11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Baştuğ O, Canpolat A, Kafadar D et al. · 2026 · American journal of perinatology
Objective This study aimed to evaluate the renal effects and safety of adjunct aminophylline therapy in neonates with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). Study design This retrospective cohort…
View details →Kasai N, Ihara H, Iemitsu M et al. · 2026 · Experimental physiology
Prolonged sitting disrupts lower-limb endothelial and microvascular function, likely via reduced shear stress and blunted microvascular reactivity. We examined whether Tabata-style high-intensity interval training (HIIT) mitigates this…
View details →Ganss C, Jung K · 2026 · Journal of dentistry
Objectives To investigate Hawthorne-like research participation effects on toothbrushing-related plaque outcomes. The data source was a longitudinal flossing study without toothbrushing instruction. Methods This secondary analysis used…
View details →Nakamura S, Tajima S, Hirota T et al. · 2026 · International journal of hematology
Tacrolimus (TAC) is a pivotal immunosuppressant used to prevent graft-versus-host disease (GVHD) following hematopoietic stem cell transplantation (HSCT). However, because lymphocytes express P-glycoprotein (P-gp), which actively effluxes…
View details →Hauken MA, Gjestad R, Sekse RJT et al. · 2026 · The journal of sexual medicine
Background Hyperbaric oxygen therapy (HBOT) is an established treatment for pelvic late radiation tissue injuries (LRTIs) in cancer survivors, yet its impact on sexual health outcomes has previously not been examined. Aim To investigate…
View details →Keesing F, LaDeau SL, Canham CD et al. · 2026 · The Journal of animal ecology
Pulsed resources, including mast production by forest trees, often have knock-on effects on consumer populations and their prey, predators, parasites and mutualists. Response by small rodents to fluctuating acorn production in temperate…
View details →Pechanova O, Bulkova R, Vrankova S et al. · 2025 · Physiological research
Short-term fructose exposure may perturb the nitric oxide (NO)/reactive oxygen species (ROS) balance before hemodynamic changes development. Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) rats received 10 % fructose in…
View details →Adjekum R, Small SA, Chan S et al. · 2026 · American journal of audiology
Purpose Narrowband (NB) chirps have recently been of great interest in audiology for the electrophysiological assessment of hearing in infants, but clinicians have little information about these new stimuli and how they compare to more…
View details →Short C, Semple T, Abkir M et al. · 2026 · Thorax
Introduction The current cystic fibrosis (CF) care era, while hugely welcome, raises new challenges, particularly the need for more sensitive pulmonary outcome measures. Seeking further optimisation, we previously developed a Short…
View details →Mol BM, de Bresser CJM, de Kleijn PV et al. · 2026 · European stroke journal
Carotid endarterectomy (CEA) is performed to lower the long-term risk of stroke in patients with carotid stenosis. Data evaluating long-term outcomes after CEA are scarce, but crucial for accurately determining long-term benefits. We aimed…
View details →Langeskov-Christensen M, Nygaard MKE, Eskildsen SF et al. · 2026 · Neurorehabilitation and neural repair
Objectives Medical disease-modifying treatments are lacking in Parkinson's disease (PD). Physical exercise is potentially an inexpensive and easily accessible disease-modifying therapy, but this remains to be studied using recent promising…
View details →Anderson M, Bodén R, Wass CE et al. · 2026 · Journal of affective disorders
Background Impaired plasticity has been implicated in major depressive disorder (MDD), which is reflected in impaired automatic sensory detection as measured using mismatch negativity (MMN). Intermittent theta-burst stimulation (iTBS) is…
View details →van Houten P, van de Ven AC, van Herwaarden AE et al. · 2026 · Journal of clinical & translational endocrinology
Endogenous Cushing's syndrome (CS) is characterized by chronic hypercortisolism. After achieving remission, morbidity remains increased and quality of life remains impaired. Moreover, the incidence of inflammatory disorders increases after…
View details →Ould Ismail AA, Pettus JR, Tafe LJ et al. · 2026 · Head & neck
Purpose To evaluate whether comprehensive sampling of cervical lymphadenectomy tissue increases lymph node yield (LNY) and improves staging adequacy beyond standard grossing practice. Methods At a single academic center, a comprehensive…
View details →Söylemez E, Dağ M · 2026 · Applied neuropsychology. Adult
This study examined how smartphone-related cognitive load interferes with motor control during static balance and mobility tasks. Excessive smartphone use has been associated with attentional shifts and divided cognitive resources,…
View details →Shvetsova AA, Zakirjanova GF, Ostapchuk KP et al. · 2026 · Pflugers Archiv : European journal of physiology
The beneficial effects of statins for cardiovascular system were widely described in various pathologies. However, much less is known about the effects of statins in healthy organism, especially in systemic resistance arteries. We aimed to…
View details →Hoekstra SP, Leicht CA, Kellogg D Jr et al. · 2026 · Experimental physiology
Passive heat therapy can improve cardiometabolic health outcomes in some clinical populations, making it a potential therapeutic tool for individuals with spinal cord injury (SCI), who exhibit elevated cardiometabolic disease risk and face…
View details →Wenk MJ, Rademacher N, Liedl B et al. · 2026 · Urologia internationalis
Introduction The aim of the study was to prospectively evaluate patient and clinician reported outcomes of voiding function, pain levels and patient satisfaction of transgender women preoperatively (t0), 6 months (t1), and 12 months (t2)…
View details →Tyrell E, Lau KGY, Bednorz M et al. · 2026 · Acta obstetricia et gynecologica Scandinavica
Introduction To assess longitudinal changes in serum sFlt-1 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control ( Material and methods This was a…
View details →Yokoyama K, Shimokihara S, Miyajima R et al. · 2026 · Community mental health journal
This study examined whether overall and domain-specific self-disclosure to peers at baseline was prospectively associated with changes in personal recovery over one-year among community-dwelling adults with mental disorders in Japan. A…
View details →Di Girolamo A, Cristallo M, Daddato MF et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Chronic rhinosinusitis with nasal polyps (CRSwNP) manifests as either a solitary upper airway involvement or as part of a more intricate clinical picture, such as Cystic Fibrosis (CF). The altered viscoelastic properties of mucus…
View details →Piper FI, Paula S, Urrutia-Jalabert R · 2026 · Annals of botany
Background and aims Long-term droughts reduce the carbon (C) and water pools of trees, causing mortality. However, the underlying physiological mechanisms explaining tree mortality remain unclear, and evidence from mature forests is…
View details →Metz AK, Loughmiller SK, Braathen DL et al. · 2026 · The Journal of arthroplasty
Background The use of alternative alignment strategies has become commonplace in performing total knee arthroplasty (TKA). A primary reported benefit of these techniques is a reduction in the need for soft-tissue releases for appropriate…
View details →Froon-Torenstra D, Renting L, Ijpma I et al. · 2026 · Clinical nutrition ESPEN
Background and aims Malnutrition is common among children with cancer and is related to treatment-related toxicity, mortality and lower quality of life. So far, it remains unknown whether changes in resting energy expenditure (REE)…
View details →Mai K, Salim SR, Tilstra-Ferrell E et al. · 2026 · Journal of forensic nursing
Aims To examine data from an early intervention program for mental health following recent sexual assault (SA) to compare referral and service utilization rates before and after a community-based outreach model was implemented. Methods In…
View details →Schumacher KR, Dillman J, Goldberg DJ et al. · 2026 · Pediatric cardiology
Fontan-associated liver disease (FALD) is a fibrotic liver disease in individuals with Fontan physiology. This study sought to determine the efficacy of treatment with udenafil, a phosphodiesterase type 5 inhibitor, for reducing liver…
View details →Tsutsumi T, Kashiwagi H, Imai S et al. · 2026 · Drug research
Background Nausea and vomiting are commonly reported side effects of long-term linezolid therapy, which is indispensable for tuberculosis and osteoarticular infections. Since the mechanism underlying the development of nausea and vomiting…
View details →Karabacak DD, Doğruya S, Altınışık M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
PURPOSE: This study aimed to evaluate the impact of panretinal photocoagulation (PRP) on macular and optic nerve head microvascular parameters using optical coherence tomography angiography (OCTA) in eyes with proliferative diabetic…
View details →Renner A, Estanich EB, Lynch EA et al. · 2026 · Journal of Applied Poultry Research.
Thermal processes during steam conditioning and pellet die extrusion aid in pelleting but may degrade exogenous feed enzymes. This study determined how ambient temperature interacts with varying steam conditioning temperatures to influence…
View details →McQueen K, Sivle LD, Khodabandeloo B et al. · 2025 · Marine environmental research
Sparkers are seismic sources commonly used to survey the seabed in areas planned for offshore wind farms. The almost continuous sounds produced by sparkers, with most energy in the frequency range 50Hz - 4 kHz, are audible to both fish and…
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