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Browse the failure-mode index

11,314 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Industry Interactions at Medical Conferences: Representatives' Credentials and the Disclosure of Data Limitations Influence Clinician Perceptions.

O'Donoghue AC, Aikin KJ, Amoozegar JB et al. · 2025 · Journal of the American Board of Family Medicine : JABFM

Purpose Exhibit hall booths at medical conferences are a key avenue for promoting prescription drugs to health care providers (HCPs). Because HCPs spend considerable time interacting with industry representatives at conferences, we…

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Negative / Null Result ReportMedicine

Should Communication Campaigns Promoting Vaccination Address Misinformation Beliefs? Implications from a Nationally Representative Longitudinal Survey Study among U.S. Adults.

Clark D, Kikut-Stein A, Jesch E et al. · 2024 · Journal of health communication

Public health communication campaign planners must carefully consider whether misinformation beliefs are important to target and, ideally, correct. Guided by the reasoned action approach, we hypothesized that behavior-specific beliefs…

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Negative / Null Result ReportOpen accessMedicine

Social working memory in adolescence.

Grunewald K, Andrews JL, Schweizer S · 2026 · Child development

Little is known about how social network associations are tracked in cognition during adolescence, when social networks change in size and complexity. In 2023, 123 ethnically diverse adolescents and emerging adults (13-24 years; 52.9%…

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Negative / Null Result ReportOpen accessMedicine

Environmental Supports, Expectations, and Barriers to Leisure-Time Physical Activity During Pregnancy: A Rural-Urban Comparison.

Rogers CW, Crisp A, Wilhite K et al. · 2026 · The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association

Background Physical activity (PA) during pregnancy has well-documented benefits, yet pregnant rural residents may face additional barriers to PA. Objective To examine whether leisure-time physical activity (LTPA) and correlates of LTPA,…

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Negative / Null Result ReportMedicine

Cardiac autonomic function in young, healthy adults: Influence of race and sex.

Taherzadeh Z, Kissell CE, Young BE et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology

Non-Hispanic Black (BL) adults living in the United States are more likely to develop cardiovascular disease (CVD) compared with their non-Hispanic White (WH) counterparts. Although measures of cardiac autonomic function [i.e., spontaneous…

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Negative / Null Result ReportOpen accessMedicine

Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder.

Iwabuchi T, Hirai T, Umeda N et al. · 2025 · Autism research : official journal of the International Society for Autism Research

Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some…

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Negative / Null Result ReportOpen accessMedicine

Psychotic-Like Experiences and White Matter Microstructure: A Fixel-Based Analysis Approach With Robust Replication Across Two Cohorts.

Goodwin I, Larsen KM, Sangchooli A et al. · 2025 · Human brain mapping

Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non-clinical psychotic-like experiences, predating illness onset.…

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Negative / Null Result ReportOpen accessMedicine

Breath-Holding Maneuvers and Airway Closure in Healthy Adults and Parkinson's Disease: Effects of Maneuver Type, Health Status, and Vocal Fold Bowing.

Curtis JA, Beam AB, Nam J et al. · 2025 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction Breath-holding maneuvers are frequently used to improve airway closure and swallowing safety in people with dysphagia. While their effects on airway closure have been studied in healthy adults, little is known about their…

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Negative / Null Result ReportOpen accessMedicine

Influence of Immobilization, Stretching, and Activity on the Morphological Properties of Spastic Gastrocnemius Muscles.

Habersack A, Kruse A, Guggenberger B et al. · 2026 · Children (Basel, Switzerland)

Background/Objectives: Children with cerebral palsy (CP) often develop altered muscle architecture and calf muscle contractures. Orthotic immobilization aims to provide prolonged stretch to lengthen the muscle belly and muscle-tendon unit…

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Negative / Null Result ReportMedicine

Effects of Time of Arrival on Trauma Patient Outcomes.

LaRosa SK, Stone XA, Fenninger AA et al. · 2024 · The American surgeon

Background Arriving during "off hours" to the hospital can put patients at greater risk of complications or mortality given lesser staff. Our goal was to investigate this in trauma patients with an Injury Severity Score (ISS) of >15. We…

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Negative / Null Result ReportMedicine

Climatic resilience: Marine heatwaves do not influence the variations of green crab (Carcinus maenas) megalopae supply patterns to a Western Iberian estuary.

Monteiro M, Azeiteiro UM, Queiroga H · 2024 · Marine environmental research

Extreme climatic events like marine heatwaves (MHWs) are becoming more frequent, intense, and longer lasting all around the world. The consequences of these anomalously warm periods are devastating for marine ecosystems. Still, little is…

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Negative / Null Result ReportMedicine

An acute social stressor decreases reinforcing value of both high and low energy-dense food in college students in a randomized controlled trial.

McKay NJ, Horvatits EJ, Jean M et al. · 2024 · Physiology & behavior

It is well known that a large portion of the population elevates their intake of high energy-dense foods during times of stress; however, it is understudied whether stress affects the reinforcing value of a food reward. Further knowledge…

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Negative / Null Result ReportOpen accessMedicine

Oxytocin administration during labor does not affect maternal serum oxytocin levels, early postpartum breastfeeding attitude and maternal attachment.

Özdemir M, Çeber Turfan E, Keskin HL · 2025 · PloS one

The goal was to investigate the effects of synthetic oxytocin administration during labor on maternal and neonatal serum oxytocin levels, early breastfeeding attitudes, and postpartum maternal attachment immediately after birth. This…

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Negative / Null Result ReportMedicine

Greater Emotional and Psychological Well-being Are Associated With Reduced Employee Self-report Illness-Related Absenteeism: A Multi-Industry, Cross-sectional Study Conducted During COVID-19 Pandemic.

Fannin A, Hooley C, Nelson EJ · 2024 · Journal of occupational and environmental medicine

Objective The purpose of this study is to determine the relationship that emotional, psychological, and social well-being has with self-reported illness-related absenteeism. Methods This study examines the relationship between three…

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Negative / Null Result ReportOpen accessMedicine

Impact of Blood Group on Contralateral Suppression of Otoacoustic Emissions, Speech Perception in Noise, and Binaural Integration.

Ponnana S A P, Tauro JP, S NP et al. · 2026 · International archives of otorhinolaryngology

Introduction Understanding the relationship between blood groups (A, B, AB, and O) and auditory functioning can provide valuable insights into individual differences in hearing ability and potential risks for hearing loss. Objective To…

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Negative / Null Result ReportMedicine

Neurocognitive Profile of Avoidant/Restrictive Food Intake Disorder: Cognitive Flexibility, Delay Discounting, and Detail Orientation.

McPherson IK, Dalton AG, Armstrong K et al. · 2026 · The International journal of eating disorders

Objective Neurocognitive deficits are well-documented across psychiatric disorders and may indicate novel treatment targets. However, empirical data on the neurocognitive profile of avoidant/restrictive food intake disorder (ARFID) are…

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Negative / Null Result ReportMedicine

A shift to a standard diet after exposure to a high-fat, high-sucrose diet from gestation to weaning restores brain metabolism and behavioral flexibility in adult rats.

Sal-Sarria S, López-Taboada I, González-Pardo H et al. · 2024 · Behavioural brain research

Prolonged consumption of diets high in saturated fat and sugar has been related to obesity and overweight, which in turn are linked to cognitive impairment in both humans and rodents. This has become a current issue, especially in children…

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