11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Mildner FO, Sykora MM, Hackl H et al. · 2024 · Lung cancer (Amsterdam, Netherlands)
Background Cancer immune evasion is critical in non-small cell lung cancer (NSCLC) and has been targeted by immunotherapy. High soluble (s)PD-L1 is associated with reduced survival and treatment failure in advanced stages. Here we…
View details →Le NT, Nguyen TG, Huynh NYN et al. · 2025 · Scientific reports
Dietary calcium's role in human health and disease prevention is inconclusive. We examined the associations between dietary calcium intake and the risk of overall and specific causes of mortality. A prospective cohort study was performed…
View details →Manni G, Pambianco M, Sicuro C et al. · 2025 · International journal of molecular sciences
Hepatic actinomycosis (HA) and IgG4-related inflammatory pseudotumors are rare and often overlooked causes of liver mass, which can easily be misdiagnosed as primary liver cancer or metastasis. Diagnosis is arduous due to unspecified…
View details →Borz-Baba L, Aydin A, Parvin R · 2026 · Cureus
Metabolic-associated steatotic liver disease (MASLD) is a common medical condition that can progress to metabolic-associated steatohepatitis (MASH) and advanced fibrosis, leading to severe outcomes. Liver biopsy continues to be the…
View details →Sakuma K, Yoshimura K · 2026 · Journal of environmental radioactivity
Tritium ( 3 H) is the principal radionuclide remaining in ALPS-treated water discharged from the Fukushima Dai-ichi Nuclear Power Plant (FDNPP), and its potential environmental impact has drawn considerable attention. To evaluate possible…
View details →Needle R, Yu Y, Soualhine H et al. · 2025 · Biomedicines
Background/Objectives : The diagnosis of Mycobacterium tuberculosis complex (MTBC) and nontuberculous mycobacterial (NTM) infections is accomplished by three main diagnostics methods: smear microscopy, culture, and molecular testing.…
View details →Kirby C, Baldwin JA, Elwell K et al. · 2026 · Healthcare (Basel, Switzerland)
Background The literature shows inconclusive results from utilizing motivational interviewing (MI) in indigenous populations to address early childhood caries (ECC). Great Beginnings for Healthy Native Smiles (GBHNS) (NIDCR U01DE028508), a…
View details →Zhang Y, Baharani J, Ajayi B et al. · 2025 · BMC nephrology
Background Fibrillary glomerulonephritis (FGN) is a rare immune complex-mediated glomerulonephritis characterised by the deposition of anomalous fibrillary structures within the glomeruli. The prognosis for patients with FGN is usually…
View details →Gobishangar S, Abiharan P, Jenil A et al. · 2026 · Cureus
Background The appendix is a vermiform structure with a variable position, length, and thickness. Imaging plays a critical role in diagnosing an inflamed appendix, with non-contrast computed tomography (NCCT) being an effective modality…
View details →Bronkhorst H, Kalaykova S, Huysmans MC et al. · 2024 · Journal of dentistry
Objective This study presents a scoping review to determine the association between tooth wear and bruxism. Data A protocol was developed a priori (Open Science Framework (DOI 10.17605/OSF.IO/CS7JX)). Established scoping review methods…
View details →Nieminen V, Martikainen MV, Kalliomäki S et al. · 2024 · International journal of radiation biology
Purpose Earlier evidence suggests that extremely low frequency magnetic fields (ELF MFs) can modify the effects of carcinogenic agents. However, the studies conducted so far with ionizing radiation as the co-exposure agent are sparse and…
View details →Gaviria M, Arave M, Phan N et al. · 2026 · Military medicine
Introduction Peripheral nerve injuries (PNIs) are associated with significant morbidity, and traditional repair techniques often result in incomplete functional recovery. Polyethylene glycol (PEG) fusion has been proposed as a technique to…
View details →Larson ME, Pan Y, Reidy L et al. · 2026 · PloS one
People with HIV (PWH) experience elevated cardiovascular disease risk compared to people without HIV. Stimulant use may further increase subclinical myocardial injury among PWH, but data on cardiovascular biomarkers, including serum…
View details →Geamănu A, Pîrvulescu RA, Tricorache D et al. · 2026 · Diagnostics (Basel, Switzerland)
Background: Hydroxychloroquine (HCQ) is widely used in systemic lupus erythematosus (SLE), yet cumulative exposure may result in progressive retinal toxicity. Structural biomarkers capable of identifying subclinical damage remain…
View details →Sung K · 2026 · Environmental management
Trail penetration within strictly designated protected areas is often treated as a conservation concern, yet its consequences for vegetation trends at national scales remain empirically unresolved. This study evaluated whether trail…
View details →Simonis L, Marcour Y, Embacher J et al. · 2026 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Assessment of hepatic steatosis is key for diagnosis and monitoring of steatotic liver disease. Controlled attenuation parameter is widely used, but concerns regarding its measurement variability exist. We evaluated the…
View details →Ünlü C, Aksoy H · 2026 · BMC pregnancy and childbirth
Background Anti-D immunoglobulin administered in the early third trimester to Rhesus D negative women with Rhesus D incompatibility is widely assumed to provide protection against silent fetomaternal haemorrhage until delivery. However,…
View details →Corn E, Becht K, Adefres B et al. · 2026 · Gynecologic oncology reports
Purpose Cervical cancer is the number one cause of cancer-related mortality for women in Botswana, where care is complicated by the country's severe shortage of gynecologic oncologists. Recent data suggests that "low-risk" stage I cervical…
View details →Martinos N, Kroupis C, Gypari M et al. · 2026 · Current issues in molecular biology
Background/objectives Histologic mucosal healing is an increasingly recognized therapeutic target in inflammatory bowel disease (IBD), yet reliable non-invasive correlates remain limited. This study aimed to evaluate circulating cytokine…
View details →Walmsley SL, Nabipoor M, Qi F et al. · 2026 · Clinical & translational immunology
Objectives To assess neutralizing antibody responses to emerging SARS-CoV-2 variants. Methods We explored SARS-CoV-2 neutralizing antibodies in140 adults participating in a longitudinal study of antibody responses to COVID vaccines.…
View details →Bermingham MD, Meredith RT, Mills H et al. · 2026 · Frontiers in allergy
Quantifying food allergens in complex matrices is hindered by thermal processing, particularly in baked products used for oral food challenges (OFCs), where limited data exists on effects on clinically relevant allergens. To address this,…
View details →Kennedy J, Cooley SA, Roman Fox J et al. · 2026 · The Journal of infectious diseases
Background As persons with human immunodeficiency virus (PWH) live longer, interactions between human immunodeficiency virus (HIV), aging, and structural brain integrity become increasingly vital for understanding cognitive disorders. This…
View details →Kuo MC, Younan SA, Williams PJ et al. · 2026 · Techniques in coloproctology
Background Robotic approach is increasingly being used for surgery in Crohn's disease. Robotic ileocolic resection (ICR) for Crohn's disease (CD) is comparable to laparoscopic ICR for short term outcomes; however, no studies have compared…
View details →Jankovič P, Chodzyński KJ, Vanrossomme AE et al. · 2026 · Neurology international
Background The risk stratification of unruptured intracranial aneurysms (UIAs) relies largely on static clinical and morphological parameters, which may not fully capture aneurysm-specific wall behavior. ECG-gated four-dimensional computed…
View details →Mirza S, Fine L, McClure JA et al. · 2026 · Antibiotics (Basel, Switzerland)
Background Staphylococcus aureus acquires methicillin resistance genes through the SCC mec element. Although spontaneous SCC mec excision has been observed, its frequency, type-specific variation, and responsiveness to environmental…
View details →Buttke DE, Kaplan BS, Jones LC et al. · 2026 · Journal of wildlife diseases
Mycoplasma bovis is a growing threat to American bison (Bison bison) health and restoration efforts, causing significant mortality and disease in affected bison herds. Despite this, little is known about the epidemiology or clinical course…
View details →Oehring D · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Purpose Non-invasive tear film metrics from automated topographers are used increasingly, yet device-specific analytical performance remains incompletely characterised. This study quantified the analytical performance of the Oculus…
View details →Torkan A, Zoghi M, Foroughimehr N et al. · 2026 · Sensors (Basel, Switzerland)
The rapid global expansion of 5G technology has increased concerns regarding its potential health effects. Postural balance, a complex sensorimotor function reflecting central nervous system integrity, may be susceptible to electromagnetic…
View details →Aguiar Pavesi RO, Boening A, Meyrelles SDS et al. · 2026 · Physiotherapy research international : the journal for researchers and clinicians in physical therapy
Background The 6-minuteute step test is an alternative for estimating cardiorespiratory fitness after stroke. Objective To investigate its measurement properties and minimal detectable change early after stroke. Methods Cross-sectional,…
View details →Bell KS, Chen R, Weitzner AS et al. · 2026 · Journal of biological rhythms
The circadian system coordinates daily physiology across nearly all tissues to temporally organize metabolism and maintain homeostasis. In the brain, circadian timing regulates neural activity, cellular function, and neuroimmune signaling,…
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