A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1934 results for "Mpro" · page 64 of 65
Mismetti, Patrick, Decousus, Hervé, Moulin, Nathalie et al. · 2006
International audienceIn a prospective study, nine patients with phlegmasia caerulea dolens (PCD) related to iliac occlusive thrombosis were treated with intravenous thrombolysis. After thrombolysis, despite no significant improvement in…
Seung Whan Doo (703584), Young Myoung Ko (703588), Hwa Yeon Sun (3628463) et al. · 2017
Total IPSS and Qmax showed no significant improvement. Storage IPSS and QoL showed significant improvement and PVR showed significant increase. The black diamond signifies that the mean difference is in favor of IPSS. The size of each…
田原, 靖昭, 西澤, 昭, 管原, 正志 et al. · 1991
Aerobic exercise class was opened and blood and physical composition were examined. Results indicated that no significant improvement on measured items was observed. Frequency of participation is suggested to be increased or class goal…
J. R. Mondt, D. C. Siegla · 1974
Heat transfer and flow friction behavior have been measured for plain and perforated plate-fin and 10-deg herringbone surfaces. For the range of geometries and Reynolds numbers studied, the perforations produced no significant improvement…
ÖZGEN ALPAYDIN, AYLİN, Begum GORGULU, Aylin Özgen ALPAYDIN et al. · 2022
Background: Specific breathing exercises are reported to improve quality of life and reduce symptoms; although no significant benefit on lung function or reduction of exacerbation risk is indicated. Additionally, inspiratory muscle…
· 2011
Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…
Khalid Mustafa Ali (4461853), Christine Roffe (220471), Anushka Warusevitane (220475) et al. · 2011
Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…
Akerley, Wallace, Herndon, James E. 2nd, Vokes, Everett E. et al. · 2017
BACKGROUND: In Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…
Akerley, Wallace, Vokes, Everett E., Cicchetti, M Giulia et al. · 2009
BackgroundIn Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…
Macleod, Malcolm R.; id_orcid, Donnan, Geoffrey A., Traystman, RJ et al. · 2009
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating…
Marc Fisher, Ulrich Dirnagl, Geoffrey A Donnan et al. · 2020
Background and Purpose-As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review-Accumulating…
Claire L. Gibson (6162488), Philip M. Bath (3111867) · 2015
Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts…
Claire L. Gibson (6162488), Philip M. Bath (3111867) · 2015
Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts…
N. Stocchetti · 2014
Aggressive therapy after traumatic brain injury, for instance surgical decompression of the skull, is effective in reducing intracranial pressure. However in a randomized trial it has failed to improve outcome. Careful identification of…
Dr. Abu Elias Sarker, Dr. Mohammad Habibur Rahman · 2014
In spite of different approaches being experimented over the past six decades, poverty alleviation programs in the developing world have largely failed to improve poverty situation. Of all the factors responsible for the growing trend of…
Luisa Seguella (2806498), Stefano Gigli (2806501), Luca Steardo (214519) et al. · 2018
PEA failed to improve diarrhea course in PPARα−/− mice. HIV-1 Tat (130 ng/Kg)-induced diarrhea in PPARα−/− mice, increasing (a) daily defecation frequency, (b) average daily number of wet spots, and (c) fluid accumulation within 7 days…
John H. Strickler · 2018
Abstract Summary: Anti-EGFR therapies have failed to improve survival for unselected patients with metastatic gastroesophageal cancer, but in a subset of patients, EGFR amplification may predict treatment benefit. Maron and colleagues…
Sharafuddin, Melhem, Katz, Daniel, Reddy, Geeta et al. · 2005
Monthly access flow monitoring with increased prophylactic angioplasty did not improve fistula patency.BackgroundRegular access monitoring is recommended to detect and treat access stenosis in order to prevent access thrombosis and…
Amritanshu Pandey, Marko Jereminov, Gabriela Hug et al. · 2017 · arXiv
Recent advances in power system simulation have included the use of complex rectangular current and voltage (I-V) variables for solving the power flow and three-phase power flow problems. This formulation has demonstrated superior convergence properties over conventional polar coordinate based formulations for three-phase power flow, but has failed to replicate the same advantages for power flow in general due to convergence issues with systems containing PV buses. In this paper, we demonstrate how circuit simulation techniques can provide robust convergence for any complex I-V formulation tha
James Kirby, Ioana Krehan, Michele Gubian · 2026 · arXiv
This study examines the extent to which the wav2vec2.0 architecture exhibits evidence of compensation for phonological context. We conducted a pseudo-replication of a perceptional compensation experiment on Mandarin Chinese tones, and compared the embedding similarities and probing classifier outputs between a purely self-supervised pre-trained model and a model fine-tuned for Mandarin ASR. No evidence of compensation was found in the embedding similarities of the purely pre-trained model. Probing classifiers showed some evidence of compensation in addition to the expected layer-wise improveme
Jaroslaw Kornowicz · 2024 · arXiv
This study empirically examines the "Evaluative AI" framework, which aims to enhance the decision-making process for AI users by transitioning from a recommendation-based approach to a hypothesis-driven one. Rather than offering direct recommendations, this framework presents users pro and con evidence for hypotheses to support more informed decisions. However, findings from the current behavioral experiment reveal no significant improvement in decision-making performance and limited user engagement with the evidence provided, resulting in cognitive processes similar to those observed in tradi
Agnès Ferté, Kevin Hong · 2023 · arXiv
We highlight the role of weak lensing measurements from current and upcoming stage-IV imaging surveys in the search for cosmic inflation, specifically in measuring the scalar spectral index $n_s$. To do so, we combine the Dark Energy Survey 3 years of observation weak lensing and clustering data with BICEP/Keck, Planck and Sloan Digital Sky Survey data in $rΛ$CDM where $r$ is the tensor-to-scalar ratio. While there is no significant improvement in constraining power, we obtain a 1$σ$ shift on $n_s$. Additionally, we forecast a weak lensing and clustering data vector from the 10-year Legacy Sur
Karam Ahmed, Sherif Abuelenin, Heba Soliman et al. · 2015 · arXiv
V-BLAST detection method suffers large computational complexity due to its successive detection of symbols. In this paper, we propose a modified V-BLAST algorithm to decrease the computational complexity by reducing the number of detection iterations required in MIMO communication systems. We begin by showing the existence of a maximum number of iterations, beyond which, no significant improvement is obtained. We establish a criterion for the number of maximum effective iterations. We propose a modified algorithm that uses the measured SNR to dynamically set the number of iterations to achieve
Alp Atici · 2003 · arXiv
It is an established fact that for many of the interesting problems quantum algorithms based on queries of the standard oracle bring no significant improvement in comparison to known classical algorithms. It is conceivable that there are other oracles of algorithmic importance acting in a less intuitive fashion to which such limitations do not apply. Thus motivated this article suggests a broader understanding towards what a general quantum oracle is. We propose a general definition of a quantum oracle and give a classification of quantum oracles based on the behavior of the eigenvalues and ei
James Large, Paul Southam, Anthony Bagnall · 2018 · arXiv
tl;dr: no, it cannot, at least not on average on the standard archive problems. We assess whether using six smoothing algorithms (moving average, exponential smoothing, Gaussian filter, Savitzky-Golay filter, Fourier approximation and a recursive median sieve) could be automatically applied to time series classification problems as a preprocessing step to improve the performance of three benchmark classifiers (1-Nearest Neighbour with Euclidean and Dynamic Time Warping distances, and Rotation Forest). We found no significant improvement over unsmoothed data even when we set the smoothing param
Dimitrios Exadaktylos, Massimo Riccaboni, Armando Rungi · 2020 · arXiv
In this paper, we test the contribution of foreign management on firms' competitiveness. We use a novel dataset on the careers of 165,084 managers employed by 13,106 companies in the United Kingdom in the period 2009-2017. We find that domestic manufacturing firms become, on average, between 7% and 12% more productive after hiring the first foreign managers, whereas foreign-owned firms register no significant improvement. In particular, we test that previous industry-specific experience is the primary driver of productivity gains in domestic firms (15.6%), in a way that allows the latter to ca
F. M. Brunbauer, R. Aleksan, Y. Angelis et al. · 2026 · arXiv
The combination of a Cherenkov radiator with a semi-transparent photocathode and a Micromegas based amplification stage allows PICOSEC Micromegas detectors to achieve a time resolution of better than 15ps. While tileable prototypes with 10x10 channels feature 1x1 cm^2 readout pads, finer readout granularity can be used to improve the spatial resolution. We report on the study of high readout granularity PICOSEC Micromegas prototypes which achieve around 0.5mm spatial resolution with 3.5mm large pads. No significant improvement was found when readout pad size was further reduced to 2.2mm. The t
Hao Guo, Han Wang, Di Zhu et al. · 2025 · arXiv
Modeling spatial heterogeneity in the data generation process is essential for understanding and predicting geographical phenomena. Despite their prevalence in geospatial tasks, neural network models usually assume spatial stationarity, which could limit their performance in the presence of spatial process heterogeneity. By allowing model parameters to vary over space, several approaches have been proposed to incorporate spatial heterogeneity into neural networks. However, current geographically weighting approaches are ineffective on graph neural networks, yielding no significant improvement
Filip K. Malinowski, Frederico Martins, Peter D. Nissen et al. · 2017 · arXiv
We operate a resonant exchange qubit in a highly symmetric triple-dot configuration using IQ-modulated RF pulses. At the resulting three-dimensional sweet spot the qubit splitting is an order of magnitude less sensitive to all relevant control voltages, compared to the conventional operating point, but we observe no significant improvement in the quality of Rabi oscillations. For weak driving this is consistent with Overhauser field fluctuations modulating the qubit splitting. For strong driving we infer that effective voltage noise modulates the coupling strength between RF drive and the qubi
Guoliang Shang, Lukas Maiwald, Hagen Renner et al. · 2018 · arXiv
Non-iridescent structural colors based on disordered arrangement of monodisperse spherical particles, also called photonic glass, show low color saturation due to gradual transition in reflectivity. No significant improvement is usually expected from particles optimization, as the Mie resonances are broad for small dielectric particles with moderate refractive index. Moreover, the short range order of a photonic glass alone is also insufficient to cause sharp spectral features. We show here, that the combination of a well-chosen particle geometry with the short range order of a photonic glass