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21 real negative results, null findings, and replication failures in Chemistry · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessChemistry

Effect of Metal–Organic Framework (MOF) Database Selection on the Assessment of Gas Storage and Separation Potentials of MOFs

Hilal Daglar, Hasan Can Gülbalkan, Gökay Avcı et al. · 2021 · Angewandte Chemie International Edition

Abstract Development of computation‐ready metal–organic framework databases (MOF DBs) has accelerated high‐throughput computational screening (HTCS) of materials to identify the best candidates for gas storage and separation. These DBs…

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Negative / Null Result ReportChemistry

Reliable Identification of Significant Differences in Differential Hydrogen Exchange-Mass Spectrometry Measurements Using a Hybrid Significance Testing Approach

Tyler S. Hageman, David D. Weis · 2019 · Analytical Chemistry

Differential hydrogen exchange-mass spectrometry (HX-MS) measurements are valuable for identification of differences in the higher order structures of proteins. Typically, the data sets are large with many differential HX values…

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Negative / Null Result ReportOpen accessChemistry

Significant Association between Sulfate-Reducing Bacteria and Uranium-Reducing Microbial Communities as Revealed by a Combined Massively Parallel Sequencing-Indicator Species Approach

Erick Cardenas, Wei‐Min Wu, Mary Beth Leigh et al. · 2010 · Applied and Environmental Microbiology

Massively parallel sequencing has provided a more affordable and high-throughput method to study microbial communities, although it has mostly been used in an exploratory fashion. We combined pyrosequencing with a strict indicator species…

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Negative / Null Result ReportOpen accessChemistry

Quantitative, Time-Resolved Proteomic Analysis by Combining Bioorthogonal Noncanonical Amino Acid Tagging and Pulsed Stable Isotope Labeling by Amino Acids in Cell Culture

John D. Bagert, Yushu Joy Xie, Michael J. Sweredoski et al. · 2014 · Molecular & Cellular Proteomics

An approach to proteomic analysis that combines bioorthogonal noncanonical amino acid tagging (BONCAT) and pulsed stable isotope labeling with amino acids in cell culture (pSILAC) provides accurate quantitative information about rates of cellular protein synthesis on time scales of minutes. The method is capable of quantifying 1400 proteins produced by HeLa cells during a 30 min interval, a time scale that is inaccessible to isotope labeling techniques alone. Potential artifacts in protein quantification can be reduced to insignificant levels by limiting the extent of noncanonical amino acid t

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Negative / Null Result ReportOpen accessChemistry

Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus

Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi et al. · 2015 · Current Pharmaceutical Design

There is a growing concern by regulatory authorities for the selection of antibiotic resistance caused by the use of biocidal products. We aimed to complete the detailed information on large surveys by investigating the relationship…

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Negative / Null Result ReportChemistry

Intrinsic Optical Activity and Conformational Flexibility: The Role of Size-Dependent Ring Morphology in Model Cycloketones

Priyanka Lahiri, Kenneth B. Wiberg, Patrick H. Vaccaro · 2013 · The Journal of Physical Chemistry A

The optical rotatory dispersion of two monocyclic ketones, (R)-3-methylcyclopentanone [R-3MCP] and (R)-3-methylcyclohexanone [R-3MCH], has been investigated under isolated and solvated conditions to explore the role of ring size/morphology…

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Negative / Null Result ReportOpen accessChemistry

Data‐Independent Acquisition Mass Spectrometry as a Tool for Metaproteomics: Interlaboratory Comparison Using a Model Microbiome

Andrew T. Rajczewski, J. Alfredo Blakeley‐Ruiz, Annaliese Meyer et al. · 2025 · PROTEOMICS

Mass spectrometry (MS)-based metaproteomics is used to identify and quantify proteins in microbiome samples, with the frequently used methodology being data-dependent acquisition mass spectrometry (DDA-MS). However, DDA-MS is limited in…

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Negative / Null Result ReportOpen accessChemistry

Net Analyte Signal-based Quantitative Determination of Fusel Oil in Korean Alcoholic Beverage Using FT-NIR Spectroscopy

Santosh Lohumi, Lalit Mohan Kandpal, Young Wook Seo et al. · 2016 · Journal of Biosystems Engineering

Purpose: Fusel oil is a potent volatile aroma compound found in many alcoholic beverages. At low concentrations, it makes an essential contribution to the flavor and aroma of fermented alcoholic beverages, while at high concentrations, it…

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Negative / Null Result ReportOpen accessChemistry

Contribution of the Locus of Heat Resistance to Growth and Survival of Escherichia coli at Alkaline pH and at Alkaline pH in the Presence of Chlorine

Tongbo Zhu, Zhiying Wang, Lynn M. McMullen et al. · 2021 · Microorganisms

The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the genes comprising the LHR and the contribution of the LHR to alkaline pH response. The presence of the LHR did not affect the activity of the Cpx two-component regulatory system in E. coli, which was measured to quantify cell envelope stress. The LHR did not alter E. coli MG1655 growth rate in the range of pH 6.9 to 9.2. However, RT-qPCR results ind

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Negative / Null Result ReportOpen accessChemistry

PCSK9 concentrations in different stages of subclinical atherosclerosis and their relationship with inflammation

Tóth Štefan, Olexa Peter, Hertelyová Zdenka et al. · 2020 · Open Chemistry

The aim of this study was to detect the concentrations of PCSK9 in various subclinical stages of atherosclerosis and to highlight its relationship with inflammation. One hundred and fifty-nine healthy patients were divided into three groups, based on the extent of atherosclerotic changes in the carotid artery: a group without identifiable atherosclerosis, cIMT>75‰ and an asymptomatic plaque group. The PCSK9 was measured by ELISA and hsCRP by the immunoturbidimetric method. Vascular changes were identified by a carotid ultrasound. PCSK9 was elevated, when comparing the healthy group with the cI

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Negative / Null Result ReportOpen accessChemistry

Trehalose may prevent postsurgical adhesions in a rabbit model of hysterotomy.

H. Fujino, Soojung Lee, Shigeki Suzuki et al. · 2011 · Journal of Veterinary Medical Science

The adhesion-preventing effect of trehalose in visceral organs was evaluated in a rabbit model. All rabbits underwent a hysterotomy, during which mild abrasion and desiccation was induced on the surfaces of visceral organs. In the control…

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Negative / Null Result ReportOpen accessChemistry

Biomaterials Based on Carbon Nanotube Nanocomposites of Poly(styrene- b -isobutylene- b -styrene): The Effect of Nanotube Content on the Mechanical Properties, Biocompatibility and Hemocompatibility

Maria A. Rezvova, Pavel A. Nikishau, Miraslau I. Makarevich et al. · 2022 · Nanomaterials

Nanocomposites based on poly(styrene- block -isobutylene- block -styrene) (SIBS) and single-walled carbon nanotubes (CNTs) were prepared and characterized in terms of tensile strength as well as bio- and hemocompatibility. It was shown that modification of CNTs using dodecylamine (DDA), featured by a long non-polar alkane chain, provided much better dispersion of nanotubes in SIBS as compared to unmodified CNTs. As a result of such modification, the tensile strength of the nanocomposite based on SIBS with low molecular weight (M n = 40,000 g mol –1 ) containing 4% of functionalized CNTs was in

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Negative / Null Result ReportOpen accessChemistry

Influence de l’Agitation Mécanique sur les Reactions Chimiques Oscillantes en Présence d’Oxygène ou d’Azote

Vincent J. Farage, Désimir Janjic · 1981 · CHIMIA

In certain cases, and particularly for the BrO3-/Ce4+/malonic acid system, oxygen seems to inhibit oscillations and the mechanical stirring in a N2 atmosphere has no significant effect on the oscillations. However, for the BrO3-/Ce4+/Cyclohexanon and BrO3-/Ce4+/Cyclopentanon systems under specific experimental conditions, stirring plays a determining part and oxygen has no notable effect on the oscillations.

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Negative / Null Result ReportOpen accessChemistry

Calculations of optical rotation: Influence of molecular structure

Yu Jia, Cao Yu, Song Hang et al. · 2012 · Journal of the Serbian Chemical Society

Ab initio Hartree-Fock (HF) method and Density Functional Theory (DFT) were used to calculate the optical rotation of 26 chiral compounds. The effects of theory and basis sets used for calculation, solvents influence on the geometry and values of calculated optical rotation were all discussed. The polarizable continuum model, included in the calculation, did not improve the accuracy effectively, but it was superior to γs. Optical rotation of five or sixmembered of cyclic compound has been calculated and 17 pyrrolidine or piperidine derivatives which were calculated by HF and DFT methods gave a

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Negative / Null Result ReportOpen accessChemistry

A Practical Approach for Measuring Chemical Oxygen Demand (COD) of Fats, Oils, and Grease (FOG) Using Tween 80 in Wastewater

Naveed Ahmed, Andrea Straub · 2025 · ChemEngineering

This study aims to estimate the organic load of oily wastewater by using Chemical Oxygen Demand (COD) measurements, addressing the analytical challenges posed by the hydrophobic, nonpolar, and often emulsified nature of Fats, oil and grease (FOG). This study established a reproducible and practical methodology for measuring COD in wastewater containing FOG at a laboratory scale, utilizing the nonionic surfactant T80 as a solubilizing and emulsifying agent. Precise gravimetric methods were employed to measure the mass of T80 (indirectly from volume (100–1400 µL/L)) added, and its correlation wi

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