A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
14 results in Methods Dead-End for "Mpro"
Till Francke, Gabriele Baroni, Arlena Brosinsky et al. · 2018 · Water Resources Research
Abstract Modelers can improve a model by addressing the causes for the model errors (data errors and structural errors). This leads to implementing model enhancements (MEs), for example, meteorological data based on more monitoring…
Manuel Rosinus, Jan Lansky · 2025 · International Journal of Financial Studies
As investors increasingly use Environmental, Social, and Governance (ESG) criteria, a key challenge remains: ESG data is typically reported annually, while financial markets move much faster. This study investigates whether incorporating annual ESG scores can improve monthly stock return forecasts for German DAX-listed firms. We employ a multivariate long short-term memory (LSTM) network, a machine learning model ideal for time series data, to test this hypothesis over two periods: an 8-year analysis with a full set of ESG scores and a 16-year analysis with a single disclosure score. The evalu
Luis Sangoi, Ricardo Salvador · 1997 · Ciência Rural
This experiment was conducted in Ames, Iowa, USA, to compare dry matter accumulation patterns of maize genotypes contrasting in height and leafiness, and to test whether reduction in plant height an leaf number through the use of dwarfing genes or earliness can improve grain dry matter allocation. Five plant genotypes were tested: a full season hybrid adapted to central lowa (NK 4525), a short season hybrid adapted to northern Minnesota (C1070), and three dwarf lines (156-A, 302-E and I17- A). The dwarves contained, respectively, the homozygous, independent, recessive dwarfing genes d3, d1 and
Foteini Aikaterini Pikouli, Despina Moraitou, Georgia Papantoniou et al. · 2023 · Journal of Intelligence
Mild cognitive impairment (MCI) is associated with deficits in decision-making, which is of utmost importance for daily functioning. Despite evidence of declined decision-making abilities, research on decision-making interventions for MCI is scarce. As metacognition seems to play an important role in decision-making, the present study’s aim was to examine whether a metacognitive strategy training can improve MCI patients’ decision-making abilities. Older adults—patients of a day care center, diagnosed with amnestic MCI (n = 55) were randomly allocated in two groups, which were matched in gende
Dexter F, Rolfzen ML, Hoffman J et al. · 2025 · Anesthesia and analgesia
Background Earlier studies have not examined the extent to which reducing postoperative opioid use after patient discharge would improve the quality of life of opioid naïve patients, knowledge needed for economic evaluations of drugs and…
Saito M, Tanaka H, Matsui M et al. · 2026 · Preprint
Abstract Background Intradialytic exercise is recommended to improve exercise capacity, physical function, and quality of life in patients undergoing maintenance hemodialysis (HD). However, objective and practical physiological indicators…
Some DY, Kiemde F, Kabore B et al. · 2026 · PloS one
Objective To evaluate the field accuracy of a malaria diagnostic algorithm combining sequential interpretation of two-step malaria RDT detecting PfHRP2 and pLDH with information on previous antimalarial treatments within the past four…
Reis da Silva T · 2024 · British journal of community nursing
Aim This study reviews research into the effects of the supplementation of B12 in the prevention and recovery of mental illness, and the potentiation of psychotropic medication. Methodology This literature review follows a systematic…
Kim EJ, Kim SY, Kee YK et al. · 2026 · Preprint
Abstract Far-infrared (FIR) therapy has been proposed to improve vascular access flow (Qa) in patients receiving maintenance hemodialysis through an arteriovenous fistula (AVF) or arteriovenous graft (AVG). However, vascular access blood…
Kadesch, Weiss, Hetjens et al. · 2026 · Obesity surgery
Preoperative multidisciplinary team assessment (MTA) for bariatric surgery is complex and associated with high attrition rates. Digital health applications may improve patient engagement and completion rates, but evidence remains limited.…
Vrinzen, Stadhouders, Bloemendal et al. · 2026 · BMJ open
Concentration of care and collaborations between hospitals increasingly reorganise oncological care into Comprehensive Cancer Networks (CCNs), aiming to improve care outcomes and reduce costs. This study aims to evaluate the effect of four…
Fadi Fadil, Claudia Samol, Raffaela S. Berger et al. · 2022 · Metabolites
Metabolic fingerprinting by mass spectrometry aims at the comprehensive, semiquantitative analysis of metabolites. Isotope dilution, if successfully implemented, may provide a more reliable, relative quantification. Therefore, the 13 C labeled yeast extract of the IROA TruQuant kit was added as an internal standard (IS) to human urine samples measured in full-scan mode on a high-performance liquid chromatography-time-of-flight mass spectrometer (HPLC–TOFMS) system. The isotope ratio approach enabled the analysis of 112 metabolites. The correlation with reference data did not improve significan
Pierre Boullier · 1996 · arXiv
In this paper we present a new parsing algorithm for linear indexed grammars (LIGs) in the same spirit as the one described in (Vijay-Shanker and Weir, 1993) for tree adjoining grammars. For a LIG $L$ and an input string $x$ of length $n$, we build a non ambiguous context-free grammar whose sentences are all (and exclusively) valid derivation sequences in $L$ which lead to $x$. We show that this grammar can be built in ${\cal O}(n^6)$ time and that individual parses can be extracted in linear time with the size of the extracted parse tree. Though this ${\cal O}(n^6)$ upper bound does not impro
Gogebakan KC, Kunst N, Ghodsi A et al. · 2026 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The TheraP trial demonstrated that 177 Lu-PSMA-617 improved progression-free survival (PFS) compared with cabazitaxel, with no significant difference in overall survival (OS). However, 177 Lu-PSMA-617 was associated with fewer severe…