11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Maffezzoli M, Nagpal R, Elewaily M et al. · 2025 · Current oncology reports
PURPOSE OF REVIEW: Adjuvant immunotherapy has improved outcomes in several cancers, although patient selection and toxicity remain challenges. Circulating tumor DNA (ctDNA) has emerged as a biomarker for minimal residual disease (MRD)…
View details →Viderman D, Kalikanov S, Mazhibiyeva A et al. · 2026 · Frontiers in pain research (Lausanne, Switzerland)
Background and objectives Chronic knee pain is highly prevalent in various knee diseases. It significantly decreases patients' quality of life. Among non-surgical interventions, exercise is considered a promising approach for alleviating…
View details →Planello AC, Loureiro T, Alencar-Cupertino D et al. · 2025 · Revista da Associacao Medica Brasileira (1992)
Objective This study aimed to evaluate whether the increased use of exome sequencing as a primary next-generation sequencing test provides a higher diagnostic yield compared to multi-gene panels for various clinical indications within a…
View details →Mansikkaniemi L, Stewart JA, Sinisalo J et al. · 2025 · Scandinavian cardiovascular journal : SCJ
Background. Invasive coronary angiography (ICA) is the gold standard in evaluating stent patency after percutaneous coronary intervention (PCI), but it carries a risk of potentially life-threatening complications. Third-generation coronary…
View details →Naim S, Sraidi S, Salam S et al. · 2025 · Clinical case reports
We present a rare case of bone metastatic Neuroblastoma without a diagnosis of an identifiable primary lesion in a 16-year-old patient who presented with intermittent right knee pain and soft tissue swelling for 7 months. Initial…
View details →Sabatini P, Zhang T, Boruvka N et al. · 2025 · American journal of clinical pathology
Objective Somatic hypermutation at immunoglobulin heavy chain variable (IGHV) genes, an established prognostic and predictive biomarker for chronic lymphocytic leukemia (CLL), is assessed by gene sequencing. We developed a single…
View details →Holopainen A, Verhage ML, Schuengel C et al. · 2025 · Journal of reproductive and infant psychology
Background Fear of childbirth and negative birth experiences have suggested to been associated with parenting behaviour and thereby indirectly with child outcomes. The current study contributes to this knowledge by investigating fear of…
View details →Young RP, Ward RC, Scott RJ et al. · 2025 · Annals of the American Thoracic Society
Rationale: Current eligibility criteria for lung cancer (LC) screening are derived from randomized controlled trials and largely based on age and smoking history. However, the individualized benefits of screening are highly variable and…
View details →Garabedian C, Girault A · 2025 · Journal of gynecology obstetrics and human reproduction
Fetal monitoring during labor is crucial for detecting potential hypoxic situations that could lead to severe outcomes like cerebral palsy or peripartum death. The current standard, fetal heart rate (FHR) monitoring, is subjective and…
View details →Racano E, Spinelli C, Sacco G et al. · 2026 · Scientific reports
Early detection and documentation of anterior segment opacities in infants (aged 1–6 months) is limited by resource constraints and specialist availability. This study aimed to evaluate the usefulness of digital infrared reflex testing…
View details →Shah KV, Jung C, Talian D et al. · 2025 · OTO open
Objective While the etiology of Meniere's disease (MD) is likely multifactorial, genetics are thought to play a role. Several previous studies have yielded inconclusive results, potentially due to phenotypic uncertainty and variable…
View details →Nguyen MD, Park D, Scott JW et al. · 2026 · Science advances
Landau predicted that transverse sound propagates in a Fermi liquid with sufficiently strong interactions such as for liquid 3 He, unlike a classical fluid that cannot support shear oscillations. Previous attempts to observe this unique…
View details →Gay A, Laudet F, Meynard P et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Introduction Infection is a significant and challenging complication of total hip and knee arthroplasties. Diagnosing chronic periprosthetic joint infection (PJI) can be difficult, particularly when joint aspiration yields inconclusive…
View details →Payton C, Kvaratskhelia N, Chalfin M et al. · 2025 · Journal of immigrant and minority health
Cancer screening can detect cancer at an early stage and decrease cancer morbidity and mortality. Refugee populations may have had limited access to cancer screening before arrival in the United States. A cross-sectional analysis of…
View details →Kaseb A, Benider H, Treglia G et al. · 2025 · European journal of clinical investigation
Background 4D-CT has garnered attention as complementary imaging for patients with primary hyperparathyroidism (pHPT). Herein we evaluated a diagnostic strategy using [ 18 F]Fluorocholine Positron Emission Tomography/Computed Tomography…
View details →Kuyucu M, Erdogan KM, Adiyaman D et al. · 2025 · Medicine
This study shares our 5-year experience with chorionic villus sampling (CVS) and analyzes the indications, results, and complications of this procedure. We conducted a retrospective analysis of data from singleton pregnancies that…
View details →Shebli B, Ghabally M, Shabouk MB et al. · 2025 · Frontiers in cardiovascular medicine
Background Beta-agonists like Levalbuterol and Albuterol are used in the treatment of Hyperkalemia. However, few studies in the medical literature have directly compared the cardiac effects and potassium-lowering efficacy of levalbuterol…
View details →Cohen M, Slae M, Gamliel A et al. · 2025 · Respiratory medicine
Background -Nasal Potential Difference (NPD) is an established diagnostic tool for CF. However, standardized values for very young patients are lacking. Aim - To evaluate the feasibility of performing NPD testing in young children. Methods…
View details →Chen Y, Bhatti P, Dummer T et al. · 2025 · Cancer epidemiology
Background Studies of the relationship between diabetes medications and pancreatic cancer risk have produced inconclusive results. We aimed to examine associations between classes, subclasses, and individual diabetes medications with…
View details →Baldini GM, Ferri D, Lot D et al. · 2026 · Gynecologic and obstetric investigation
Objectives The objective of the study was to evaluate the impact of male human papillomavirus (HPV) sexually transmitted infection on sperm parameters, embryo morphokinetics, and clinical pregnancy outcomes in assisted reproductive…
View details →Sunman B, Yalcin E, Alboga D et al. · 2025 · Pediatric allergy, immunology, and pulmonology
Background: Although the forced oscillation technique has been used for many years in children, there is still inconclusive results about its efficiency in cystic fibrosis (CF). Moreover, no studies have been conducted on impulse…
View details →He S, Wen J, Zou Z et al. · 2025 · International journal of cancer
Studies on multiple myeloma (MM), the second most common hematologic malignancy, have shown inconclusive results regarding the role of exercise in treatment. This study evaluated the relationship between physical exercise and MM treatment…
View details →Pierucci UM, Paraboschi I, Ardenghi C et al. · 2024 · Translational pediatrics
Background Inflammatory myofibroblastic tumors (IMTs) are rare, often non-metastasizing neoplasms characterized by fibro/myofibroblastic spindle cells with varying infiltrates of plasma cells, lymphocytes, and/or eosinophils. Despite their…
View details →Rohrhofer J, Ebner L, Schweighardt J et al. · 2025 · Diagnostics (Basel, Switzerland)
Background/Objectives: Growing evidence suggests that mast cell activation (MCA) may contribute to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating disorder characterized by persistent fatigue and post-exertional…
View details →Suksard K, Millard GM, Teravichitchainan U et al. · 2025 · Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
Background ABO discrepancies, inconclusive results between forward and reverse typing, are one of the significant challenges encountered in transfusion medicine. Their frequency and etiologies can vary among ethnicities. This study aimed…
View details →Hashem S, Murhega RB, Migabo PA · 2026 · Radiology case reports
The ectopic posterior pituitary represents a rare congenital malformation attributable to aberrant embryogenesis of the neurohypophysis. Although it may occur as an isolated anomaly, it is frequently concomitant with other congenital…
View details →Ramasindrazana B, Rahalison ZA, Gauthier P et al. · 2025 · PLoS neglected tropical diseases
Background The plague, caused by Yersinia pestis, remains a critical public health issue, particularly in endemic regions like Madagascar. Rapid and accurate detection of this pathogen is essential for effective outbreak management and…
View details →Espada-Musitu D, Manero-Azua Á, Vado Y et al. · 2025 · Anales de pediatria
Advances in next-generation sequencing (NGS) technologies have made the detection of the molecular causes of paediatric diseases increasingly affordable, accessible and rapid. While exome sequencing and genome sequencing were until…
View details →Paracino R, De Domenico P, Ricciuti RA et al. · 2025 · Surgical neurology international
Background Idiopathic normal pressure hydrocephalus (iNPH) is a benign neurologic condition with treatment response rates ranging only between 30 and 50%. Several studies have attempted to identify clinical or radiological predictive…
View details →Pelegrín-Mateo FJ, Zambrano CB, Vázquez EB et al. · 2025 · European journal of internal medicine
Cancer-associated thrombosis (CAT) remains a leading cause of morbidity and mortality among oncology patients, with an incidence influenced by tumor type, stage, treatment, and molecular characteristics. This review explores the molecular…
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