Negative / Null Result ReportOpen accessMedicine
van Mourik M, Spierings J, Koca P et al. · 2026 · Journal of tissue engineering and regenerative medicine
Providing a functional pericellular matrix (PCM) by fine-tuning the microenvironment of the articular chondrocytes (ACs) can greatly improve the outcomes of articular cartilage tissue engineering. While harvesting ACs with their PCM…
View details →DOI: 10.1155/term/9947868 Negative / Null Result Report
Li F, Wang C, Fan X et al. · 2026 · Preprint
Abstract Objective The objective of this study was to evaluate the efficacy of acupuncture as an approach for improving visual function and to predict the long-term efficacy of this approach in controlling myopia progression. Methods…
View details →DOI: 10.21203/rs.3.rs-9724822/v1 Negative / Null Result ReportOpen accessMedicine
Raafat MH, Mourad KE, Elsyad MA · 2026 · BMC oral health
Background Reviewing the literature, the optimal implant position for 2-implant retained mandibular overdentures, which would be associated with improved peri-implant tissues, higher retention values, and better patient satisfaction,…
View details →DOI: 10.1186/s12903-026-08441-0 Negative / Null Result ReportOpen accessMedicine
Refai OM, Abdelfattah Mohamed AM, Ali El-Fiky AM · 2026 · BMC oral health
Background Mandibular complete dentures often lack stability, leading to prolonged occlusion and disocclusion times. Immediate-loading implant overdentures can improve functional control, but evidence comparing splinted and non-splinted…
View details →DOI: 10.1186/s12903-026-08855-w Negative / Null Result ReportOpen accessMedicine
Salim O, Chari A, Tahir MZ · 2026 · Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Purpose Hemispherotomy is an established treatment for children with drug-resistant epilepsy. Recent reports have suggested a superiority of outcomes with the vertical approach compared to the traditional lateral approach. This study…
View details →DOI: 10.1007/s00381-026-07353-2 Negative / Null Result ReportOpen accessMedicine
Bugacov H, Cusmai C, Li K et al. · 2026 · Transplant international : official journal of the European Society for Organ Transplantation
This study investigated acute rejection in ABO-compatible versus ABO-identical lung transplants from 2005-2023, with a secondary objective of comparing 5-year survival. Lung transplantation improves quality of life and survival; however,…
View details →DOI: 10.3389/ti.2026.15722 Negative / Null Result Report
Li S, Chai H, Bao W et al. · 2026 · Preprint
Abstract Background: It is commonly recommended to restore the mechanical axis to within –0° ± 3° in valgus knee. However, the situation is quite different when the alignment is –3° or 3° in the presence of a compromised MCL in Ranawat…
View details →DOI: 10.21203/rs.3.rs-9715753/v1 Negative / Null Result ReportOpen accessMedicine
Yan J, Feng L, Wu P et al. · 2026 · Animal nutrition (Zhongguo xu mu shou yi xue hui)
Taurine is a multifunctional feed additive that is abundant in fish meal but scarce in plant protein sources. The aim of this study was to investigate the effects of taurine supplementation in fish meal-free diet on sub-adult grass carp (…
View details →DOI: 10.1016/j.aninu.2025.10.016 Negative / Null Result ReportOpen accessMedicine
Gao J, Hu CC, Wang XY et al. · 2026 · Frontiers in medicine
Background Perinatal sleep disturbance is highly prevalent among women undergoing elective cesarean section. Dexmedetomidine has been proven effective in improving sleep quality in patients undergoing general surgery, and this study aimed…
View details →DOI: 10.3389/fmed.2026.1823100 Negative / Null Result ReportMedicine
Checchi V, Cavani F, Vistola M et al. · 2026 · Operative dentistry
Objective Single-shade materials are favored for simplifying clinical workflows without compromising the esthetics of restorations, although evidence supporting their use remains limited. Therefore, this laboratory evaluated color match of…
View details →DOI: 10.2341/24-114-l Negative / Null Result ReportOpen accessMedicine
Wei C, An J, Lin Y et al. · 2026 · PeerJ
Background Badminton is a physically demanding sport requiring a combination of aerobic endurance, anaerobic power, agility, and explosive strength. Repeated sprint training (RST) has emerged as a time-efficient strategy for improving…
View details →DOI: 10.7717/peerj.21111 Negative / Null Result ReportOpen accessAnesthesiology
Suborov Evgeny V, Smetkin Alexey A, Kondratiev Timofey V et al. · 2012 · BMC Anesthesiology
Abstract Background Mechanical ventilation with high tidal volumes may cause ventilator-induced lung injury (VILI) and enhanced generation of nitric oxide (NO). We demonstrated in sheep that pneumonectomy followed by injurious ventilation promotes pulmonary edema. We wished both to test the hypothesis that neuronal NOS (nNOS), which is distributed in airway epithelial and neuronal tissues, could be involved in the pathogenesis of VILI and we also aimed at investigating the influence of an inhibitor of nNOS on the course of VILI after pneumonectomy. Methods Anesthetized sheep underwent right pn
View details →DOI: 10.1186/1471-2253-12-10 Negative / Null Result ReportOpen accessMedicine
William Coley, Sree Rayavarapu, Jack H van der Meulen et al. · 2013 · PLoS ONE
BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis) focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle
View details →DOI: 10.1371/journal.pone.0065970 Negative / Null Result ReportOpen accessOphthalmology
V S Vijitha, Tarjani Vivek Dave, Somasheila I Murthy et al. · 2021 · Indian Journal of Ophthalmology
Purpose: To describe a series of sight-threatening ocular and adnexal involvement associated with dengue hemorrhagic fever and their treatment options. Methods: Retrospective, interventional, non-comparative case series. Medical records of patients who presented with ocular symptoms attributed to dengue hemorrhagic fever were reviewed. Demography, presenting features, and treatment outcomes were recorded. Outcome measures assessed included globe salvage, vision salvage, and visual improvement. The outcome was deemed as favorable if vision salvage was possible and unfavorable if the vision was
View details →DOI: 10.4103/ijo.ijo_1588_20 Negative / Null Result ReportOpen accessPublic aspects of medicine
Rob Horne, Caroline Sabin, Trudie Chalder et al. · 2025 · Programme Grants for Applied Research
Background Antiretroviral therapy has transformed human immunodeficiency virus infection intoa chronic condition associated with normal life expectancy. In the United Kingdom, the uptake of antiretroviral therapy is generally high, but a delay in starting antiretroviral therapy and non-adherence compromise the health and well-being of people living with human immunodeficiency virus, increase the risk of transmission of human immunodeficiency virus and increase National Health Service costs. Objectives The overall aim was to improve antiretroviral therapy uptake and adherence by addressing perc
View details →DOI: 10.3310/kppw8401 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Wang J, Lu S, Zhang C et al. · 2025 · Drug Design, Development and Therapy
Jinglong Wang, Shijia Lu, Chenxiao Zhang, Junjie Wang, Huiru Wu, Guofei Li Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Guofei Li, Department of Pharmacy, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, People’s Republic of China, Tel/Fax +86-24-23925108, Email sylgf2009@163.comPropose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisti
Negative / Null Result ReportOpen accessMedicine
Galiya Iskakova, Bauyrzhan Iztayev, Auyelbek Iztayev et al. · 2025 · Scientific Reports
Abstract The quality of food products and a balanced diet play a key role in maintaining health and improving the quality of life. Due to the high popularity of pasta, a promising direction is the development of recipes that include whole grain flour, carrot powder and ion-ozonated water, which increase the nutritional value of the product and improve its chemical composition. The aim of this study was to optimise the technological modes of production of durum wheat pasta using carrot powder and ion-ozonated water to minimise the loss of dry matter (DM) during cooking and increase the protein
View details →DOI: 10.1038/s41598-025-28027-0 Negative / Null Result ReportOpen accessBusiness
Ivan Ramos, Lilik Noor Yuliati, Megawati Simanjuntak · 2022 · Jurnal Aplikasi Bisnis dan Manajemen
Advancement in sophisticated information technology can be used for innovation in access to public services. In this study, the public service studied was the Online Passport Queue Registration Application (APAPO) at the Class I Non-TPI Bogor Immigration Office. This study aims to analyze the effect of system quality, information quality, service quality, user characteristics, usage rate, user satisfaction on net benefits APAPO using DeLone and McLean and find out the priority factors for improvement using the Important-Performance Analysis (IPA) method. The sampling technique used was conveni
View details →DOI: 10.17358/jabm.8.1.33 Negative / Null Result ReportOpen accessBusiness
Dewa Nyoman Benni Kusyana, Putu Sri Hartati, Ida Ayu Widani Sugianingrat et al. · 2024 · Jurnal Ekonomi dan Bisnis
This research was conducted to determine the influence of organizational culture on business performance, mediated by innovation and moderated by catur purusa artha. The subjects of this research were the cooperative heads or managers of 503 cooperative units in Denpasar City. The Yamane formula was used to determine the sample size, which was determined to be 83 cooperative heads/managers using a proportionate random sampling technique. Data analysis was carried out using structural equation modelling – partial least squares (SEM-PLS). Data analysis using PLS was carried out with two measurem
View details →DOI: 10.24914/jeb.v27i2.10287 Negative / Null Result ReportOpen accessDiseases of the respiratory system
Ahmed Magdy, Khaled Shokry, Hany Foad et al. · 2017 · Egyptian Journal of Chest Disease and Tuberculosis
Objectives: This study sought to examine the pre-interventional parameters for procedural success of CTO angioplasty and to assess improvement of Left ventricular ejection fraction after successful angioplasty of CTO. Background: Chronic total occlusions (CTOs) are the most technically challenging lesion subset that interventional cardiologists might face, and that recanalization of these lesions will have the most impact on future percutaneous coronary interventions (PCI) success. Considering the recent development of catheter based technologies specific for CTO recanalization and the potenti
View details →DOI: 10.1016/j.ejcdt.2017.03.007 Negative / Null Result ReportOpen accessMedicine (General)
Mohamed Ibrahim Fathallah Abdelhay, Mohamed Hussein Elgendy, Yasser Ramzy Lasheen · 2017 · International Journal of Physiotherapy
Background: Postural hypnosis can lead to cervical pain or bad cosmetic appearance.There is a lack in the literature supporting the efficacy of spinal mobilization techniques in restoring normal thoracic curvature.Mulligan and Maitland's mobilization were used to improve range of motion and referred pain not to restore normal kyphotic angle. The purpose: this study was conducted to compare the efficacy of Mulligan and Maitland spinal mobilization on a kyphotic angle in postural kyphosis. Subjects: seventy-five male subjects with postural kyphosis their age (17-21) years were included in the st
View details →DOI: 10.15621/ijphy/2017/v4i3/149069 Negative / Null Result ReportOpen accessBusiness
Imam Sumardjoko · 2016 · Jurnal Ekonomi dan Bisnis Airlangga
The issue of inter-regional development imbalances and fiscal disparities into the current fiscal decentralization issues. The toughest challenge in building fiscal decentralization not only gives funds to local governments, but creating impact of improving the quality of public services and economic growth. Transfer to the area has increased every year. However, this increase has not been maximized to reduce poverty, equitable distribution of infrastructure, fiscal gap, and competitive regional economy. Research funds for fiscal decentralization in some countries have done long before the imp
View details →DOI: 10.20473/jeba.v26i12016.24-35 Negative / Null Result ReportOpen accessMathematics
Ange Wang, Hongzhi Guan, Yan Han et al. · 2021 · Discrete Dynamics in Nature and Society
The shared parking scheme improves the utilization rate of existing parking resources and contributes to the sustainable development of cities, but many private parking spaces that are not included in the shared parking scheme have a low utilization rate in China. In order to better promote the shared parking scheme, it is necessary to study the intention of the owners of private parking spaces to share their parking spaces. Therefore, this paper used the Unified Theory of Acceptance and Use of Technology (UTAUT) and Benefit-Risk Analysis Model (BRA) as the combined theoretical framework (C-UT
View details →DOI: 10.1155/2021/9283686 Negative / Null Result ReportOpen accessMedicine
Viktoriia V. Yevsieieva, Volodimyr I. Cherniy, Kateryna V. Kharchenko et al. · 2023 · Клінічна та профілактична медицина
Introduction. One of the main factors affecting postoperative outcomes in patients with advanced ovarian cancer is the cardiopulmonary status. Several studies have reported that preoperative multifactorial rehabilitation and physical fitness can lead to reduced postoperative morbidity, mortality, shorter length of stay, and improved quality of life in cancer patients. The issue of adaptability to physical activity of overweight and obese patients who undergoing debulking surgery is insufficiently studied. The study of compensatory changes that occur in physically inactive obese patients remain
View details →DOI: 10.31612/2616-4868.7.2023.04 Negative / Null Result ReportOpen accessPublic aspects of medicine
Chabot Isabelle, Potvin Louise, Moisan Jocelyne et al. · 2006 · BMC Health Services Research
Abstract Background Drug utilization review (DUR) programs are being conducted in Canadian hospitals with the aim of improving the appropriateness of prescriptions. However, there is little evidence of their effectiveness. The objective of this study was to assess the impact of both a retrospective and a concurrent DUR programs on the quality of in-hospital prescribing. Methods We conducted an interrupted time series quasi-experimental study. Using explicit criteria for quality of prescribing, the natural history of cisapride prescription was established retrospectively in three university-aff
View details →DOI: 10.1186/1472-6963-6-33 Negative / Null Result ReportOpen accessAgriculture
Haixing Zhang, Wei Shi, Shahzad Ali et al. · 2022 · Agronomy
Legume/maize intercropping has been practiced in many countries as a sustainable cropping system, but the effects of intercropping legumes with maize together with N application rates on biomass yield, quality, water-use efficiency (WUE), and nitrogen use efficiency (NUE) are limited under arid conditions in Northwest China. Field experiments were carried out in arid areas of Northwest China from 2019 to 2020 with three planting patterns (LM: Dolichos lablab ( Lablab purpureus L.)/silage maize ( Zea mays L.) intercropping; FM: Fodder soybean ( Glycine max L.)/silage maize intercropping; M: sil
View details →DOI: 10.3390/agronomy12081777 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Tanja Elnaz Hassanzadeh, Tanja Elnaz Hassanzadeh, Carina Hohmann et al. · 2024 · Frontiers in Pharmacology
Polypharmacy is common among patients with antithrombotic medication, giving rise to concerns about Drug-Related Problems (DRPs). Therefore, these patients would benefit from a Medication Review (MR) along with pharmacist counselling to reduce the risks accompanying polymedication. This prospective study presents a concept for MRs that are applicable in German community pharmacies and can efficiently support pharmacist counselling and improve the safety of drug therapy. As this is a major challenge in everyday pharmacy practice, we used a Decision Support System (DSS) to evaluate its ability t
View details →DOI: 10.3389/fphar.2024.1194201 Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Qiwei Li, Jie Zhou · 2025 · Journal of Medical Internet Research
BackgroundNews portrayals of physicians, especially in China, often depict them as vulnerable—overworked, with inadequate compensation, or as victims of violence. These portrayals may send mixed signals to the public, yet their impact remains underexplored. Understanding their impact is essential for informing media strategies and improving physician-patient relationships. ObjectiveThis study investigated how portrayals of physicians as vulnerable influence public evaluations of their competence, warmth, morality, and overall trust and considered the moderating effects of involvement (ie, hosp
View details →DOI: 10.2196/67947 Negative / Null Result ReportOpen accessMedicine
Amin Ebneshahidi, Mojtaba Akbari, Masood Mohseni · 2013 · Advanced Biomedical Research
Introduction: Haloperidol has an established role in nausea and vomiting prophylaxis and possible effects on multiple aspects of postoperative recovery including pain and sedation. The purpose of this study was to evaluate the effects of low-dose intraoperative intravenous haloperidol on quality of recovery (QoR) and pain control after general anesthesia and surgery. Methods: Ninety eight American Society of Anesthesiologists (ASA) physical status I-II patients undergoing elective general, gynecologic or orthopedic surgery under general anesthesia were enrolled. Participants were randomly allo
View details →DOI: 10.4103/2277-9175.122501 Negative / Null Result ReportOpen accessAnesthesiology
Nitika Vyas, Dinesh K Sahu, Reena Parampill · 2010 · Journal of Anaesthesiology Clinical Pharmacology
Background: Sufentanil added to intrathecal bupivacaine for cesarean section has shown to improve intraoperative and postoperative analgesia with no adverse effects on the mother and neonate. We compared the effects of intrathecal sufentanil 5 mcg and placebo when administered with hyperbaric bupivacaine 0.5% 11 mg for cesarean section. Patients and Methods: Sixty parturients of ASA grading I and II of age between 18 to 45 years scheduled for elective cesarean section under subarachnoid block were randomly allocated into one of the two groups to receive 5μg sufentanil + 0.2ml sterile, preserva
