11,287 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Jared W. Magnani, Carlee Moser, Joanne M. Murabito et al. · 2014 · Circulation Arrhythmia and Electrophysiology
BACKGROUND: Endogenous sex hormones have been related to cardiovascular outcomes and mortality. We hypothesized that sex hormones are related to atrial fibrillation (AF) in a community-based cohort of middle-aged to older men. METHODS AND…
View details →Ling Ji, Todd Chaba, Lin-Fu Zhu et al. · 2011 · Hepatology
UNLABELLED: A major predictor of failed liver resection and transplantation is nonalcoholic fatty liver disease (NAFLD). NAFLD is linked to a wide spectrum of diseases including obesity and diabetes that are increasingly prevalent in…
View details →Joel B. Nelson, Karim Fizazi, Kurt Miller et al. · 2012 · Cancer
BACKGROUND: Endothelin-1 and the endothelin A (ET(A) ) receptor have been implicated in prostate cancer progression in bone. This study aimed to determine whether the specific ET(A) receptor antagonist, zibotentan, prolonged overall…
View details →Monique Maas, Patty J. Nelemans, Vincenzo Valentini et al. · 2014 · International Journal of Cancer
Recent literature suggests that the benefit of adjuvant chemotherapy (aCT) for rectal cancer patients might depend on the response to neoadjuvant chemoradiation (CRT). Aim was to evaluate whether the effect of aCT in rectal cancer is…
View details →Marius M. Hoeper, Juergen Behr, Matthias Held et al. · 2015 · PLoS ONE
BACKGROUND: Pulmonary hypertension (PH) is a common finding in patients with chronic fibrosing idiopathic interstitial pneumonias (IIP). Little is known about the response to pulmonary vasodilator therapy in this patient population. COMPERA is an international registry that prospectively captures data from patients with various forms of PH receiving pulmonary vasodilator therapies. METHODS: We retrieved data from COMPERA to compare patient characteristics, treatment patterns, response to therapy and survival in newly diagnosed patients with idiopathic pulmonary arterial hypertension (IPAH) and
View details →Bo Abrahamsen, Henrik L. Jørgensen, Anne Sofie Laulund et al. · 2014 · Journal of Bone and Mineral Research
The relationship between thyrotoxicosis and osteoporotic fractures remains controversial, particularly in men. Register-based cohort study including all patients with a serum thyrotropin (TSH) measurement in the region of Funen 1996-2010.…
View details →Yoshio N. Hall, Brett Larive, Patricia Painter et al. · 2012 · Clinical Journal of the American Society of Nephrology
BACKGROUND AND OBJECTIVES: Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study examined changes in physical performance…
View details →Christian von Bodman, Kazuhito Matsushita, Caroline Savage et al. · 2012 · The Journal of Urology
PURPOSE: We determined whether pelvic soft tissue and bony dimensions on endorectal magnetic resonance imaging influence the recovery of continence after radical prostatectomy, and whether adding significant magnetic resonance imaging…
View details →Christiane Al‐Haddad, Georges M. El Mollayess, Carol Cherfan et al. · 2011 · British Journal of Ophthalmology
BACKGROUND/AIMS: To study peripapillary retinal nerve fibre layer (RNFL) and macular thickness in amblyopia using high-definition spectral-domain optical coherence tomography (SD-OCT) and to compare the results with available literature…
View details →Yoshinobu Onuma, Patrick W. Serruys, J.A. Fernández Gómez et al. · 2011 · Catheterization and Cardiovascular Interventions
OBJECTIVES: The ABSORB cohort A trial using the bioresorbable everolimus-eluting scaffold (BVS revision 1.0, Abbott Vascular) demonstrated a slightly higher acute recoil with BVS than with metallic stents. To reinforce the mechanical…
View details →Alex P. Di Battista, John E. Buonora, Shawn G. Rhind et al. · 2015 · Frontiers in Neurology
BACKGROUND: Blood biomarkers are valuable tools for elucidating complex cellular and molecular mechanisms underlying traumatic brain injury (TBI). Profiling distinct classes of biomarkers could aid in the identification and characterization of initial injury and secondary pathological processes. This study characterized the prognostic performance of a recently developed multi-marker panel of circulating biomarkers that reflect specific pathogenic mechanisms including neuroinflammation, oxidative damage, and neuroregeneration, in moderate-to-severe TBI patients. MATERIALS AND METHODS: Periphera
View details →J. Randolph Hecht, Sara Lonardi, Johanna C. Bendell et al. · 2021 · Journal of Clinical Oncology
PURPOSE SEQUOIA compared efficacy and safety of adding pegilodecakin (PEG), a pegylated recombinant human interleukin (IL)-10, with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) in patients following progression on first-line…
View details →Michael R. Sperling, Bassel Abou‐Khalil, Jay Harvey et al. · 2014 · Epilepsia
OBJECTIVE: To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in patients with refractory partial-onset seizures. METHODS: This randomized, placebo-controlled, double-blind, parallel-group, phase III study was…
View details →Hyun Jin Jo, Jaeyeon Kim, Nayoung Kim et al. · 2016 · Helicobacter
BACKGROUND: Little is known about the role of gastric microbiota except for Helicobacter pylori (HP) in human health and disease. We compared the differences of human gastric microbiota according to gastric cancer or control and HP…
View details →C. Avendaño, António Ramos, Elena Múñez et al. · 2021 · Journal of Clinical Investigation
BACKGROUNDPassive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19. Evidence from controlled clinical trials is inconclusive.METHODSWe conducted a randomized, open-label, controlled clinical trial at 27…
View details →Alice Tseng, Leah Szadkowski, Sharon Walmsley et al. · 2013 · Annals of Pharmacotherapy
BACKGROUND: Interactions between antiretroviral (ARV) therapy and medications to treat age-related comorbidities are a growing concern in the aging HIV population. OBJECTIVE: To investigate the association of age with potential drug-drug…
View details →Charles de Mestral · 2011 · Canadian Journal of Surgery
BACKGROUND: A multidisciplinary tracheostomy team was created in 2005 to follow critically ill patients who had undergone a tracheostomy until their discharge from hospital. Composed of a surgeon, surgical resident, respiratory therapist,…
View details →Deborah H. Ndao, Elena J. Ladas, Bin Cheng et al. · 2010 · Psycho-Oncology
OBJECTIVE: Though often lifesaving, stem cell transplantation (SCT) is a period of great distress for both child and parent. METHODS: We conducted a double-blind, placebo-controlled randomized study evaluating the effect of the respiratory…
View details →Stewart R. Walsh, S.A.R. Nouraei, Tjun Yip Tang et al. · 2010 · Vascular and Endovascular Surgery
Remote ischemic preconditioning (RIPC) is a physiological mechanism whereby brief ischemia-reperfusion episodes attenuate damage by subsequent prolonged ischemic insults. It reduces myocardial injury following cardiac and aortic aneurysm…
View details →Lena Koch‐Gallenkamp, Heike Bertram, Andrea Eberle et al. · 2016 · Health Psychology
OBJECTIVE: Fear of recurrence (FoR) is among the most important concerns for cancer survivors. Studies on potentially influencing variables, like time since diagnosis, cancer type, and sex, have yielded heterogeneous results. Also social…
View details →Kathryn G. Ewens, Michelle R. Jones, Wendy Ankener et al. · 2011 · PLoS ONE
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in women. It is also associated with metabolic disturbances that place women at increased risk for obesity and type 2 diabetes. There is strong evidence for familial clustering of PCOS and a genetic predisposition. However, the gene(s) responsible for the PCOS phenotypes have not been elucidated. This two-phase family-based and case-control genetic study was designed to address the question of whether SNPs identified as susceptibility loci for obesity in genome-wide association studies (GWAS) are also associated w
View details →Alexander G. Thompson, Elizabeth Gray, Alexander Bampton et al. · 2019 · Journal of Neurology Neurosurgery & Psychiatry
Objective To evaluate the classifier performance, clinical and biochemical correlations of cerebrospinal fluid (CSF) levels of the chitinase proteins Chitotriosidase-1 (CHIT1), Chitinase-3-like protein 1 (CHI3L1) and Chitinase-3-like…
View details →Charles M. Rudin, Stephen V. Liu, Ross A. Soo et al. · 2023 · Journal of Clinical Oncology
PURPOSE The phase III SKYSCRAPER-02 study determined whether the benefits of atezolizumab plus carboplatin and etoposide (CE) could be enhanced by the addition of tiragolumab in untreated extensive-stage small-cell lung cancer (ES-SCLC).…
View details →Dinesh Khanna, Yannick Allanore, Christopher P. Denton et al. · 2020 · Annals of the Rheumatic Diseases
OBJECTIVES: Riociguat is approved for pulmonary arterial hypertension and has antiproliferative, anti-inflammatory and antifibrotic effects in animal models of tissue fibrosis. We evaluated the efficacy and safety of riociguat in patients with early diffuse cutaneous systemic sclerosis (dcSSc) at high risk of skin fibrosis progression. METHODS: In this randomised, double-blind, placebo-controlled, phase IIb trial, adults with dcSSc of <18 months' duration and a modified Rodnan skin score (mRSS) 10-22 units received riociguat 0.5 mg to 2.5 mg orally three times daily (n=60) or placebo (n=61). T
View details →Patrick J. Denard, Alexandre Lädermann, Stephen S. Burkhart · 2012 · Arthroscopy The Journal of Arthroscopic and Related Surgery
PURPOSE: The purpose of this study was to determine the long-term functional outcome of anatomic arthroscopic repair of type II SLAP lesions with suture anchors. METHODS: We examined all arthroscopic repairs of isolated type II SLAP…
View details →Jennifer L. Dearborn, Yiyi Zhang, Ye Qiao et al. · 2017 · Neurology
OBJECTIVE: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. METHODS: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the…
View details →Ioannis Pavlidis, Panagiotis Tsiamyrtzis, Dvijesh Shastri et al. · 2012 · Scientific Reports
In the present study we quantify stress by measuring transient perspiratory responses on the perinasal area through thermal imaging. These responses prove to be sympathetically driven and hence, a likely indicator of stress processes in…
View details →Carlos Cruchaga · 2011 · Archives of Neurology
BACKGROUND: Apolipoprotein E (APOE) is the most statistically significant genetic risk factor for late-onset Alzheimer disease (LOAD). The linkage disequilibrium pattern around the APOE gene has made it difficult to determine whether all…
View details →Étienne Cavaignac, V. Lafontan, Nicolas Reina et al. · 2013 · The Bone & Joint Journal
The significance of weight in the indications for unicompartmental knee replacement (UKR) is unclear. Our hypothesis was that weight does not affect the long-term rate of survival of UKRs. We undertook a retrospective study of 212 UKRs at…
View details →Yi‐Han Hsiao, Yung‐Tai Chen, Ching-Min Tseng et al. · 2015 · SLEEP
STUDY OBJECTIVES: To explore the association between the non-apnea sleep disorder (NSD) and autoimmune diseases. DESIGN: Cohort study. SETTING: Nationwide database research. PARTICIPANTS: 84,996 adult patients with NSD diagnoses recorded…
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