Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Song Wang, Cecilie L. Bager, M.A. Karsdal et al. · 2021 · Journal of Translational Medicine
BACKGROUND: Extensive extracellular matrix (ECM) remodeling is a hallmark of metastatic pancreatic ductal adenocarcinoma (mPDA). We investigated fragments of collagen types III (C3M, PRO-C3), VI (PRO-C6), and VIII (C8-C), and versican (VCANM) in plasma as biomarkers for predicting progression-free survival (PFS) and overall survival (OS) in patients with mPDA treated with pegvorhyaluronidase alfa, a biologic that degrades the ECM component hyaluronan (HA), in a randomized phase 2 study (HALO109-202). METHODS: HALO109-202 comprised a discovery cohort (Stage 1, n = 94) and a validation cohort (S
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna L. Guyatt, Kimberley Burrows, Philip A. I. Guthrie et al. · 2017 · Mitochondrion
The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69.4 (5.5) years (N=2872). Mitochondrial DNA copy number was assayed by qua
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Bart de Boer · 2010 · Journal of Evolutionary Psychology
This paper investigates the effect of larynx position on the articulatory abilities of a human-like vocal tract. Previous work has investigated models that were built to resemble the anatomy of existing species or fossil ancestors. This…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anarkali Mahmood, Zdeněk Otruba, Alan W. Weisgerber et al. · 2023 · Biophysical Journal
When multivesicular endosomes (MVEs) fuse with the plasma membrane, exosomes are released into the extracellular space where they can affect other cells. The ability of exosomes to regulate cells nearby or further away depends on whether…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Araiz Hussain · 2025 · Cardiovascular Diabetology – Endocrinology Reports
Chronic hyperglycemia is the defining feature of type 2 diabetes mellitus (T2DM) and a central driver of its long-term complications, including microvascular and macrovascular diseases. Among these, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in individuals with T2DM. Persistent glucose elevation activates multiple interrelated biochemical pathways, including the polyol pathway, formation of advanced glycation end-products, protein kinase C activation, oxidative stress via several cellular mechanisms, as well as the hexosamine biosynthetic pathway. These p
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Juan Zeng, Yukun Li, Feifei Quan et al. · 2020 · Molecular Medicine Reports
Propofol, a commonly used intravenous anesthetic agent during surgery, has relatively widespread pharmacological actions. Previous studies have reported that propofol may act as an antitumor drug in several cancer types, such as pancreatic…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jorma J. de Ronde, Christiaan Klijn, Arno Velds et al. · 2010 · BMC Research Notes
BACKGROUND: Most approaches used to find recurrent or differential DNA Copy Number Alterations (CNA) in array Comparative Genomic Hybridization (aCGH) data from groups of tumour samples depend on the discretization of the aCGH data to gain, loss or no-change states. This causes loss of valuable biological information in tumour samples, which are frequently heterogeneous. We have previously developed an algorithm, KC-SMART, that bases its estimate of the magnitude of the CNA at a given genomic location on kernel convolution (Klijn et al., 2008). This accounts for the intensity of the probe sign
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mark O. Goodarzi, Nicholette D Palmer, Jinrui Cui et al. · 2019 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Genome-wide association studies have identified more than 450 single nucleotide polymorphisms (SNPs) for type 2 diabetes (T2D). OBJECTIVE: To facilitate use of these SNPs in future genetic risk score (GRS)-based analyses, we aimed…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Carmella Evans‐Molina, Richard A. Oram · 2025 · Diabetes Obesity and Metabolism
Type 1 diabetes (T1D) has been historically regarded as a childhood-onset disease; however, recent epidemiological data indicate that adult-onset T1D accounts for a substantial proportion of cases worldwide. There is evidence that…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sergio Garnica-Galvez, Stefanie Korntner, Ioannis Skoufos et al. · 2021 · Cells
The use of macromolecular crowding in the development of extracellular matrix-rich cell-assembled tissue equivalents is continuously gaining pace in regenerative engineering. Despite the significant advancements in the field, the optimal macromolecular crowder still remains elusive. Herein, the physicochemical properties of different concentrations of different molecular weights hyaluronic acid (HA) and their influence on equine adipose-derived stem cell cultures were assessed. Within the different concentrations and molecular weight HAs, the 10 mg/mL 100 kDa and 500 kDa HAs exhibited the high
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Martin Boegemann, Katrin Schlack, Ann-Kathrin Fischer et al. · 2016 · PLoS ONE
OBJECTIVE: Even though the exact mechanism is largely unknown until now, statins are supposed to improve survival outcomes in various malignancies. For prostate cancer however, statins are known to compete with dehydroepiandrosterone (DHEAS) for the transport into the cytosol both using the cell by the Solute Carrier Transporter and thus diminish the cellular uptake of DHEAS as a precursor of androgens. Abiraterone inhibits CYP17A1 and thus effectively decreases the production of all relevant androgens including DHEAS. In this study we examined whether statins still affect survival outcome in
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Neil D. Clarke, James R. Thomas, Marion Kagka et al. · 2016 · The Journal of Strength and Conditioning Research
Clarke, ND, Thomas, JR, Kagka, M, Ramsbottom, R, and Delextrat, A. No dose-response effect of carbohydrate mouth rinse concentration on 5-km running performance in recreational athletes. J Strength Cond Res 31(3): 715-720, 2017-Oral…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthijs J. H. M. van der Loos, Philipp Koellinger, Patrick J. F. Groenen et al. · 2011 · Small Business Economics
Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Benjamin L. Rambo‐Martin, Jennifer G. Mulle, David J. Cutler et al. · 2017 · G3 Genes Genomes Genetics
One in five people with Down syndrome (DS) are born with an atrioventricular septal defect (AVSD), an incidence 2000 times higher than in the euploid population. The genetic loci that contribute to this risk are poorly understood. In this study, we tested two hypotheses: (1) individuals with DS carrying chromosome 21 copy number variants (CNVs) that interrupt exons may be protected from AVSD, because these CNVs return AVSD susceptibility loci back to disomy, and (2) individuals with DS carrying chromosome 21 genes spanned by microduplications are at greater risk for AVSD because these microdup
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Laura Marcos-Kovandzic, Michele Avagliano, Myriam Ben Khelil et al. · 2025 · Cancer Discovery
This study investigates the clinical relevance of the gut microbiome at taxonomic and metabolic levels in anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, both in patients and in a preclinical syngeneic tumor model. Patients with…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Takeshi Kuroda, Naohito Tanabe, Daisuke Kobayashi et al. · 2012 · BMC Nephrology
BACKGROUND: The kidney is a major target organ for systemic amyloidosis that often affects the kidney including proteinura, and elevated serum creatinine (Cr). The correlation between amount of amyloid deposits and clinical parameters is not known. The aim of this study was to clarify correlation the amyloid area in all renal biopsy specimen and clinical parameters. METHODS: Fifty-eight patients with an established diagnosis of AL amyloidosis participated in the study. All patients showed amyloid deposits in renal biopsies. We retrospectively investigated the correlation between clinical data
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Xue Zhou, Yang Xu, Jia Wang et al. · 2011 · PLoS ONE
BACKGROUND: Autism is a common, severe and highly heritable neurodevelopmental disorder in children, affecting up to 100 children per 10,000. The MET gene has been regarded as a promising candidate gene for this disorder because it is located within a replicated linkage interval, is involved in pathways affecting the development of the cerebral cortex and cerebellum in ways relevant to autism patients, and has shown significant association signals in previous studies. PRINCIPAL FINDINGS: Here, we present new ASD patient and control samples from Heilongjiang, China and use them in a case-contro
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ryan Zenhausern, Bora Jang, Elisa Schrader Echeverri et al. · 2025 · Nature Biotechnology
Understanding how well delivery in mice predicts delivery in nonhuman primates (NHPs) could make lipid nanoparticle (LNP) discovery more efficient. Yet, few LNP-mRNA drug candidates are tested in NHPs, in part because the experiments…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Christos Mavrommatis, Daniel W. Belsky, Kejun Ying et al. · 2025 · Nature Communications
Epigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes - typically using small datasets and a limited number of clocks. Here, we present a large-scale (n = 18,859), unbiased comparison of 14 widely used clocks as predictors of 174 incident disease outcomes and all-cause mortality over 10-years of follow up. Second- and third-generation clocks significantly outperform first-generation clocks, which have limited applications in disease settings. Of the 176 Bonferroni significant (P 1%. However, the
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Stephanie Loomis, Man Li, Nisa M. Maruthur et al. · 2018 · Diabetes
Fructosamine and glycated albumin are potentially useful alternatives to hemoglobin A1c (HbA1c) as diabetes biomarkers. The genetic determinants of fructosamine and glycated albumin, however, are unknown. We performed genome-wide…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
April R. Giles, Martin Lock, Shu‐Jen Chen et al. · 2023 · Human Gene Therapy
For successful vector-based gene therapy manufacturing, the selected adeno-associated virus (AAV) vector production system must produce vector at sufficient scale. However, concerns have arisen regarding the quality of vector produced…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Beau J. Fenner, Jonathan F. Russell, Arlene V. Drack et al. · 2023 · Frontiers in Medicine
Introduction X-linked retinoschisis (XLRS) is an inherited retinal disease (IRD) caused by pathogenic mutations in the retinoschisin gene, RS1 . Affected individuals develop retinal layer separation, leading to loss of visual acuity (VA). Several XLRS gene therapy trials have been attempted but none have met their primary endpoints. An improved understanding of XLRS natural history and clinical outcomes may better inform future trials. Here, we report the long-term functional and structural outcomes of XLRS and the relevance of RS1 genotypes to the visual prognosis of affected individuals. Met
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Caroline R. Amendola, William T. Cordell, Colin M. Kneucker et al. · 2023 · Metabolic Engineering
Pseudomonas putida KT2440 is a robust, aromatic catabolic bacterium that has been widely engineered to convert bio-based and waste-based feedstocks to target products. Towards industrial domestication of P. putida KT2440, rational genome…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Luiz Carlos Vieira, Morgan L. Handojo, Claus O. Wilke · 2025 · Scientific Reports
Protein language models (pLMs) can offer deep insights into evolutionary and structural properties of proteins. While larger models, such as the 15 billion parameter model ESM-2, promise to capture more complex patterns in sequence space, they also present practical challenges due to their high dimensionality and high computational cost. We systematically evaluated the performance of various ESM-style models across multiple biological datasets to assess the impact of model size on transfer learning via feature extraction. Surprisingly, we found that larger models do not necessarily outperform
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Weitao Zhou, Xiaoyong Li, Daochao Huang et al. · 2015 · Current Alzheimer Research
It is reported that 7,8-dihydroxyflavone (DHF), a TrkB agonist, has beneficial effects on neuronal excitotoxicity, stroke, and Parkinson disease in animal models by enhancing axon regeneration, muscle reinnervation and neuromuscular…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Cheng Peng, Martijn den Dekker, Andrés Cárdenas et al. · 2018 · Environmental Health Perspectives
BACKGROUND: Epigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health. OBJECTIVE: We sought to examine the associations of residential proximity to roadways at birth and epigenome-wide DNA methylation. We also assessed associations of differential methylation with child cognitive outcomes. METHODS: We estimated residential proximity to roadways at birth using a geographic information system (GIS) and cord blood methylation using Illumina's HumanMethylation450-array in 482 mother-child pairs in Project Viva. We ide
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Liza C. Villaruz, Grace Huang, Marjorie Romkes et al. · 2015 · Clinical Epigenetics
BACKGROUND: Carboplatin/paclitaxel (CP), with or without sorafenib, result in objective response rates of 18-20 % in unselected chemotherapy-naïve patients. Molecular predictors of survival and response to CP-based chemotherapy in metastatic melanoma (MM) are critical to improving the therapeutic index. Intergroup trial E2603 randomized MM patients to CP with or without sorafenib. Expression data were collected from pre-treatment formalin-fixed paraffin-embedded (FFPE) tumor tissues from 115 of 823 patients enrolled on E2603. The selected patients were balanced across treatment arms, BRAF stat
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Annie Gott, Clare Andrews, María Larriva et al. · 2018 · PeerJ
) found that a marker of biological age predicted the strength of the stress response even in individuals of the same chronological age. Specifically, birds that had experienced greater developmental telomere attrition (DTA) showed a lower peak corticosterone (CORT) response to an acute stressor, and more rapid recovery of CORT levels towards baseline. Here, we performed a follow-up study using the same capture-handling-restraint stressor in a separate cohort of starlings that had been subjected to a developmental manipulation of food availability and begging effort. We measured the CORT respo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Nathalie Goemans, M. Tulinius, Anna‐Karin Kroksmark et al. · 2016 · Neuromuscular Disorders
Duchenne muscular dystrophy is a rare genetic disorder with life-limiting pathology. Drisapersen induces exon 51 skipping, thereby producing a shorter but functional dystrophin protein. The longest available data are from an open-label…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Satoru Taniguchi, Kohei Ninomiya, Itaru Kushima et al. · 2019 · Psychiatry and Clinical Neurosciences
AIMS: Recent studies have revealed that the interplay between polygenic risk scores (PRS) and large copy number variants (CNV; >500kb) is essential for the etiology of schizophrenia (SCZ). To replicate previous findings, including those for smaller CNV (>10kb), the PRS between SCZ patients with and without CNV were compared. METHODS: The PRS were calculated for 724 patients with SCZ and 1178 healthy controls (HC), genotyped using array-based comparative genomic hybridization and single nucleotide polymorphisms chips, and comparisons were made between cases and HC, or between subjects with and
View details →