A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1898 results for "Mpro" · page 56 of 64
Zhang, Jiang, Jiang · 2026 · The journal of sexual medicine
Hypertension is a major cause of erectile dysfunction (ED). The impact of hypertension on the transcriptome and proteome of penile corpus cavernosum tissue, as well as its relationship with erectile dysfunction, is not clear. This study…
Tsiotsios, Vamvakas, Labropoulou et al. · 2026 · Acta haematologica
Introduction Patients with homozygous β-thalassemia show continuously improved survival, which has contributed to the development of kidney complications, predominantly expressed as increased albuminuria. In particular, patients with…
Ani, Hameed · 2026 · Wiadomosci lekarskie (Warsaw, Poland : 1960)
Aim: This study aimed to evaluate the effectiveness of a structured intravenous infusion protocol in improving the quality of care and reducing IV-related complications among hospitalized patients. Materials and Methods: A purposive sample…
Chilundo, Xinavane, Huo et al. · 2026 · Frontiers in reproductive health
Despite national policies promoting adolescent- and youth-friendly health services, implementation gaps hinder improvements in adolescent sexual and reproductive health outcomes in Mozambique. S-NICE is a structured, participatory…
Sheikh, Singh, Smith et al. · 2026 · Frontiers in cardiovascular medicine
The impact of catheter-directed thrombolysis (CDT), catheter-directed embolectomy (CDE) and surgical pulmonary embolectomy (SPE) on long term RV function among patients with acute PE remains unclear. We investigated the association of…
Navidifar, Kaveh, Hosseini et al. · 2026 · Veterinary and animal science
Efficient estrus synchronization is important for improving reproductive performance in dairy herds; however, variations in ovarian activity among cows of different parities may influence responses to synchronization protocols. The present…
Baier, Miao, Schirrmacher et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background : Zirconium-89 ( 89 Zr) is a key PET radionuclide and the limited in vivo stability of its clinically used 89 Zr-DFO complexes has driven the pursuit of improved chelator architectures. Among these, DFO* has attracted particular…
Li H, Li X, Gao W et al. · 2026 · Frontiers in sports and active living
Background Basketball requires players to perform complex technical actions under conditions of dynamic instability. Traditional stability and strength training mainly improves muscle strength; however, it is often insufficient for…
van Mourik M, Spierings J, Koca P et al. · 2026 · Journal of tissue engineering and regenerative medicine
Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM…
Li F, Wang C, Fan X et al. · 2026 · Preprint
Abstract Objective The objective of this study was to evaluate the efficacy of acupuncture as an approach for improving visual function and to predict the long-term efficacy of this approach in controlling myopia progression. Methods…
Raafat MH, Mourad KE, Elsyad MA · 2026 · BMC oral health
Background Reviewing the literature, the optimal implant position for 2-implant retained mandibular overdentures, which would be associated with improved peri-implant tissues, higher retention values, and better patient satisfaction,…
Refai OM, Abdelfattah Mohamed AM, Ali El-Fiky AM · 2026 · BMC oral health
Background Mandibular complete dentures often lack stability, leading to prolonged occlusion and disocclusion times. Immediate-loading implant overdentures can improve functional control, but evidence comparing splinted and non-splinted…
Salim O, Chari A, Tahir MZ · 2026 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Purpose Hemispherotomy is an established treatment for children with drug-resistant epilepsy. Recent reports have suggested a superiority of outcomes with the vertical approach compared to the traditional lateral approach. This study…
Bugacov H, Cusmai C, Li K et al. · 2026 · Transplant international : official journal of the European Society for Organ Transplantation
This study investigated acute rejection in ABO-compatible versus ABO-identical lung transplants from 2005-2023, with a secondary objective of comparing 5-year survival. Lung transplantation improves quality of life and survival; however,…
Li S, Chai H, Bao W et al. · 2026 · Preprint
Abstract Background: It is commonly recommended to restore the mechanical axis to within –0° ± 3° in valgus knee. However, the situation is quite different when the alignment is –3° or 3° in the presence of a compromised MCL in Ranawat…
Yan J, Feng L, Wu P et al. · 2026 · Animal nutrition (Zhongguo xu mu shou yi xue hui)
Taurine is a multifunctional feed additive that is abundant in fish meal but scarce in plant protein sources. The aim of this study was to investigate the effects of taurine supplementation in fish meal-free diet on sub-adult grass carp (…
Gao J, Hu CC, Wang XY et al. · 2026 · Frontiers in medicine
Background Perinatal sleep disturbance is highly prevalent among women undergoing elective cesarean section. Dexmedetomidine has been proven effective in improving sleep quality in patients undergoing general surgery, and this study aimed…
Checchi V, Cavani F, Vistola M et al. · 2026 · Operative dentistry
Objective Single-shade materials are favored for simplifying clinical workflows without compromising the esthetics of restorations, although evidence supporting their use remains limited. Therefore, this laboratory evaluated color match of…
Wei C, An J, Lin Y et al. · 2026 · PeerJ
Background Badminton is a physically demanding sport requiring a combination of aerobic endurance, anaerobic power, agility, and explosive strength. Repeated sprint training (RST) has emerged as a time-efficient strategy for improving…
Suborov Evgeny V, Smetkin Alexey A, Kondratiev Timofey V et al. · 2012 · BMC Anesthesiology
Abstract Background Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Methods Anesthetized sheep underwent right pn
William Coley, Sree Rayavarapu, Jack H van der Meulen et al. · 2013 · PLoS ONE
BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis) focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle
V S Vijitha, Tarjani Vivek Dave, Somasheila I Murthy et al. · 2021 · Indian Journal of Ophthalmology
Purpose: To describe a series of sight-threatening ocular and adnexal involvement associated with dengue hemorrhagic fever and their treatment options. Methods: Retrospective, interventional, non-comparative case series. Medical records of patients who presented with ocular symptoms attributed to dengue hemorrhagic fever were reviewed. Demography, presenting features, and treatment outcomes were recorded. Outcome measures assessed included globe salvage, vision salvage, and visual improvement. The outcome was deemed as favorable if vision salvage was possible and unfavorable if the vision was
Rob Horne, Caroline Sabin, Trudie Chalder et al. · 2025 · Programme Grants for Applied Research
Background Antiretroviral therapy has transformed human immunodeficiency virus infection intoa chronic condition associated with normal life expectancy. In the United Kingdom, the uptake of antiretroviral therapy is generally high, but a delay in starting antiretroviral therapy and non-adherence compromise the health and well-being of people living with human immunodeficiency virus, increase the risk of transmission of human immunodeficiency virus and increase National Health Service costs. Objectives The overall aim was to improve antiretroviral therapy uptake and adherence by addressing perc
Wang J, Lu S, Zhang C et al. · 2025 · Drug Design, Development and Therapy
Jinglong Wang, Shijia Lu, Chenxiao Zhang, Junjie Wang, Huiru Wu, Guofei Li Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Guofei Li, Department of Pharmacy, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, People’s Republic of China, Tel/Fax +86-24-23925108, Email sylgf2009@163.comPropose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisti
Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports
Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein
Ivan Ramos, Lilik Noor Yuliati, Megawati Simanjuntak · 2022 · Jurnal Aplikasi Bisnis dan Manajemen
Advancement in sophisticated information technology can be used for innovation in access to public services. In this study, the public service studied was the Online Passport Queue Registration Application (APAPO) at the Class I Non-TPI Bogor Immigration Office. This study aims to analyze the effect of system quality, information quality, service quality, user characteristics, usage rate, user satisfaction on net benefits APAPO using DeLone and McLean and find out the priority factors for improvement using the Important-Performance Analysis (IPA) method. The sampling technique used was conveni
Dewa Nyoman Benni Kusyana, Putu Sri Hartati, Ida Ayu Widani Sugianingrat et al. · 2024 · Jurnal Ekonomi dan Bisnis
This research was conducted to determine the influence of organizational culture on business performance, mediated by innovation and moderated by catur purusa artha. The subjects of this research were the cooperative heads or managers of 503 cooperative units in Denpasar City. The Yamane formula was used to determine the sample size, which was determined to be 83 cooperative heads/managers using a proportionate random sampling technique. Data analysis was carried out using structural equation modelling – partial least squares (SEM-PLS). Data analysis using PLS was carried out with two measurem
Ahmed Magdy, Khaled Shokry, Hany Foad et al. · 2017 · Egyptian Journal of Chest Disease and Tuberculosis
Objectives: This study sought to examine the pre-interventional parameters for procedural success of CTO angioplasty and to assess improvement of Left ventricular ejection fraction after successful angioplasty of CTO. Background: Chronic total occlusions (CTOs) are the most technically challenging lesion subset that interventional cardiologists might face, and that recanalization of these lesions will have the most impact on future percutaneous coronary interventions (PCI) success. Considering the recent development of catheter based technologies specific for CTO recanalization and the potenti
Mohamed Ibrahim Fathallah Abdelhay, Mohamed Hussein Elgendy, Yasser Ramzy Lasheen · 2017 · International Journal of Physiotherapy
Background: Postural hypnosis can lead to cervical pain or bad cosmetic appearance.There is a lack in the literature supporting the efficacy of spinal mobilization techniques in restoring normal thoracic curvature.Mulligan and Maitland's mobilization were used to improve range of motion and referred pain not to restore normal kyphotic angle. The purpose: this study was conducted to compare the efficacy of Mulligan and Maitland spinal mobilization on a kyphotic angle in postural kyphosis. Subjects: seventy-five male subjects with postural kyphosis their age (17-21) years were included in the st
Imam Sumardjoko · 2016 · Jurnal Ekonomi dan Bisnis Airlangga
The issue of inter-regional development imbalances and fiscal disparities into the current fiscal decentralization issues. The toughest challenge in building fiscal decentralization not only gives funds to local governments, but creating impact of improving the quality of public services and economic growth. Transfer to the area has increased every year. However, this increase has not been maximized to reduce poverty, equitable distribution of infrastructure, fiscal gap, and competitive regional economy. Research funds for fiscal decentralization in some countries have done long before the imp