11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Rodak O, Alkali IM, Peris-Diaz MD et al. · 2026 · Reproduction in domestic animals = Zuchthygiene
Ovarian tissue vitrification holds great promise as a preservation technique for endangered wild felids; however, the development of an optimal protocol remains desired. One potential factor affecting success is the equilibration…
View details →Gillessen S, Gobat K, Cathomas R et al. · 2026 · European urology oncology
Background and objective The aim of our study is to determine whether the addition of metformin to enzalutamide can improve the outcomes of men with metastatic castration-resistant prostate cancer (mCRPC). Methods From 2016 to 2021,…
View details →Lizama E, Carcamo-Herrera B, López G et al. · 2026 · Psychoneuroendocrinology
Performance in precision sports such as golf depends on the athlete's ability to regulate psychophysiological responses under competitive pressure. Heart rate variability (HRV), cortisol, and DHEA provide complementary indices of autonomic…
View details →Ho K, Adjei-Afriyie O, Carmona-Martinez R et al. · 2026 · Brain communications
Congenital myasthenic syndromes (CMS) are a group of rare disorders characterized by fatigable muscle weakness and caused by impaired neuromuscular junction (NMJ) function. CMS symptoms are highly variable, but it can be detrimental and…
View details →Morales AA, Camarena V, Peart L et al. · 2026 · Scientific reports
Geleophysic dysplasia (GD) is a rare genetic disorder characterized by short stature, joint contractures, and cardiopulmonary complications, with early mortality, and linked to mutations in ADAMTSL2 (GD1), FBN1 (GD2), or LTBP3 (GD3) genes.…
View details →Halko ML, Halonen J, Laukkanen M et al. · 2026 · Cognition & emotion
Political and economic challenges, amplified by social media algorithms, are increasingly polarising how people receive and evaluate information. This study examines how political views and immediate emotional reactions shape the perceived…
View details →Kongkhuntian P, Aunmeungtong W, Khongkhunthian P · 2026 · Clinical implant dentistry and related research
Objective This study aimed to compare the effect of PTFE tape wrapping and PTFE-coated titanium alloy screws on the removal torque after cyclic loading and on preload values under repetitive tightening. Methods A total of 60 titanium…
View details →Tournu E, Tourdot-Maréchal R, Coelho C · 2026 · International journal of food microbiology
Phytosanitary and copper treatments in viticulture are essential to protect vines against biotic and abiotic stresses. However, residues from these treatments can persist in grape musts and wines, potentially raising risks to consumer…
View details →McClure Z, Fuller-Tyszkiewicz M, Messer M et al. · 2026 · The International journal of eating disorders
Objective Although a range of evidence-based treatments for eating disorders exist, treatment response varies substantially. The ability to match individuals to a treatment which they are most likely to benefit from may help improve…
View details →Khatri D, Poudel S, Pun Magar L et al. · 2026 · Frontiers in plant science
Soybean meal quality for monogastric animals is limited by low sulfur-containing amino acids, especially methionine and cysteine, while oil oxidative stability is restricted by the high polyunsaturated fatty acid content. This two-year…
View details →Wall A, Fisher JA, Watkinson EK et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
Background Early warning scores like the National Early Warning Score 2 (NEWS2) identify patient deterioration but do not incorporate clinician-intuitive assessment. Previous research suggests facial expressions can be critical indicators…
View details →Larsen LJ, Dornbusch MR, Hines-Snider C et al. · 2026 · Plant disease
Seed rot and damping-off of alfalfa ( Medicago sativa L.) is caused by a soilborne disease complex resulting in thin initial stands of plants with continuing damage during wet soil conditions decreasing forage yields and winter survival.…
View details →Giese H, Gaissmaier W, Kuss O et al. · 2026 · Medical decision making : an international journal of the Society for Medical Decision Making
BackgroundTime-to-event outcomes from randomized controlled trials (RCTs) are often communicated without clearly conveying how treatment effects evolve over time. This can limit clinicians' ability to interpret results and support patient…
View details →Müller D, Gillani A, Hirschmann MT et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
Purpose Accurate risk adjustment in total knee arthroplasty (TKA) is essential for outcome prediction and quality assessment. Most existing prediction models rely solely on patient demographics and comorbidities and do not account for…
View details →Jiang PP, Huang HY, Zhao L et al. · 2026 · Pediatric research
Background Fortification of human milk for very preterm infants (VPIs) with alternatives to conventional bovine milk-based fortifiers remains minimally studied. This trial tested whether fortification with protein-rich bovine colostrum…
View details →Bourdin A, Dureau S, Algret N et al. · 2026 · Retina (Philadelphia, Pa.)
Purpose To report safety outcomes of transscleral fine-needle aspiration biopsy (FNAB) followed by irradiation for uveal melanoma (UM) in a tertiary ocular oncology center over 10 years, and assess whether FNAB modified the overall…
View details →Velez T, Badaki-Makun O, Hirsch D et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objective Early identification of mortality risk in critically ill children with suspected infection remains challenging. Whether severity scores (SIRS, pSOFA, Phoenix) add incremental value beyond data-derived physiologic features in…
View details →Al-Ibraheem A, Moghrabi S, Alsyouf B et al. · 2026 · Cancers
Background : [ 68 Ga]Ga-FAPI PET/CT demonstrates high sensitivity for tumor detection but limited specificity because benign fibro-inflammatory conditions may also show tracer uptake. Dual-time-point imaging has been proposed to improve…
View details →Embry KR, Jayaraman C, Yang C et al. · 2026 · Journal of neuroengineering and rehabilitation
Background Powered knee and ankle prostheses generate mechanical energy to replicate biological leg function, yet direct comparisons with more commonly prescribed microprocessor-controlled knee prostheses are limited by methodological…
View details →Herrera-Elizondo JL, Jiménez-Castillo RA, García-Compeán D et al. · 2026 · Revista de gastroenterologia de Mexico (English)
Introduction and aims The usefulness of metoclopramide for improving endoscopic visualization in upper gastrointestinal bleeding (UGIB) is controversial. Our primary aim was to evaluate the utility of metoclopramide 20 mg/IV for endoscopic…
View details →Tamura T, Abe S, Matsui H et al. · 2026 · Journal of affective disorders
Background Dopaminergic dysfunction has been implicated in major depressive disorder (MDD), but dopamine transporter (DAT) imaging studies using conventional mean binding have yielded inconsistent findings. One possible contributor is that…
View details →Naghizade B, Özyazgan İ, Bozkurt F et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Background Autologous fat grafting is widely used in plastic surgery, but graft survival remains unpredictable, particularly under compromised conditions such as cigarette smoking. Smoking impairs microcirculation and tissue oxygenation,…
View details →Taylor-Williams O, Nossent J, Inderjeeth CA · 2026 · The Journal of rheumatology
Objective Rheumatoid arthritis (RA) is a potentially devastating autoimmune disease associated with multiple comorbidities, including osteoporosis and cardiovascular disease, which exert significant morbidity and mortality burdens. Despite…
View details →Song BM, Ford CA, Schneider AM et al. · 2026 · The Journal of arthroplasty
Background Inflammatory arthritis (IA) has been considered an absolute indication for patellar resurfacing (PR) in total knee arthroplasty (TKA), yet limited data supports this. The purpose of this study was (1) to compare outcomes of TKA…
View details →Sileika E, Cerkauskaite D, Bausys A et al. · 2026 · International journal of colorectal disease
Background The optimal interval between neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) in locally advanced rectal cancer (LARC) remains controversial. This randomized controlled trial evaluated whether prolonging…
View details →Blackman J, Friesen D, Sikkel MB et al. · 2026 · Applied clinical informatics
Objectives The objective of this study is to evaluate whether ChatGPT models can reliably apply the DISCERN instrument, a 16-question human-scored rubric developed in 1999 to evaluate consumer health information, and assess the impact of…
View details →Stewart KM, Sawicki GS, Young AJ et al. · 2026 · Journal of biomechanics
Individuals post-stroke with hemiparetic gait often experience impaired mobility, which can be restored using powered exoskeletons. Specifically, hip exoskeletons can deliver positive work to the leg to help initiate leg swing; however, it…
View details →Norling M, Eriksson N, Westerberg E et al. · 2026 · Muscle & nerve
Introduction/aims Physical activity and sleep influence fatigue in myasthenia gravis (MG), and digital health technologies (DHT) enable objective monitoring of these behaviors in daily life. Using this approach, we evaluated whether a…
View details →Orlowska M, Saleh MHA, Decker A et al. · 2026 · Journal of periodontology
Background This randomized controlled trial aims to evaluate alveolar ridge preservation (ARP) with or without a biologically active amnion-chorion membrane (BACM). Methods Thirty patients requiring tooth extraction in the esthetic zone…
View details →Nehme Z, Mahony E, Nehme E et al. · 2026 · Resuscitation
Aim To determine whether defibrillation with manual pressure augmentation (MPA) reduces transthoracic impedance and improves cardioversion and survival from initially shockable out-of-hospital cardiac arrest (OHCA) compared with standard…
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