Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder
Varun Kilaru; Shruti V. Iyer; Lynn M. Almli; Jennifer S. Stevens; Adriana Lori; Tanja Jovanović; Timothy D. Ely; Bekh Bradley · 2016 · Translational Psychiatry
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
Post-traumatic stress disorder (PTSD) develops in only some people following trauma exposure, but the mechanisms differentially explaining risk versus resilience remain largely unknown. PTSD is heritable but candidate gene studies and genome-wide association studies (GWAS) have identified only a modest number of genes that reliably contribute to PTSD. New gene-based methods may help identify additional genes that increase risk for PTSD development or severity. We applied gene-based testing to GWAS data from the Grady Trauma Project (GTP), a primarily African American cohort, and identified two
Abstract by Varun Kilaru; Shruti V. Iyer; Lynn M. Almli; Jennifer S. Stevens; Adriana Lori; Tanja Jovanović; Timothy D. Ely; Bekh Bradley, Translational Psychiatry (2016) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/tp.2016.69