BRD9 Degraders Unleash GBAF Chromatin Remodeling Activity in Synovial Sarcoma.
Li; Nelson; Li; Xia; Stephan; Modzelewska; Yu; Mulford · 2026 · Cancer research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Synovial sarcoma (SyS) incorporates the SS18::SSX fusion oncoprotein into GLTSCR1-containing BRG1/BRM and associated factors (GBAF) complexes, which confers a dependency on the GBAF subunit BRD9. However, SyS clinical trials with multiple…
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Metadata source: PubMed · DOI 10.1158/0008-5472.can-25-5405