TUDCA promotes intracellular clearance of Burkholderia pseudomallei by inhibiting endoplasmic reticulum stress-induced apoptosis in RAW264.7 cells
ZHAO Guangqiang; NAN Dongqi; YUAN Siqi · 2024 · 陆军军医大学学报
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective To explore the action mechanism of tauroursodeoxycholic acid (TUDCA) promoting intracellular clearance of Burkholderia pseudomallei (B. pseudomallei) in RAW264.7 macrophages. Methods After TUDCA of different concentrations were used to treat RAW264.7 cells pre-infected with B. pseudomallei for 8 h or not, flow cytometry was applied to detect the apoptosis of the infected and control cells. In addition, another endoplasmic reticulum stress (ERS) inhibitor 4-PBA was used to detect the apoptosis and proliferation of host cells after B. pseudomallei infection with Annexin-V/PI double sta
Abstract by ZHAO Guangqiang; NAN Dongqi; YUAN Siqi, 陆军军医大学学报 (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.16016/j.2097-0927.202304046