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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 43 of 65

Negative / Null Result ReportMedicine

Lack of association between corticospinal excitability changes during motor imagery and explicit sequence learning performance.

Takenaka Y, Maeda K, Yamada M et al. · 2026 · Behavioural brain research

Background Motor imagery (MI) improves motor performance, but standardized objective quality evaluation methods are lacking. The relationship between MI quality and actual performance improvements also remains unclear. Purpose We…

View details →DOI: 10.1016/j.bbr.2026.116299
Negative / Null Result ReportMedicine

Lack of Association Between Dietary Fiber Intake and Kidney Failure Among Patients With Chronic Kidney Disease: The Chronic Kidney Disease-Japan Cohort Study.

Hattori K, Sakaguchi Y, Isaka Y et al. · 2025 · Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation

Objective It remains unclear whether dietary fiber intake improves kidney outcome. The objective of our study was to examine the association between dietary fiber intake and the risk of kidney failure among patients with proteinuric…

View details →DOI: 10.1053/j.jrn.2025.06.003
Negative / Null Result ReportOpen accessMedicine

Visually assessed ischemia on cardiac magnetic resonance, but not quantitative perfusion metrics, predicts symptomatic improvement in coronary artery bypass.

Akbari T, Mach L, Hammersley DJ et al. · 2025 · Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Background Serial perfusion cardiovascular magnetic resonance (CMR) in symptomatic patients undergoing coronary artery bypass grafting (CABG) may provide mechanistic insight into dynamic abnormalities of the myocardium. Objectives To…

View details →DOI: 10.1016/j.jocmr.2025.101953
Negative / Null Result ReportMedicine

Is Obesity a Factor in Lethal Opioid Toxicity?

Hunter JWS, Van Den Heuvel C, Stephenson L et al. · 2025 · The American journal of forensic medicine and pathology

Abstract Both obesity and opioid abuse are increasing in numbers globally. As these entities may be associated with significant respiratory compromise, it was hypothesized that synergism may occur and that as a result of this obese…

View details →DOI: 10.1097/paf.0000000000001029
Negative / Null Result ReportOpen accessMedicine

Are high residual chlorhexidine skin concentrations associated with improved clinical outcomes? Lessons from the CLEAR trial.

Khoja R, Catuna TD, Gussin GM et al. · 2026 · Infection control and hospital epidemiology

Residual chlorhexidine gluconate (CHG) skin concentrations are thought to improve disease prevention. In the Changing Lives by Eradicating Antibiotic Resistance (CLEAR) trial, posthospitalization decolonization of MRSA carriers reduced…

View details →DOI: 10.1017/ice.2026.10424
Negative / Null Result ReportOpen accessMedicine

Relationship between the anxiety of labor companion and labor satisfaction among laboring women.

Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports

The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…

View details →DOI: 10.1038/s41598-025-04754-2
Negative / Null Result ReportMedicine

Lack of Association Between Immunotherapy and Improvement of Survival for Non-small Cell Lung Cancer Patients With Hemodialysis: A Nationwide Retrospective Cohort Study.

Sawa K, Ihara Y, Imai T et al. · 2024 · Clinical lung cancer

Background The number of patients undergoing hemodialysis continues to increase globally, and the incidence of cancer is high among these patients. Immune checkpoint inhibitors are widely used in patients with advanced cancer, especially…

View details →DOI: 10.1016/j.cllc.2023.11.003
Negative / Null Result ReportOpen accessMedicine

Retrospective analysis of Claudin18.2 expression in ethnically diverse patients with gastroesophageal adenocarcinoma.

Wallam S, Park J, Wu LW et al. · 2025 · Journal of gastrointestinal oncology

Background Claudin18.2 (CLDN18.2), a tight junction molecule, is a novel therapeutic target for patients with advanced gastroesophageal adenocarcinoma. Recent phase III trials demonstrated improved survival with the addition of an…

View details →DOI: 10.21037/jgo-2025-111
Negative / Null Result ReportMedicine

Whole cottonseed and palmitic and oleic acid supplementation improve production responses during the immediate postpartum in multiparous dairy cows.

Parales-Girón JE, Dos Santos Neto JM, Lock AL · 2026 · Journal of dairy science

We evaluated the effects of whole cottonseed (WCS) and fatty acid (FA) supplementation on the production responses of early-lactation cows. Fifty-two multiparous cows were used in a randomized complete block design with a 2 × 2 factorial…

View details →DOI: 10.3168/jds.2025-26931
Negative / Null Result ReportMedicine

Lack of effect of renal function on uptake of 99m Tc-sestamibi in renal masses.

Amindarolzarbi A, Satcowitz K, Khalil A et al. · 2025 · Nuclear medicine communications

Objective The appropriate clinical management of indeterminate small renal masses can be improved based on accurate risk stratification. This study aimed to investigate the impact of renal function on the uptake of technetium-99m ( 99m…

View details →DOI: 10.1097/mnm.0000000000001960
Negative / Null Result ReportMedicine

Action observation with motor simulation of reactive stepping: A randomized study in older adults with a history of falls.

Hagedoorn L, Ruiz-Rodríguez A, Leijen I et al. · 2025 · Experimental gerontology

Background Perturbation-based training improves reactive stepping responses to prevent falling following a loss-of-balance. As there is currently no safe and feasible method for home-based practice, this randomized study investigated…

View details →DOI: 10.1016/j.exger.2024.112645
Negative / Null Result ReportMedicine

Theory-guided process evaluation of a multicomponent, technology-based 'SMART Eating' trial among Indian adults: an embedded mixed-methods study.

Kaur J, Kaur M, Chakrapani V et al. · 2023 · Health education research

We report process evaluation findings from the 'SMART Eating' intervention trial, which significantly improved fat, sugar and salt (FSS), and fruits and vegetables (FVs) intake among adults. Intervention used information technology [short…

View details →DOI: 10.1093/her/cyad020
Failed Experiment ReportOpen accessMedicine

A Pilot Study on the Influence of Self-Paced Auditory Cues and Preferred Music on Gait in Persons with Parkinson's Disease.

Brant M, Barrick C, Muno L et al. · 2025 · Brain sciences

Background : Gait disturbance in Parkinson's Disease (PD) significantly impacts quality of life and is not completely mitigated by dopaminergic treatment. Auditory cueing has been shown to help improve certain aspects of gait, but its…

View details →DOI: 10.3390/brainsci15050528
Negative / Null Result ReportMedicine

COVID-19 Inpatient Caseloads in General Hospitals Did Not Affect Quality Indicator Compliance Rates in Israel.

Bronshtein O, Konson A, Kuniavsky M et al. · 2025 · Quality management in health care

Background and objectives Early in the global COVID-19 pandemic, a concern was raised that potentially high volumes of COVID-19 inpatients in general hospitals might compromise the hospitals' capabilities to maintain high-quality care for…

View details →DOI: 10.1097/qmh.0000000000000458
Negative / Null Result ReportOpen accessMedicine

Seven-Year Intervention Rate and Effect of Early Rehabilitation in China: A National-Wide Hospital-Based Study.

Zhang Y, Zhang H, Zhou M et al. · 2025 · American journal of physical medicine & rehabilitation

Abstract The improvement of early rehabilitation service capacity is of great importance for meeting health needs of the population; however, there is still a lack of information on early rehabilitation interventions in hospitals in China.…

View details →DOI: 10.1097/phm.0000000000002778
Negative / Null Result ReportMedicine

Nitrogen leaching and soil nutrient supply vary spatially within a temperate tree-based intercropping system

Rivest D, Martin-Guay MO · 2024 · Nutrient cycling in agroecosystems.

Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…

View details →DOI: 10.1007/s10705-024-10347-8
Negative / Null Result ReportOpen accessMedicine

A cross-sectional survey of the safety attitudes questionnaire subscale stress recognition and the effect of non-technical skills training in operating theatre staff.

Leuschner S, Schenk P, Gräbsch C et al. · 2025 · Innovative surgical sciences

Objectives Non-technical skills (NTS) training of surgical staff is a quality improvement measure to improve patient safety. One factor that can compromise patient safety is impaired staff performance due to stressors such as tiredness.…

View details →DOI: 10.1515/iss-2024-0025
Negative / Null Result ReportMedicine

Outcome evaluation of the p drivers Program: Randomised controlled trial of a program to improve safe driving among novice drivers.

Stephan K, Stephens AN, Scully M et al. · 2024 · Accident; analysis and prevention

Background Globally, road traffic crashes are the leading cause of death for young adults. The P Drivers Project was a trial of a behavioural change program developed for, and targeted at, young Australian drivers in their initial months…

View details →DOI: 10.1016/j.aap.2024.107569
Negative / Null Result ReportMedicine

Impact of Maternal Exercise on Mice Offspring Development, Pulmonary Hypertension, and Vascular Remodeling in Chronic Hypoxia.

Leslie E, Gonzalez Bosc LV, Specht J et al. · 2024 · Medicine and science in sports and exercise

Purpose Chronic, high-altitude hypoxic exposure increases the risk of high-altitude pulmonary hypertension (PH). Emerging evidence shows maternal exercise may improve offspring resistance to disease throughout life. The purpose of this…

View details →DOI: 10.1249/mss.0000000000003479
Negative / Null Result ReportOpen accessMedicine

Does tDCS Enhance Complex Motor Skill Acquisition? Evidence from a Golf-Putting Task.

Lopez-Alonso V, López-Bermúdez G, Pagaduan JC et al. · 2025 · Sensors (Basel, Switzerland)

Transcranial direct current stimulation (tDCS) modulates cortical excitability, thus inducing improvements in motor learning of simple tasks. In this study, we aimed to evaluate the effect of different tDCS conditions-anodal stimulation…

View details →DOI: 10.3390/s25144297
Negative / Null Result Report

Nitrogen leaching and soil nutrient supply vary spatially within a temperate tree-based intercropping system but are unaffected by tree root pruning

Rivest D, Martin-Guay M · 2023 · Preprint

Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…

View details →DOI: 10.21203/rs.3.rs-3398528/v1
Negative / Null Result ReportOpen accessMedicine

Surgical Risk and Long-Term Mortality With PCI and CABG in Ischemic Left Ventricular Systolic Dysfunction.

Marquis-Gravel G, Tong G, Dodd M et al. · 2025 · Journal of the Society for Cardiovascular Angiography & Interventions

Background Coronary artery bypass grafting (CABG) improves survival compared with optimal medical therapy (OMT) alone in patients with ischemic left ventricular systolic dysfunction (iLVSD), but percutaneous coronary intervention (PCI) did…

View details →DOI: 10.1016/j.jscai.2025.103820
Negative / Null Result ReportOpen accessMedicine

Does word flickering improve reading? Negative evidence from four experiments using low and high frequencies.

Lubineau M, Watkins CP, Glasel H et al. · 2023 · Proceedings. Biological sciences

Does word flickering facilitate reading? Despite a lack of scientific evidence, flickering glasses and lamps for dyslexia are being marketed in various countries. We conducted four experiments to assess their efficacy. Two experiments…

View details →DOI: 10.1098/rspb.2023.1665
Negative / Null Result ReportOpen accessMedicine

Effect of a mHealth intervention on health literacy in patients completing cardiac rehabilitation: A randomized controlled trial with one- and five-year follow-up.

Lunde P, Finbråten HS, Pripp AH et al. · 2025 · International journal of cardiology. Cardiovascular risk and prevention

Background and aims Adherence to treatment is a significant challenge for patients with cardiac disease. Optimizing health literacy (HL) is essential in this context. Mobile health (mHealth) interventions have been suggested to improve…

View details →DOI: 10.1016/j.ijcrp.2025.200445