11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Park SJ, Manson JE, Kim E et al. · 2026 · Thrombosis and haemostasis
Epidemiological and experimental studies suggest cocoa flavanols and multivitamin-multimineral (MVM) supplements may confer arterial vascular benefits. However, their effects on clinical venous thromboembolic events have been infrequently…
View details →McGregor D, Shynkaruk T, Adler CAB et al. · 2026 · Poultry science
Commercial transport of newly hatched poultry species typically occurs under darkness. The impact of providing light during chick transportation has not been investigated and previous research suggests blue light may have a calming effect…
View details →Prandin G, Naccarato M, Furlanis G et al. · 2025 · Clinical autonomic research : official journal of the Clinical Autonomic Research Society
Background Sympathetic activation, inflammation, and neuro-endocrine response after an ischemic stroke contribute to the development of the stroke heart syndrome (SHS). One marker of SHS is a troponin "rise and fall pattern" > 30%. Among…
View details →Dinleyici EC, Indrio F, Szajewska H et al. · 2026 · Journal of pediatric gastroenterology and nutrition
For many years, biotics (including probiotics, prebiotics, human identical milk oligosaccharides, synbiotics, and postbiotics) have been added to infant formula to influence the gut microbiota of formula-fed infants, aiming to bring it…
View details →Xu C, Annapureddy H, Carson L et al. · 2026 · JCI insight
Antiretroviral therapy (ART) has prolonged the life expectancy of persons living with HIV, the majority of whom are now older than 50 years. Aging people with HIV are at increased risk for cardiovascular events driven by HIV-related…
View details →Brandt RB, Lansbergen CS, Kollenburg L et al. · 2025 · Headache
Background/objective Occipital nerve stimulation (ONS) has become an established therapy for medically intractable chronic cluster headache (MICCH), but unfortunately, one third of the patients do not respond satisfactorily. Reliable…
View details →Hagedoorn L, Ruiz-Rodríguez A, Leijen I et al. · 2025 · Experimental gerontology
Background Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated…
View details →Chiang Yu Y, Lu D, Rege B et al. · 2024 · Journal of pharmaceutical sciences
The addition of antioxidants to pharmaceutical products is a potential approach to inhibit nitrosamine formation, particularly in solid oral dosage forms like tablets and capsules. The objective was to assess the effect of ten antioxidants…
View details →Gootjes C, Zwaginga JJ, Nikolic T et al. · 2026 · PloS one
Iscalimab is a nondepleting anti-CD40 monoclonal antibody, expected to suppress immune responses by blocking the costimulation by antigen-presenting cells through CD40-CD40L ligation. This therapeutic antibody indeed inhibited…
View details →Forde G, Brucker BM, Becker Ifantides K et al. · 2024 · Toxins
OnabotulinumtoxinA (onabotA) is approved in the US for 12 therapeutic indications. Real-world data on onabotA multi-indication use are limited, often leading to delayed or reduced treatment. This study provides real-world evidence on the…
View details →Goettel M, Werner C, Honarvar N et al. · 2024 · Toxicology
The fungicide fluxapyroxad (BAS 700 F) has been shown to significantly increase the incidence of liver tumours in male Wistar rats at dietary levels of 1500 and 3000 ppm and in female rats at a dietary level of 3000 ppm via a non-genotoxic…
View details →Kornienko TE, Chepanova AA, Kolobenko MV et al. · 2026 · Current issues in molecular biology
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the…
View details →Dalla Via J, Radavelli-Bagatini S, Sim M et al. · 2026 · Aging clinical and experimental research
Background Provision of vascular imaging results has been investigated to prompt changes towards healthy lifestyle behaviours, but effects on body composition and muscle health are unknown. Aim This secondary analysis of a 12-week…
View details →Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research
We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…
View details →Dekhne MS, Kunze KN, Chiu YF et al. · 2025 · Arthroplasty today
Background Patient-reported outcome measures (PROMs) assess quality of care after total joint arthroplasty (TJA) and will be mandatory for reporting by 2027 under the Center for Medicare and Medicare Services. This study evaluated the…
View details →Robinson HL, Banks ML · 2026 · ASPET discovery
Rationale Mesocorticolimbic dopamine neurotransmission is hypothesized to play a central role in both cocaine reinforcement and amphetamine maintenance-induced decreases in cocaine self-administration. One method to selectively modulate…
View details →Rahimi A, Fatehi F, Rafiee H et al. · 2026 · Veterinary medicine and science
Background Beet vinasse (VIN), a by-product of sugar beet processing, is rich in non-protein nitrogen (NPN), potassium, and prebiotic compounds, offering potential as a feed additive to enhance dairy cow performance while reducing…
View details →Cuezva JM, Domínguez-Zorita S · 2024 · Cancers
The relevant role played by the ATPase Inhibitory Factor 1 (IF1) as a physiological in vivo inhibitor of mitochondrial ATP synthase in cancer and non-cancer cells, and in the mitochondria of different mouse tissues, as assessed in…
View details →Djuric N, Rochman CM, Riskin SH · 2026 · PloS one
Agroecosystems are increasingly recognized as major basins for terrestrial microplastics. Many agricultural practices have led to high loading of plastic mulch films, synthetic microfibers, and other microplastics onto fields. There is…
View details →Abbasi A, Ahmad K, Ferguson C et al. · 2024 · European journal of applied physiology
Purpose Pathogen transmission during cardio-pulmonary exercise testing (CPET) is caused by carrier aerosols generated during respiration. Methods Ten healthy volunteers (age range: 34 ± 15; 4 females) were recruited to see if the…
View details →Gerhart BJ, Pellerin D, Danzi MC et al. · 2024 · Neurology. Genetics
Background and objectives The number of GAA repeats in the FXN gene is a major but not sole determinant of the clinical presentation of Friedreich ataxia (FRDA). The objective of this study was to establish whether the length of the GAA…
View details →Rodríguez Rondón AV, Prins K, Volker F et al. · 2026 · Human molecular genetics
Melanocortin-2 receptor accessory protein-2 (MRAP2) modulates the activity of hypothalamic melanocortin-4 (MC4R) and growth hormone-secretagogue (GHSR) receptors, which suppress and promote appetite, respectively. We investigate whether…
View details →Ruiz-López A, Montalvo-Alonso JJ, Martín-Rivas I et al. · 2026 · Nutrients
Background/Objectives : Caffeine is a well-established ergogenic aid in many strength- and endurance-based sports, but its efficacy in sport climbing remains underexplored despite the sport's unique physical demands on grip strength,…
View details →Zhang Y, Zhang H, Zhou M et al. · 2025 · American journal of physical medicine & rehabilitation
Abstract The improvement of early rehabilitation service capacity is of great importance for meeting health needs of the population; however, there is still a lack of information on early rehabilitation interventions in hospitals in China.…
View details →Sridhar A, Khan D, Flatt PR et al. · 2023 · Peptides
Effects of sustained activation of glucagon-like peptide-1 (GLP-1) receptors (GLP-1R) as well as antagonism of receptors for glucose-dependent insulinotropic peptide (GIP) on intestinal morphology and related gut hormone populations have…
View details →Mohammadi F, Razmjooei N, Mohsenpour MA et al. · 2025 · BMC nutrition
Background and aim Probiotics play an important role in the control and treatment of non-alcoholic fatty liver disease (NAFLD). Kefir drink is a fermented beverage and has indicated some beneficial health effects. The aim of this study was…
View details →Margolis LM, Wilson MA, Drummer DJ et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology
Insulin insensitivity decreases exogenous glucose oxidation and metabolic clearance rate (MCR) during aerobic exercise in unacclimatized lowlanders at high altitude (HA). Whether use of an oral insulin sensitizer before acute HA exposure…
View details →Kloft HM, Shelby AM, Pasloske K · 2025 · Journal of feline medicine and surgery
ObjectivesThe aim of the present study was to assess the gamma-aminobutyric acid type A (GABA A ) receptor antagonist flumazenil and its effect on the anesthetic activity of the GABA A receptor agonist alfaxalone when administered…
View details →Martins MM, Gheller LS, Noronha BL et al. · 2026 · Animals : an open access journal from MDPI
The objective of this study was to evaluate the effects of sodium butyrate and organic zinc supplementation, alone or combined, on performance, zinc metabolism, blood parameters, and gut health in Holstein calves highly challenged by heat…
View details →Wang X, Dowty ME, Tripathy S et al. · 2024 · European journal of drug metabolism and pharmacokinetics
Background and objective Abrocitinib is an oral small-molecule Janus kinase (JAK)-1 inhibitor approved for the treatment of moderate-to-severe atopic dermatitis. In vitro studies indicated that abrocitinib is a weak time-dependent…
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