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11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A study comparing the efficacy of R-CHOP and R-DA-EPOCH regimens in young, high-risk treatment-naïve diffuse large B-cell lymphoma patients: a multicenter retrospective analysis.

Lan H, Ding Y, Liu M · 2026 · American journal of cancer research

Background Patients with high-risk diffuse large B-cell lymphoma (DLBCL) have poor prognoses, and the comparative efficacy between R-CHOP and R-DA-EPOCH regimens remains controversial. Objective To compare the efficacy and safety of R-CHOP…

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Negative / Null Result ReportMedicine

Novel use of intrauterine instillation of Hyaluronan enriched media on clinical outcomes of intrauterine insemination treatment: a pilot randomized controlled trial.

Yadav D, Ghuman NK, Kathuria P et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objective To study the effect of intrauterine instillation of Hyaluronan enriched media on reproductive outcomes of intrauterine insemination treatment. Design and participants 100 couples with unexplained infertility were approached and…

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Negative / Null Result ReportOpen accessMedicine

Screening and Cohorting of CRE Patients: The Strategic Role of Bed Management in a Monocentric Pre-Post Observational Study.

Altavilla S, Di Pietro N, Loconsole D et al. · 2026 · Antibiotics (Basel, Switzerland)

Background Carbapenem-resistant Enterobacterales (CRE) require early identification and appropriate patient placement to prevent in-hospital transmission. Bed Management plays a key organizational role in coordinating screening results and…

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Negative / Null Result ReportMedicine

The clinicopathologic characteristics and outcomes of uncommon KRAS mutations in patients with non-small cell lung cancer.

Zhang Y, Zhao J, Gao Q et al. · 2026 · Virchows Archiv : an international journal of pathology

Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25-30% of non-small cell lung cancer (NSCLC) patients. Pooled analyses in previous research have largely focused on the prognostic and predictive value of overall or…

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Negative / Null Result ReportOpen accessMedicine

Efficacy and Safety of PHPV Fusion Factor Vaginal Gel (PHPV®) in Clearing Cervical Persistent High-Risk Human Papillomavirus Infection: A Randomized Controlled Clinical Trial.

Yan L, Yin H, Shi L et al. · 2026 · Drug design, development and therapy

Purpose To evaluate the efficacy and safety of PHPV in the treatment of persistent high-risk papillomavirus (hrHPV) infection of the cervix. Patients and methods A randomized controlled trial (RCT) was conducted on patients with persistent…

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Negative / Null Result ReportMedicine

Evaluating the Effectiveness of Bloom's Taxonomy-Based Occupational Exposure Prevention in Oral Emergency Departments: A Quasi-Experimental Study.

Shi Y, Shen Y, Zhou X et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Objective To evaluate a Bloom's Taxonomy-based occupational exposure (OE) prevention program's impact on dental trainees' competencies compared to conventional training, assessing knowledge, skills, satisfaction, and exposure rates to…

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Negative / Null Result ReportMedicine

CLINICAL CHARACTERISTICS, IMAGING EFFICACY, AND SAFETY OF MRI-GUIDED FOCUSED ULTRASOUND ABLATION (FUS-MRI) IN THE TREATMENT OF UTERINE FIBROIDS: A SINGLE-CENTER EXPERIENCE.

Meirmanova M, Abiltayeva A, Noso Y et al. · 2026 · Georgian medical news

Introduction Uterine fibroids remain one of the most common benign tumors of the female reproductive system and a significant cause of menorrhagia, pain, symptoms of pelvic organ compression, and a reduced quality of life. Due to the…

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Negative / Null Result ReportMedicine

A Biodegradable Polymeric Sealant Applied to Transected Margin Following Stapled Distal Pancreatectomy Reduces Overall Complication: A Randomised Controlled Trial.

Furtado R, Weinberg L, Haghighi KS et al. · 2026 · ANZ journal of surgery

Background Postoperative pancreatic fistula (POPF) is the primary cause of morbidity after distal pancreatectomy (DP). This trial investigated the application of a combined polyethylene glycol (PEG) and recombinant human albumin sealant…

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Negative / Null Result ReportMedicine

Functional and quality of life outcomes following surgical treatment for cauda equina syndrome: A retrospective tertiary centre study.

Kumar A, Aduri TT, Dhatt SS et al. · 2026 · Journal of clinical orthopaedics and trauma

Background This study evaluated bladder, bowel, and sexual function outcomes following surgical decompression for cauda equina syndrome (CES) using urodynamic studies (UDS) and patient-reported outcome measures (PROMs), and explored the…

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Negative / Null Result ReportMedicine

Effect of 0.01% Atropine on Choroidal Thickness and Ocular Growth in Pre-myopic Children.

He M, Wang L, Zhang S et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose To investigate the effect of nightly 0.01% atropine eye drops on choroidal thickness (ChT) in pre-myopic children (at risk of myopia). Methods In a 12-month randomised, double-blind, placebo-controlled trial, 54 children aged 5-12…

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Negative / Null Result ReportMedicine

Potentially impaired dynamic ankle control despite increased eversion and first-ray plantarflexion strength after peroneus longus tendon harvest for anterior cruciate ligament reconstruction: an observational study.

Masoud M, El-Assal MA, Ibrahim MA et al. · 2026 · International orthopaedics

Background The peroneus longus tendon (PLT) has emerged as a promising graft option for anterior cruciate ligament reconstruction (ACLR), with acceptable outcomes; however, concerns have been raised about potential donor-site morbidity,…

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Negative / Null Result ReportMedicine

Association between echocardiographic parameters and white matter hyperintensities in patients with ischemic cerebrovascular disease.

Zhang Y, Wang Y, You S et al. · 2026 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background White matter hyperintensities (WMHs) are associated with an increased risk of stroke, cognitive decline, and all-cause mortality. However, the relationship between cardiac function, particularly left ventricular ejection…

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Negative / Null Result ReportMedicine

Evaluation of 4 Different Suture Threads in A Sample of Dentistry Suture-Naïve Students: A Randomised Controlled Trial.

Davide S, Domenico M, Fabio C et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Introduction Suturing is a crucial step in oral surgery, directly affecting wound healing quality. Simple interrupted suture is widely used in dentistry, often performed by novices using silk sutures due to their ease of use and low cost.…

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Negative / Null Result ReportMedicine

Effect of Arthroscopic Rotator Cuff Repair Combined With Different Long Head of the Biceps Tendon Fixation Techniques on Postoperative Clinical Outcomes and Shoulder Function.

Guan J, Chen Y, Ye J et al. · 2026 · Annali italiani di chirurgia

Aim Rotator cuff tears and long head of the biceps tendon (LHBT) injuries are primary causes of shoulder pain. During rotator cuff repair, concurrent LHBT injuries are frequently identified. Surgical management of LHBT injuries can…

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Negative / Null Result ReportMedicine

Enhanced biomechanical outcomes of split-thickness skin grafts with a three-dimensional collagen-elastin matrix in deep second-degree burns: A 12-month comparative study.

Nicklas A, Bienger K, Rudari M et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Background Split-thickness skin grafting (STSG) remains the standard for deep second-degree burns, but grafted skin often shows suboptimal biomechanical properties. The dermal substitute MatriDerm® may improve elasticity, structural…

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Negative / Null Result ReportMedicine

Mid- and long-term results of primary vs. secondary total elbow arthroplasty after index intra-articular fracture of the distal humerus in the elderly.

Deml O, Schenk P, Fritsche C et al. · 2026 · Journal of shoulder and elbow arthroplasty

Background Geriatric distal humerus fractures are difficult to manage. Open reduction and internal fixation remain the standard, but total elbow arthroplasty (TEA) appears to be a viable alternative. This study evaluated the long-term…

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Negative / Null Result ReportMedicine

Validation of aortic valve calcification quantification on contrast-enhanced computed tomography against ex vivo gravimetric analysis: comparison of fixed Hounsfield unit thresholds and deep learning segmentation.

Jiang D, Zhang W, Liu L et al. · 2026 · BMC cardiovascular disorders

Background Accurate quantification of aortic valve calcification (AVC) on contrast-enhanced computed tomography angiography (CTA) is pivotal for planning surgical and transcatheter aortic valve replacement. The optimal Hounsfield unit (HU)…

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Negative / Null Result ReportMedicine

Examination of elevated myocardial extracellular volume and exercise capacity in pediatric Fontan patients at moderate altitude.

Arnouts EC, Drysdale ND, Gerstner Saucedo J et al. · 2026 · Pediatric radiology

Background Diffuse myocardial fibrosis, as measured by T1 (longitudinal relaxation time) mapping and extracellular volume, may be associated with ventricular dysfunction in the Fontan circulation. However, the relationship between diffuse…

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Negative / Null Result ReportMedicine

Development and evaluation of the IPEConnect model: A quasi-experimental study to enhance interprofessional collaboration among health students.

Hadi M, Natashia D, Purwati NH et al. · 2026 · Nurse education today

Background Effective interprofessional collaboration is essential for optimal patient care, but inadequate training often hinders teamwork and communication among healthcare professionals. Interprofessional Education (IPE) can address this…

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Negative / Null Result ReportMedicine

Night shift work and epigenetic modifications: cardiovascular-related miRNA expression within a European cohort of night shift workers.

Harding BN, Jiang Z, Pineda D et al. · 2026 · Environmental health : a global access science source

Background The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to…

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Negative / Null Result ReportMedicine

Development of a therapeutic education program for patients with chronic rhinosinusitis with nasal polyps.

Perrignon C, Baudouin R, Perrignon M et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease that affects 1-4% of the population and markedly impairs quality of life, daily functioning, and socio-professional activities. As no…

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