Negative / Null Result ReportOpen accessMedicine
Marie Bakitas, Tor D. Tosteson, Zhigang Li et al. · 2015 · Journal of Clinical Oncology
PURPOSE: Randomized controlled trials have supported integrated oncology and palliative care (PC); however, optimal timing has not been evaluated. We investigated the effect of early versus delayed PC on quality of life (QOL), symptom…
View details →DOI: 10.1200/jco.2014.58.6362Cited by 1,221 Negative / Null Result ReportOpen accessPsychology
Russell Fulmer, Angela Joerin, Breanna Gentile et al. · 2018 · JMIR Mental Health
BACKGROUND: Students in need of mental health care face many barriers including cost, location, availability, and stigma. Studies show that computer-assisted therapy and 1 conversational chatbot delivering cognitive behavioral therapy (CBT) offer a less-intensive and more cost-effective alternative for treating depression and anxiety. Although CBT is one of the most effective treatment methods, applying an integrative approach has been linked to equally effective posttreatment improvement. Integrative psychological artificial intelligence (AI) offers a scalable solution as the demand for affor
View details →DOI: 10.2196/mental.9782Cited by 693 Negative / Null Result ReportMedicine
Nereo Segnan, Paola Armaroli, L Bonelli et al. · 2011 · JNCI Journal of the National Cancer Institute
BACKGROUND: A single flexible sigmoidoscopy at around the age of 60 years has been proposed as an effective strategy for colorectal cancer (CRC) screening. METHODS: We conducted a randomized controlled trial to evaluate the effect of…
View details →DOI: 10.1093/jnci/djr284Cited by 624 Replication FailureMedicine
F.G.R. Fowkes · 2010 · JAMA
CONTEXT: A low ankle brachial index (ABI) indicates atherosclerosis and an increased risk of cardiovascular and cerebrovascular events. Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to…
View details →DOI: 10.1001/jama.2010.221Cited by 624 Negative / Null Result ReportMedicine
Neil A. Smart, Mark Waldron, Hashbullah Ismail et al. · 2015 · International Journal of Evidence-Based Healthcare
INTRODUCTION: Several established tools are available to assess study quality and reporting of randomized controlled trials; however, these tools were designed with clinical intervention trials in mind. In exercise training intervention…
View details →DOI: 10.1097/xeb.0000000000000020Cited by 479 Negative / Null Result ReportNeuroscience
Rebecca Landa, Katherine C. Holman, Allison H. O’Neill et al. · 2010 · Journal of Child Psychology and Psychiatry
BACKGROUND: Social and communication impairments are core deficits and prognostic indicators of autism. We evaluated the impact of supplementing a comprehensive intervention with a curriculum targeting socially synchronous behavior on…
View details →DOI: 10.1111/j.1469-7610.2010.02288.xCited by 352 Negative / Null Result ReportMedicine
Andrew J. Coldman, Norm Phillips, Christine Wilson et al. · 2014 · JNCI Journal of the National Cancer Institute
BACKGROUND: Screening with mammography has been shown by randomized controlled trials to reduce breast cancer mortality in women aged 40 to 74 years. Estimates from observational studies following screening implementation in different…
View details →DOI: 10.1093/jnci/dju261Cited by 296 Negative / Null Result ReportOpen accessMedicine
Philippe Bégin, Jeannie Callum, Erin Jamula et al. · 2021 · Nature Medicine
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 d of respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml of convalescent plasma or standard of care. The composite primary outcome was intubation or death by 30 d. Exploratory analyses
View details →DOI: 10.1038/s41591-021-01488-2Cited by 275 Negative / Null Result ReportOpen accessMedicine
Alessandro Tarozzi, Aprajit Mahajan, Brian G. Blackburn et al. · 2014 · American Economic Review
We describe findings from the first large-scale cluster randomized controlled trial in a developing country that evaluates the uptake of a health-protecting technology, insecticide-treated bednets (ITNs), through micro-consumer loans, as…
View details →DOI: 10.1257/aer.104.7.1909Cited by 246 Negative / Null Result ReportPsychology
Judith T. Moskowitz, Adam W. Carrico, Larissa G. Duncan et al. · 2017 · Journal of Consulting and Clinical Psychology
OBJECTIVE: We conducted a randomized controlled trial to determine whether IRISS (Intervention for those Recently Informed of their Seropositive Status), a positive affect skills intervention, improved positive emotion, psychological…
View details →DOI: 10.1037/ccp0000188Cited by 229 Negative / Null Result ReportOpen accessMedicine
Davy Vancampfort, Joseph Firth, Christoph U. Correll et al. · 2019 · World Psychiatry
We summarized and compared meta-analyses of pharmacological and non-pharmacological interventions targeting physical health outcomes among people with schizophrenia spectrum disorders. Major databases were searched until June 1, 2018. Of…
View details →DOI: 10.1002/wps.20614Cited by 224 Negative / Null Result ReportOpen accessPsychology
Per Carlbring, Maria Apelstrand, Helena Sehlin et al. · 2012 · BMC Psychiatry
BACKGROUND: Computerized cognitive bias modification for social anxiety disorder has in several well conducted trials shown great promise with as many as 72% no longer fulfilling diagnostic criteria after a 4 week training program. To test if the same program can be transferred from a clinical setting to an internet delivered home based treatment the authors conducted a randomized, double-blind placebo-controlled trial. METHODS: After a diagnostic interview 79 participants were randomized to one of two attention training programs using a probe detection task. In the active condition the partic
View details →DOI: 10.1186/1471-244x-12-66Cited by 217 Negative / Null Result ReportOpen accessMedicine
Giuseppe Boriani, Antoine Da Costa, Aurelio Quesada et al. · 2016 · European Journal of Heart Failure
AIMS: The aim of this study was to evaluate the clinical efficacy and safety of remote monitoring in patients with heart failure implanted with a biventricular defibrillator (CRT-D) with advanced diagnostics. METHODS AND RESULTS: The…
View details →DOI: 10.1002/ejhf.626Cited by 214 Negative / Null Result ReportOpen accessPsychology
Mahvash Shahidi, Ali Mojtahed, Amirhossein Modabbernia et al. · 2010 · International Journal of Geriatric Psychiatry
BACKGROUND: Laughter Yoga founded by M. Kataria is a combination of unconditioned laughter and yogic breathing. Its effect on mental and physical aspects of healthy individuals was shown to be beneficial. OBJECTIVE: The objective of this…
View details →DOI: 10.1002/gps.2545Cited by 203 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Konstantinos K. Tsilidis, Despoina Capothanassi, Naomi E. Allen et al. · 2014 · Diabetes Care
OBJECTIVE: Meta-analyses of epidemiologic studies have suggested that metformin may reduce cancer incidence, but randomized controlled trials did not support this hypothesis. RESEARCH DESIGN AND METHODS: A retrospective cohort study,…
View details →DOI: 10.2337/dc14-0584Cited by 183 Negative / Null Result ReportOpen accessPsychology
David C. Mohr, Jenna Duffecy, Joyce Ho et al. · 2013 · PLoS ONE
BACKGROUND: Web-based interventions for depression that are supported by coaching have generally produced larger effect-sizes, relative to standalone web-based interventions. This is likely due to the effect of coaching on adherence. We evaluated the efficacy of a manualized telephone coaching intervention (TeleCoach) aimed at improving adherence to a web-based intervention (moodManager), as well as the relationship between adherence and depressive symptom outcomes. METHODS: 101 patients with MDD, recruited from primary care, were randomized to 12 weeks moodManager+TeleCoach, 12 weeks of self-
View details →DOI: 10.1371/journal.pone.0070086Cited by 177 Negative / Null Result ReportMedicine
RBC Kavia, Dirk De Ridder, Cris S. Constantinescu et al. · 2010 · Multiple Sclerosis Journal
BACKGROUND: Bladder dysfunction is a common feature of multiple sclerosis (MS). OBJECTIVE: In this study we aimed to assess the efficacy, tolerability and safety of Sativex(®) (nabiximols) as an add-on therapy in alleviating bladder…
View details →DOI: 10.1177/1352458510378020Cited by 171 Negative / Null Result ReportOpen accessMedicine
Stefan Hagel, Friedhelm Bach, Thorsten Brenner et al. · 2022 · Intensive Care Medicine
PURPOSE: Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves outcomes. METHODS: Randomized, multicenter, controlled…
View details →DOI: 10.1007/s00134-021-06609-6Cited by 171 Negative / Null Result ReportMedicine
Rebecca Erwin Wells, Rebecca Burch, Randall H. Paulsen et al. · 2014 · Headache The Journal of Head and Face Pain
OBJECTIVE: Our objective was to assess the safety, feasibility, and effects of the standardized 8-week mindfulness-based stress reduction (MBSR) course in adults with migraines. BACKGROUND: Stress is a well-known trigger for headaches.…
View details →DOI: 10.1111/head.12420Cited by 170 Negative / Null Result ReportOpen accessMedicine
Silvia Fernández-Serrano, Jordi Dorca, Carolina García‐Vidal et al. · 2011 · Critical Care
INTRODUCTION: The benefit of corticosteroids as adjunctive treatment in patients with severe community-acquired pneumonia (CAP) requiring hospital admission remains unclear. This study aimed to evaluate the impact of corticosteroid treatment on outcomes in patients with CAP. METHODS: This was a prospective, double-blind and randomized study. All patients received treatment with ceftriaxone plus levofloxacin and methyl-prednisolone (MPDN) administered randomly and blindly as an initial bolus, followed by a tapering regimen, or placebo. RESULTS: Of the 56 patients included in the study, 28 (50%)
View details →DOI: 10.1186/cc10103Cited by 169 Replication FailureOpen accessMathematics
Amelia Averitt, Chunhua Weng, Patrick Ryan et al. · 2020 · npj Digital Medicine
Randomized controlled trials (RCTs) are regarded as the most reputable source of evidence. In some studies, factors beyond the intervention itself may contribute to the measured effect, an occurrence known as heterogeneity of treatment effect (HTE). If the RCT population differs from the real-world population on factors that induce HTE, the trials effect will not replicate. The RCTs eligibility criteria should identify the sub-population in which its evidence will replicate. However, the extent to which the eligibility criteria identify the appropriate population is unknown, which raises conce
View details →DOI: 10.1038/s41746-020-0277-8Cited by 141 Negative / Null Result ReportOpen accessPsychology
Philip T. Yanos, David Roe, Michelle L. West et al. · 2012 · Psychological Services
Elevated internalized stigma is common and is linked to subjective and objective outcomes for severe mental illness. The authors developed a manualized group-based intervention (Narrative Enhancement/Cognitive Therapy; NECT) to address…
View details →DOI: 10.1037/a0028048Cited by 139 Negative / Null Result Report
KJ Dodd, NF Taylor, N Shields et al. · 2011 · Multiple Sclerosis Journal
Background: Few high-quality trials have examined the effects of progressive resistance training (PRT) on people with multiple sclerosis (MS). Objective: To determine the effectiveness of PRT for people with MS, focusing on improving the…
View details →DOI: 10.1177/1352458511409084Cited by 126 Replication FailureOpen accessMedicine
Manaf AlQahtani, Abdulkarim Abdulrahman, Abdulrahman Almadani et al. · 2021 · Scientific Reports
Convalescent plasma (CP) therapy in COVID-19 disease may improve clinical outcome in severe disease. This pilot study was undertaken to inform feasibility and safety of further definitive studies. This was a prospective, interventional and randomized open label pilot trial in patients with severe COVID-19. Twenty COVID-19 patients received two 200 ml transfusions of convalescent patient CP over 24-h compared with 20 who received standard of care. The primary outcome was the requirement for ventilation (non-invasive or mechanical ventilation). The secondary outcomes were biochemical parameters
View details →DOI: 10.1038/s41598-021-89444-5Cited by 104 Negative / Null Result ReportOpen accessPsychology
John E. Pachankis, Audrey Harkness, Kaitlin R. Maciejewski et al. · 2022 · Journal of Consulting and Clinical Psychology
OBJECTIVE: Effective Skills to Empower Effective Men (ESTEEM) represents the first intervention to address the psychological pathways through which minority stress undermines young sexual minority men's (SMM's) mental and sexual health…
View details →DOI: 10.1037/ccp0000724Cited by 100 Negative / Null Result ReportPsychology
David D. Luxton, Larry D. Pruitt, Amy W. Wagner et al. · 2016 · Journal of Consulting and Clinical Psychology
OBJECTIVE: Evidence of feasibility, safety, and effectiveness of home-based telebehavioral health (HBTBH) needs to be established before adoption of HBTBH in the military health system can occur. The purpose of this randomized controlled…
View details →DOI: 10.1037/ccp0000135Cited by 95 Negative / Null Result ReportOpen accessNursing
Theresa J. Ochoa, Jaime Zegarra, Luis Cam et al. · 2014 · The Pediatric Infectious Disease Journal
BACKGROUND: Lactoferrin (LF) is a broad-spectrum antimicrobial and immunomodulatory milk glycoprotein. OBJECTIVE: To determine the effect of bovine LF on the prevention of the first episode of late-onset sepsis in Peruvian infants.…
View details →DOI: 10.1097/inf.0000000000000593Cited by 87 Negative / Null Result ReportOpen accessPsychology
Matthew J. Hirshberg, Corrina Frye, Cortland J. Dahl et al. · 2022 · Journal of Educational Psychology
s<.031 corrected except mindful action at follow-up). We found no evidence for elevated adverse events and the HMP was equally effective among participants with elevated baseline anxiety and depressive symptoms. These data suggest that the…
View details →DOI: 10.1037/edu0000739Cited by 74 Negative / Null Result ReportOpen accessPsychology
Carine Meslot, Aurélie Gauchet, B. Allenet et al. · 2016 · Frontiers in Psychology
Interventions to assist individuals in initiating and maintaining regular participation in physical activity are not always effective. Psychological and behavioural theories advocate the importance of both motivation and volition in interventions to change health behaviour. Interventions adopting self-regulation strategies that foster motivational and volitional components may, therefore, have utility in promoting regular physical activity participation. We tested the efficacy of an intervention adopting motivational (mental simulation) and volitional (implementation intentions) components to
View details →DOI: 10.3389/fpsyg.2016.01789Cited by 67 Negative / Null Result ReportOpen accessPsychology
Tammi R. A. Kral, Kaley Davis, Cole Korponay et al. · 2022 · Science Advances
Studies purporting to show changes in brain structure following the popular, 8-week mindfulness-based stress reduction (MBSR) course are widely referenced despite major methodological limitations. Here, we present findings from a large, combined dataset of two, three-arm randomized controlled trials with active and waitlist (WL) control groups. Meditation-naïve participants ( n = 218) completed structural magnetic resonance imaging scans during two visits: baseline and postintervention period. After baseline, participants were randomly assigned to WL ( n = 70), an 8-week MBSR program ( n = 75)
View details →DOI: 10.1126/sciadv.abk3316Cited by 67 