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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Partial replacement of soybean meal with sprouted peas or sprouted soybeans in dairy diets in a dual-flow continuous culture system.

Vicente ACS, Salas-Solis GK, Johnson ML et al. · 2026 · Journal of dairy science

Peas (Pisum sativum L.) have 24% CP and could have the potential to partially replace soybean meal (SBM), which is the most used protein source in dairy diets in the USA. Sprouting can improve nutrient availability via enzymatic and…

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Negative / Null Result ReportMedicine

Impaired growth after immunization with a bivalent oil-adjuvanted vaccine occurs without detectable changes to aerobic capacity in juvenile rainbow trout.

Wallbom N, Khansari AR, Sandblom E et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

The trade-off between growth and immunity in fish has been assumed to relate to energetic costs associated with immune functions. Here, we hypothesized that immunization with a bivalent mineral oil-adjuvanted vaccine elevates standard…

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Negative / Null Result ReportMedicine

Inositol biosynthesis is inversely regulated by glycolytic activity.

Onu CJ, Adu M, Jabbar D et al. · 2026 · Biochimica et biophysica acta. Molecular and cell biology of lipids

Inositol is an essential metabolite required for membrane biogenesis, cell signaling and trafficking, and gene expression. Its importance is underscored by the fact that inositol depletion leads to death in eukaryotic cells ranging from…

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Negative / Null Result ReportMedicine

<i>In vitro</i> and <i>in vivo</i> inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.

Tiburcio MA, Cali MP, Pereira LMB et al. · 2026 · Dalton transactions (Cambridge, England : 2003)

Amyloid deposits of amyloid-β (Aβ) and hyperphosphorylated tau are pathological hallmarks of Alzheimer's disease (AD), which accounts for most dementia cases worldwide. This study investigates the effect of the complex [Ru(phen) 2 (pNDIp)]…

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Negative / Null Result ReportOpen accessMedicine

Effects of Dietary Fermented Black Garlic Powder Supplementation on Performance, Carcass Traits, Serum Parameters, Immune Response and Antioxidant Status of Japanese Male Quails.

Sevim B · 2026 · Tropical animal health and production

This study investigated the effects of dietary supplementation with fermented black garlic powder on performance, carcass characteristics, serum parameters, immunological responses and antioxidant status in male Japanese quail. A total of…

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Negative / Null Result ReportMedicine

The Association of Persistent Fecal White Blood Cell Excretion with Impaired Weight Gain and Food Allergy Among Children with Allergic Proctocolitis.

Fattahi Z, Talakesh T, Kheiri S et al. · 2026 · Recent advances in inflammation & allergy drug discovery

Introduction/objective In children affected by allergic proctocolitis, impaired weight gain and developmental failure to thrive can be a prominent manifestation. However, it remains unclear whether the association between White Blood Cell…

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Negative / Null Result ReportMedicine

Hypothetical Bias in the SG and TTO.

Baillon A, Bleichrodt H, Granic GD · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making

BackgroundHealth state utility measurements are central in health policy and medical decision making. Common methods are the standard gamble (SG) and the time tradeoff (TTO). They typically use hypothetical questions. It is unknown whether…

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Negative / Null Result ReportMedicine

Risk factors of biliary cast syndrome among liver transplant recipients.

Nakamura M, Nishioka Y, Akamatsu N et al. · 2026 · Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Biliary cast syndrome (BCS) remains a significant concern that can lead to graft failure and mortality. Data on the etiology and outcomes are limited, particularly with regard to the differences in the risk of occurrence of BCS between…

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Negative / Null Result ReportMedicine

Effect of dietary phosphorus and calcium depletion-repletion on pig performance and bone quality.

Palacios-Duchicela R, Létourneau-Montminy MP, Lizardo R et al. · 2026 · Animal : an international journal of animal bioscience

Feeding strategies such as P and Ca depletion and repletion have been proposed to reduce the use of phosphate or improve P utilisation efficiency in pig diets, thereby contributing to the sustainability of the sector. A total of 48 entire…

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Negative / Null Result ReportMedicine

Acute Effects of Accentuated Eccentric Loading in Comparison to Traditional Resistance Loading on Velocity and Other Parameters in Concentric and Eccentric Phases in Barbell Back Squat.

Najafi A, Nosaka K, Javidi M et al. · 2026 · Journal of strength and conditioning research

Abstract Najafi, A, Nosaka, K, Javidi, M, Naddafha, S, Kumagawa, D, Bertochi, GFA, and Latella, C. Acute effects of accentuated eccentric loading in comparison to traditional resistance loading on velocity and other parameters in…

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Negative / Null Result ReportMedicine

Impact of formaldehyde application in commercial hatchers on chick intestinal microbiota.

Meisinger BD, Coufal CD, Olson EG et al. · 2026 · Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes

Reducing microbial contamination during late-stage incubation is important for hatchery sanitation and early chick microbial exposure. Formaldehyde is commonly applied in commercial hatchers to reduce airborne and eggshell-associated…

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Negative / Null Result ReportMedicine

Nasal shedding of bovine coronavirus during commingling is associated with reduced average daily gain and lung lesions in weaned seropositive calves.

Urbaniec J, Anagnostopoulos A, Davies P et al. · 2026 · Journal of dairy science

Bovine coronavirus (BCV) is a common calf pathogen and has been proposed as a potential contributor to bovine respiratory disease (BRD); however, little is known about its epidemiology and genetic diversity on UK farms. The aim of this…

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Negative / Null Result ReportMedicine

Differential Antioxidant Capacities of Human Endometriotic and Endometrial Cell Models Under H<sub>2</sub>O<sub>2</sub> Exposure.

Coelho JA, Gomes KS, Cerchiaro G · 2026 · International journal of molecular sciences

Endometriosis is associated with oxidative stress and debilitating symptoms, yet its pathophysiology remains incompletely understood, and current treatments are still limited. In this study, oxidative stress responses were compared in 2D…

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