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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 44 of 65

Negative / Null Result ReportMedicine

Previous use of statins does not improve the outcome of bloodstream infection after kidney transplantation.

Fernández-Ruiz M, Sánchez Moreno B, Santiago Almeda J et al. · 2023 · Transplant infectious disease : an official journal of the Transplantation Society

Previous studies have suggested that exposure to statins confers a protective effect in bloodstream infection (BSI) due to the anti-inflammatory and immunomodulatory properties attributed to these lipid-lowering drugs. Scarce evidence is…

View details →DOI: 10.1111/tid.14132
Negative / Null Result ReportOpen accessMedicine

Randomized, double-blind trial of preoperative pregabalin versus placebo to improve quality of recovery after breast cancer surgery.

Toledo FV, Meletti JFA, Silva LMC et al. · 2026 · Brazilian journal of anesthesiology (Elsevier)

Introduction Surgery remains one of the most important treatments for breast cancer. In this context, the quality of postoperative recovery has become a key concern. Adequate control of acute pain is essential to optimize patient comfort…

View details →DOI: 10.1016/j.bjane.2026.844749
Negative / Null Result ReportOpen accessMedicine

The Use of Microporous Polysaccharide Hemospheres in Thyroid Surgery: A Retrospective Study on Safety and Clinical Outcomes.

Mariani C, Al Dababsekh A, Carta F et al. · 2025 · Medicina (Kaunas, Lithuania)

Background and Objectives : Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic…

View details →DOI: 10.3390/medicina61122209
Negative / Null Result ReportOpen accessMedicine

Effects on nonverbal numerical acuity performance after a single-session transient random noise stimulation over the intraparietal sulcus or dorsolateral prefrontal cortex.

Ó Dúinín E, Steopan JK, Kessler K et al. · 2025 · Scientific reports

We investigated the effects of cognitive training with transcranial random noise stimulation (tRNS) applied to the intraparietal sulcus (IPS) or dorsolateral prefrontal cortex (DLPFC) on improving a multidirectional number line estimation…

View details →DOI: 10.1038/s41598-025-21890-x
Negative / Null Result ReportOpen accessMedicine

Resolution rate of prescribing errors after advice from a specialised hospital pharmacist or a substitute hospital pharmacist: a retrospective cross-sectional study.

Wilkes S, Kalfsvel L, van Rosse F et al. · 2026 · European journal of hospital pharmacy : science and practice

Objectives Specialised hospital pharmacists, integrated in medical teams on the ward, can improve medication safety. When a specialised hospital pharmacist is temporarily not available, the pharmaceutical care will be conducted by a…

View details →DOI: 10.1136/ejhpharm-2024-004392
Negative / Null Result ReportOpen accessMedicine

Therapeutic Drug Monitoring of Psychotropic Drugs in Inpatient Psychiatry: Local Practice and Improvement.

Pfeifer P, Mathys B, Alan EM et al. · 2025 · Psychiatry and clinical psychopharmacology

Background Therapeutic drug monitoring (TDM) is an important tool to personalize psychopharmacotherapy, thereby optimizing its effectiveness and tolerability. Despite consensus on medications, indications, and implementation of TDM,…

View details →DOI: 10.5152/pcp.2025.24981
Negative / Null Result ReportMedicine

Ischemic Preconditioning Does Not Improve Climbing Specific Performance in Elite Athletes.

Platzer HP, Köck A, Schobersberger W et al. · 2026 · Journal of strength and conditioning research

Abstract Platzer, H-P, Köck, A, Schobersberger, W, and Dünnwald, T. Ischemic preconditioning does not improve climbing specific performance in elite athletes. J Strength Cond Res 40(1): e69-e75, 2026-The aim of the present investigation…

View details →DOI: 10.1519/jsc.0000000000005271
Negative / Null Result ReportOpen accessMedicine

Design characteristics of studies evaluating the effect of non-surgical periodontal treatment on systemic health outcomes.

Treat T, Jones D, Lorenzano N et al. · 2026 · Journal of periodontology

Background Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this…

View details →DOI: 10.1002/jper.24-0847
Negative / Null Result ReportOpen accessMedicine

The effect of citicoline administration on visual function improvement in stroke patients at Prof. Dr. Chairuddin Panusunan Lubis Hospital, University of Sumatera Utara, and affiliated network hospitals.

Fransisca S, Sitepu BRE, Delfi · 2026 · Frontiers in medicine

Background Visual disturbances are a common and often debilitating complication following stroke, significantly impairing patients' functional independence and quality of life. Among various neuroprotective agents, Citicoline…

View details →DOI: 10.3389/fmed.2026.1769632
Negative / Null Result ReportMedicine

The effect of far infrared radiation on maturation in arteriovenous fistulas in patients on hemodialysis: A randomized controlled, multicenter trial.

Lindhard K, Hansen HP, Gliese K et al. · 2026 · The journal of vascular access

Introduction Improved arteriovenous fistula (AVF) maturation is crucial for reducing the dependency on central venous catheters in patients undergoing hemodialysis (HD). Far-infrared radiation (FIR) is a treatment modality that may enhance…

View details →DOI: 10.1177/11297298251385043
Negative / Null Result ReportOpen accessMedicine

Nocturnal Cardiac Arrhythmias in Sleep Apnoea After Acute Myocardial Infarction and the Effect of Adaptive Servo-Ventilation: An Ancillary Study of the TEAM-ASV I Trial.

Pec J, Nigl M, Fox H et al. · 2026 · Journal of cardiovascular development and disease

(1) Background: Early treatment of sleep-disordered breathing (SDB) with adaptive servo-ventilation (ASV) after acute myocardial infarction (AMI) has been shown to improve myocardial salvage. This analysis evaluates nocturnal…

View details →DOI: 10.3390/jcdd13040157
Negative / Null Result ReportMedicine

The Role of Circulating Tumor DNA in Patients Treated with Adjuvant Immune Checkpoint Inhibitors: Clinical Reality or Distant Horizon?

Maffezzoli M, Nagpal R, Elewaily M et al. · 2025 · Current oncology reports

PURPOSE OF REVIEW: Adjuvant immunotherapy has improved outcomes in several cancers, although patient selection and toxicity remain challenges. Circulating tumor DNA (ctDNA) has emerged as a biomarker for minimal residual disease (MRD)…

View details →DOI: 10.1007/s11912-025-01701-2
Failed Experiment ReportOpen accessMedicine

Persistent cognitive deficits in ACL-injured athletes despite of rehabilitation: an observational longitudinal study.

Jiménez-Martínez J, Alarcón-López F, Chirosa-Ríos LJ et al. · 2025 · Frontiers in sports and active living

Background Rehabilitation programs following an anterior cruciate ligament (ACL) injury tend to focus on improving conditional aspects such as biomechanics. Recently, some studies have analyzed the relationship between cognition and ACL…

View details →DOI: 10.3389/fspor.2025.1601744
Negative / Null Result ReportOpen accessMedicine

Improving Non-Invasive Prediction of Thyroid Nodule Malignancy: A Machine Learning-Based Clinical Approach.

Reiner M, Drobińska H, Miciak M et al. · 2026 · Cancer management and research

Background Thyroid cancer (TC) is the most commonly diagnosed endocrine malignancy, with rising global incidence. Current diagnostic techniques, including ultrasound and fine-needle aspiration biopsy (FNAB), often yield inconclusive…

View details →DOI: 10.2147/cmar.s571308
Negative / Null Result ReportMedicine

Sharpening the lens to evaluate interprofessional education and interprofessional collaboration by improving the conceptual framework: a critical discussion.

Neubauer FB, Wagner FL, Lörwald A et al. · 2024 · BMC medical education

It has been difficult to demonstrate that interprofessional education (IPE) and interprofessional collaboration (IPC) have positive effects on patient care quality, cost effectiveness of patient care, and healthcare provider satisfaction.…

View details →DOI: 10.1186/s12909-024-05590-0
Methods Dead-End

Far-Infrared Therapy and Vascular Access Flow in Hemodialysis Patients With Arteriovenous Fistula or Graft: A Prospective Minimal Detectable Change Analysis

Kim EJ, Kim SY, Kee YK et al. · 2026 · Preprint

Abstract Far-infrared (FIR) therapy has been proposed to improve vascular access flow (Qa) in patients receiving maintenance hemodialysis through an arteriovenous fistula (AVF) or arteriovenous graft (AVG). However, vascular access blood…

View details →DOI: 10.21203/rs.3.rs-9732400/v1
Negative / Null Result ReportOpen accessMedicine

Three-dimensional Bovine Collagen-Elastin Matrix in Soft Tissue Reconstruction: No Detectable Bovine DNA After 1 Year.

Nicklas A, Rudari M, Reidow N et al. · 2026 · Plastic and reconstructive surgery. Global open

Background Postoperative wound healing remains a critical challenge, particularly in complex reconstructions such as free flap surgeries. Despite technical improvements, perfusion-related complications may cause partial flap loss.…

View details →DOI: 10.1097/gox.0000000000007662
Negative / Null Result ReportMedicine

Prospective Study of Cytomegalovirus Reactivation in Patients With Multiple Myeloma Receiving Anti-CD38 and BCMA Therapies.

Baneman E, Jacobs SE, Rana M et al. · 2026 · Clinical lymphoma, myeloma & leukemia

Background Cytomegalovirus (CMV) is an opportunistic pathogen that causes infection in certain immunocompromised hosts, but the risk of clinically significant CMV infection in patients with multiple myeloma (MM) is not well understood.…

View details →DOI: 10.1016/j.clml.2026.05.008
Negative / Null Result ReportOpen accessMedicine

Baseline Data on Viral Suppression, Treatment Adherence and Mental Health in Peripartum Girls and Young Women With HIV in Zimbabwe.

Chawana-Mutingwende TD, Ngara B, Mudadi LS et al. · 2026 · Journal of the International AIDS Society

Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir-based regimens and psychosocial peer motivation may improve viral…

View details →DOI: 10.1002/jia2.70117
Failed Experiment ReportMedicine

Dentin Bond Strength of Resin Cements Under Simulated Intraoral Humidity Conditions.

Washino T, Nikaido T, Burrow MF et al. · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology

Background/aims Adhesive procedures performed after dental trauma are often carried out in emergency settings with compromised isolation due to bleeding, limited access, and patient cooperation. This study evaluated how variation in…

View details →DOI: 10.1111/edt.70087