A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
459 results in Negative / Null Result Report for "randomized controlled trial" · page 9 of 16
Podoly TY, Even-Ezra H, Doron G · 2025 · Journal of affective disorders
Misophonia is a condition characterized by strong, aversive reactions to specific sounds produced by others, often manifesting as intense negative emotions like anger or rage in response to nearby noises. The present study aimed to…
El-Nagdy NK, Mansour NO, Diab AAA et al. · 2025 · Pharmacotherapy
Background Midodrine has been primarily studied as an adjunctive oral therapy to reduce the need for vasopressors in intensive care units (ICU). Nonetheless, the available results evaluating midodrine as an adjuvant therapy in the…
van Lennep JPA, van Middendorp H, Leong OV et al. · 2025 · Scandinavian journal of pain
Objectives To understand how different individuals respond to placebo effects, it is relevant to disentangle the influence of someone's personality and genetic variations. The aim of this exploratory study was to investigate the role of…
Jones N, Humm K, Tinson EW · 2026 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
Objective To determine the cardiovascular and respiratory effects of bolus IV isotonic crystalloid fluid therapy before pericardiocentesis in dogs with pericardial effusion. Design Prospective, randomized, nonblinded clinical trial…
Panzenböck LF, Abdel Nour G, Dürrschnabel DL et al. · 2026 · Global spine journal
Study DesignRandomized controlled trial.ObjectivesTo characterize postoperative C-reactive protein (CRP) trajectories as predictors of surgical site infection (SSI) following lumbar spine surgery, to determine optimal CRP thresholds, and…
Pihlaja S, Lipsanen J, Ritola V et al. · 2026 · Frontiers in psychology
Among patients receiving internet-delivered cognitive behavioral therapy (iCBT) for depression in routine clinical practice, 101 patients were randomized to either iCBT as usual or to iCBT with add-on scheduled telephone support (STS).…
Xiao C, Jing S, Yang G et al. · 2025 · Preprint
Abstract Background Regional anesthesia techniques, including the serratus anterior plane block (SAPB), reduce postoperative pain after minimally invasive cardiac surgery. However, the evidence regarding its impact on transapical…
Randy H, Perrin TP, Ghaith A et al. · 2025 · American journal of physiology. Regulatory, integrative and comparative physiology
Aging is associated with cerebrovascular impairment, increasing the risk for neurovascular and degenerative diseases. Intermittent hypoxic conditioning (IHC) has been proposed as a valuable strategy to enhance vascular health. However, its…
Pulliainen H, Kataja E, Löyttyniemi E et al. · 2025 · Preprint
Abstract Background We examined whether an interactive four-dimensional (4D) ultrasound intervention decreases prenatal and early postnatal depressive symptoms and improves maternal-fetal attachment. Methods This randomized controlled…
Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA
Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…
Narang BJ, Štritof A, Debevec T · 2025 · International journal of sport nutrition and exercise metabolism
The ergogenic effects of caffeine for endurance performance at sea level are well established. However, whether caffeine enhances exercise capacity or modulates cardiorespiratory responses in hypoxia remains unclear. Twenty-nine healthy,…
Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport
Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…
Rocchetto S, Rondonotti E, Alicante S et al. · 2025 · Endoscopy
Both computer-aided detection (CADe) systems and mucosal exposure devices can enhance adenoma detection during colonoscopy. This research investigates whether combining a CADe system with a balloon-based mucosal exposure device increases…
El-Salam SA, Aboalnaga AA, Tawfik WA et al. · 2026 · BMC oral health
OBJECTIVE: To evaluate the effect of gradually increasing orthodontic force magnitude compared with a constant force magnitude on the rate of tooth movement during maxillary canine retraction. METHODS: This split-mouth randomized…
de Castro T, Viana LH, Botelho S et al. · 2026 · International urogynecology journal
Introduction and hypothesis Approximately 60% of women experience some degree of perineal laceration following vaginal delivery. Although there is evidence supporting the use of photobiomodulation (PBM) for pain relief and wound healing in…
Cowan C, Harmon EY, Melewski M et al. · 2026 · The American journal of occupational therapy : official publication of the American Occupational Therapy Association
Importance Understanding how upper extremity (UE) robotic therapy (RT) affects efficiency and effectiveness of inpatient rehabilitation is important to advancing poststroke treatment and recovery. Objective To determine whether UE RT…
Kirkham MS, Carlson HB, Merrill E et al. · 2026 · Journal of shoulder and elbow surgery
Hypothesis Cutibacterium acnes is the most frequent cause of shoulder prosthetic joint infection with skin edges as a source of wound contamination. The primary purpose of this study was to determine if the use of a wound protector device…
Bosqui T, Brown FL, Farah S et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines
Background There are no evaluated family-based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole-family interventions in low- and middle-income…
Åberg S, Nordin E, Iversen KN et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)
Background and aims Wholegrain rye foods have shown promising effects on metabolic regulation and weight-loss, which may be mediated via gut microbiota and derived metabolites. This study aimed to investigate effects of hypocaloric diets…
Kim B, Boustany C, Fethney J et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Purpose This study aimed to report the incidence, common reasons, and associated risk factors for unplanned hospital presentations during chemotherapy treatment. Methods A secondary analysis using data from a randomized controlled trial…
Türkiş NA, Taşdemir N · 2026 · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses
Purpose Postoperative nausea and vomiting (PONV) is one of the most common complications in surgical patients during the first 24 hours after general anesthesia. This research aimed to evaluate the effect of cold application on early PONV…
Janssen JC, Schurink AW, Verhoef C et al. · 2026 · European journal of cancer (Oxford, England : 1990)
Background Adjuvant systemic therapy for resected stage III melanoma was introduced in clinical practice following the improved recurrence free survival in randomized controlled trials. However, after ten years of follow-up, adjuvant…
Santaularia N, Arnau A, Torà N et al. · 2026 · Journal of cardiopulmonary rehabilitation and prevention
Purpose Our purpose was to assess the efficacy of a phase III cardiac rehabilitation (CR) program, based on counseling in the maintenance of physical exercise, on the time spent on physical exercise per week in patients with ischemic heart…
Pohl V, Haas R, Rosen R et al. · 2025 · Clinical implant dentistry and related research
Objective This randomized controlled trial aimed to evaluate the impact of early versus delayed change of abutment on bone levels, soft tissue, and patient satisfaction with single-tooth immediate implants. Material and methods In 26…
Bodensohn R, Kaempfel AL, Boulesteix AL et al. · 2023 · Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Background and purpose There is no randomized evidence comparing whole-brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) in the treatment of multiple brain metastases. This prospective nonrandomized controlled single arm trial…
Lee JH, Hwang K, Jeong WK · 2026 · Clinics in orthopedic surgery
Background Arthroscopic rotator cuff repair is widely performed; yet tendon healing failure still occurs in some cases and remains a challenge. To address this issue, several studies have investigated intraoperative injection or patch…
Pirracchio R, Fong N, Legrand M · 2025 · Intensive care medicine
Background The best blood pressure target in sepsis is a matter of debate. SEPSIS-PAM, a large multicenter pragmatic randomized controlled trial, compared two mean arterial pressure targets (65-70 mmHg vs 80-85 mmHg) in septic shock and…
Chowdhury R, Maiti U, Devi S et al. · 2025 · Preprint
Background Early-life interventions targeting maternal and child health, nutrition, and psychosocial care may influence infant growth and immune development by modulating systemic inflammation and growth factor pathways. However, causal…
Taylor LM, Parsons J, Moyes SA et al. · 2024 · Journal of the American Medical Directors Association
Objectives To investigate the effect of an exercise program on falls in intermediate and high-level long-term care (LTC) residents and to determine whether adherence, physical capacity, and cognition modified outcomes. Design Randomized…
Chen J, Chen Z, Yan Q et al. · 2025 · BMC oral health
Objectives To evaluate patient-reported outcome measures (PROMs) of povidone-iodine rinse and chlorhexidine rinse for patients undergoing dental implant treatments, as well as their bacteriostatic efficacy. Materials and methods Patients…