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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 56 of 65

Negative / Null Result ReportOpen accessComputer Science

Parallel-SFT: Improving Zero-Shot Cross-Programming-Language Transfer for Code RL

Zhaofeng Wu, Shiqi Wang, Boya Peng et al. · 2026 · arXiv

Modern language models demonstrate impressive coding capabilities in common programming languages (PLs), such as C++ and Python, but their performance in lower-resource PLs is often limited by training data availability. In principle, however, most programming skills are universal across PLs, so the capability acquired in one PL should transfer to others. In this work, we propose the task of zero-shot cross-programming-language transfer for code RL. We find that, for Llama-3.1, RL training for code generation in a source PL fails to improve, and sometimes even degrades, the performance on othe

Negative / Null Result ReportOpen accessMathematics

Forecasting Multivariate Time Series under Predictive Heterogeneity: A Validation-Driven Clustering Framework

Ziling Ma, Ángel López Oriona, Hernando Ombao et al. · 2026 · arXiv

We study adaptive pooling under predictive heterogeneity in high-dimensional multivariate time series forecasting, where global models improve statistical efficiency but may fail to capture heterogeneous predictive structure, while naive specialization can induce negative transfer. We formulate adaptive pooling as a statistical decision problem and propose a validation-driven framework that determines when and how specialization should be applied. Rather than grouping series based on representation similarity, we define partitions through out-of-sample predictive performance, thereby aligning

Negative / Null Result ReportOpen accessMathematics

Inference in matrix-valued time series with common stochastic trends and multifactor error structure

Rong Chen, Simone Giannerini, Greta Goracci et al. · 2025 · arXiv

We develop an estimation methodology for a factor model for high-dimensional matrix-valued time series, where common stochastic trends and common stationary factors can be present. We study, in particular, the estimation of (row and column) loading spaces, of the common stochastic trends and of the common stationary factors, and the row and column ranks thereof. In a set of (negative) preliminary results, we show that a projection-based technique fails to improve the rates of convergence compared to a "flattened" estimation technique which does not take into account the matrix nature of the da

Negative / Null Result ReportOpen accessComputer Science

Reinforcement Learning vs. Distillation: Understanding Accuracy and Capability in LLM Reasoning

Minwu Kim, Anubhav Shrestha, Safal Shrestha et al. · 2025 · arXiv

Recent studies have shown that reinforcement learning with verifiable rewards (RLVR) enhances overall accuracy (pass@1) but often fails to improve capability (pass@k) of LLMs in reasoning tasks, while distillation can improve both. In this paper, we investigate the mechanisms behind these phenomena. First, we demonstrate that RLVR struggles to improve capability as it focuses on improving the accuracy of the easier questions to the detriment of the accuracy of the most difficult questions. Second, we show that RLVR does not merely increase the success probability for the easier questions, but

Negative / Null Result ReportOpen accessComputer Science

Toward Understanding Adversarial Distillation: Why Robust Teachers Fail

Hongsin Lee, Hye Won Chung · 2026 · arXiv

Adversarial Distillation aims to enhance student robustness by guiding the student with a robust teacher's soft labels within the min-max adversarial training framework, yet its success is notoriously inconsistent: a more robust teacher often fails to improve, or even harms, the student's robust generalization. In this paper, we identify a key mechanism of this teacher dependency: the misalignment between the teacher's supervisory confidence and the student's representational limitations on a consistent subset of training data -- the Robustly Unlearnable Set. We present a theoretical framework

Negative / Null Result ReportOpen accessEngineering

A Unified Approach to Enforce Non-Negativity Constraint in Neural Network Approximation for Optimal Voltage Regulation

Jiaqi Wu, Jingyi Yuan, Yang Weng et al. · 2025 · arXiv

Power system voltage regulation is crucial to maintain power quality while integrating intermittent renewable resources in distribution grids. However, the system model on the grid edge is often unknown, making it difficult to model physical equations for optimal control. Therefore, previous work proposes structured data-driven methods like input convex neural networks (ICNN) for "optimal" control without relying on a physical model. While ICNNs offer theoretical guarantees based on restrictive assumptions of non-negative neural network parameters, can one improve the approximation power with

Negative / Null Result ReportOpen accessEngineering

Learning-based Axial Video Motion Magnification

Kwon Byung-Ki, Oh Hyun-Bin, Kim Jun-Seong et al. · 2023 · arXiv

Video motion magnification amplifies invisible small motions to be perceptible, which provides humans with a spatially dense and holistic understanding of small motions in the scene of interest. This is based on the premise that magnifying small motions enhances the legibility of motions. In the real world, however, vibrating objects often possess convoluted systems that have complex natural frequencies, modes, and directions. Existing motion magnification often fails to improve legibility since the intricate motions still retain complex characteristics even after being magnified, which may di

Negative / Null Result Report

A Case Report of Korean Medicine Treatment, including Jakyakgamcho-tang, in a Patient with Unilateral Vocal Cord Paralysis That Did Not Improve After Injection Laryngoplasty

Ye-seul Park, Ja-eun Kwak, Ho-ryong Yoo et al. · 2024 · The Journal of Internal Korean Medicine

Background: Unilateral vocal cord paralysis can occur due to various causes. Among them, unilateral vocal cord paralysis that takes place after endotracheal intubation is often caused by damage to the left recurrent nerve branch during…

View details →DOI: 10.22246/jikm.2024.45.6.1309
Negative / Null Result ReportMedicine

Effect of a Multidimensional Digital Health Intervention on Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial.

Fuentes-Expósito, Frid, Muñoz-Mateu et al. · 2026 · JCO clinical cancer informatics

We evaluated whether offering access to a multicomponent mHealth app improves quality of life (QoL) and psychosocial outcomes among breast cancer survivors under pragmatic, nonprescriptive conditions. In this single-center, randomized,…

View details →DOI: 10.1200/cci-26-00025
Negative / Null Result ReportMedicine

Deep and repetitive transcranial magnetic stimulation improves motor dysfunction after basal ganglia infarction: preliminary findings on efficacy and electrophysiological mechanisms.

Yang, Zhu, Chen et al. · 2026 · Frontiers in neuroscience

To observe the therapeutic effects of deep transcranial magnetic stimulation (dTMS) and repetitive transcranial magnetic stimulation (rTMS) on upper and lower limb motor dysfunction in patients with basal ganglia infarction, and to…

View details →DOI: 10.3389/fnins.2026.1870537
Negative / Null Result ReportMedicine

Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.

Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology

Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…

View details →DOI: 10.1007/s10735-026-10874-4
Negative / Null Result ReportMedicine

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…

View details →DOI: 10.3390/diagnostics16121756
Negative / Null Result ReportMedicine

Rural medical disparities in multimodal glioblastoma treatment.

Momii, Hata, Fudaba et al. · 2026 · Scientific reports

Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…

View details →DOI: 10.1038/s41598-026-48867-8
Negative / Null Result ReportMedicine

Comparative Evaluation of Bond Strength of Bioflx Crowns with Resinous and Nonresinous Luting Agents on Primary Teeth: An In Vitro Study.

Tasgaonkar, Rathi, Agrawal et al. · 2026 · International journal of clinical pediatric dentistry

Preserving primary teeth with crowns is vital in pediatric dentistry, especially for those compromised by dental caries, previous treatments, or malformations. To address the limitations of traditional esthetic crowns, Bioflx crowns have…

View details →DOI: 10.5005/jp-journals-10005-3480
Negative / Null Result ReportMedicine

Investigating the Association between the Presence of Pulp Stone and Anesthesia Failure in Upper and Lower Molar Teeth.

Parirokh, Manochehrifar, Nakahee et al. · 2026 · Iranian endodontic journal

The close relationship between pulp stones in the pulp chamber and pulp neurovascular tissues suggests that the presence of pulp stones may compromise successful anesthesia. The present study assessed the effect of pulp stone presence on…

View details →DOI: 10.22037/iej.v21i1.46586
Negative / Null Result ReportMedicine

The effectiveness of a cognitive behavioural therapy for insomnia based intervention to improve sleep quality in nursing home residents, a cluster randomised controlled trial.

Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine

To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…

View details →DOI: 10.1007/s41999-026-01519-6
Negative / Null Result ReportMedicine

Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.

Abelovska, Malinova, Sucha et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

This pilot study evaluated "Your Health Belongs to You," a six-week group intervention combining psychotherapy and exercise to improve quality of life, emotional health, and symptom management in individuals with Multiple Sclerosis (MS),…

View details →DOI: 10.1007/s10072-026-09130-0
Negative / Null Result ReportMedicine

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum.

Bakhshalipoor, Bolandi, Nahidi et al. · 2026 · Scientific reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

View details →DOI: 10.1038/s41598-026-52693-3
Negative / Null Result ReportMedicine

Persistent deficits in the motor unit following mono and dual administration of SMN up-regulators in the SmnΔ7 mouse model of spinal muscular atrophy.

Partlova, Comley, Haigh et al. · 2026 · Experimental neurology

Spinal muscular atrophy (SMA) is characterized by motor neuron loss and neuromuscular junction (NMJ) pathology. Although SMN-upregulating therapies such as Nusinersen markedly improve survival and motor function for many patients,…

View details →DOI: 10.1016/j.expneurol.2026.115898
Negative / Null Result ReportMedicine

Refractory Neonatal Apnea Revealing Congenital Central Hypoventilation Syndrome: Improved Outcome through Early Multidisciplinary Intervention.

Shalamov, Cromwell, Guha · 2026 · AJP reports

Background: Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder that causes alveolar hypoventilation because of impaired chemoreceptor response to hypercapnia and hypoxia occurring due to a dysfunctional central…

View details →DOI: 10.1055/a-2873-6868
Negative / Null Result ReportMedicine

Quality Improvement Analysis of Operative Regimen on Urinary Tract Infections.

Bonglack, Carrel-Lammert, Hoehn et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Acute urinary tract infections (UTIs) are common after prolapse and anti-incontinence surgery, with incidence rates varying from 14% to 64%. The objective was to decrease rates of symptomatic urinary tract infections in patients undergoing…

View details →DOI: 10.1097/spv.0000000000001742
Negative / Null Result ReportMedicine

The impact of urinary catheterization on urinary tract infection and renal function in elderly patients undergoing hip fracture surgery: A prospective randomized controlled trial.

Serttas, Uysal, Deği̇rmenci̇ et al. · 2026 · Injury

Urinary tract infection(UTI) is a common complication following hip fracture surgery in elderly patients. Urinary catheterization is frequently used to improve patient comfort during prolonged preoperative immobilization; however, its…

View details →DOI: 10.1016/j.injury.2026.113449
Negative / Null Result ReportMedicine

Patient Trust in Healthcare Providers among People on Methadone Maintenance Treatment Using Methamphetamine in Vietnam.

Vu, Nguyen, Nguyen et al. · 2026 · Substance use & misuse

Patient trust in healthcare providers (PTP) is critical for improving treatment adherence and outcomes in substance use disorders. As concurrent opioid and methamphetamine use increasingly complicates methadone maintenance treatment (MMT),…

View details →DOI: 10.1080/10826084.2026.2676993
Negative / Null Result ReportMedicine

Association Between Early Versus Delayed Outpatient Follow-Up After Hospital Discharge and Short-Term Healthcare Utilization Among ICU Survivors.

Oletu, Oladimeji, Osueni et al. · 2026 · Cureus

Intensive care unit (ICU) survivors experience high rates of healthcare utilization after hospital discharge, including readmissions and emergency department (ED) visits. Timely outpatient follow-up has been proposed to improve care…

View details →DOI: 10.7759/cureus.107746