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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1898 results for "Mpro" · page 55 of 64

Negative / Null Result ReportOpen accessEngineering

Learning-based Axial Video Motion Magnification

Kwon Byung-Ki, Oh Hyun-Bin, Kim Jun-Seong et al. · 2023 · arXiv

Video motion magnification amplifies invisible small motions to be perceptible, which provides humans with a spatially dense and holistic understanding of small motions in the scene of interest. This is based on the premise that magnifying small motions enhances the legibility of motions. In the real world, however, vibrating objects often possess convoluted systems that have complex natural frequencies, modes, and directions. Existing motion magnification often fails to improve legibility since the intricate motions still retain complex characteristics even after being magnified, which may di

Negative / Null Result Report

A Case Report of Korean Medicine Treatment, including Jakyakgamcho-tang, in a Patient with Unilateral Vocal Cord Paralysis That Did Not Improve After Injection Laryngoplasty

Ye-seul Park, Ja-eun Kwak, Ho-ryong Yoo et al. · 2024 · The Journal of Internal Korean Medicine

Background: Unilateral vocal cord paralysis can occur due to various causes. Among them, unilateral vocal cord paralysis that takes place after endotracheal intubation is often caused by damage to the left recurrent nerve branch during…

View details →DOI: 10.22246/jikm.2024.45.6.1309
Negative / Null Result ReportMedicine

Effect of a Multidimensional Digital Health Intervention on Quality of Life in Breast Cancer Survivors: A Randomized Controlled Trial.

Fuentes-Expósito, Frid, Muñoz-Mateu et al. · 2026 · JCO clinical cancer informatics

We evaluated whether offering access to a multicomponent mHealth app improves quality of life (QoL) and psychosocial outcomes among breast cancer survivors under pragmatic, nonprescriptive conditions. In this single-center, randomized,…

View details →DOI: 10.1200/cci-26-00025
Negative / Null Result ReportMedicine

Deep and repetitive transcranial magnetic stimulation improves motor dysfunction after basal ganglia infarction: preliminary findings on efficacy and electrophysiological mechanisms.

Yang, Zhu, Chen et al. · 2026 · Frontiers in neuroscience

To observe the therapeutic effects of deep transcranial magnetic stimulation (dTMS) and repetitive transcranial magnetic stimulation (rTMS) on upper and lower limb motor dysfunction in patients with basal ganglia infarction, and to…

View details →DOI: 10.3389/fnins.2026.1870537
Negative / Null Result ReportMedicine

Alveolar socket preservation with human umbilical cord mesenchymal stem cell-seeded hydroxyapatite-chitosan scaffolds: An in vivo assessment of osteoprotegerin and receptor activator of nuclear factor-κB expression.

Alshaibani, Kamadjaja, Sitalaksmi et al. · 2026 · Journal of molecular histology

Tooth extraction is a common procedure often followed by alveolar bone resorption, which may compromise future implant placement, prosthetic rehabilitation, esthetics, and periodontal support. Hydroxyapatite-chitosan (HA-Chi) scaffolds…

View details →DOI: 10.1007/s10735-026-10874-4
Negative / Null Result ReportMedicine

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Nomura, Kimata, Ito et al. · 2026 · Diagnostics (Basel, Switzerland)

Background/Objectives: To directly compare the capabilities of hybrid-type iterative reconstruction (IR) with the newly developed deep learning reconstruction (DLR) for the inner ear on high-definition CT (HDCT) obtained using the…

View details →DOI: 10.3390/diagnostics16121756
Negative / Null Result ReportMedicine

Rural medical disparities in multimodal glioblastoma treatment.

Momii, Hata, Fudaba et al. · 2026 · Scientific reports

Glioblastoma continues to have a poor prognosis, although recent advancements in multimodal treatments have gradually improved outcomes. However, treatment options have become increasingly complex and highly specialized. In rural areas,…

View details →DOI: 10.1038/s41598-026-48867-8
Negative / Null Result ReportMedicine

Comparative Evaluation of Bond Strength of Bioflx Crowns with Resinous and Nonresinous Luting Agents on Primary Teeth: An In Vitro Study.

Tasgaonkar, Rathi, Agrawal et al. · 2026 · International journal of clinical pediatric dentistry

Preserving primary teeth with crowns is vital in pediatric dentistry, especially for those compromised by dental caries, previous treatments, or malformations. To address the limitations of traditional esthetic crowns, Bioflx crowns have…

View details →DOI: 10.5005/jp-journals-10005-3480
Negative / Null Result ReportMedicine

Investigating the Association between the Presence of Pulp Stone and Anesthesia Failure in Upper and Lower Molar Teeth.

Parirokh, Manochehrifar, Nakahee et al. · 2026 · Iranian endodontic journal

The close relationship between pulp stones in the pulp chamber and pulp neurovascular tissues suggests that the presence of pulp stones may compromise successful anesthesia. The present study assessed the effect of pulp stone presence on…

View details →DOI: 10.22037/iej.v21i1.46586
Negative / Null Result ReportMedicine

The effectiveness of a cognitive behavioural therapy for insomnia based intervention to improve sleep quality in nursing home residents, a cluster randomised controlled trial.

Lahaye, Haegdorens, Franck et al. · 2026 · European geriatric medicine

To evaluate the effectiveness of a structured, team-delivered intervention based on cognitive behavioural therapy for insomnia (CBT-I) on sleep and related outcomes in nursing home residents. A cluster randomised controlled trial with…

View details →DOI: 10.1007/s41999-026-01519-6
Negative / Null Result ReportMedicine

Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.

Abelovska, Malinova, Sucha et al. · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

This pilot study evaluated "Your Health Belongs to You," a six-week group intervention combining psychotherapy and exercise to improve quality of life, emotional health, and symptom management in individuals with Multiple Sclerosis (MS),…

View details →DOI: 10.1007/s10072-026-09130-0
Negative / Null Result ReportMedicine

Improving ricotta cheese shelf life using saffron petal extract double nanoemulsions stabilized by plant proteins and Lepidium sativum L. gum.

Bakhshalipoor, Bolandi, Nahidi et al. · 2026 · Scientific reports

This study evaluated the effects of double nanoemulsions of saffron petal extract (DN-SPE), stabilized with soybean (SPI) and pea protein isolates (PPI), alone or combined with Lepidium sativum L. seed gum (LSG) (SL or PL), on the quality…

View details →DOI: 10.1038/s41598-026-52693-3
Negative / Null Result ReportMedicine

Persistent deficits in the motor unit following mono and dual administration of SMN up-regulators in the SmnΔ7 mouse model of spinal muscular atrophy.

Partlova, Comley, Haigh et al. · 2026 · Experimental neurology

Spinal muscular atrophy (SMA) is characterized by motor neuron loss and neuromuscular junction (NMJ) pathology. Although SMN-upregulating therapies such as Nusinersen markedly improve survival and motor function for many patients,…

View details →DOI: 10.1016/j.expneurol.2026.115898
Negative / Null Result ReportMedicine

Refractory Neonatal Apnea Revealing Congenital Central Hypoventilation Syndrome: Improved Outcome through Early Multidisciplinary Intervention.

Shalamov, Cromwell, Guha · 2026 · AJP reports

Background: Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder that causes alveolar hypoventilation because of impaired chemoreceptor response to hypercapnia and hypoxia occurring due to a dysfunctional central…

View details →DOI: 10.1055/a-2873-6868
Negative / Null Result ReportMedicine

Quality Improvement Analysis of Operative Regimen on Urinary Tract Infections.

Bonglack, Carrel-Lammert, Hoehn et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Acute urinary tract infections (UTIs) are common after prolapse and anti-incontinence surgery, with incidence rates varying from 14% to 64%. The objective was to decrease rates of symptomatic urinary tract infections in patients undergoing…

View details →DOI: 10.1097/spv.0000000000001742
Negative / Null Result ReportMedicine

The impact of urinary catheterization on urinary tract infection and renal function in elderly patients undergoing hip fracture surgery: A prospective randomized controlled trial.

Serttas, Uysal, Deği̇rmenci̇ et al. · 2026 · Injury

Urinary tract infection(UTI) is a common complication following hip fracture surgery in elderly patients. Urinary catheterization is frequently used to improve patient comfort during prolonged preoperative immobilization; however, its…

View details →DOI: 10.1016/j.injury.2026.113449
Negative / Null Result ReportMedicine

Patient Trust in Healthcare Providers among People on Methadone Maintenance Treatment Using Methamphetamine in Vietnam.

Vu, Nguyen, Nguyen et al. · 2026 · Substance use & misuse

Patient trust in healthcare providers (PTP) is critical for improving treatment adherence and outcomes in substance use disorders. As concurrent opioid and methamphetamine use increasingly complicates methadone maintenance treatment (MMT),…

View details →DOI: 10.1080/10826084.2026.2676993
Negative / Null Result ReportMedicine

Association Between Early Versus Delayed Outpatient Follow-Up After Hospital Discharge and Short-Term Healthcare Utilization Among ICU Survivors.

Oletu, Oladimeji, Osueni et al. · 2026 · Cureus

Intensive care unit (ICU) survivors experience high rates of healthcare utilization after hospital discharge, including readmissions and emergency department (ED) visits. Timely outpatient follow-up has been proposed to improve care…

View details →DOI: 10.7759/cureus.107746
Negative / Null Result ReportMedicine

Reliability and patient-centered feasibility of the Gross Motor Function Measure in children diagnosed with central nervous system tumor.

Mantovani, Chagas, Horiquini-Barbosa · 2026 · Developmental neurorehabilitation

Children diagnosed with central nervous system (CNS) tumors frequently present with persistent motor impairments that compromise independence and participation. Although the Gross Motor Function Measure (GMFM-88) is widely used in…

View details →DOI: 10.1080/17518423.2026.2679487
Negative / Null Result ReportMedicine

Motor imagery and resistance training improve strength in older adults through distinct effects on agonist-antagonist coordination.

Yao, Mamone, Wu et al. · 2026 · Frontiers in psychology

Age-related declines in muscle strength are partly attributable to altered neural drive and agonist-antagonist coordination. This study aimed to evaluate the effects of motor imagery training (MIT) on maximal force production and…

View details →DOI: 10.3389/fpsyg.2026.1817866
Negative / Null Result ReportMedicine

The effectiveness of vitrified zygote banking for managing the severe diminished ovarian reserve in infertile women: A retrospective cohort study.

Huang, Tsai, Lin et al. · 2026 · Taiwanese journal of obstetrics & gynecology

A higher oocyte yield is generally associated with improved outcomes in assisted reproductive technology (ART). Vitrification enables the accumulation of oocytes, zygotes, or embryos across multiple cycles, offering a potential strategy to…

View details →DOI: 10.1016/j.tjog.2025.06.010
Negative / Null Result ReportMedicine

Telemedicine-Assisted vs Conventional Telephone Instruction in Cardiopulmonary Resuscitation: The TACTIC Cluster Randomized Trial.

Riyapan, Laopran, Chantanakomes et al. · 2026 · Resuscitation

Dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) has been shown to increase bystander CPR rates and improve outcomes after out-of-hospital cardiac arrest (OHCA). However, dispatchers cannot directly visualize the scene, which may…

View details →DOI: 10.1016/j.resuscitation.2026.111191
Negative / Null Result ReportMedicine

Can Knowledge and Motivation for Lymphedema Self-Management Be Improved with the Use of ICG Lymphography? A Prospective Observational Repeated Measures Study.

Trevethan, Doig, Patterson et al. · 2026 · Lymphology

ICG lymphography is a lymphatic imaging tool that can inform lymphedema treatment, including self-management. Self-management requires patient engagement in a multimodal treatment program. However, lack of knowledge about lymphedema,…