Negative / Null Result ReportMedicine
Susanna Wiegand, Dagmar l’Allemand, Hanna Hübel et al. · 2010 · European Journal of Endocrinology
OBJECTIVE: To study whether metformin reduces obesity, homeostasis model assessment for insulin resistance index (HOMA-IR), and the metabolic syndrome (MtS) in obese European adolescents in addition to previous unsuccessful lifestyle…
View details →Negative / Null Result ReportOpen accessMedicine
Claudia Torino, Fabio Manfredini, Davide Bolignano et al. · 2014 · Kidney & Blood Pressure Research
BACKGROUND/AIMS: Scarce physical activity predicts shorter survival in dialysis patients. However, the relationship between physical (motor) fitness and clinical outcomes has never been tested in these patients. METHODS: We tested the…
View details →Negative / Null Result ReportMedicine
Leigh L. van den Heuvel, Nathaniel Chishinga, Eugene Kinyanda et al. · 2013 · AIDS Care
We determined the frequency and correlates of current common mental disorders (CMDs) in a consecutive series of 649 adult patients with human immunodeficiency virus (HIV), tuberculosis (TB) or both receiving treatment at 16 primary health…
View details →Negative / Null Result ReportOpen accessMedicine
Kelly A. Liebman, Steven T. Stoddard, Amy C. Morrison et al. · 2012 · PLoS neglected tropical diseases
BACKGROUND: Knowledge of spatial patterns of dengue virus (DENV) infection is important for understanding transmission dynamics and guiding effective disease prevention strategies. Because movement of infected humans and mosquito vectors plays a role in the spread and persistence of virus, spatial dimensions of transmission can range from small household foci to large community clusters. Current understanding is limited because past analyses emphasized clinically apparent illness and did not account for the potentially large proportion of inapparent infections. In this study we analyzed both c
View details →Negative / Null Result ReportOpen accessMedicine
Rachna T. Shroff, Mark Yarchoan, Ashley O’Connor et al. · 2017 · British Journal of Cancer
BACKGROUND: Cholangiocarcinoma is an aggressive malignancy with limited therapeutic options. MEK inhibition and antiangiogenic therapies have individually shown modest activity in advanced cholangiocarcinoma, whereas dual inhibition of…
View details →Negative / Null Result ReportOpen accessMedicine
H Grubek-Jaworska, Magdalena Paplińska‐Goryca, Joanna Hermanowicz-Salamon et al. · 2012 · Respiration
BACKGROUND: IL-6 is strongly implicated in the development of chronic obstructive pulmonary disease (COPD). IL-13 is the well-documented central mediator in allergic asthma. IL-6 is attributed to the proinflammatory activities in COPD as…
View details →Negative / Null Result ReportMedicine
Ali A. Farooqui, Bradley Hiser, Stephen L. Barnes et al. · 2013 · Journal of neurosurgery
OBJECT: Patients with traumatic brain injury (TBI) are at risk for development of thromboembolic disease. The use of chemoprophylaxis in this patient group has not fully been characterized. The authors hypothesize that early…
View details →Negative / Null Result ReportOpen accessMedicine
Francesco Sclafani, Tae‐Yop Kim, David Cunningham et al. · 2015 · JNCI Journal of the National Cancer Institute
BACKGROUND: Insulin-like growth factor type 1 receptor (IGF-1R) mediates resistance to epidermal growth factor receptor (EGFR) inhibition and may represent a therapeutic target. We conducted a multicenter, randomized, double blind, phase…
View details →Negative / Null Result ReportMedicine
Edward S. Brewer, B. I. Reznikov, Rebecca F. Liberman et al. · 2010 · The Journal of Trauma: Injury, Infection, and Critical Care
BACKGROUND: The yield of head computed tomography (CT) for patients who suffered head trauma with a presenting Glasgow Coma Scale (GCS) score of 15 has been reported to be low, even in patients who are anticoagulated or on antiplatelet…
View details →Negative / Null Result ReportOpen accessMedicine
Susan M. Smith, Tom Fahey, John Smucny et al. · 2017 · Cochrane Database of Systematic Reviews
Background The benefits and risks of antibiotics for acute bronchitis remain unclear despite it being one of the most common illnesses seen in primary care. Objectives To assess the effects of antibiotics in improving outcomes and to…
View details →Negative / Null Result ReportMedicine
Sung‐Wan Kim, Joon‐An Yoo, S. Y. Lee et al. · 2010 · Human Psychopharmacology Clinical and Experimental
OBJECTIVE: This study compared the effectiveness of risperidone and olanzapine in the treatment of delirium. METHODS: This was a 7-day, randomized, comparative clinical trial of risperidone and olanzapine in patients with delirium. The…
View details →Negative / Null Result ReportOpen accessMedicine
Syed Khalid, Ravi S. Nunna, Samantha Maasarani et al. · 2020 · Neurosurgical FOCUS
OBJECTIVE: Patients with osteopenia or osteoporosis who require surgery for symptomatic degenerative spondylolisthesis may have higher rates of postoperative pseudarthrosis and need for revision surgery than patients with normal bone…
View details →Negative / Null Result ReportOpen accessMedicine
Patricia Baxter, Jack M. Su, Arzu Onar‐Thomas et al. · 2020 · Neuro-Oncology
BACKGROUND: A Pediatric Brain Tumor Consortium (PBTC) phase I/II trial of veliparib and radiation followed by veliparib and temozolomide (TMZ) was conducted in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). The…
View details →Negative / Null Result ReportOpen accessMedicine
William W. Ho, Igor L. Gomes‐Santos, Shuichi Aoki et al. · 2021 · Proceedings of the National Academy of Sciences
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair-proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here…
View details →Negative / Null Result ReportMedicine
Mark A. Hyde, Michael L. Hadley, Payam Tristani‐Firouzi et al. · 2012 · Archives of Dermatology
OBJECTIVE: To determine if the complete response rates of lentigo maligna (LM) to imiquimod, 5%, cream can be improved by the addition of a topical retinoid. DESIGN: Prospective randomized study of patients treated with imiquimod alone vs…
View details →Negative / Null Result ReportOpen accessMedicine
Allon N. Friedman, Mary Chambers, Lisa M. Kamendulis et al. · 2013 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Obesity precedes and is strongly linked to the development of type 2 diabetic nephropathy in most patients, yet little is known about the effects of weight reduction on this disease. This study aimed to establish…
View details →Negative / Null Result ReportOpen accessMedicine
Elisa Maria Stroppa, Ilaria Toscani, Chiara Citterio et al. · 2020 · Future Oncology
Background: We describe cancer patients with coronavirus disease-2019 (COVID-19) infection treated at the Piacenza’s general hospital (north Italy). Materials & methods: 25 cancer patients infected by COVID-19 admitted at the Piacenza’s…
View details →Negative / Null Result ReportOpen accessMedicine
David Hodgson, Richard Pebody, Jasmina Panovska‐Griffiths et al. · 2020 · BMC Medicine
BACKGROUND: With a suite of promising new RSV prophylactics on the horizon, including long-acting monoclonal antibodies and new vaccines, it is likely that one or more of these will replace the current monoclonal Palivizumab programme. However, choosing the optimal intervention programme will require balancing the costs of the programmes with the health benefits accrued. METHODS: To compare the next generation of RSV prophylactics, we integrated a novel transmission model with an economic analysis. We estimated key epidemiological parameters by calibrating the model to 7 years of historical ep
View details →Negative / Null Result ReportOpen accessMedicine
Xuling Lin, M. Lee, Olivia Buck et al. · 2016 · American Journal of Neuroradiology
BACKGROUND AND PURPOSE: Glioblastoma and primary CNS lymphoma dictate different neurosurgical strategies; it is critical to distinguish them preoperatively. However, current imaging modalities do not effectively differentiate them. We aimed to examine the use of DWI and T1-weighted dynamic contrast-enhanced–MR imaging as potential discriminative tools. MATERIALS AND METHODS: We retrospectively reviewed 18 patients with primary CNS lymphoma and 36 matched patients with glioblastoma with pretreatment DWI and dynamic contrast-enhanced–MR imaging. VOIs were drawn around the tumor on contrast-enhan
View details →Negative / Null Result ReportOpen accessMedicine
Martin D. Hoffman, Julie L. Ingwerson, Ian R. Rogers et al. · 2012 · Wilderness and Environmental Medicine
OBJECTIVE: Very high blood creatine kinase (CK) concentrations have been observed among recent finishers of the 161-km Western States Endurance Run (WSER), and it has been suggested that there is a link between rhabdomyolysis and…
View details →Negative / Null Result ReportMedicine
Caner Süsal, Dániel Wettstein, Bernd Döhler et al. · 2015 · Transplantation
BACKGROUND: The association of donor-specific HLA antibodies (DSA) with kidney graft failure has been addressed previously; however, the majority of studies were based on small numbers of patients with graft failure. METHODS: We…
View details →Negative / Null Result ReportOpen accessMedicine
Azra Fatima, Shao Kaifeng, Sven Dittmann et al. · 2013 · PLoS ONE
Long QT syndromes (LQTS) are heritable diseases characterized by prolongation of the QT interval on an electrocardiogram, which often leads to syncope and sudden cardiac death. Here we report the generation of induced pluripotent stems (iPS) cells from two patients with LQTS type 3 carrying a different point mutation in a sodium channel Nav1.5 (p.V240M and p.R535Q) and functional characterization of cardiomyocytes (CM) derived from them. The iPS cells exhibited all characteristic properties of pluripotent stem cells, maintained the disease-specific mutation and readily differentiated to CM. Th
View details →Negative / Null Result ReportMedicine
A. Sertaç Batıoğlu, Uğraş Şahin, Beril Gürlek et al. · 2011 · Gynecological Endocrinology
The aim of the study was to evaluate the efficacy of melatonin administration on oocyte quality in women underwent in vitro fertilization (IVF) cycles. Eighty-five women undergoing IVF cycles were randomized in two groups during IVF-embryo…
View details →Negative / Null Result ReportOpen accessMedicine
Martin Michaelis, Bishr Agha, Florian Rothweiler et al. · 2015 · Scientific Reports
Flubendazole was shown to exert anti-leukaemia and anti-myeloma activity through inhibition of microtubule function. Here, flubendazole was tested for its effects on the viability of in total 461 cancer cell lines. Neuroblastoma was identified as highly flubendazole-sensitive cancer entity in a screen of 321 cell lines from 26 cancer entities. Flubendazole also reduced the viability of five primary neuroblastoma samples in nanomolar concentrations thought to be achievable in humans and inhibited vessel formation and neuroblastoma tumour growth in the chick chorioallantoic membrane assay. Resis
View details →Negative / Null Result ReportOpen accessMedicine
Raffaele Garofalo, Brody A. Flanagin, Alessandro Castagna et al. · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Complex proximal humeral fractures are very difficult to treat particularly in patients older than 65 years with an osteoporotic bone and tuberosities compromised. The goal of this paper is to evaluate radiological outcomes at mid-term follow-up of proximal humerus fractures treated with reverse shoulder arthroplasty using a dedicated fracture stem. MATERIALS AND METHODS: The study population included 98 patients who underwent reverse shoulder with a dedicated fracture stem for an acute proximal humerus fracture; 87/98 patients were available for analysis. There were 62 female and
View details →Negative / Null Result ReportOpen accessMedicine
Karolina Partheen, Björg Kristjánsdóttir, Karin Sundfeldt · 2011 · Journal of Gynecologic Oncology
OBJECTIVE: Women presenting with a large or complex ovarian cyst are referred to extensive surgical staging to ensure the correct diagnosis and treatment of a possible epithelial ovarian cancer. We hypothesized that measurement of the…
View details →Negative / Null Result ReportOpen accessMedicine
Yan Xu, Sam Schulman, Dar Dowlatshahi et al. · 2017 · CHEST Journal
BackgroundDirect oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin…
View details →Negative / Null Result ReportMedicine
Bill Hesselmar, Robert Saalman, Anna Rudin et al. · 2010 · Acta Paediatrica
OBJECTIVE: To investigate if the development of allergic diseases during the child's first 18 months of life is influenced by the time at which different food items were introduced into the child's diet. METHOD: A birth cohort of 184…
View details →Negative / Null Result ReportOpen accessMedicine
Elisa V. Bandera, Melony King, Urmila Chandran et al. · 2011 · BMC Women s Health
BACKGROUND: While there is extensive literature evaluating the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer has received little attention. METHODS: We conducted a population-based case-control study to evaluate phytoestrogen intake from foods and supplements and epithelial ovarian cancer risk. Cases were identified in six counties in New Jersey through the New Jersey State Cancer Registry. Controls were identified by random digit dialing, CMS (Centers for Medicare and Medicaid Service) lists, and area sampling. A total of 205 cases and 390 controls were
View details →Negative / Null Result ReportOpen accessMedicine
Junya Ako, Kiyoshi Hibi, Kenichi Tsujita et al. · 2019 · Circulation Journal
BACKGROUND: In patients with acute coronary syndrome (ACS), alirocumab reduced the risk of recurring ischemic events. ODYSSEY J-IVUS assessed the effect of alirocumab on coronary atheroma volume in Japanese patients recently hospitalized…
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