Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

All Replication Failure Negative / Null Result Report Failed Experiment Report Abandoned Hypothesis Methods Dead-End Short Note Null Dataset Protocol

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

By fieldMedicine 12,301 Computer Science 753 Biochemistry, Genetics and Molecular Biology 443 Social Sciences 312 Psychology 309 Physics 280 Neuroscience 258 Economics, Econometrics and Finance 209 Environmental Science 186 Mathematics 161 Agricultural and Biological Sciences 151 Engineering 150

1 result in Replication Failure for "SARS-CoV-2"

Replication FailureOpen accessMedicine

Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients

Christopher C. Butler, Andrew Pinto, Victoria Harris et al. · 2026 · New England Journal of Medicine

BACKGROUND: Nirmatrelvir-ritonavir has been shown to reduce progression to severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unvaccinated high-risk outpatients. The effectiveness of nirmatrelvir-ritonavir in persons who have been vaccinated, infected naturally, or both is unclear. METHODS: In two open-label platform trials (PANORAMIC in the United Kingdom and CanTreatCOVID in Canada), we enrolled higher-risk adults (≥50 years of age or ≥18 years of age with coexisting conditions) in the community who tested positive for SARS-CoV-2 and had been unwell for 5 day

View details →DOI: 10.1056/nejmoa2502457Cited by 9