11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Ma Y, Mayes MD, Guo X et al. · 2024 · Scientific reports
This study aimed to examine whether a reported SSc-associated SNP rs2841277 in the PLD4 gene identified in an Asian population was also associated with SSc in European American (EA). The EA cohort consisting of 1005 SSc patients and 961…
View details →Reveley M, Owen GR, Tumba N et al. · 2026 · Developmental neurobiology
Autism spectrum disorder (ASD) has recently been described as a synaptopathy where dysregulation at the level of the synapse is thought to evoke an excitation-inhibition (E/I) imbalance implicated in its pathogenesis. The mechanisms…
View details →McHenry MS, Huo Y, Williams PL et al. · 2026 · Journal of acquired immune deficiency syndromes (1999)
Background Our objective was to evaluate the association between inflammatory biomarkers and NIH Toolbox cognitive outcomes in young adults with perinatal HIV exposure but uninfected (YAPHEU) and those with perinatal HIV (YAPHIV), with or…
View details →Hunter JWS, Van Den Heuvel C, Stephenson L et al. · 2025 · The American journal of forensic medicine and pathology
Abstract Both obesity and opioid abuse are increasing in numbers globally. As these entities may be associated with significant respiratory compromise, it was hypothesized that synergism may occur and that as a result of this obese…
View details →Eskandarian S, Zafarani A, Tandel P et al. · 2025 · Molecular biology reports
Background Clopidogrel is a widely used antiplatelet drug for treating acute coronary syndrome. Its metabolism primarily involves the CYP2C19 isoenzyme, with CYP2C192 and CYP2C193 alleles associated with reduced metabolic activity.…
View details →Dias ALB, Nascimento JR, Brito-Sousa JD et al. · 2025 · PloS one
Background Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections,…
View details →van Dijkman SC, Félices M, Pandurangavittal B et al. · 2026 · British journal of clinical pharmacology
Aims Paroxetine is a selective serotonin reuptake inhibitor (SSRI), approved for treatment of major depressive disorder and anxiety disorders. Some SSRIs are known to prolong the QT interval; however, clinical evidence to establish a lack…
View details →Soffer GK, Feinberg T, Kroll H et al. · 2025 · The Journal of asthma : official journal of the Association for the Care of Asthma
Objectives To assess the prevalence and perceived efficacy of complementary and alternative medicine (CAM) use among urban adolescents with asthma, building on a previous landmark study, and to determine if CAM use varied by asthma…
View details →Zhou C, Cui GY, Tang YH et al. · 2025 · World journal of diabetes
Background The association between ambient air pollution and glycolipid metabolic disorders (GMDs, including diabetes mellitus and dyslipidemia) is still not well understood, especially when it comes to the different effects of long-term…
View details →Mayntz SP, Warncke S, Ladefoged LG et al. · 2025 · Journal of cardiology
Background Cardiovascular disease is a leading cause of mortality globally, with air pollution, particularly fine particulate matter (PM 2.5 ), recognized as a significant risk factor. While long-term accumulated exposure to PM 2.5 has…
View details →Plischuk M, Garizoain G, Mancuso RG · 2025 · International journal of paleopathology
Objective This study examines how age at death, sex, and socio-historical context relate to the frequency, location, and severity of Schmorl's nodes. Materials The sample comprised thoracic and lumbar vertebrae of 192 skeletons from two…
View details →Ekrami A, Taheri B, Daneshfar S et al. · 2025 · BMC infectious diseases
BACKGROUND: So far, few studies have examined the association between CRISPR-Cas and antibiotic resistance in Shigella isolates. Hence, this study sought to address this issue in Shigella species isolated from stool samples of patients…
View details →Alharethi R, Knight S, Luikart HI et al. · 2024 · Clinical transplantation
Cardiac allograft vasculopathy (CAV) is a leading cause of death after heart transplantation (HT). We evaluated donor-derived cell-free DNA (dd-cfDNA) as a noninvasive biomarker of CAV development after HT. The INSPIRE registry at the…
View details →Vidal SI, Silverberg JI · 2024 · Archives of dermatological research
Background Asthma is one of the most well-recognized comorbidities of atopic dermatitis (AD). However, the relationship of AD severity and morphology with asthma characteristics in adults is not well defined. Objectives To understand…
View details →Maclennan APH, Sitner-Medvedovsky E, Varon D et al. · 2024 · Oxford medical case reports
Supraventricular tachycardia (SVT) is a narrow QRS complex tachyarrhythmia with a heart rate above 220 beats per minute in infants and children. Ventricular tachycardia can be due to electrolyte abnormalities, cardiomyopathies, congenital…
View details →Normann SS, Andersen HR, Lund LC et al. · 2025 · Environmental Research
Over the past decade, the use of organophosphate insecticides including chlorpyrifos has faced increasing restrictions due to health concerns, leading to a rise in use of pyrethroids. Concerns about neurodevelopmental insults following…
View details →Biersma AGW, van Leer B, Renes MH et al. · 2026 · BMC nephrology
BACKGROUND: Kidney function is associated with kidney volume. This study aims to explore automated segmentation for measuring total kidney volume (TKV) and to analyse the association between (changes in) TKV and acute kidney injury (AKI)…
View details →Ahuja S, Dubey A, Zaheer S · 2024 · Korean journal of clinical oncology
Purpose Endometrial cancer (EC) ranks as one of the most prevalent gynecological malignancies globally. The presence and role of stromal tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment have garnered interest due to…
View details →Godina E, Khromov-Borisov N, Bondareva E · 2025 · Journal of physiological anthropology
Background Prediction of sports success (sports talent) based on individual genetic characteristics is the main goal of sports genetics/genomics. Most often, markers of predisposition to speed-strength sports, or endurance, are…
View details →El Shahed A, Chau V, Terry J et al. · 2025 · Pediatric research
Aim To determine the relationship between presumed preterm birth (PTB) etiology and the incidence of brain injury, and neurodevelopmental outcomes at 3 and 4.5 years. Subjects and methods Prospective cohort study including 222 neonates…
View details →Salas J, Sheth P, Cohen BE et al. · 2025 · General hospital psychiatry
Background Posttraumatic stress disorder (PTSD) is associated with risk for cardiovascular disease (CVD). Improved physical health often follows large decreases in PTSD severity, but it is not known if better CVD outcomes follow PTSD…
View details →Dyer AH, Dolphin H, Morrison L et al. · 2026 · EBioMedicine
Background Both low-grade systemic inflammation and acute inflammatory events may contribute to Alzheimer Disease (AD) progression. However, studies examining the prognostic utility of systemic inflammatory biomarkers in AD, and how…
View details →Cantilena A, Han KL, Cai Y et al. · 2026 · Cytotherapy
Children with B-cell acute lymphoblastic leukemia (B-ALL) are increasingly treated with immunotherapeutic agents such as blinatumomab and inotuzumab. Thus, those who present in relapse for chimeric antigen receptor (CAR) T-cell therapy are…
View details →Skelton K, Moritz C, Day KA et al. · 2025 · Ecology and evolution
Behavioural and physiological adaptations are important for maintaining stable hydric states and viable body temperatures under challenging conditions experienced in variable terrestrial environments. For example, reptiles from arid…
View details →Kilicaslan MB, Dikme O, Girgin MC et al. · 2026 · BMC gastroenterology
Aims This study aimed to investigate the relationship between admission serum lipase levels, prognostic clinical scoring systems, and in-hospital mortality in patients presenting to the emergency department with acute pancreatitis. Methods…
View details →Abedalqader T, Migliorini A, Cerecedo LG et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives: Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed metabolic and bariatric surgeries worldwide. Marginal ulcers (MU) are a common complication following RYGB, yet their pathophysiology and the…
View details →Antunes RA, Souza MDCB, Souza MM et al. · 2024 · Fertility and sterility
Objective To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates. Design A retrospective cohort study. Setting A private…
View details →Pogorielova OS, Korniienko VV, Chumachenko YD et al. · 2025 · Cardiology research and practice
This study probes the relationship between serum matrix metalloproteinase-9 (MMP-9) levels, the genetic variant rs17576 in the MMP-9 gene, and the extent of coronary atherosclerosis among Ukrainian patients diagnosed with coronary artery…
View details →Toklu E, Göknar G, Adıyeke SK · 2026 · BMC ophthalmology
BACKGROUND: Idiopathic epiretinal membrane (iERM) is a common age-related vitreoretinal disorder characterized by fibrocellular proliferation on the inner limiting membrane. Although systemic inflammation has been suggested to play a…
View details →Schiemer C, Horswill MS, Hill A et al. · 2025 · Journal of safety research
Introduction As the medically prescribed use of cannabis flower continues to increase, there is a need to understand how vaporized cannabis can acutely affect driving-related skills and risk-taking behaviors in medicinal populations.…
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