11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Walsh RW, Meledeo MA, Nicolson SE et al. · 2026 · Transfusion
Background Hypocalcemia is correlated with poor outcomes in trauma patients and is considered the fourth component in the "diamond of death" alongside acidosis, coagulopathy, and hypothermia. Study design and methods We characterized the…
View details →Pelletier M, Yang J, Joshi M et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Background Transforming Growth Factor Beta (TGFβ) plays a dual role in cancer, acting as a tumor suppressor early in disease but promoting progression and immune evasion when dysregulated. In pancreatic ductal adenocarcinoma (PDAC),…
View details →De S Ferreira JM, Rodrigues HP, Alba HDR et al. · 2026 · Animal : an international journal of animal bioscience
High-concentrate diets supplemented with rumen-protected fats are widely used in feedlot lamb systems to improve energy supply and performance; however, the metabolic efficacy of these lipid sources may depend on the availability of…
View details →· 2025 · Nephron
In the article "Immunosuppressant Agents as Add-On Therapy Failed to Improve the Outcome of Immunoglobulin A Nephropathy with Crescent Score C1" [Nephron. 2024;148:587-600; https://doi.org/10.1159/000534788] by Bi et al., the funding grant…
View details →Ngeve SM, Khoury AL, Long JM · 2026 · Journal of visualized experiments : JoVE
Vanishing Lung Syndrome (VLS) is a rare, severe form of bullous pulmonary disease characterized by giant bullae occupying more than 30% of the hemithorax, which can easily be misdiagnosed as a pneumothorax. While cigarette smoking is the…
View details →Stahl M, Zeidan AM · 2026 · Blood
Abstract Aside from allogeneic transplantation, the current standard-of-care approach for higher-risk myelodysplastic syndromes/neoplasms (HR-MDS) remains monotherapy with a hypomethylating agent (HMA), including azacitidine, decitabine,…
View details →Matsushita H, Oba K, Kurono K et al. · 2026 · Shock (Augusta, Ga.)
Introduction In cardiogenic shock (CS), persistent microcirculatory impairment despite improved macrocirculatory parameters is associated with poor outcomes. Therapeutic strategies must therefore address both macro- and micro-circulation.…
View details →Florens N · 2026 · Nephrologie & therapeutique
Cardiovascular mortality among hemodialysis patients remains strikingly high—around 10% per year—despite substantial advances in dialysis technology and medical care. Historically, several strategies extrapolated from the general…
View details →Sekiguchi Y, Tsutsumi H, Kudo M et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
84-year-old male was diagnosed with diffuse large B-cell lymphoma.He had Stage Ⅳ, performance status was 2, and 'high risk' according to the International Prognostic Index.He was started on Pola-R-mini-CHP.The day after completion of the 4…
View details →Al Hindawi MA, Omran NE, Mostafa MH et al. · 2026 · European journal of pharmacology
In metastatic melanoma with a BRAF V600 mutation, inhibitors of BRAF and MEK have improved survival. Resistance may be acquired through late genetic alterations that restore mitogen-activated protein kinase (MAPK) signaling. Resistance can…
View details →Chen H, Wang J, Fan C et al. · 2026 · Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Background and aim The benefit of combining linaclotide with polyethylene glycol (PEG) for improving bowel preparation quality and adenoma detection in patients at risk for inadequate bowel preparation remains uncertain. This study aimed…
View details →Huang JQ, Xiao HM, Ma CX et al. · 2026 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
To compare survival outcomes and safety between concurrent chemoradiotherapy (CCRT) and CCRT with concurrent immune checkpoint inhibitor (ICI) in patients with locally advanced esophageal squamous cell carcinoma. This multicenter cohort…
View details →Moura RP, Mwema A, Bottemanne P et al. · 2026 · Journal of controlled release : official journal of the Controlled Release Society
Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting over 2.5 million people worldwide. Despite available therapies, no current treatment halts disease progression or specifically targets remyelination. Here, we…
View details →Wu F, Wu R, Chen L et al. · 2026 · New biotechnology
Enhancing enzyme thermostability is crucial for industrial applications requiring robust performance under extreme conditions. Structure-based protein design models excel at improving thermal stability but often compromise enzymatic…
View details →Liu X, Wang Y, Medina AA et al. · 2026 · Pharmacological research
Gut-liver axis disturbance is the unifying pathogenesis of cholestatic liver diseases. The purpose of this study was to explore the underlying mechanisms of the probiotic Lactobacillus amylovorus (LA) and its secreted extracellular…
View details →Timimi S · 2025 · Child and adolescent mental health
Because definitions of mental disorder are inescapably subjective, they can be continuously expanded in response to commercial, guild and social interests and pressures. In this article, I argue that this has resulted in young people…
View details →Fujii T, Nogami Y, Seo T · 2026 · BMJ open
Objectives Cognitive behavioural therapy (CBT) is recommended as a first-line treatment for depression and anxiety disorders, but its utilisation under Japan's national health insurance remains poorly understood. This study aimed to…
View details →Ead AS, Wirkus J, Machuca J et al. · 2026 · The Journal of nutrition
Background Pancreatic ductal adenocarcinoma is a deadly cancer linked to obesity. Adipose tissue contributes to tumor progression by promoting inflammation and supplying lipids and cytokines that support cancer growth. Although omega-6…
View details →Mudupula Vemula SS, Adhikari S, Motkur S et al. · 2026 · Cureus
Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ dysfunction, with high untreated mortality that can…
View details →Alpat SE, Kaya B, Nakkaş HG et al. · 2026 · Burns : journal of the International Society for Burn Injuries
Objective Despite notable advancements in burn care, morbidity and mortality remain high, with progressive tissue loss typically occurring in the first 48 h post-injury. While microneedling and topical retinyl palmitate are recognized for…
View details →Uyanık G, Yüksel M, Abay M et al. · 2026 · Animal reproduction science
This study aimed to evaluate the effects of TAK-683 administered to suckling goats in lactational anestrus on the 4th day (D4) after mating on luteal function, serum progesterone (P₄) levels, and reproductive performance. Forty-five Aleppo…
View details →Gardner JD, Triadafilopoulos G · 2026 · Digestive diseases and sciences
Purpose For unclear reasons, up to 50% of subjects with gastroesophageal reflux disease have an inadequate symptomatic response to treatment with a proton pump inhibitor. Our primary objective was to examine esophageal acid in subjects who…
View details →Huang Y, Chen Q, Chen R et al. · 2025 · BMC gastroenterology
OBJECTIVE: To explore disease severity thresholds beyond which endoscopic intervention fails to reduce mortality in the context of renal insufficiency and upper gastrointestinal bleeding (UGIB), and to develop predictive models for…
View details →Lee KA, Kim YH, Kim HS · 2026 · Clinical rheumatology
Objectives To evaluate the diagnostic concordance between salivary gland ultrasound (SGUS) and minor salivary gland biopsy (MSGB) in suspected primary Sjögren disease (SjD), and to assess the added value of Doppler ultrasound and extended…
View details →Schmidt US, Van Rickstal R, Van Goethem V et al. · 2026 · Palliative medicine
Background Supporting psychoeducational functioning for advanced cancer patients and informal caregivers (dyads) can be challenging. Self-managed digital interventions offer a possible cost-effective alternative but often face low…
View details →de Freitas ALS, Guth G, Araújo ALD et al. · 2026 · Archives of oral biology
Objective To investigate the temporal evolution and predictive value of individual histopathological features of oral epithelial dysplasia (OED) during carcinogenesis, and to evaluate the diagnostic utility of optical fluorescence imaging…
View details →Barham E, Khan M, Del-Cristo M et al. · 2026 · Cureus
Chylothorax, a rare complication of hepatic cirrhosis, is often under-recognized in the absence of ascites or other classical signs of portal hypertension. The diagnosis can be challenging due to its infrequent presentation, which…
View details →Lee KK, Lin YN · 2026 · Cureus
Non-purulent skin and soft tissue infections (NP-SSTIs) are commonly managed with antibiotic therapy; however, a subset of patients demonstrate inadequate clinical response and develop refractory disease. At present, no standardized…
View details →Dirisala A, Uchida S, Toh K et al. · 2025 · Journal of Controlled Release
Polycation-based mRNA delivery systems have an issue with mRNA integrity in the physiological milieu, particularly in blood compartments, despite their vast potential in mRNA therapeutics. Without comprehensive mechanistic analyses, design…
View details →Pouplard C, Charuel N, Archer E et al. · 2026 · International journal of laboratory hematology
Background Immunoassays detecting anti-PF4/H antibodies must be sensitive to exclude heparin-induced thrombocytopenia (HIT), and optical density (OD) values are useful for confirming HIT, but no calibration is currently available.…
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