalised <i>vs.</i> non-personalised nutrition advice.

Abrahams M, Bunting BP, Frewer LJ et al. · 2026 · Food & function

Although personalised nutrition is more effective than generic approaches to dietary health promotion, effect sizes tend to be small. Behaviour change theory implies the importance of goal setting to successful health intervention. This…

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Negative / Null Result ReportMedicine

Supraphysiological androgen administration does not exert any additive benefits on hippocampal plasticity-related markers and behavior in previously untrained male mice.

Ben-Zeev T, Levi C, Ratamess NA et al. · 2026 · Hormones and behavior

This study examined the effects of resistance training (RT) and supraphysiological nandrolone decanoate (ND) administration on hippocampal neurogenesis, neurotrophic signaling, and behavior. Forty 3-month-old male C57BL/6 J mice were…

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Negative / Null Result ReportMedicine

Effect of transdermal testosterone on postmenopausal sexual desire: placebo-controlled randomized clinical trial.

Ceccatto Andrade VP, Araujo Júnior E, Callado GY et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objective The transdermal administration of testosterone is a promising alternative to improve sexual health in postmenopausal women with decreased sexual desire, although its use remains off-label in Brazil and several other countries.…

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Negative / Null Result ReportMedicine

Maternal exercise is associated with enhanced systolic reserve and altered mitochondrial respiration in adult female offspring.

Fang YJ, Gonzalez K, Konecny F et al. · 2026 · American journal of physiology. Heart and circulatory physiology

Maternal exercise may influence long-term cardiovascular health in offspring, yet its effects on intrinsic myocardial performance and mitochondrial metabolism remain incompletely defined. We investigated whether maternal voluntary wheel…

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