11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bermingham MD, Meredith RT, Mills H et al. · 2026 · Frontiers in allergy
Quantifying food allergens in complex matrices is hindered by thermal processing, particularly in baked products used for oral food challenges (OFCs), where limited data exists on effects on clinically relevant allergens. To address this,…
View details →Kennedy J, Cooley SA, Roman Fox J et al. · 2026 · The Journal of infectious diseases
Background As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This…
View details →Kuo MC, Younan SA, Williams PJ et al. · 2026 · Techniques in coloproctology
Background Robotic approach is increasingly being used for surgery in Crohn's disease. Robotic ileocolic resection (ICR) for Crohn's disease (CD) is comparable to laparoscopic ICR for short term outcomes; however, no studies have compared…
View details →Jankovič P, Chodzyński KJ, Vanrossomme AE et al. · 2026 · Neurology international
Background The risk stratification of unruptured intracranial aneurysms (UIAs) relies largely on static clinical and morphological parameters, which may not fully capture aneurysm-specific wall behavior. ECG-gated four-dimensional computed…
View details →Mirza S, Fine L, McClure JA et al. · 2026 · Antibiotics (Basel, Switzerland)
Background Staphylococcus aureus acquires methicillin resistance genes through the SCC mec element. Although spontaneous SCC mec excision has been observed, its frequency, type-specific variation, and responsiveness to environmental…
View details →Buttke DE, Kaplan BS, Jones LC et al. · 2026 · Journal of wildlife diseases
Mycoplasma bovis is a growing threat to American bison (Bison bison) health and restoration efforts, causing significant mortality and disease in affected bison herds. Despite this, little is known about the epidemiology or clinical course…
View details →Oehring D · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Purpose Non-invasive tear film metrics from automated topographers are used increasingly, yet device-specific analytical performance remains incompletely characterised. This study quantified the analytical performance of the Oculus…
View details →Torkan A, Zoghi M, Foroughimehr N et al. · 2026 · Sensors (Basel, Switzerland)
The rapid global expansion of 5G technology has increased concerns regarding its potential health effects. Postural balance, a complex sensorimotor function reflecting central nervous system integrity, may be susceptible to electromagnetic…
View details →Aguiar Pavesi RO, Boening A, Meyrelles SDS et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Background The 6-minuteute step test is an alternative for estimating cardiorespiratory fitness after stroke. Objective To investigate its measurement properties and minimal detectable change early after stroke. Methods Cross-sectional,…
View details →Bell KS, Chen R, Weitzner AS et al. · 2026 · Journal of biological rhythms
The circadian system coordinates daily physiology across nearly all tissues to temporally organize metabolism and maintain homeostasis. In the brain, circadian timing regulates neural activity, cellular function, and neuroimmune signaling,…
View details →Scilipoti P, Callenmark M, Garmo H et al. · 2026 · European urology open science
Background and objective There are several methods for estimating prostate-specific antigen (PSA) doubling time (DT), and many men exhibit long periods of undetectable PSA below 0.1 ng/ml after radical prostatectomy (RP). We quantified…
View details →van Caelenberg E, Belpaire A, Dewaele D et al. · 2026 · Clinical and experimental dermatology
Background The Severity of Alopecia Tool (SALT) score is widely used. However, its inter- and intrarater reliability and smallest detectable difference (SDD) have not been rigorously evaluated. Objectives To determine the interrater and…
View details →Keshavarzi F, Arazpour M, Behzadipour S · 2026 · JMIR biomedical engineering
Background The application of spinal orthoses and local vibration in the treatment of hyperkyphosis is a developing concept. Further research is needed to determine the impact of leaf springs and local vibration techniques on the…
View details →McCaughan KJ, Danyluk MD, Kniel KE · 2026 · Applied and environmental microbiology
Tilling under is a method growers employ in an effort to remediate instances of widespread contamination in fields of crops, but its effectiveness with respect to specific pathogens remains poorly understood. This study had two overarching…
View details →Zhang S, Zhang H, Dong X et al. · 2026 · Frontiers in immunology
Background Radical cystectomy remains a standard curative treatment for muscle-invasive bladder cancer (MIBC). Bladder preservation after systemic therapy without immediate surgery remains investigational and requires careful patient…
View details →Swaine T, Bhagani S · 2026 · Current opinion in HIV and AIDS
Purpose of review Two-drug regimens (2DR) for antiretroviral therapy are increasingly being recommended for people living with HIV to reduce pill burden and reduce short and long-term toxicity. The exclusion of tenofovir and lamivudine or…
View details →Nicklas A, Rudari M, Reidow N et al. · 2026 · Plastic and reconstructive surgery. Global open
Background Postoperative wound healing remains a critical challenge, particularly in complex reconstructions such as free flap surgeries. Despite technical improvements, perfusion-related complications may cause partial flap loss.…
View details →Antaky CC, Leinbach IL, Plissner JH et al. · 2026 · PloS one
The use of rodenticides is a primary method for eradicating rodents from islands for conservation purposes. Rodenticide residue monitoring is often incorporated into rodent eradication project planning to understand the potential effects…
View details →Aderibigbe AS · 2026 · Poultry science
Despite increasing attention to broiler welfare, there is still limited information comparing physiological stress responses between fast-growing (FG) and slow-growing (SG) genotypes under evolving production conditions. Investigating this…
View details →Popiolek I, Hydzik P, Ciszowski K et al. · 2026 · Journal of clinical medicine
Background/Objectives: Alcohol-related liver disease (ALD) lacks widely adopted biomarkers that reflect disease activity and severity. High-mobility group box 1 (HMGB1), a damage-associated molecular pattern, has been implicated in ALD…
View details →Awadallah M, Singh A, Hale GL et al. · 2026 · Case reports in transplantation
Hepatitis E virus (HEV) infection is an increasingly recognized cause of acute and chronic hepatitis in immunosuppressed individuals, including solid organ transplant recipients. Although typically self-limited in immunocompetent hosts,…
View details →Yoon HJ, Kim GC, Nam SH · 2026 · Pathogens (Basel, Switzerland)
Background Oral candidiasis is an opportunistic infection caused by Candida albicans (C. albicans) , highlighting the need to evaluate candidate substances that ensure both antifungal efficacy and mucosal safety. This study aimed to assess…
View details →Carretero D, Giménez E, Pérez A et al. · 2026 · Enfermedades infecciosas y microbiologia clinica (English ed.)
Introduction Studies assessing SARS-CoV-2 antibodies and functional T-cell responses in hematological patients following receipt of a three-dose mRNA vaccine schedule have yielded conflicting results. Methods We conducted a retrospective…
View details →Chmielewska B, Marzec M, Szarejko I et al. · 2026 · Plant Science.
Root hairs, tubular extensions of the rhizodermal cells, facilitate nutrient uptake, yet their role in water acquisition remains debated and may be species- and soil-specific. To elucidate the genetic basis of root hair development and…
View details →Lee HL, Choi SM, Cho SH et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives: Head trauma (HT) has been suggested as a risk factor for Parkinson's disease (PD), but its impact on the motor and non-motor manifestations remains unclear. We investigated whether patients with early PD and a…
View details →Anand M, Kashyap R, Bhat P et al. · 2026 · BMC sports science, medicine & rehabilitation
Background Prolonged sedentary work is associated with hamstring tightness, reduced flexibility, and functional limitations among information technology (IT) professionals. Comparative evidence for static stretching and myofascial release…
View details →Willems R, Cappelletti M, Schüre JR et al. · 2026 · Scientific reports
Messenger ribonucleic acid (mRNA)-based vaccines delivered via lipid nanoparticles (LNP) were pivotal in managing the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic. While mild systemic reactions are common after…
View details →Zaryczańska A, Sokołowska-Wojdyło M, Wilkowska A et al. · 2026 · Contact dermatitis
Background Chronic exposure to topical corticosteroids (TCS) in patients with atopic dermatitis (AD) may increase the risk of allergic contact dermatitis (ACD), which can mimic flares of the underlying disease and remain underrecognized.…
View details →Baneman E, Jacobs SE, Rana M et al. · 2026 · Clinical lymphoma, myeloma & leukemia
Background Cytomegalovirus (CMV) is an opportunistic pathogen that causes infection in certain immunocompromised hosts, but the risk of clinically significant CMV infection in patients with multiple myeloma (MM) is not well understood.…
View details →Srivastava A, Maienschein-Cline M, Pabalan A et al. · 2026 · Methods (San Diego, Calif.)
MicroRNAs (miRNAs) are promising biomarkers and therapeutic targets; however, reliable extracellular miRNA quantification by RT-qPCR depends on appropriate normalization, and no universal endogenous reference has been established. This…
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