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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

A cross-sectional survey of the safety attitudes questionnaire subscale stress recognition and the effect of non-technical skills training in operating theatre staff.

Leuschner S, Schenk P, Gräbsch C et al. · 2025 · Innovative surgical sciences

Objectives Non-technical skills (NTS) training of surgical staff is a quality improvement measure to improve patient safety. One factor that can compromise patient safety is impaired staff performance due to stressors such as tiredness.…

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Negative / Null Result ReportOpen accessMedicine

Progression of Established Atherosclerotic Lesions Is Not Inhibited by Endothelial Knockout of Caveolin-1-Brief Report.

Muñiz-Anquela R, Redondo-Angulo I, Lewis EA et al. · 2026 · Arteriosclerosis, thrombosis, and vascular biology

Background Eradicating endothelial caveolae by deleting the Cav1 (caveolin-1) gene reduces LDL (low-density lipoprotein) uptake in arteries and efficiently prevents early atherogenesis, but the role in established atherosclerosis is…

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Negative / Null Result ReportMedicine

Outcome evaluation of the p drivers Program: Randomised controlled trial of a program to improve safe driving among novice drivers.

Stephan K, Stephens AN, Scully M et al. · 2024 · Accident; analysis and prevention

Background Globally, road traffic crashes are the leading cause of death for young adults. The P Drivers Project was a trial of a behavioural change program developed for, and targeted at, young Australian drivers in their initial months…

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Negative / Null Result ReportMedicine

Impact of Maternal Exercise on Mice Offspring Development, Pulmonary Hypertension, and Vascular Remodeling in Chronic Hypoxia.

Leslie E, Gonzalez Bosc LV, Specht J et al. · 2024 · Medicine and science in sports and exercise

Purpose Chronic, high-altitude hypoxic exposure increases the risk of high-altitude pulmonary hypertension (PH). Emerging evidence shows maternal exercise may improve offspring resistance to disease throughout life. The purpose of this…

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Negative / Null Result ReportOpen accessMedicine

Notch1 regulates Orai1 and Orai3 expression in breast cancer cells.

Nieto-Felipe J, Macias-Diaz A, Alvarado S et al. · 2025 · Scientific reports

Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of…

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Negative / Null Result ReportOpen accessMedicine

<i>In Silico</i> Analysis of Potential Off-Target Effects of a Next-Generation dsRNA Acaricide for Varroa Mites (<i>Varroa destructor</i>) and Lack of Effect on a Bee-Associated Arthropod.

Bulgarella M, Reason A, Baty JW et al. · 2025 · Insects

Double-stranded RNA (dsRNA) biopesticides offer the potential for highly targeted pest control with minimal off-target impacts. Varroa mites ( Varroa destructor ) are an important pest of honey bees ( Apis mellifera ) that are primarily…

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Negative / Null Result ReportMedicine

Mechanisms underlying the laxative effect of lactulose: A randomized placebo-controlled trial showing increased small bowel water and motility unaltered by the 5-HT 3 receptor antagonist, ondansetron.

Gunn D, Yeldho C, Hoad C et al. · 2024 · Neurogastroenterology and motility

Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron. Methods A…

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Negative / Null Result ReportOpen accessMedicine

Effect of Supplementing Lysine and Isoleucine as Limiting Amino Acids on Growth Performance and Amino Acid Deposition of <i>Tenebrio molitor</i> Larvae Reared on a Cereal-Based Substrate.

Fondevila G, Fatmi H, Fernando P et al. · 2025 · Insects

The effects of Lys and Ile supplementation in a barley-based substrate on growth performance and nutrient deposition in Tenebrio molitor larvae were evaluated. Six trays per treatment containing sixty larvae were assigned to five…

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Negative / Null Result ReportOpen accessMedicine

Effects of a shared decision-making implementation programme on patient-centred communication in oncology-Secondary analysis of a randomised controlled trial.

Lindig A, Mannagottera L, Hahlweg P et al. · 2024 · Health expectations : an international journal of public participation in health care and health policy

Background There is a need for better implementation of patient-centred (PC) communication and shared decision-making (SDM) in routine cancer care. Objective The aim of this study was to assess whether a programme to implement SDM in…

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Negative / Null Result ReportMedicine

Dobutamine effects on systolic and diastolic left ventricular long-axis excursion and timing - significance for the interpretation of s' and e'.

Peverill RE, Narayan O, Cameron JD · 2023 · Scandinavian cardiovascular journal : SCJ

Background Dobutamine effects on the relationships of the peak velocity of left ventricular (LV) long-axis systolic motion (s') with systolic excursion (SExc), systolic duration (SDur) and heart rate, of LV long-axis early diastolic…

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Negative / Null Result ReportOpen accessMedicine

Should the Dermatological Assessment of Patients with Inflammatory Bowel Disease Become Standard during Qualifications for Biological Treatment? A Retrospective, Single-Center Experience from a Tertiary Center.

Lewandowski K, Kaniewska M, Tulewicz-Marti E et al. · 2024 · Journal of clinical medicine

Background : Oncological anxiety associated with biological therapy is a particular challenge in inflammatory bowel disease (IBD), and it has raised questions about the need for the dermatological assessment of the skin before starting…

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Negative / Null Result ReportOpen accessMedicine

Muscle creatine levels and sprint performance in young adult vegans and vegetarians after 7 days of creatine monohydrate supplementation.

Bonne TC, Arthemalle V, Doherty CS et al. · 2025 · Physiological reports

Athletes use creatine monohydrate (CM) to enhance high-intensity exercise performance by increasing creatine phosphate availability. While CM supplementation is known to raise muscle creatine levels in vegans and vegetarians, its impact on…

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Negative / Null Result ReportMedicine

Process evaluation of a comprehensive approach to reintegration of disability benefit recipients with multiple problems (CARm) into the labour market.

Brongers K, Hoekstra T, Wilming L et al. · 2024 · Disability and rehabilitation

Purpose As the effect evaluation of our randomized controlled trial the "Comprehensive Approach of Reintegration for clients with Multiple problems" (CARm) showed no superior effect on re-integration into paid employment of the clients…

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Negative / Null Result ReportOpen accessMedicine

Mediation of modifiable risk factors in two multidomain dementia prevention trials.

Hoevenaar-Blom MP, Shourick J, van Dalen JW et al. · 2025 · Alzheimer's & dementia : the journal of the Alzheimer's Association

Introduction We explored which dementia risk factors in two multidomain prevention trials mediate beneficial, neutral, or counteracting effects on dementia incidence. Methods We pooled data from the multidomain MAPT (Multidomain Alzheimer…

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Negative / Null Result ReportOpen accessMedicine

A Comparison of Currently Approved Small Interfering RNA (siRNA) Medications to Alternative Treatments by Costs, Indications, and Medicaid Coverage.

Sehgal I, Eells K, Hudson I · 2024 · Pharmacy (Basel, Switzerland)

Small interfering RNA (siRNA)-based medications offer the ability to target previously undruggable targets and have now received FDA approval in five instances for orphan or uncommon diseases. The current siRNA "-sirans" are directed…

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