Negative / Null Result ReportMedicine
Drieghe B, De Buyzere M, Bové T et al. · 2024 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Randomized clinical trials failed to show additional benefit of renal artery stenting on top of medical therapy. Instead of writing an obituary on renal artery stenting, we try to explain these disappointing results. A transstenotic…
View details →DOI: 10.1002/ccd.31117 Negative / Null Result ReportOpen accessSpecial aspects of education
Ning Zhang, Fan Ouyang · 2023 · International Journal of Educational Technology in Higher Education
Abstract Collaborative knowledge construction (CKC) involved students’ sharing of information, improvement of ideas, and construction of collective knowledge. In this process, knowledge extraction and analysis can provide valuable insights into students’ knowledge capacities, depths, and levels in order to improve the CKC quality. However, existing studies tended to extract and analyze knowledge from a single perspective (e.g., the number of certain knowledge types and knowledge structures), which failed to demonstrate the complexity and dynamics of knowledge construction and advancement. To f
View details →DOI: 10.1186/s41239-023-00414-5 Negative / Null Result ReportMedicine
Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery
Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…
View details →DOI: 10.1097/ta.0000000000004643 Negative / Null Result ReportMedicine
Bhardwaj A, Saili A, Yadav DK et al. · 2025 · Journal of neonatal-perinatal medicine
BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography…
View details →DOI: 10.1177/19345798251343494 Negative / Null Result ReportOpen accessComputer Science
CLEO Collaboration, K. Edwards et al · 1997 · arXiv
We have searched for the decay of the tau lepton into seven charged particles and zero or one pi0. The data used in the search were collected with the CLEO II detector at the Cornell Electron Storage Ring (CESR) and correspond to an integrated luminosity of 4.61 fb^(-1). No evidence for a signal is found. Assuming all the charged particles are pions, we set an upper limit on the branching fraction, B(tau- -> 4pi- 3pi+ (pi0) nu_tau) < 2.4 x 10^(-6) at the 90% confidence level. This limit represents a significant improvement over the previous limit.
Negative / Null Result ReportMedicine
Choi, Gutman, Iglesia et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Studies have shown that sexual function improves after surgical correction for stress urinary incontinence and pelvic organ prolapse. Current data suggest no significant difference in sexual function between transobturator and retropubic…
View details →DOI: 10.1097/spv.0000000000001888 Negative / Null Result ReportMedicine
Park K, Özgüroğlu M, Vansteenkiste J et al. · 2021 · Lung cancer (Amsterdam, Netherlands)
Objectives The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects…
View details →DOI: 10.1016/j.lungcan.2021.01.026 Negative / Null Result ReportOpen accessMedicine
Sameed M, Meng Z, Marciniak ET · 2019 · Breathe (Sheffield, England)
In the EOLIA trial, early use of ECMO did not significantly improve mortality at 60 days in patients with severe ARDS, but when used as a rescue modality ECMO might help improve survival http://bit.ly/2XOjwSE.
View details →DOI: 10.1183/20734735.0363-2018 Negative / Null Result ReportMedicine
Finkelstein A, Cantor JC, Gubb J et al. · 2024 · Health affairs (Project Hope)
When a randomized evaluation finds null results, it is important to understand why. We investigated two very different explanations for the finding from a randomized evaluation that the Camden Coalition's influential care management…
View details →DOI: 10.1377/hlthaff.2023.01151 Negative / Null Result ReportMedicine
Adams MS, Mensink RP, Plat J et al. · 2026 · European journal of clinical nutrition
Background Previous almond intervention studies involving relatively healthy populations did not demonstrate improvements in cognitive performance. However, a long-term study with participants at risk of cognitive decline, such as those…
View details →DOI: 10.1038/s41430-026-01705-6 Negative / Null Result ReportMedicine
Imam R, Chastang KM, Olowojesiku R et al. · 2025 · The Pediatric infectious disease journal
Background Multiple clinical trials evaluating therapies for cerebral malaria (CM) have failed to demonstrate improved outcomes. This may derive from inclusion of children at all risk levels, including those at low risk of mortality or…
View details →DOI: 10.1097/inf.0000000000004581 Negative / Null Result ReportMedicine
Diz-Lopes M, Rovetta CF, Pollastri F et al. · 2026 · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
We evaluated how romosozumab affects bone structure, density, and strength at the wrist over 12 months. Volumetric bone mineral density did not increase, but high-resolution quantitative computed tomography imaging showed modest…
View details →DOI: 10.1007/s00198-026-08113-3 Negative / Null Result ReportMedicine
Diprose W, Fahed R, Volders D et al. · 2026 · Journal of neurointerventional surgery
Background Randomized trials showed that endovascular thrombectomy (EVT) did not improve outcomes in medium vessel occlusion (MeVO) stroke compared with usual care. We investigated whether patients randomized to EVT who achieved…
View details →DOI: 10.1136/jnis-2025-024733 Negative / Null Result ReportOpen accessMedicine
Hattori Y, Abe S, Kakino Y et al. · 2026 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular…
View details →DOI: 10.1016/j.neurot.2026.e00849 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 Negative / Null Result ReportMedicine
Yamaguchi T, Akai S, Uozumi N et al. · 2026 · Gan to kagaku ryoho. Cancer & chemotherapy
A 53-year-old male patient presented with dyspnea and was admitted with the diagnosis of bacterial pneumonia.His respiratory condition did not improve despite the resolution of fever with antibiotic therapy, and he was eventually diagnosed…
Negative / Null Result ReportOpen accessMedicine
Sanabria A, Rodrigo JP, Araújo ALD et al. · 2025 · Cancers
Background/Objectives : Oropharyngeal squamous cell carcinoma (OPSCC) management has shifted following recognition of HPV-driven disease. Neoadjuvant chemotherapy (NAC) has historically failed to improve overall survival (OS) in mixed head…
View details →DOI: 10.3390/cancers18010023 Negative / Null Result ReportOpen accessScience
NATALIA C. SILVA, KAREN M. LEÃO, JOÃO T. PÁDUA et al. · 2021 · Anais da Academia Brasileira de Ciências
Abstract To evaluate the addition of antioxidants in extenders on post-thaw bovine semen quality and in vitro embryo production efficiency. Six semen samples were collected from five Holstein bulls. In the experiment I, the samples were diluted with AndroMed® and Bovimix® and added antioxidants glutathione (1.5 and 2.5 mM) and melatonin (0.5 and 1.0 mM). In the experiment II, the best treatments obtained in experiment I were used for in vitro fecundation. Glutathione did not improve sperm viability. Melatonin had a negative effect on semen characteristics. Andromed® showed better results in sp
View details →DOI: 10.1590/0001-3765202120191229 Negative / Null Result ReportMedicine
Zhang H, Yang Y, Sun S · 2024 · Acta psychologica
In response to the public's puzzle about why maternity leave has unexpectedly failed to improve fertility problem in the Chinese context of a widespread extension of maternity leave, our study concentrates on a prevailing stigmatization…
View details →DOI: 10.1016/j.actpsy.2024.104413 