Chronic stress induces insulin resistance and enhances cognitive impairment in AD
Jiaying Rong; Yanyong Wang; Na Liu; Li Shen; Qinying Ma; Mingwei Wang; Bing Han · 2024 · Brain Research Bulletin
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Chronic stress can induce the cognitive impairment, and even promote the occurrence and development of Alzheimer's disease (AD). Evidence has suggested that chronic stress impacts on glucose metabolism, and both of these have been implicated in AD. Here we focused on the effect of insulin resistance in glucose metabolism, and further evaluated the changes in cognition and pathology. Methods: Male 9-month-old wild-type and APP/PS1 mice were randomly divided into 4 groups. Mice in the chronic unpredictable mild stress (CUMS) groups were exposed for 4 weeks. Homeostatic Model Assessme
Abstract by Jiaying Rong; Yanyong Wang; Na Liu; Li Shen; Qinying Ma; Mingwei Wang; Bing Han, Brain Research Bulletin (2024) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Similarities (and Differences) in the Learning Patterns of Single-Word Reading of an Alphabetic Orthography in Monolingual and Bilingual Primary School Children: A Cross-Sectional Study
Negative / Null Result ReportThe Impact of Acute Aerobic Exercise on General and Food-Related Inhibitory Function Among Young Adults with Obesity: An Event-Related Potential (ERP) Study
Negative / Null Result ReportEffects of simvastatin on white matter integrity in healthy middle‐aged adults
Negative / Null Result ReportRepetitive temporal interference stimulation improves jump performance but not the postural stability in young healthy males: a randomized controlled trial
Negative / Null Result ReportEvaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy
Negative / Null Result ReportImpact of Rural vs. Urban Residence on Survival Rates of Patients with Glioblastoma: A Tertiary Care Center Experience
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1016/j.brainresbull.2024.111083