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Browse the failure-mode index

11,316 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats.

Warren WG, Papagianni EP, Hale E et al. · 2022 · Frontiers in pharmacology

Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can…

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Negative / Null Result ReportOpen accessMedicine

Effects of High-Intensity Interval Training on Steroid Hormones and Psychological Outcomes in Healthy Male Adolescents: A Randomized Controlled Trial.

Ouerghi N, Abassi W, Jebabli N et al. · 2026 · Sports (Basel, Switzerland)

The study investigated the effects of high-intensity interval training (HIIT) on cardiorespiratory fitness, hormonal, and psychological markers in adolescents. Twenty-eight healthy male adolescents were randomized to a HIIT group or a…

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Negative / Null Result ReportOpen accessMedicine

Randomized, double-blind trial of preoperative pregabalin versus placebo to improve quality of recovery after breast cancer surgery.

Toledo FV, Meletti JFA, Silva LMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)

Introduction Surgery remains one of the most important treatments for breast cancer. In this context, the quality of postoperative recovery has become a key concern. Adequate control of acute pain is essential to optimize patient comfort…

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Negative / Null Result ReportOpen accessMedicine

The Use of Microporous Polysaccharide Hemospheres in Thyroid Surgery: A Retrospective Study on Safety and Clinical Outcomes.

Mariani C, Al Dababsekh A, Carta F et al. · 2025 · Medicina (Kaunas, Lithuania)

Background and Objectives : Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic…

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Negative / Null Result ReportOpen accessMedicine

Effects on nonverbal numerical acuity performance after a single-session transient random noise stimulation over the intraparietal sulcus or dorsolateral prefrontal cortex.

Ó Dúinín E, Steopan JK, Kessler K et al. · 2025 · Scientific reports

We investigated the effects of cognitive training with transcranial random noise stimulation (tRNS) applied to the intraparietal sulcus (IPS) or dorsolateral prefrontal cortex (DLPFC) on improving a multidirectional number line estimation…

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Negative / Null Result ReportOpen accessMedicine

Effects of Short-Term Broccoli Powder Supplementation on Acute Oxidative Stress and Recovery Following a Metabolically Demanding Exercise Session.

Cesanelli L, Venckunas T, Minderis P et al. · 2026 · Antioxidants (Basel, Switzerland)

Background/Objectives : This study aimed to evaluate the effects of short-term broccoli powder supplementation on metabolically demanding exercise performance, muscle power, and blood lactate recovery. It also investigated broccoli…

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Negative / Null Result ReportOpen accessMedicine

Opioidergic modulation of monetary incentive delay fMRI responses.

Turton S, Hawkins PCT, Muller-Pollard C et al. · 2025 · Psychopharmacology

Rationale It is hypothesised that modulation of striatal dopaminergic signalling plays a key role in the rewarding effects of opioids. The monetary incentive delay (MID) task is a functional magnetic resonance imaging (fMRI) paradigm used…

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Negative / Null Result ReportMedicine

For Tuberculosis, Not "To Screen or Not to Screen?" but "Who?" and "How?"

Farhat MR, Jacobson KR · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an…

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Negative / Null Result ReportOpen accessMedicine

Characteristics of systemic growth activation by 9,10-ketol-12(<i>Z</i>),15(<i>Z</i>)-octadecadienoic acid (KODA) in <i>Populus alba</i> cultured in vitro.

Yokoyama M, Kaida R, Miyamoto K et al. · 2024 · Plant biotechnology (Tokyo, Japan)

α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action…

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Negative / Null Result ReportOpen accessMedicine

Moderate-Intensity Aerobic Exercise Induces Ambulatory Hypotension in Young Adults with a Family History of Hypertension.

Queiroz MG, Tobar KDL, Damazo AS et al. · 2026 · International journal of environmental research and public health

This randomized crossover study aimed to evaluate the effect of a single session of aerobic exercise on 24 h ambulatory blood pressure (BP) and heart rate variability (HRV) in young adults with a family history of hypertension, FHH +…

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Negative / Null Result ReportOpen accessMedicine

Discovery of Small-Molecule Inhibitors of the KCNQ1/Kv7.1 Potassium Channel with Virtual Screening and Functional Validation in Electrophysiological Assays and KCNQ1-Knockout Neural Stem Cells.

Alam KA, Martí-Solans J, Schall D et al. · 2026 · ACS chemical neuroscience

Voltage-gated potassium channel KCNQ1 (Kv7.1) plays a critical role in electrical excitability in the heart, gut, and brain. Together with the auxiliary subunit KCNE1, KCNQ1 generates a slow delayed rectifier current ( I Ks ) that is…

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Negative / Null Result ReportOpen accessMedicine

Resolution rate of prescribing errors after advice from a specialised hospital pharmacist or a substitute hospital pharmacist: a retrospective cross-sectional study.

Wilkes S, Kalfsvel L, van Rosse F et al. · 2026 · European journal of hospital pharmacy : science and practice

Objectives Specialised hospital pharmacists, integrated in medical teams on the ward, can improve medication safety. When a specialised hospital pharmacist is temporarily not available, the pharmaceutical care will be conducted by a…

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Negative / Null Result ReportOpen accessMedicine

Effects of Luteolin and Apigenin on Adipogenesis Markers PPARγ and FABP4 and Thermogenesis Marker UCP1 in 3T3-L1 Preadipocyte Cell Line.

Uysal Yeler G, Sivaslıoğlu A, Gülsün T et al. · 2025 · International journal of molecular sciences

Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in the differentiation and maturation of preadipocytes. PPARγ promotes adipogenesis by inducing the expression of fatty acid-binding protein 4 (FABP4). Uncoupling…

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Negative / Null Result ReportOpen accessMedicine

The administration of proton pump inhibitors with the CDK4/6 inhibitor abemaciclib does not affect the clinical outcome of metastatic breast cancer patients.

Crucitta S, Cinacchi P, Bargagna I et al. · 2026 · Therapeutic advances in drug safety

Background CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib have rapidly become an established oral treatment for patients with ER+, HER2- locally advanced or metastatic breast cancer. The use of the oral route offers convenience…

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Negative / Null Result ReportOpen accessMedicine

In vitro and in vivo acaricidal properties of orally delivered ivermectin against the blacklegged tick, Ixodes scapularis.

van Oosterwijk JG, Richer L, Beimfohr-Griffing LK et al. · 2026 · Parasites & vectors

Background The lack of effective and affordable new environmental tick control products is one of the major challenges to the existing control strategies against the blacklegged tick (Ixodes scapularis), the vector of Lyme disease…

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Negative / Null Result ReportOpen accessMedicine

A Dominant Mutation in G<sub>α</sub>s-Protein Increases Hair Pigmentation.

Goff PS, Budd P, Logan DW et al. · 2025 · Pigment cell & melanoma research

We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the G α s subunit of…

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Negative / Null Result ReportMedicine

Electrical stimulation of the dorsal motor nucleus of the vagus in male mice can regulate inflammation without affecting the heart rate.

Falvey A, Palandira SP, Chavan SS et al. · 2024 · Brain, behavior, and immunity

Background The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal…

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