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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The role of allopurinol in metabolic dysfunction-associated steatotic liver disease: A randomized clinical trial.

Khani E, Khoshbaten M, Jafarabadi MA et al. · 2026 · Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

Background and study aims Despite being the leading cause of liver-related mortality, the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD) remains challenging. This study aimed to assess the effects of…

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Negative / Null Result ReportMedicine

BDNF Val66Met polymorphism is linked to elevated levels of serotonin-transporter in the medial prefrontal cortex but not to altered eating behavior.

McLeod A, Rullmann M, Hinderberger P et al. · 2026 · Neuroscience

A single nucleotide polymorphism in the brain derived neurotrophic factor (BDNF)-encoding gene leads to diminished BDNF signaling resulting from Val66Met and has been linked to obesity. Previous imaging studies regarding the impact of BDNF…

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Negative / Null Result ReportMedicine

Presence and correlation of potentially toxic elements in honey, pollen, and soil samples in Kosovo.

Kastrati G, Sopaj F, Bytyqi V et al. · 2025 · Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

The study involved the determination of the concentrations of 11 potentially toxic elements (PTEs) in soil, honey, and pollen samples collected in the territory of Kosovo, followed by a statistical analysis. Inductively coupled…

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Negative / Null Result ReportMedicine

Peer victimization and emotion regulation strategies in adolescents: A cross-lagged panel model.

Alexander KN, Turner MS, Salazar JP et al. · 2025 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Many adolescents experience peer victimization during this critical period for development. Emotion regulation strategies, including cognitive reappraisal and emotional suppression, can help adolescents cope with such experiences. Although…

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Negative / Null Result ReportMedicine

Age, Intersectional Discrimination, and Health in Black Transgender Women.

Grant S, Goldberg E, Gadipudi A et al. · 2025 · Journal of racial and ethnic health disparities

Black transgender women report high levels of discrimination, which is associated with poor health outcomes. Some evidence suggests that intersectional discrimination-that is, interacting forms of marginalization related to one's real or…

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Negative / Null Result ReportOpen accessMedicine

Understanding how a tap on/tap off system supports clinical work in an emergency department: a qualitative study.

Baysari M, Stanceski K, Bamgboje-Ayodele A et al. · 2026 · BMC medical informatics and decision making

Background Single sign-on (SSO), tap-on-tap-off (TOTO) and virtual desktops (VD) are increasingly being used in hospitals to reduce the burden and risks of password management, but we know little about how these systems are used in…

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Negative / Null Result ReportMedicine

AI and healthcare: surveying patient perspectives on artificial intelligence in neurosurgery.

Shah H, Ali M, Kilgallon JL et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Neurosurgery and neurosurgical care continues to evolve and to embrace technological advances. AI is used to interpret radiological studies and to distill medical information, with the potential to help guide physicians and patients in…

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Negative / Null Result ReportMedicine

Changes in Peri-Implant Soft Tissue Dimensions Following Soft Tissue Contour Augmentation: A 3-Year Follow-Up of a Multi-Center RCT.

Jepsen K, Jepsen S, Hämmerle CHF et al. · 2026 · Clinical oral implants research

Aim To assess 3-year changes of peri-implant tissues following previous soft tissue (volume) augmentation (STA) with a volume-stable collagen matrix (VCMX) or connective tissue (SCTG) at single-implant restorations. Material and methods In…

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Negative / Null Result ReportMedicine

Parental care liberates juvenile growth: a common-garden test of the evolutionary benefits of care.

Eggert AK, Prang MA, Capodeanu-Nägler A et al. · 2026 · Evolution; international journal of organic evolution

Effects on juvenile growth have long been considered an important benefit of parental care, but they have rarely been tested empirically. Protection and feeding by parents might accelerate offspring growth by allowing offspring to allocate…

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Negative / Null Result ReportMedicine

Evaluation of passive immunity from dams previously immunized with an inactivated glycoprotein E-deleted infectious bovine rhinotracheitis marker vaccine after challenge infection with wild-type bovine alphaherpesvirus 1 in calves

Petrini S, Martucciello A, Righi C et al. · 2025 · Vaccine: X

Bovine alphaherpesvirus 1 (BoAHV-1) is a major cattle pathogen that causes infectious bovine rhinotracheitis (IBR) and other respiratory and reproductive disorders, resulting in substantial global economic losses to the cattle industry.…

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Negative / Null Result ReportMedicine

Comparative population genetic structure of the mitochondrial 16S ribosomal RNA gene of Haemaphysalis flava (Acari: Ixodidae) between Nantong, China, and regions along the East Asia-Australasian Flyway.

Su J, Zhang WB, Sun B et al. · 2025 · Experimental & applied acarology

Haemaphysalis flava Neumann, 1897 is recognized as a vector for Dabie bandavirus (severe fever with thrombocytopenia syndrome virus, SFTSV), which is the etiological agent of severe fever with thrombocytopenia syndrome (SFTS). The tick…

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Negative / Null Result ReportOpen accessMedicine

Comparison of Extraction Socket Healing in Patients with Type 2 Diabetes on Oral Hypoglycemics Versus Nondiabetic-Original Research.

Edsor E, Jose M, Sajesh S et al. · 2025 · Journal of pharmacy & bioallied sciences

Background The aim of this study is to assess whether there is a difference in the wound healing process following the extraction of a tooth between type 2 diabetes patients on oral hypoglycemic medications and nondiabetic patients.…

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