e-ISSN: Pending

Browse the failure-mode index

11,317 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Introduction of central fetal monitoring and impact on neonatal outcome - a retrospective observational cohort study.

Söröd M, Gyllencreutz E · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Introduction Cardiotocography (CTG) is used for fetal surveillance to prevent asphyxia related neonatal outcomes during pregnancy and delivery. In Sweden, all delivery wards have transitioned from CTG registered and printed on paper inside…

View details →
Negative / Null Result ReportMedicine

Dissecting the Impact of α-MSH-MC1R-cAMP Signaling on UVA-Induced Stress in Fibroblasts - Implications for Regulation of Cutaneous Photoaging.

Böhm M, Stegemann A, Wolnicka-Głubisz A et al. · 2026 · Aging and disease

Alpha-melanocyte-stimulating hormone (α-MSH) is a key endocrine mediator of photoprotection in the ultraviolet (UV)B-induced skin response. Its effects are mediated by the melanocortin-1 (MC1R) receptor and include increased eumelanin…

View details →
Negative / Null Result ReportMedicine

Relationship Between Mean Faecal Gastrointestinal Nematode Egg Excretion in Horses and Its Variability: Implications for Control.

Cabaret J, Guerrero Molina C, Martínez-Ortiz-de Montellano C et al. · 2026 · Pathogens (Basel, Switzerland)

Faecal egg counts (FECs) are used to assess the intensity of gastrointestinal nematode (GIN) infections in herbivores. FEC distribution is aggregated, meaning that approximately 20% of animals harbour 80% of infections. In times of…

View details →
Negative / Null Result ReportMedicine

High Programmed Death-Ligand 1 Expression is Associated With a Shorter Progression Free Survival in ALK-Rearranged Lung Cancer Patients Treated With First Line Tyrosine Kinase Inhibitors.

Nie Y, Staley A, Hinz TK et al. · 2026 · Clinical lung cancer

Background Although ALK-positive non-small cell lung cancer (NSCLC) derives limited benefit from immune checkpoint inhibitors, PD-L1 expression is frequently elevated at diagnosis. The clinical relevance of PD-L1 expression for the…

View details →
Negative / Null Result ReportMedicine

Acute effects of ketone monoester ingestion on monocyte phenotype and cytokine secretion in healthy humans.

Marcotte-Chénard A, Sandilands RE, Teixeira AA et al. · 2026 · American journal of physiology. Cell physiology

Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human…

View details →
Negative / Null Result ReportMedicine

The neuropsychophysiological correlates of compassion: A transcranial direct current stimulation (tDCS) study.

Vieira Y, Sobral M, Mateus V et al. · 2026 · International journal of psychophysiology : official journal of the International Organization of Psychophysiology

Transcranial direct current stimulation (tDCS) has emerged as a promising tool to investigate and modulate emotional and social processes, including compassion. By targeting cortical regions implicated in empathy and prosocial behaviour…

View details →
Negative / Null Result ReportMedicine

Control of breathing during hibernation in golden-mantled ground squirrels.

Harris MB, Milsom WK · 2025 · Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

During hibernation, golden-mantled ground squirrels (Spermophilus lateralis) breathe in distinct multi-breath episodes separated by prolonged periods of apnea. We hypothesized that vagal afferent feedback from pulmonary stretch receptors,…

View details →
Negative / Null Result ReportMedicine

Impact of orally and vaginally administered estradiol on live birth and neonatal outcomes in frozen-thawed embryo transfer cycles: A retrospective cohort study.

Liu Y, Sun J, Hu Y et al. · 2026 · Clinical and experimental reproductive medicine

Objective Previous studies have reported a higher rate of small for gestational age (SGA) newborns from fresh embryo transfers compared with frozen-thawed embryo transfers (FET), potentially due to the supraphysiologic serum estradiol…

View details →
Negative / Null Result ReportMedicine

Advanced glycation end-products accumulate preferentially in type I muscle fibers of aging adults but are unchanged by training and polyphenol supplementation.

Flensted-Jensen M, Kleis-Olsen AS, Weinreich CM et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)

Advanced glycation end-products (AGEs) accumulate with age and may contribute to skeletal muscle decline, yet their distribution within muscle compartments is unknown. Resistance training (RT) and high-intensity interval training (HIIT)…

View details →
Negative / Null Result ReportMedicine

Lipocalin-2 Is Induced by Uromodulin Aggregates without Affecting Kidney Disease Progression in Autosomal Dominant Tubulointerstitial Kidney Disease- UMOD.

Lake J, Mariniello M, Schiano G et al. · 2026 · Journal of the American Society of Nephrology : JASN

Key points Lipocalin-2 upregulation paralleled intracellular uromodulin aggregates in mouse and cellular models of autosomal dominant tubulointerstitial kidney disease because of pathogenic uromodulin. The induction of lipocalin-2 was…

View details →
Negative / Null Result ReportMedicine

Development and Evaluation of a Sham Diet Intended as a Placebo-Control Diet for Food-Based Interventional Trials in Ulcerative Colitis.

Day AS, Ballard TM, Benetti M et al. · 2026 · Journal of the Academy of Nutrition and Dietetics

Background The "gold standard" for successful blinding in controlled food-based dietary interventional trials includes a sham diet. Objective This study aimed to develop and evaluate a sham diet intended for use as a comparator in…

View details →
Negative / Null Result ReportMedicine

Impacts of methionine oxidation on product quality and anti-tumor activity of a therapeutic monoclonal antibody.

Sun Q, Miao Z, Bian L et al. · 2026 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Methionine oxidation in monoclonal antibodies (mAbs) could critically compromise drug stability and efficacy. This investigation comprehensively evaluated the structural and functional impacts of oxidation on a mAb An under long-term…

View details →
Negative / Null Result ReportMedicine

Bi-functional activity of chlorophyllin: Antifungal action against Botrytis cinerea and induction of grapevine defense genes.

Messanh KV, Muhie Ddine M, Ambrosini V et al. · 2026 · Journal of photochemistry and photobiology. B, Biology

Botrytis cinerea (B. cinerea) is a fungus with a high mutation rate and infects more than 200 plant species, causing significant yield losses. Therefore, new strategies to fight against this ubiquitous phytopathogen are highly sought…

View details →
Negative / Null Result ReportOpen accessMedicine

Postoperative C-Reactive Protein Trajectories in Spine Surgery - Influence of Vancomycin Powder: A Secondary Analysis of a Prospective Randomized Controlled Trial.

Panzenböck LF, Abdel Nour G, Dürrschnabel DL et al. · 2026 · Global spine journal

Study DesignRandomized controlled trial.ObjectivesTo characterize postoperative C-reactive protein (CRP) trajectories as predictors of surgical site infection (SSI) following lumbar spine surgery, to determine optimal CRP thresholds, and…

View details →
Negative / Null Result ReportMedicine

The potential of cell-free supernatants from Lacticaseibacillus paracasei B1 and Lactiplantibacillus plantarum O24 as antioxidant and antimicrobial agents

Kęska P, Zielińska D, Karbowiak M et al. · 2025 · Food Chemistry

The aim of this study was to evaluate the effectiveness of cell-free supernatants (CFS) produced by selected lactic acid bacteria (LAB) strains: Lacticaseibacillus paracasei B1 and Lactiplantibacillus plantarum O24 as antioxidant and…

View details →