Failed Experiment ReportOpen accessMedicine
Darryl Falzarano, David Safronetz, Joseph Prescott et al. · 2015 · Emerging infectious diseases
The antimalarial drug chloroquine has been suggested as a treatment for Ebola virus infection. Chloroquine inhibited virus replication in vitro, but only at cytotoxic concentrations. In mouse and hamster models, treatment did not improve survival. Chloroquine is not a promising treatment for Ebola. Efforts should be directed toward other drug classes.
View details →DOI: 10.3201/eid2106.150176Cited by 63 Failed Experiment ReportOpen accessBiochemistry, Genetics and Molecular Biology
Shobana Raghunath, Siba K. Samal, Subbiah Elankumaran · 2013 · Journal of Virology
Oncolytic virus (OV) therapies of cancer are based on the use of replication-competent, tumor-selective viruses with limited toxicity. Newcastle disease virus (NDV), an avian paramyxovirus, is a promising OV and is inherently tumor…
View details →DOI: 10.1128/jvi.02394-12Cited by 39 Failed Experiment ReportOpen accessPsychology
Masataka Takebe, Kenta Tsumura, Ken'ichiro Nakashima · 2023 · Current Research in Ecological and Social Psychology
Rodeheffer et al. (2012) showed that when people perceive resource scarcity, they are more likely to judge racially ambiguous people as out-group members. In their first experiment, 71 White participants viewed a slideshow depicting either resource scarcity or abundance; subsequently, they judged 20 biracial faces created by averaging a White and a Black face. We conducted this experiment's preregistered conceptual replication study in Japan. Specifically, after observing a slideshow depicting either resource scarcity or abundance, East Asian participants judged 20 biracial faces produced by a
View details →DOI: 10.1016/j.cresp.2023.100169 Failed Experiment ReportOpen accessMedicine
Jan Walleczek, Nikolaus von Stillfried, Stefan Schmidt et al. · 2025 · PLoS ONE
This metascientific project studied the replicability of Bem Experiment 1, which had claimed a precognitive effect, i.e., the ability to successfully guess the outcome of future random events (Bem. J Pers Soc Psychol. 2011;100: 407-25). The use of advanced methodologies-based on the advanced meta-experimental protocol (AMP) and transparent psi project (TPP) procedures-reduced the risk of false discoveries as a function of (i) confirmation bias, (ii) non-transparency, and (iii) intrinsic measurement bias. The combined AMP-TPP test strategy performed three replication studies with a total of 26,
View details →DOI: 10.1371/journal.pone.0335330 Failed Experiment Report
Skorb L, Hartshorne JK · 2022 · Preprint
As part of an ongoing project to replicate major findings regarding statistical word segmentation in adults, we replicated Experiment 2 in Newport and Aslin (2004) ‘Learning at a distance I. Statistical learning of non-adjacent…
View details →DOI: 10.31234/osf.io/vh9u6 Failed Experiment ReportMedicine
Stepanova EV, Strube MJ, Mazur KD · 2023 · The Journal of social psychology
In two studies, participants completed an implicit attractiveness task with faces as primes varying on (a) facial features from Afrocentric to Eurocentric and (b) skin tone from dark to light, and target pictures of environmental scenes…
View details →DOI: 10.1080/00224545.2021.2000355 Failed Experiment Report
Bradley A, Gmiro Y, Stoakes A et al. · 2026 · Preprint
Concerns about the impact of social media on young adult mental health persists despite weak and inconclusive empirical evidence. This study aimed to replicate a highly-cited study showing improved well-being after limiting time on social…
View details →DOI: 10.31234/osf.io/pehxw_v2 Failed Experiment ReportMedicine
Lohmann A · 2020 · Phonetica
The present article describes an extended replication of a reading study by Sereno and Jongman (1995) that reported acoustic differences between noun and verb pronunciations of English disyllabic, non-stress-shifting homophone pairs, for…
View details →DOI: 10.1159/000506138 Failed Experiment ReportMedicine
Dowling EW, Sloman KN, McGarry KM et al. · 2026 · Journal of applied behavior analysis
Previous research on the relation between heart rate patterns and severe behavior has yielded mixed findings. Specifically, some studies have identified distinct heart rate patterns surrounding challenging behavior, whereas others have…
View details →DOI: 10.1002/jaba.70072 Failed Experiment ReportOpen accessMedicine
Yuka Takahashi, Toshiyuki Himichi, Ayumi Masuchi et al. · 2023 · PLoS ONE
Previous studies have revealed that reading fiction is associated with dispositional empathy and theory-of-mind abilities. Earlier studies established a correlation between fiction reading habits and the two measures of social cognition: trait fantasy (i.e., the tendency to transpose oneself into fictitious characters) and performance on the Reading the Mind in the Eyes Test (RMET; a test of the ability to identify others’ mental states based on their eyes). Recently, experimental studies have shown that brief exposure to fiction enhances RMET performance. Nevertheless, these studies have been
