Negative / Null Result ReportMedicine
Jiang, Wang, Wei et al. · 2026 · Geriatric nursing (New York, N.Y.)
Peripheral Intravenous Cannulas (PIVCs) are extensively used for infusion therapy. Although current evidence suggests that adult patients may have PIVCs removed based on clinical indications, the indication in elderly patients remains…
View details →DOI: 10.1016/j.gerinurse.2026.104100 Negative / Null Result ReportOpen accessGeriatrics
Kendra Cooling, Danielle R. Bouchard, Molly Gallibois et al. · 2025 · JAR Life
Objective: To examine the effects of a standing intervention on gait speed for older adults living in long term care (LTC) residences. Design: A parallel superiority cluster randomized controlled trial. Setting and participants: LTC residences. A total of 95 LTC residents (n = 47 control; n = 48 intervention) participated in the study. Methods: LTC residences and therefore the residents from the homes were randomized to either the intervention group (standing up to 100 minutes/week) for 22 weeks or the control group (socializing with staff with no encouragement to stand for up to 100 minutes/w
View details →DOI: 10.1016/j.jarlif.2025.100015 Negative / Null Result ReportMedicine
Mokhtar, Gawish, Abdelgawad et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet-rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard…
View details →DOI: 10.1002/ksa.70484 Negative / Null Result ReportMedicine
Villalón López, Escaffi-Schwarz · 2026 · Journal of medical Internet research
Parental burnout is an underrecognized syndrome characterized by emotional exhaustion, detachment from children, and reduced parental efficacy. It is associated with sleep disturbance, addictive behaviors, suicidal ideation, and increased…
View details →DOI: 10.2196/87416 Negative / Null Result ReportMedicine
Ishiwatari, Nakahara, Kawaguchi et al. · 2026 · Gastrointestinal endoscopy
Endoscopic retrograde cholangiopancreatography with metal stent (MS) placement is the standard treatment for biliary drainage in patients with unresectable pancreatic cancer. A 10-mm diameter MS is generally used; however, a larger stent…
View details →DOI: 10.1016/j.gie.2026.06.037 Negative / Null Result ReportOpen accessNursing
孔德华, 张蕾, 储静 · 2018 · Huli yanjiu
Abstract Objective:To systematically review the clinical effect of venousaccess ports(VPA/VAP)and peripheral venous catheterization(PICC)in patients with tumor chemotherapy.Methods:Randomized controlled trial(RCT),semirandomized controlled trial,and cohort study of comparison the application effect of VAP and PICC in patients with tumor chemotherapy were retrieved from the Cochrane CDSR,PubMed,Embase,CINAHL,SCIE,Chinese biomedical literatures service system(CBM),Wanfang,and VIP database.According to the inclusion criteria,two researchers selected the literature,extracted the data,and evaluated
Negative / Null Result ReportMedicine
Esposito, Bocari, Cho et al. · 2026 · The International journal of oral & maxillofacial implants
This multicenter randomized controlled trial compared the clinical effectiveness of 7.0-mm wide-diameter implants with 5.0-mm conventional-diameter implants placed immediately after molar extraction. Thirty-nine patients needing a single…
View details →DOI: 10.11607/jomi.11536 Negative / Null Result ReportMedicine
Fuentes-Expósito, Frid, Muñoz-Mateu et al. · 2026 · JCO clinical cancer informatics
We evaluated whether offering access to a multicomponent mHealth app improves quality of life (QoL) and psychosocial outcomes among breast cancer survivors under pragmatic, nonprescriptive conditions. In this single-center, randomized,…
View details →DOI: 10.1200/cci-26-00025 Negative / Null Result ReportMedicine
Rocha, Dos Anjos, Pinho et al. · 2026 · Journal of dentistry
This 12-month, double-blind, parallel, randomized controlled trial compared the material fracture/retention rates of occluso-proximal direct composite resin restorations associated with polyethylene fiber (CR+PF; Ribbond®) with…
View details →DOI: 10.1016/j.jdent.2026.106863 Negative / Null Result ReportMedicine
Peng, Wang, Xiao et al. · 2026 · Journal of minimally invasive gynecology
To compare the effectiveness and safety of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) pelvic reconstruction (PRC), vNOTES presacral-uterosacral ligament suspension (PULS), and sacrospinous ligament fixation…
View details →DOI: 10.1016/j.jmig.2026.06.024 Negative / Null Result ReportMedicine
Yang, Mueller, D'Andrea et al. · 2026 · Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
Resident physicians experience high rates of depression, anxiety, burnout, and loneliness, yet few evidence-based interventions have been evaluated in this population. This randomized controlled pilot trial examined the feasibility,…
View details →DOI: 10.1007/s40596-026-02384-y Negative / Null Result ReportMedicine
Gou, He, Zhuo · 2026 · Frontiers in medicine
To investigate the effect and safety of astragalus injection at Neiguan (PC6) for chronic heart failure (CHF; HF) with qi-deficiency and blood-stasis syndrome, and its effect on the renin-angiotensin-aldosterone system (RAAS). A…
View details →DOI: 10.3389/fmed.2026.1836620 Negative / Null Result ReportMedicine
Bieglecka, Kęszycka, Czerwińska et al. · 2026 · Nutrients
Patients with psoriasis, a non-contagious, chronic, systemic inflammatory skin disease, often suffer from carbohydrate metabolism disorders, which can exacerbate systemic inflammation. This randomized, double-blind, placebo-controlled…
View details →DOI: 10.3390/nu18121843 Failed Experiment ReportOpen accessMedicine
Se-Hee Min, Suk Hyung Choe, Won Shik Kim et al. · 2022 · Scientific Reports
Abstract Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles
View details →DOI: 10.1038/s41598-022-12374-3 Negative / Null Result ReportMedicine
Anusuya, Balaji, Manikandan · 2026 · Journal of Indian Society of Periodontology
Periodontal regeneration aims to restore the natural structure of the periodontium, therefore improving the long-term stability and function of the affected teeth. Traditional bone graft materials such as allografts, autografts,…
View details →DOI: 10.4103/jisp.jisp_210_24 Negative / Null Result ReportOpen accessNursing
Maryam Ahmadinezhad, Marzieh Kargar, Fatemeh Vizeshfar et al. · 2017 · Iranian Journal of Nursing and Midwifery Research
Background: Postmenopausal women experience a variety of symptoms, among which sleep disorder is one of the most common problems. Acupressure and Pilates exercise programs are effective nonpharmaceutical treatments which can improve sleep quality. In the present study, we aimed to compare the effects of acupressure and Pilates-based exercises on the sleep quality of postmenopausal women referred to medical clinics. Materials and Methods: In this single-blinded randomized controlled clinical trial, we recruited 108 women aged 40–60 years who were randomly assigned into one control and two inter
View details →DOI: 10.4103/1735-9066.205954 Negative / Null Result ReportOpen accessMedicine
Tobias Lohaus, Sally Reckelkamm, Patrizia Thoma · 2024 · PLoS ONE
Objective Acquired brain injuries (ABIs), such as traumatic brain injuries (TBIs), often entail impairments of general cognition (e.g., memory, attention or executive functions) and social cognition (e.g. emotion recognition, theory of mind [ToM], social problem-solving). The availability of fully computerized interventions targeting sociocognitive deficits specifically in neurologically impaired patients is extremely limited. Therefore, the Treatment Program for Deficits in Social Cognition and Social Competencies of the Ruhr University Bochum (SoCoBo), a fully computerized online therapy des
View details →DOI: 10.1371/journal.pone.0294767 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Ye Li Lee, Sang Yeoup Lee, Sang Yeoup Lee et al. · 2022 · Frontiers in Nutrition
IntroductionOysters possess an excellent nutritional profile containing γ-aminobutyric acid (GABA). Previous data suggest that GABA is a potent bioactive compound for improving muscle health. Lactic acid fermentation is thought to increase GABA content. However, the effect of oral supplementation of fermented oyster extracts (FO) on human muscle strength and mass is unclear. Therefore, we tested the effects and safety of consumption of FO combined with regular walking for 12 weeks on muscle strength and mass in older adults with relatively low muscle mass.Materials and methodsA randomized cont
View details →DOI: 10.3389/fnut.2022.935395 Negative / Null Result ReportOpen accessMedicine
Michael R Gionfriddo, Yirui Hu, Bhumika Maddineni et al. · 2022 · JMIR Formative Research
BackgroundDespite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources. ObjectiveWe aim to evaluate th
View details →DOI: 10.2196/33488 Negative / Null Result ReportOpen accessComputer Science
Neil K. R. Sehgal, Manuel Tonneau, Andy Tan et al. · 2025 · arXiv
Large language model (LLM) chatbots show increasing promise in persuasive communication. Yet their real-world utility remains uncertain, particularly in clinical settings where sustained conversations are difficult to scale. In a pre-registered randomized controlled trial, we enrolled 915 U.S. adults (ages 45-75) who had never completed colorectal cancer (CRC) screening. Participants were randomized to: (1) no message control, (2) expert-written patient materials, (3) single AI-generated message, or (4) a motivational interviewing chatbot. All participants were required to remain in their assi
Negative / Null Result ReportMedicine
Liu, Yu, Gao et al. · 2026 · Drug design, development and therapy
To compare the analgesic efficacy and safety of deep, superficial and combined deep-superficial erector spinae plane block (ESPB) combined with subanesthetic-dose esketamine in patients undergoing percutaneous kyphoplasty (PKP). A total of…
View details →DOI: 10.2147/dddt.s601168 Negative / Null Result ReportMedicine
Zheng, Chen, Sui et al. · 2026 · Drug design, development and therapy
Laparoscopic sleeve gastrectomy (LSG) is associated with substantial postoperative pain and a high rate of postoperative nausea and vomiting. Tegileridine fumarate, a biased µ-opioid receptor agonist, may offer effective analgesia…
View details →DOI: 10.2147/dddt.s611241 Negative / Null Result ReportMedicine
Rawal, Asawa, Das et al. · 2026 · Cureus
Background Gingivitis, a reversible inflammatory condition of the gingiva, is primarily caused by plaque accumulation. Chlorhexidine is the gold standard for plaque control, but it is associated with side effects on prolonged use.…
View details →DOI: 10.7759/cureus.109382 Negative / Null Result ReportMedicine
Katheria, Lakshminrusimha, Morales et al. · 2026 · Pediatric research
We sought to evaluate oxidative changes in premature infants receiving 100% oxygen compared with 30% during deferred cord clamping (DCC). Premature infants born at 22 0/7 to 28 6/7 weeks received DCC in conjunction with either 30% (LO…
View details →DOI: 10.1038/s41390-026-05199-7 Negative / Null Result ReportMedicine
Chen, Wen, Zheng · 2026 · Shock (Augusta, Ga.)
Sepsis is a clinical syndrome marked by a dysregulated host response to infection, impairing oxygen delivery and utilization and causing organ dysfunction. Hypoxemia, which can cause significant tissue and organ damage, commonly occurs in…
View details →DOI: 10.1097/shk.0000000000002865 Replication FailureOpen accessDiseases of the digestive system. Gastroenterology
Ben-Gang Zhou, Ming-Wen Guo, Li-Juan Zhang et al. · 2024 · Therapeutic Advances in Gastroenterology
Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.
View details →DOI: 10.1177/17562848241309870 Negative / Null Result ReportMedicine
Chen, Spadaccini, Sahai et al. · 2026 · Endoscopy international open
Endoscopic ultrasound-guided choledochoduodenostomy using a lumen-apposing metal stent (EUS-CDSL) has been shown in randomized controlled trials (RCTs) to be effective compared with endoscopic retrograde cholangiopancreatography (ERCP) in…
View details →DOI: 10.1055/a-2863-1621 Negative / Null Result ReportMedicine
Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing
Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…
View details →DOI: 10.1007/s10877-026-01459-3 Negative / Null Result ReportOpen accessMedicine
Belnap MA, Witkiewitz K, Schacht JP et al. · 2026 · Alcohol, clinical & experimental research
Background The U.S. Food and Drug Administration (FDA) recommends a minimum duration of 6 months for randomized controlled trials (RCTs) evaluating pharmacotherapies for alcohol use disorder (AUD). The relationship between trial length and…
View details →DOI: 10.1111/acer.70306 Negative / Null Result ReportOpen accessScience
Ákos Bérczi, Fanni Éva Szablics, Anita Nelli Simon et al. · 2025 · Life
Digital subtraction angiography (DSA) remains an important reference modality for evaluating chronic limb-threatening ischemia (CLTI), with left transradial access (TRA) increasingly favored for its lower complication rates and patient comfort. Radiation safety for operators is paramount, yet the impact of patient positioning on scatter radiation during lower limb diagnostic catheter angiography (CA) is understudied. This single-center randomized controlled trial evaluated whether head-first (HF) vs. feet-first (FF) supine patient orientation affects operator radiation exposure during lower ex
View details →DOI: 10.3390/life15091433 