11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Krakowian D, Lach M, Żemła P et al. · 2025 · Cytotechnology
The HeLa 9903 cell line is used in the in vitro endocrine disruption assay (OECD 455). After treatment with an estrogen receptor agonist, the luminescence of these cells increases. However, some autoactivation of this test system may…
View details →Nannoni E, Martelli G, Militerno G et al. · 2024 · Animal Feed Science and Technology.
The experiment aimed to obtain information on the water requirements, drinking behavior and drinking motivation of liquid-fed pigs and was conducted during the hot season. Eighty castrated male pigs (initial body weight: 36 kg) fed a…
View details →Schumacher JD, van Holstein M, Zhou P et al. · 2025 · The Journal of neuroscience : the official journal of the Society for Neuroscience
Converging evidence suggests that orbitofrontal cortex (OFC) subregions subserve distinct roles in decision-making across a variety of tasks. Cost/benefit decisions can require an organism to choose between options based on information…
View details →Dekhne MS, Kunze KN, Chiu YF et al. · 2025 · Arthroplasty today
Background Patient-reported outcome measures (PROMs) assess quality of care after total joint arthroplasty (TJA) and will be mandatory for reporting by 2027 under the Center for Medicare and Medicare Services. This study evaluated the…
View details →Robinson HL, Banks ML · 2026 · ASPET discovery
Rationale Mesocorticolimbic dopamine neurotransmission is hypothesized to play a central role in both cocaine reinforcement and amphetamine maintenance-induced decreases in cocaine self-administration. One method to selectively modulate…
View details →Rahimi A, Fatehi F, Rafiee H et al. · 2026 · Veterinary medicine and science
Background Beet vinasse (VIN), a by-product of sugar beet processing, is rich in non-protein nitrogen (NPN), potassium, and prebiotic compounds, offering potential as a feed additive to enhance dairy cow performance while reducing…
View details →Cuezva JM, Domínguez-Zorita S · 2024 · Cancers
The relevant role played by the ATPase Inhibitory Factor 1 (IF1) as a physiological in vivo inhibitor of mitochondrial ATP synthase in cancer and non-cancer cells, and in the mitochondria of different mouse tissues, as assessed in…
View details →Djuric N, Rochman CM, Riskin SH · 2026 · PloS one
Agroecosystems are increasingly recognized as major basins for terrestrial microplastics. Many agricultural practices have led to high loading of plastic mulch films, synthetic microfibers, and other microplastics onto fields. There is…
View details →Abbasi A, Ahmad K, Ferguson C et al. · 2024 · European journal of applied physiology
Purpose Pathogen transmission during cardio-pulmonary exercise testing (CPET) is caused by carrier aerosols generated during respiration. Methods Ten healthy volunteers (age range: 34 ± 15; 4 females) were recruited to see if the…
View details →Gerhart BJ, Pellerin D, Danzi MC et al. · 2024 · Neurology. Genetics
Background and objectives The number of GAA repeats in the FXN gene is a major but not sole determinant of the clinical presentation of Friedreich ataxia (FRDA). The objective of this study was to establish whether the length of the GAA…
View details →Rodríguez Rondón AV, Prins K, Volker F et al. · 2026 · Human molecular genetics
Melanocortin-2 receptor accessory protein-2 (MRAP2) modulates the activity of hypothalamic melanocortin-4 (MC4R) and growth hormone-secretagogue (GHSR) receptors, which suppress and promote appetite, respectively. We investigate whether…
View details →Laso-García F, Díaz-Gamero N, Gallego-Ruiz R et al. · 2025 · International journal of molecular sciences
Extracellular vesicles (EVs) have emerged as potential therapeutic agents for neurological disorders. Their molecular cargo may reflect the clinical status of the donor and has been identified as a biomarker for the cellular damage and…
View details →Kant N, Garssen SH, Vernooij CA et al. · 2024 · Internal and emergency medicine
In Acute Admission Wards, vital signs are commonly measured only intermittently. This may result in failure to detect early signs of patient deterioration and impede timely identification of patient stability, ultimately leading to…
View details →Bronshtein O, Konson A, Kuniavsky M et al. · 2025 · Quality management in health care
Background and objectives Early in the global COVID-19 pandemic, a concern was raised that potentially high volumes of COVID-19 inpatients in general hospitals might compromise the hospitals' capabilities to maintain high-quality care for…
View details →Renko K, Thomas R, Hawks M et al. · 2026 · Frontiers in toxicology
Thyroid hormone (TH) availability is particularly critical for early brain development. TH transport across the blood-brain barrier is facilitated through two main transmembrane transporters: monocarboxylate transporter 8 (MCT8) and…
View details →Lavigna G, Grasso A, Pasini C et al. · 2025 · PloS one
There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. Previously, we showed that the PERK kinase inhibitor GSK2606414 delays…
View details →Myhre MG, Azeem A, Barrett M · 2024 · New Zealand veterinary journal
Case history Medical records from 2009 to 2021 from a private equine referral hospital in Rochester, NH, USA were analysed for cases that underwent general anaesthesia for low-field MRI of the distal limb. These were used to determine…
View details →Carney C, Jenkins L, Jewell C et al. · 2025 · microPublication biology
Several lines of evidence suggest a potential link between stemness and vitamin B12, which contributes to S-adenosylmethionine (SAM) generation and hence methylation-dependent epigenetic control. Here we found that the vitamin B12…
View details →Ruiz-López A, Montalvo-Alonso JJ, Martín-Rivas I et al. · 2026 · Nutrients
Background/Objectives : Caffeine is a well-established ergogenic aid in many strength- and endurance-based sports, but its efficacy in sport climbing remains underexplored despite the sport's unique physical demands on grip strength,…
View details →Zhang Y, Zhang H, Zhou M et al. · 2025 · American journal of physical medicine & rehabilitation
Abstract The improvement of early rehabilitation service capacity is of great importance for meeting health needs of the population; however, there is still a lack of information on early rehabilitation interventions in hospitals in China.…
View details →Sridhar A, Khan D, Flatt PR et al. · 2023 · Peptides
Effects of sustained activation of glucagon-like peptide-1 (GLP-1) receptors (GLP-1R) as well as antagonism of receptors for glucose-dependent insulinotropic peptide (GIP) on intestinal morphology and related gut hormone populations have…
View details →Mohammadi F, Razmjooei N, Mohsenpour MA et al. · 2025 · BMC nutrition
Background and aim Probiotics play an important role in the control and treatment of non-alcoholic fatty liver disease (NAFLD). Kefir drink is a fermented beverage and has indicated some beneficial health effects. The aim of this study was…
View details →Margolis LM, Wilson MA, Drummer DJ et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology
Insulin insensitivity decreases exogenous glucose oxidation and metabolic clearance rate (MCR) during aerobic exercise in unacclimatized lowlanders at high altitude (HA). Whether use of an oral insulin sensitizer before acute HA exposure…
View details →Kloft HM, Shelby AM, Pasloske K · 2025 · Journal of feline medicine and surgery
ObjectivesThe aim of the present study was to assess the gamma-aminobutyric acid type A (GABA A ) receptor antagonist flumazenil and its effect on the anesthetic activity of the GABA A receptor agonist alfaxalone when administered…
View details →Martins MM, Gheller LS, Noronha BL et al. · 2026 · Animals : an open access journal from MDPI
The objective of this study was to evaluate the effects of sodium butyrate and organic zinc supplementation, alone or combined, on performance, zinc metabolism, blood parameters, and gut health in Holstein calves highly challenged by heat…
View details →Wang X, Dowty ME, Tripathy S et al. · 2024 · European journal of drug metabolism and pharmacokinetics
Background and objective Abrocitinib is an oral small-molecule Janus kinase (JAK)-1 inhibitor approved for the treatment of moderate-to-severe atopic dermatitis. In vitro studies indicated that abrocitinib is a weak time-dependent…
View details →Austin DK, Amador LMD, Li LM et al. · 2025 · Neuropsychopharmacology reports
Aim Selective serotonin reuptake inhibitors are thought to exert a clinical effect through various mechanisms, including through alteration in synaptic plasticity. Repetitive transcranial magnetic stimulation can induce temporary changes…
View details →Kattler KR, Watkins HV, Perretta KN et al. · 2024 · Biol Invasions.
Organisms that settle and grow on other organisms (i.e., epibionts) are often costly to their hosts in terms of locomotion, growth, and/or reproduction. Such costs can potentially result in biotic resistance against invasion when native…
View details →Cerpelloni F, Collignon O, Op de Beeck H · 2026 · Psychonomic bulletin & review
Most written systems share basic shape features with natural objects such as line junctions, a commonality thought to be at the basis of fluent reading. Studies that compared reading acquisition for different scripts used line-based…
View details →Rivest D, Martin-Guay MO · 2024 · Nutrient cycling in agroecosystems.
Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…
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