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WASTE Journal
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

AllReplication FailureNegative / Null Result ReportFailed Experiment ReportAbandoned HypothesisMethods Dead-EndShort NoteNull DatasetProtocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,218Computer Science 744Biochemistry, Genetics and Molecular Biology 414Social Sciences 302Psychology 299Physics 280Neuroscience 244Economics, Econometrics and Finance 196Environmental Science 172Mathematics 155Agricultural and Biological Sciences 138Engineering 135

2 results in Null Dataset for "drug discovery"

Null DatasetOpen accessComputer Science

DCDB 2.0: a major update of the drug combination database

Yu Liu, Qichun Wei, Guocan Yu et al. · 2014 · Database

Experience in clinical practice and research in systems pharmacology suggested the limitations of the current one-drug-one-target paradigm in new drug discovery. Single-target drugs may not always produce desired physiological effects on the entire biological system, even if they have successfully regulated the activities of their designated targets. On the other hand, multicomponent therapy, in which two or more agents simultaneously interact with multiple targets, has attracted growing attention. Many drug combinations consisting of multiple agents have already entered clinical practice, esp

View details →DOI: 10.1093/database/bau124Cited by 120