11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Kayode GA, Zagkos L, Oboli G et al. · 2025 · PloS one
Background Subarachnoid haemorrhage (SAH) poses a life-threatening risk, contributing to half of all haemorrhagic strokes, with aneurysmal SAH (aSAH) affecting approximately 6 individuals per 100,000 annually. Following aSAH, the influx of…
View details →Rodrigues CAS, Albano TR, Pereira Melo AK et al. · 2024 · Journal of bodywork and movement therapies
Background Y-Balance Test (YBT) assesses postural stability. When is applied to patients after anterior cruciate ligament reconstruction (ACLR), it is not clear which variables influence its result. Objective To connect YBT and postural…
View details →Harik L, Gregg AC, Wu Y et al. · 2026 · Journal of the American Heart Association
Background Patient-surgeon sex concordance influences postoperative outcomes in general surgery, but its relevance in cardiac surgery is unknown. Methods This was a cohort study of 223 065 Medicare beneficiaries undergoing coronary artery…
View details →Lee SE, Kim CW, Bae JE et al. · 2025 · Epidemiology and health
Objectives This study investigated the associations between usual source of care (USC) characteristics, which incorporate primary care functions, and medication adherence and healthy behaviors in Korean adults with diabetes. Methods We…
View details →Jiang W, Cheng A, Wang J et al. · 2025 · Frontiers in neurology
Background Febrile seizures (FSs) are a common neurological manifestation in children, affecting 2%-5% of children worldwide. While acute-phase recurrences during the same febrile illness are frequent, their risk factors and implications…
View details →Wakayama T, Saita Y, Uchino S et al. · 2025 · Journal of clinical medicine
Objective: Platelet-rich plasma (PRP) therapy has become a popular treatment for knee osteoarthritis. We aimed to determine the outcomes of knee osteoarthritis patients following PRP therapy using magnetic resonance imaging (MRI) findings…
View details →Nagao-Sato S, Kushida O, Kurita Y et al. · 2025 · Nutrients
Background/Objectives : Low masticatory function has been proposed as a risk factor for sarcopenia. This study investigated its potential association with body composition and physical performance in community-dwelling older adults.…
View details →Wu J, Guo J, Wang A et al. · 2023 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Background The association between nonalcoholic fatty liver disease (NAFLD) and intracerebral hemorrhage (ICH) remains unclear. This study aimed to investigate whether NAFLD and its severity predict incident ICH. Methods Participants free…
View details →Malindisa EK, Dika H, Rehman AM et al. · 2025 · European journal of clinical nutrition
Background The diabetes burden in sub-Saharan Africa is rising, but there is little African data on associations between diet, insulin resistance, and beta-cell dysfunction. Objective We investigated the association between dietary…
View details →Halawani AJ, Alhamoud AH, Kabrah SM et al. · 2024 · Medicine
Several diseases, including both noninfectious diseases and bacterial and viral diseases, are associated with the ABO and RH blood group systems. Previous studies have shown a link between blood type and the probability of coronavirus…
View details →Puhr HC, Berchtold L, Zingerle L et al. · 2026 · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Background History of malignant disease is a common exclusion criterion in clinical cancer trials, yet data on the impact of cancer survivorship on outcome in gastroesophageal cancer patients are scarce. Methods Retrospective association…
View details →Dakkak T, Silin N, Mahmood R et al. · 2025 · Journal of clinical medicine
Background/Objectives : Prediabetes is characterized by insulin resistance and systemic inflammation, which may increase susceptibility to acute pancreatitis (AP). However, limited data exist on how prediabetes influences in-hospital…
View details →Yektamoghaddam S, Forghanifard MM, Zrrinpour V et al. · 2025 · Galen medical journal
Background Background: Gallstone disease (GSD) is a prevalent gastrointestinal condition influenced by genetic, environmental, and dietary factors. The ATP-binding cassette subfamily B member 11 (ABCB11) gene, encoding the bile salt export…
View details →Meyer DB, Gifford A, Bradley T et al. · 2026 · Journal of gastrointestinal oncology
Background Prior studies have reported solid organ transplant (SOT) recipients have increased rates of colorectal cancer (CRC). While this increased incidence is established, the recurrence risk following curative-intent treatment for…
View details →Huber A, Pasquier T, Demarchi M et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT), characterized by elevated parathyroid hormone (PTH) and hypercalcemia, has been implicated in vascular calcification and increased arterial stiffness. Carotid-femoral pulse wave velocity (PWV) is…
View details →Sanghvi K, Todorova B, Sepil I · 2025 · Ecology and evolution
Sexual selection operates across pre- and post-mating episodes, driven by intra-sexual competition and inter-sexual choice for mates or gametes. While these episodes can act in the same direction, this is not always the case; for example,…
View details →Al Shboul S, Abu Al Karsaneh O, Alrjoub M et al. · 2025 · International journal of immunopathology and pharmacology
Objective The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction Cellular senescence and its secretory phenotype (the SASP) are implicated in…
View details →Arato CVB, Guerra LM, Probst LF et al. · 2025 · Revista de saude publica
Objective To investigate the impact of prenatal care on the reduction of maternal-child mortality in Brazilian municipalities following the new primary health care financing model, the Previne Brasil program. Methods This study comprised a…
View details →Gatterer C, Allmer D, Beitzke D et al. · 2026 · Journal of clinical medicine
Background/Objectives: Fabry disease (FD) is a lysosomal storage disorder characterized by progressive renal and cardiac involvement and an increased burden of cardiovascular and cerebrovascular events. While cardiac magnetic resonance…
View details →Kamian S, Azadeh P, Anbiaee R et al. · 2026 · Cardio-oncology (London, England)
BACKGROUND: Anthracyclines are widely used in the treatment of breast cancer but are associated with myocardial injury that may progress to cardiac dysfunction. Surveillance has traditionally relied on left ventricular ejection fraction…
View details →Kim H, Kipp K · 2025 · Computer methods in biomechanics and biomedical engineering
The purpose of this study was to calculate and compare (1) knee loads, (2) muscle-specific contributions to knee loads, and (3) effects of knee flexion angle on knee loads and muscle-specific load contributions during a forward…
View details →Nakamura T, Hatanaka KC, Kawamoto Y et al. · 2025 · Journal of cancer research and clinical oncology
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Despite the use of aggressive combination chemotherapy regimens, outcomes remain unsatisfactory. Schlafen family member 11 (SLFN11) has been reported to regulate the DNA…
View details →Tsui ST, Zhou N, Tan KS et al. · 2025 · JTCVS open
Objectives The study objectives were to determine whether diagnostic laparoscopy improves staging accuracy in selected patients with distal esophageal adenocarcinoma and to identify clinicopathologic features associated with positive…
View details →Tabara Y, Shoji-Asahina A, Ogawa A et al. · 2024 · International journal of obesity (2005)
Background Metabolically healthy obesity is not always a benign condition. It is associated with an increased incidence of cardiovascular disease and all-cause mortality. We investigated the prognostic significance of metabolically healthy…
View details →Tseng YT, Chen II, Wang CH · 2025 · Healthcare (Basel, Switzerland)
Background : The long-term effects of hormone replacement therapy (HRT) on inflammatory bowel disease (IBD) remain unclear, necessitating further investigations of the association between HRT and the development of ulcerative colitis and…
View details →Schiff DM, Wheeler A, Lewis D et al. · 2026 · Journal of substance use and addiction treatment
Objective Identify sociodemographic and substance use characteristics associated with pregnancy intention and explore the relationship between pregnancy intent and postpartum contraception interest among pregnant individuals with opioid…
View details →Reda B, Zanon G, Contardo L et al. · 2025 · Orthodontics & craniofacial research
Objective Orthodontic treatment is a common approach for correcting malocclusion but is often associated with discomfort. The aim of this study was to assess the longitudinal changes in oral behaviours, temporomandibular disorder…
View details →Kholili U, Hidayat AA, Bintoro UY et al. · 2026 · Cancers
Introduction Mounting evidence indicates that the p53 Pro72Arg single-nucleotide polymorphisms (SNPs) may play a role in modulating hepatocarcinogenesis in the setting of chronic HBV infection. However, there is currently a lack of studies…
View details →Petzke TM, Köteles F, Pohl A et al. · 2024 · Journal of psychosomatic research
Objective (Cardiac) interoception was long considered a key mechanism behind symptom perception in persistent somatic symptoms (PSS). In this study, we aimed to extend earlier findings to clarify this potential interoceptive mechanisms of…
View details →Kohno C, Higuchi A, Miyagawa E et al. · 2026 · Modern rheumatology
Objectives Low-dose aspirin (LDA) is widely recommended to prevent hypertensive disorders of pregnancy (HDP). However, the evidence of its effectiveness in pregnancies with systemic lupus erythematosus (SLE) remains limited. This study…
View details →