11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Bronshtein O, Konson A, Kuniavsky M et al. · 2025 · Quality management in health care
Background and objectives Early in the global COVID-19 pandemic, a concern was raised that potentially high volumes of COVID-19 inpatients in general hospitals might compromise the hospitals' capabilities to maintain high-quality care for…
View details →Renko K, Thomas R, Hawks M et al. · 2026 · Frontiers in toxicology
Thyroid hormone (TH) availability is particularly critical for early brain development. TH transport across the blood-brain barrier is facilitated through two main transmembrane transporters: monocarboxylate transporter 8 (MCT8) and…
View details →Lavigna G, Grasso A, Pasini C et al. · 2025 · PloS one
There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. Previously, we showed that the PERK kinase inhibitor GSK2606414 delays…
View details →Myhre MG, Azeem A, Barrett M · 2024 · New Zealand veterinary journal
Case history Medical records from 2009 to 2021 from a private equine referral hospital in Rochester, NH, USA were analysed for cases that underwent general anaesthesia for low-field MRI of the distal limb. These were used to determine…
View details →Carney C, Jenkins L, Jewell C et al. · 2025 · microPublication biology
Several lines of evidence suggest a potential link between stemness and vitamin B12, which contributes to S-adenosylmethionine (SAM) generation and hence methylation-dependent epigenetic control. Here we found that the vitamin B12…
View details →Ruiz-López A, Montalvo-Alonso JJ, Martín-Rivas I et al. · 2026 · Nutrients
Background/Objectives : Caffeine is a well-established ergogenic aid in many strength- and endurance-based sports, but its efficacy in sport climbing remains underexplored despite the sport's unique physical demands on grip strength,…
View details →Zhang Y, Zhang H, Zhou M et al. · 2025 · American journal of physical medicine & rehabilitation
Abstract The improvement of early rehabilitation service capacity is of great importance for meeting health needs of the population; however, there is still a lack of information on early rehabilitation interventions in hospitals in China.…
View details →Sridhar A, Khan D, Flatt PR et al. · 2023 · Peptides
Effects of sustained activation of glucagon-like peptide-1 (GLP-1) receptors (GLP-1R) as well as antagonism of receptors for glucose-dependent insulinotropic peptide (GIP) on intestinal morphology and related gut hormone populations have…
View details →Mohammadi F, Razmjooei N, Mohsenpour MA et al. · 2025 · BMC nutrition
Background and aim Probiotics play an important role in the control and treatment of non-alcoholic fatty liver disease (NAFLD). Kefir drink is a fermented beverage and has indicated some beneficial health effects. The aim of this study was…
View details →Margolis LM, Wilson MA, Drummer DJ et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology
Insulin insensitivity decreases exogenous glucose oxidation and metabolic clearance rate (MCR) during aerobic exercise in unacclimatized lowlanders at high altitude (HA). Whether use of an oral insulin sensitizer before acute HA exposure…
View details →Kloft HM, Shelby AM, Pasloske K · 2025 · Journal of feline medicine and surgery
ObjectivesThe aim of the present study was to assess the gamma-aminobutyric acid type A (GABA A ) receptor antagonist flumazenil and its effect on the anesthetic activity of the GABA A receptor agonist alfaxalone when administered…
View details →Martins MM, Gheller LS, Noronha BL et al. · 2026 · Animals : an open access journal from MDPI
The objective of this study was to evaluate the effects of sodium butyrate and organic zinc supplementation, alone or combined, on performance, zinc metabolism, blood parameters, and gut health in Holstein calves highly challenged by heat…
View details →Wang X, Dowty ME, Tripathy S et al. · 2024 · European journal of drug metabolism and pharmacokinetics
Background and objective Abrocitinib is an oral small-molecule Janus kinase (JAK)-1 inhibitor approved for the treatment of moderate-to-severe atopic dermatitis. In vitro studies indicated that abrocitinib is a weak time-dependent…
View details →Austin DK, Amador LMD, Li LM et al. · 2025 · Neuropsychopharmacology reports
Aim Selective serotonin reuptake inhibitors are thought to exert a clinical effect through various mechanisms, including through alteration in synaptic plasticity. Repetitive transcranial magnetic stimulation can induce temporary changes…
View details →Kattler KR, Watkins HV, Perretta KN et al. · 2024 · Biol Invasions.
Organisms that settle and grow on other organisms (i.e., epibionts) are often costly to their hosts in terms of locomotion, growth, and/or reproduction. Such costs can potentially result in biotic resistance against invasion when native…
View details →Cerpelloni F, Collignon O, Op de Beeck H · 2026 · Psychonomic bulletin & review
Most written systems share basic shape features with natural objects such as line junctions, a commonality thought to be at the basis of fluent reading. Studies that compared reading acquisition for different scripts used line-based…
View details →Rivest D, Martin-Guay MO · 2024 · Nutrient cycling in agroecosystems.
Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…
View details →Leuschner S, Schenk P, Gräbsch C et al. · 2025 · Innovative surgical sciences
Objectives Non-technical skills (NTS) training of surgical staff is a quality improvement measure to improve patient safety. One factor that can compromise patient safety is impaired staff performance due to stressors such as tiredness.…
View details →Muñiz-Anquela R, Redondo-Angulo I, Lewis EA et al. · 2026 · Arteriosclerosis, thrombosis, and vascular biology
Background Eradicating endothelial caveolae by deleting the Cav1 (caveolin-1) gene reduces LDL (low-density lipoprotein) uptake in arteries and efficiently prevents early atherogenesis, but the role in established atherosclerosis is…
View details →Stephan K, Stephens AN, Scully M et al. · 2024 · Accident; analysis and prevention
Background Globally, road traffic crashes are the leading cause of death for young adults. The P Drivers Project was a trial of a behavioural change program developed for, and targeted at, young Australian drivers in their initial months…
View details →Hertler C, Lohmann J, Koulidiati J et al. · 2022 · European journal of public health
Abstract Background In 2020, about one in four women in Burkina Faso faced an unmet need for family planning (FP). Between 2013 and 2017, Burkina Faso implemented a performance-based financing (PBF) program to improve primary health care…
View details →Howey C, McFetridge A, Luczak A · 2025 · International journal of molecular sciences
Epilepsy affects 50 to 70 million people worldwide and is characterized by recurring seizures that accelerate neurodegeneration; however, its mechanisms are still not well understood. It was proposed that epileptogenesis may be "hijacking"…
View details →Tadenev ALD, Hatton CL, Burgess RW · 2024 · Journal of the peripheral nervous system : JPNS
Background Inhibition of HDAC6 has been proposed as a broadly applicable therapeutic strategy for Charcot-Marie-Tooth disease (CMT). Inhibition of HDAC6 increases the acetylation of proteins important in axonal trafficking, such as…
View details →· 2022 · Journal of the Endocrine Society
Abstract Metformin, a lipophilic biguanide inhibiting hepatic gluconeogenesis and improving peripheral utilization of glucose, is a well-established medication for the management of type 2 diabetes. Furthermore, metformin has been shown to…
View details →Leslie E, Gonzalez Bosc LV, Specht J et al. · 2024 · Medicine and science in sports and exercise
Purpose Chronic, high-altitude hypoxic exposure increases the risk of high-altitude pulmonary hypertension (PH). Emerging evidence shows maternal exercise may improve offspring resistance to disease throughout life. The purpose of this…
View details →Contrada M, Pignolo L, Vatrano M et al. · 2024 · Brain sciences
Purpose Cognitive dysfunctions are still very common in the chronic phase of stroke when patients are discharged from neurorehabilitation centers. Even individuals who appear to have made a full clinical recovery may exhibit new…
View details →Nieto-Felipe J, Macias-Diaz A, Alvarado S et al. · 2025 · Scientific reports
Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of…
View details →Bulgarella M, Reason A, Baty JW et al. · 2025 · Insects
Double-stranded RNA (dsRNA) biopesticides offer the potential for highly targeted pest control with minimal off-target impacts. Varroa mites ( Varroa destructor ) are an important pest of honey bees ( Apis mellifera ) that are primarily…
View details →Gunn D, Yeldho C, Hoad C et al. · 2024 · Neurogastroenterology and motility
Background Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron. Methods A…
View details →Mattar D, Cheewasopit W, Samir M et al. · 2023 · Reproduction & fertility
Kisspeptin, a hypothalamic neuropeptide encoded by the KISS1 gene, has a pivotal role in promoting GnRH secretion in mammals. Kisspeptin and its receptor (KISS1R) are also expressed in certain peripheral tissues including gonads,…
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