e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

757 results for "aging" · page 9 of 26

Negative / Null Result ReportMedicine

Sentinel Lymph Node Mapping Compared with Selective Lymph Node Sampling in the Surgical Staging of Endometrial Cancer: A Prospective Observational Study.

Gâta, Ilieș, Mureșan-Bădescu et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives : Nowadays, lymph node assessment represents a key component in the surgical staging of endometrial cancer, as sentinel lymph node (SLN) mapping increased in adoption as an alternative to lymphadenectomy. This study…

View details →DOI: 10.3390/diagnostics16121904
Negative / Null Result ReportOpen accessComputer Science

Understanding and Analyzing Model Robustness and Knowledge-Transfer in Multilingual Neural Machine Translation using TX-Ray

Vageesh Saxena, Sharid Loáiciga, Nils Rethmeier · 2024 · arXiv

Neural networks have demonstrated significant advancements in Neural Machine Translation (NMT) compared to conventional phrase-based approaches. However, Multilingual Neural Machine Translation (MNMT) in extremely low-resource settings remains underexplored. This research investigates how knowledge transfer across languages can enhance MNMT in such scenarios. Using the Tatoeba translation challenge dataset from Helsinki NLP, we perform English-German, English-French, and English-Spanish translations, leveraging minimal parallel data to establish cross-lingual mappings. Unlike conventional meth

Negative / Null Result ReportOpen accessComputer Science

CMAX++ : Leveraging Experience in Planning and Execution using Inaccurate Models

Anirudh Vemula, J. Andrew Bagnell, Maxim Likhachev · 2020 · arXiv

Given access to accurate dynamical models, modern planning approaches are effective in computing feasible and optimal plans for repetitive robotic tasks. However, it is difficult to model the true dynamics of the real world before execution, especially for tasks requiring interactions with objects whose parameters are unknown. A recent planning approach, CMAX, tackles this problem by adapting the planner online during execution to bias the resulting plans away from inaccurately modeled regions. CMAX, while being provably guaranteed to reach the goal, requires strong assumptions on the accuracy

Negative / Null Result ReportOpen accessEngineering

Audio-Conditioned Diffusion LLMs for ASR and Deliberation Processing

Mengqi Wang, Zhan Liu, Zengrui Jin et al. · 2025 · arXiv

Diffusion-based large language models (DLLMs) have recently attracted growing interest as an alternative to autoregressive decoders. In this work, we present an empirical study on using the diffusion-based large language model LLaDA for automatic speech recognition (ASR). We first investigate its use as an external deliberation-based processing module for Whisper-LLaMA transcripts. By leveraging the bidirectional attention and denoising capabilities of LLaDA, we explore random masking, low-confidence masking, and semi-autoregressive strategies, showing that Whisper-LLaDA substantially reduces

Negative / Null Result ReportOpen accessComputer Science

Towards the Design of Effective Freehand Gestural Interaction for Interactive TV

Gang Ren, Wenbin Li, Eamonn O'Neill · 2016 · arXiv

As interactive devices become pervasive, people are beginning to looking for more advanced interaction with televisions in the living room. Interactive television has the potential to offer a very engaging experience. But most common user tasks are still challenging with such systems, such as menu selection or text input. And little work has been done on understanding and sup-porting the effective design of freehand interaction with an TV in the living room. In this paper, we perform two studies investi-gating freehand gestural interaction with a consumer level sensor, which is suitable for TV

Negative / Null Result ReportOpen accessMedicine

Functional MR Microimaging of Pancreatic β-Cell Activation

Barjor Gimi, Lara Leoni, Jose Oberholzer et al. · 2006 · Cell Transplantation

The increasing incidence of diabetes and the need to further understand its cellular basis has resulted in the development of new diagnostic and therapeutic techniques. Nonetheless, the quest to noninvasively ascertain β-cell mass and function has not been achieved. Manganese (Mn)-enhanced MRI is presented here as a tool to image β-cell functionality in cell culture and isolated islets. Similar to calcium, extracellular Mn was taken up by glucose-activated β-cells resulting in 200% increase in MRI contrast enhancement, versus nonactivated cells. Similarly, glucose-activated islets showed an in

View details →DOI: 10.3727/000000006783982151
Negative / Null Result ReportOpen accessPhysics

Ground test results of the electromagnetic interference for the x-ray microcalorimeter onboard XRISM

Miki Kurihara, Masahiro Tsujimoto, Megan E. Eckart et al. · 2023 · arXiv

Electromagnetic interference (EMI) for low-temperature detectors is a serious concern in many missions. We investigate the EMI caused by the spacecraft components to the x-ray microcalorimeter of the Resolve instrument onboard the X-Ray Imaging and Spectroscopy Mission (XRISM), which is currently under development by an international collaboration and is planned to be launched in 2023. We focus on the EMI from (a) the low-frequency magnetic field generated by the magnetic torquers (MTQ) used for the spacecraft attitude control and (b) the radio-frequency (RF) electromagnetic field generated by

Negative / Null Result ReportOpen accessPhysics

Imaging method for interface rheological characterization

Nicolas Abi Chebel, Olivier Masbernat, Frédéric Risso et al. · 2008 · arXiv

The present work investigates free damped oscillations of an oil drop in water after its release from a capillary tube. Both pure heptane drops and diluted crude oil drops are considered (in the second case the interface is covered by amphiphilic species, natural components of crude oil). Shadowgraph images of the drops are taken by means of a high speed camera and the drop contour is detected by image processing. The axisymmetric drop shape is then decomposed into spherical harmonics, which constitute the eigenmodes of oscillations predicted by the Rayleigh-Lamb theory. Time evolution of each

Negative / Null Result ReportOpen accessPhysics

Photoelectron Polarization Vortexes in Strong-Field Ionization

Pei-Lun He, Zhao-Han Zhang, Karen Z. Hatsagortsyan et al. · 2024 · arXiv

The spin polarization of photoelectrons induced by an intense linearly polarized laser field is investigated using numerical solutions of the time-dependent Schrödinger equation in companion with our analytic treatment via the spin-resolved strong-field approximation and classical trajectory Monte Carlo simulations. We demonstrate that, even though the total polarization vanishes upon averaging over the photoelectron momentum, momentum-resolved spin polarization is significant, typically exhibiting a vortex structure relative to the laser polarization axis. The polarization arises from the tra

Negative / Null Result ReportOpen accessDentistry

Dens invaginatus as a diagnostic challenge: evaluating large language models against expert endodontic reasoning

Damla Erkal, Turgut Felek, Oana-Paula Butean et al. · 2025 · BMC Oral Health

Abstract Introduction This study hypothesized that large language models (LLMs) would underperform compared to expert clinicians in diagnosing and managing complex endodontic anomalies, such as dens invaginatus, when provided with periapical radiographs. Although LLMs have shown promise in dental education and basic diagnostics, their effectiveness in nuanced clinical reasoning has remained unclear. Methods Nineteen anonymized periapical radiographs depicting challenging endodontic conditions were paired with clinical vignettes. Six advanced LLMs and one expert endodontist independently answer

View details →DOI: 10.1186/s12903-025-06987-z
Negative / Null Result Report

“Football Did Not Make Me a World Champion, but It Did Help My Wellbeing”: A Qualitative Study of Study-sport Balance Based on Fung Ka Ki

Bill Cheuk Long Chan, Billy Lee · 2024 · Studia sportiva

Managing the balance of academic and athletic responsibilities at university is a serious challenge for student athletes. This phenomenological case study illuminates how one individual successfully managed his study-sport balance at…

View details →DOI: 10.5817/sts2023-2-6
Negative / Null Result Report

Engaging Education About Risks of Opioid Use With Patients Before Elective Surgery of the Lower Extremity Did Not Reduce Postoperative Opioid Utilization: A Randomized Controlled Trial

Daniel I. Rhon, Tina A. Greenlee, Rachel Mayhew et al. · 2022 · Journal of the American Academy of Orthopaedic Surgeons

Introduction: After elective orthopaedic surgery, many individuals go on to become long-term opioid users. Mitigating this risk has become a priority for surgeons, other members of the medical care team, and healthcare systems. The purpose…

View details →DOI: 10.5435/jaaos-d-21-00603
Negative / Null Result ReportOpen accessMedicine

The neural determinants of age-related changes in fluid intelligence: a pre-registered, longitudinal analysis in UK Biobank [version 1; referees: 2 approved]

Rogier A. Kievit, Delia Fuhrmann, Gesa Sophia Borgeest et al. · 2018 · Wellcome Open Research

Background: Fluid intelligence declines with advancing age, starting in early adulthood. Within-subject declines in fluid intelligence are highly correlated with contemporaneous declines in the ability to live and function independently. To support healthy aging, the mechanisms underlying these declines need to be better understood. Methods: In this pre-registered analysis, we applied latent growth curve modelling to investigate the neural determinants of longitudinal changes in fluid intelligence across three time points in 185,317 individuals (N=9,719 two waves, N=870 three waves) from the U

View details →DOI: 10.12688/wellcomeopenres.14241.1
Negative / Null Result Report

Keep looking until you find

Nelli Tuomola · 2023 · JCEM Case Reports

Abstract The patient is 24-years old male with no previous medical history. He has worked for the last 3 years in the packaging line of Divigel, the estradiol gel of the pharmaceutical company Orion. He sought medical attention 11/2014 due…

View details →DOI: 10.1210/jcemcr/luac014.052
Negative / Null Result Report

No Introduction Necessary: Face-saving Answer Options Outperform Preambles in Reducing Social Desirability Bias

Emma Zaal, John Hoeks, Yfke Ongena · 2025 · Journal of Survey Statistics and Methodology

Abstract Social Desirability Bias (SDB), providing a favorable image of oneself in self-reports, is a persistent problem in survey research on sensitive topics. However, face-saving approaches appear promising in discouraging SDB.…

View details →DOI: 10.1093/jssam/smaf017
Negative / Null Result Report

Adrenal nodule: does computed tomography outperform chemical shift magnetic resonance imaging in differentiating benign versus malignant?

Noble Charles, Nilkanth Pal, Jeevan Vernekar · 2025 · African Journal of Urology

Abstract Background The radiologist faces the dilemma of characterizing adrenal lesions, especially in oncology patients, as this finding can alter the patient’s management and prognosis. The objectives of this study were (1) to evaluate…

View details →DOI: 10.1186/s12301-025-00499-6
Negative / Null Result Report

Later-generation epigenetic aging clocks outperform first-generation models in predicting survival in TCGA breast cancer

Xianglong Tan, Matteo Pellegrini, Su Yon Jung · 2026 · Clinical Epigenetics

Abstract Background Epigenetic aging bridges the gap between biological and chronological age by exploiting DNA methylation (DNAm) patterns. Over the past decade, successive DNAm-based clocks have been introduced, beginning with the…

View details →DOI: 10.1186/s13148-026-02102-3
Negative / Null Result Report

CT Radiomics Models Did Not Outperform Experts in Predicting [68Ga]Ga-PSMA-PET Positivity in Prostate Cancer Lymph Node Staging

Thula Cannon Walter-Rittel, Boris Gorodetski, Alexander Hartenstein et al. · 2026 · Current Oncology

Background: The use of [68Ga]Ga-PSMA-PET/CT for prostate cancer (PCa) staging is limited by cost and availability. This study evaluates whether radiomic features from contrast-enhanced (CE) CT can predict PSMA-positive lymph nodes (LNs) as…

View details →DOI: 10.3390/curroncol33030146
Negative / Null Result Report

Inflation Management In The Eu: Does The Eurozone Outperform Non-Euro States?

Anna Prucnal · 2025 · International Journal of Business & Management Studies

This study examines the effectiveness of the monetary policy of the European Central Bank (ECB) in managing inflation in the Euro Area compared to the independent monetary policy of seven European Union Member States outside the Economic…

View details →DOI: 10.56734/ijbms.v6n1a7
Negative / Null Result Report

Downstream Imaging Studies Do Not Significantly Improve Outcome in Most Patients with Chest Pain Who Did Not Reach Their Target Heart Rate on a Stress ECHO Study

Nativ Henkin, Ifat Karilker, Sergio L. Kobal et al. · 2023 · Journal of Clinical Medicine

Echocardiographic stress tests are often used to evaluate patients who complain of chest pain. However, some patients fail to reach the target heart rate required for the test to be conclusive (usually defined as 85% of the predicted…

View details →DOI: 10.3390/jcm12144832
Negative / Null Result Report

Citrulline ingestion did not improve the age‐associated reduction in nitric oxide synthesis (698.6)

Il‐Young Kim, Scott Schutzler, Nicolaas Deutz et al. · 2014 · The FASEB Journal

A reduction in nitric oxide (NO) bioavailability that impairs peripheral blood flow regulation is a natural consequence of aging. Therefore , we investigated the effect of ingestion of citrulline, the precursor of arginine, on de novo…

View details →DOI: 10.1096/fasebj.28.1_supplement.698.6
Negative / Null Result Report

Double Stigma: The Influence of Race & Mental Health

Bobbie Call, null null, null null et al. · 2020 · John Heinrichs Scholarly & Creative Activities Day

Mental health stigma is prevalent and many people are affected all around the world (Watson, 2002). Stigma often prevents individuals with a mental illness from engaging in typical life routines (Corrigan, 2004). Individuals of ethnic…

View details →DOI: 10.58809/ccrp9120
Negative / Null Result Report

The Effects of Bisphenol A on Plant A

Michelle Storey, null null, null null et al. · 2020 · John Heinrichs Scholarly & Creative Activities Day

Bisphenol A (BPA) is a ubiquitous raw material used in the production of many everyday things such as food packaging and baby bottles. While there have been many studies about the effect that this can have on water and animals, there are…

View details →DOI: 10.58809/vacy9619
Negative / Null Result Report

Engaging Students in Distance Learning Discussions

Dorothy Ochs, null null, null null et al. · 2022 · John Heinrichs Scholarly & Creative Activities Day

Purpose: The purpose of this poster is to explore various types of discussion formats in order to find ones that keep the students thoughtfully engaged and motivated. • Methods: The poster will compare and contrast several different types…

View details →DOI: 10.58809/mkeu5488
Negative / Null Result ReportOpen accessComputer Science

Model-Agnostic AI Framework with Explicit Time Integration for Long-Term Fluid Dynamics Prediction

Sunwoong Yang, Ricardo Vinuesa, Namwoo Kang · 2024 · arXiv

This study addresses the critical challenge of error accumulation in spatio-temporal auto-regressive (AR) predictions within scientific machine learning models by exploring temporal integration schemes and adaptive multi-step rollout strategies. We introduce the first implementation of the two-step Adams-Bashforth method specifically tailored for data-driven AR prediction, leveraging historical derivative information to enhance numerical stability without additional computational overhead. To validate our approach, we systematically evaluate time integration schemes across canonical 2D PDEs be

Negative / Null Result ReportOpen accessComputer Science

WiFi-based Global Localization in Large-Scale Environments Leveraging Structural Priors from osmAG

Xu Ma, Jiajie Zhang, Fujing Xie et al. · 2025 · arXiv

Global localization is essential for autonomous robotics, especially in indoor environments where the GPS signal is denied. We propose a novel WiFi-based localization framework that leverages ubiquitous wireless infrastructure and the OpenStreetMap Area Graph (osmAG) for large-scale indoor environments. Our approach integrates signal propagation modeling with osmAG's geometric and topological priors. In the offline phase, an iterative optimization algorithm localizes WiFi Access Points (APs) by modeling wall attenuation, achieving a mean localization error of 3.79 m (35.3\% improvement over tr

Negative / Null Result Report

Comparison of insulin resistance and lipid profile in clinically significant macular oedema versus non-clinically significant macular oedema in patients with type 2 diabetes mellitus

· 2025 · International Journal of Medicine and Medical Research

Lifestyle-related disorders, particularly diabetes, pose a significant global health challenge. Diabetic macular oedema, a microvascular complication, highlights the importance of managing insulin resistance and hyperlipidaemia for optimal…

View details →DOI: 10.63341/ijmmr/1.2025.22