Prevention of Morbidity in Sickle Cell Disease (POMS2a)—overnight auto-adjusting continuous positive airway pressure compared with nocturnal oxygen therapy: a randomised crossover pilot study examining patient preference and safety in adults and children
Jo Howard; Sophie A. Lee; Baba Inusa; Man Ying Edith Cheng; Cheema Bavenjit; Isabel C. Reading; Sally Ann Wakeford; Johanna C. Gavlak · 2019 · Trials
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Design This randomised crossover trial compared nocturnal auto-adjusting continuous positive airway pressure (APAP) and nocturnal oxygen therapy (NOT) in adults and children with sickle cell anaemia, with patient acceptability as the primary outcome. Secondary outcomes included pulmonary physiology (adults), safety, and daily pain during interventions and washout documented using tablet technology. Methods Inclusion criteria were age > 8 years and the ability to use an iPad to collect daily pain data. Trial participation was 4 weeks; week 1 involved baseline data collection and week 3
Abstract by Jo Howard; Sophie A. Lee; Baba Inusa; Man Ying Edith Cheng; Cheema Bavenjit; Isabel C. Reading; Sally Ann Wakeford; Johanna C. Gavlak, Trials (2019) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s13063-019-3461-x