e-ISSN: Pending

Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Assessment of eyeball findings on two sequential post-mortem computed tomography (PMCT) : no reliable marker for post-mortem interval.

Kubota H, Makino Y, Yoshida M et al. · 2026 · International journal of legal medicine

Background It is important to understand post-mortem changes in post-mortem computed tomography (PMCT) image interpretation. Only a few studies have focused on the eyeballs. This study aimed to clarify the changes in eyeball findings on…

View details →
Negative / Null Result ReportMedicine

A randomized controlled trial comparing two processes of exposure therapy: Extinction learning and habituation.

Treanor M, Zbozinek TD, Rosenberg BM et al. · 2025 · Journal of consulting and clinical psychology

Objective To investigate the role of extinction learning and habituation by comparing inhibitory retrieval to habituation-focused exposure for social anxiety and panic disorder. Method In this assessor-blinded, parallel-group, two-arm…

View details →
Negative / Null Result ReportMedicine

Prognostic and Predictive Factors in Metastatic Breast Cancer Patients Treated with CDK4/6 Inhibitors.

Demirel N, Yildiz B, Demir M · 2026 · Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

Objective To evaluate the safety and efficacy of CDK4/6 inhibitors in combination with hormone therapy, and to investigate potential predictive markers of treatment in metastatic breast cancer (MBC). Study design An observational study.…

View details →
Negative / Null Result ReportMedicine

Daily-life posttraumatic stress symptoms, posttraumatic cognitions, and affect following the processing of positive memories technique: An open-label case-control daily diary study.

Greene T, Dicker-Oren SD, Sznitman SR et al. · 2026 · Journal of traumatic stress

The processing of positive memories technique (PPMT) is a promising new treatment for posttraumatic stress disorder (PTSD) involving the detailed narration and processing of specific positive autobiographical memories. This study used an…

View details →
Negative / Null Result ReportOpen accessMedicine

The Effect of Ocrelizumab on Anti-JC Virus Antibody Index.

Virupakshaiah A, Gill AJ, Schoeps VA et al. · 2026 · Brain and behavior

Purpose/introduction The anti-JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy. B-cell-depleting therapies may…

View details →
Negative / Null Result ReportMedicine

Impact of low-flow desflurane versus sevoflurane anesthesia on thiol-disulfide homeostasis in adults undergoing elective thyroidectomy: a randomized controlled trial.

Sen E, Aytekin A · 2026 · Revista da Associacao Medica Brasileira (1992)

Objective Thiol-disulfide homeostasis is a marker of oxidative stress. The aim of the study was to compare the effects of low-flow desflurane and sevoflurane anesthesia on perioperative changes in thiol-disulfide balance in patients…

View details →
Negative / Null Result ReportMedicine

Evaluating a specialty-specific objective structured clinical examination and workplace-based assessment curriculum for radiation oncology postgraduate training: a prospective educational intervention study.

Ma CY, Chen J, Fu Y et al. · 2026 · BMC medical education

Background Competence in radiation oncology is still commonly expected to emerge through apprenticeship, although essential tasks such as target delineation, treatment-plan review, and multidisciplinary reasoning are not reliably sampled…

View details →
Negative / Null Result ReportOpen accessMedicine

Effects of Premolar Extraction on the Dimensions of the Airway Through Cephalometric Appraisal: A Retrospective Study.

Mehraj F, Bhat MA, Mangulkar A et al. · 2025 · Journal of pharmacy & bioallied sciences

Introduction In recent years, there has been a great deal of interest in research because of the changes that the extraction of premolars has caused to the structures surrounding of the upper airway. This is because it's thought that these…

View details →
Negative / Null Result ReportMedicine

The challenge of data scarcity and imbalanced classes in radiomics performance.

Rodriguez-Belenguer P, Beser-Robles M, Marfil-Trujillo M et al. · 2026 · Computer methods and programs in biomedicine

Background and objectives Radiomics-based machine learning models are increasingly used for clinical decision-making, yet their reliability is often constrained by limited sample sizes and class imbalance in imaging datasets. While prior…

View details →
Negative / Null Result ReportMedicine

Three-Year Changes in Health-Related Quality of Life after Laparoscopic Hysterectomy: A Registry-Based Cohort Study.

Denstad SE, Volløyhaug I, Lieng M et al. · 2026 · Journal of minimally invasive gynecology

Study objective To evaluate changes in health-related quality of life (HRQoL) 3 years after laparoscopic hysterectomy (LH) for benign, prophylactic, and malignant indications, and to identify baseline factors associated with these changes.…

View details →
Negative / Null Result ReportOpen accessMedicine

Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives.

Zainuddin MS, Pamidi N, Azman AS et al. · 2026 · Redox report : communications in free radical research

Alzheimer's disease (AD) is a major global neurodegenerative disorder associated with high morbidity and mortality, yet current treatments remain largely symptomatic and ineffective in halting neurodegeneration. Growing evidence links…

View details →
Negative / Null Result ReportMedicine

Effects of Janus kinase inhibition and interleukin 6 inhibition on serum cytokine/chemokine in idiopathic multicentric Castleman disease.

Fukui S, Sumiyoshi R, Koga T et al. · 2026 · Drug discoveries & therapeutics

Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disease characterized by systemic inflammation. Although IL-6 receptor blockade with tocilizumab is an established treatment, Janus kinase (JAK) inhibition may…

View details →