Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

All Replication Failure Negative / Null Result Report Failed Experiment Report Abandoned Hypothesis Methods Dead-End Short Note Null Dataset Protocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,214 Computer Science 743 Biochemistry, Genetics and Molecular Biology 414 Social Sciences 302 Psychology 299 Physics 280 Neuroscience 243 Economics, Econometrics and Finance 196 Environmental Science 171 Mathematics 155 Agricultural and Biological Sciences 137 Engineering 135

2 results for "high-throughput screening"

Negative / Null Result ReportOpen accessMaterials Science

A 3D spheroid model for assessing nanocarrier-based drug delivery to solid tumors

Chitra Yadav, Alexander S. Evtushenko, Andrea Bistrović et al. · 2025 · npj Biomedical Innovations.

3D spheroid culture has emerged as a valuable tool for studying complex intratumoral processes and screening novel therapeutics in vitro. However, spheroids face reproducibility and data interpretation issues, which limit their utility. This work describes a simple and reproducible co-culture spheroid model compatible with high-throughput screening designed to study pancreatic ductal adenocarcinoma (PDAC), a highly therapy-resistant cancer. These spheroids, composed of both cancer and stromal cells, recapitulate key features of PDAC which are difficult to study in traditional 2D cell culture,

View details →DOI: 10.1038/s44385-025-00041-xCited by 11

Negative / Null Result ReportMedicine

Testing Multiple Tissues Improves Performance of Diagnostic Assays for Chronic Wasting Disease in Elk (Cervus canadensis).

Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases

Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…

View details →DOI: 10.7589/jwd-d-25-00164