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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1934 results for "Mpro" · page 42 of 65

Negative / Null Result ReportOpen accessMedicine

Breath-Holding Maneuvers and Airway Closure in Healthy Adults and Parkinson's Disease: Effects of Maneuver Type, Health Status, and Vocal Fold Bowing.

Curtis JA, Beam AB, Nam J et al. · 2025 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction Breath-holding maneuvers are frequently used to improve airway closure and swallowing safety in people with dysphagia. While their effects on airway closure have been studied in healthy adults, little is known about their…

View details →DOI: 10.1159/000550088
Negative / Null Result ReportOpen accessMedicine

Effects of mindful breathing meditation on stereotype expression in two randomized controlled double-blinded trials.

Vieth E, von Stockhausen L · 2026 · PloS one

Models of stereotypes and discrimination propose the involvement of attentional control and executive functioning in successfully suppressing discriminatory behavior. A practice that has been shown to improve cognitive control, potentially…

View details →DOI: 10.1371/journal.pone.0347871
Negative / Null Result ReportOpen accessMedicine

Error-related potentials during multitasking involving sensorimotor control: an ERP and offline decoding study for brain-computer interface.

Yasuhara M, Nambu I · 2025 · Frontiers in human neuroscience

Humans achieve efficient behaviors by perceiving and responding to errors. Error-related potentials (ErrPs) are electrophysiological responses that occur upon perceiving errors. Leveraging ErrPs to improve the accuracy of brain-computer…

View details →DOI: 10.3389/fnhum.2025.1516721
Negative / Null Result ReportOpen accessMedicine

Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise.

Paulussen KJM, Hayden CMT, Griffin T et al. · 2025 · Matrix biology plus

Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes that are thought to facilitate inter-tissue communication. To determine the potential…

View details →DOI: 10.1016/j.mbplus.2025.100181
Negative / Null Result ReportOpen accessMedicine

The Role of Handedness and Extrainstrumental Burdens on the Course of Musicians' Dystonia.

Doll-Lee J, Passarotto E, Altenmüller E et al. · 2025 · Journal of movement disorders

Objective This study investigated the impact of extrainstrumental workload on musician's dystonia (MD) and its relationship with playing ability by testing whether dystonia onset is more severe in the dominant hand and whether improvement…

View details →DOI: 10.14802/jmd.25064
Failed Experiment ReportOpen accessMedicine

Investigating the effects of antipsychotic drugs as a treatment for improving the activity of the unc-33 /Dpysl2 gene in C. elegans .

Miranda MC, Hyde J, Salazar K et al. · 2024 · microPublication biology

Prenatal stress is hypothesized to contribute to the development of schizophrenia. Lee and colleagues determined that prenatal stress in rats decreases levels of Dpysl2, which is found to be inactivated in schizophrenic patients. UNC-33 ,…

View details →DOI: 10.17912/micropub.biology.001063
Negative / Null Result ReportOpen accessMedicine

Overuse-Induced Muscle Disorder: Establishing a Rat Model to Unravel the Role of Fibro-Adipogenic Progenitor Cells in Intramuscular Fibrosis.

Fusagawa H, Sato T, Naito A et al. · 2025 · Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Overuse-induced muscle disorders (OIMD) frequently occur in athletes due to excessive and improper use under high physical demand, often leading to muscle pain and weakness. Limited studies have shown intramuscular fibrosis in OIMD, with…

View details →DOI: 10.1002/jor.70076
Negative / Null Result ReportMedicine

EncQA: Benchmarking Vision-Language Models on Visual Encodings for Charts.

Mukherjee K, Ren D, Moritz D et al. · 2026 · IEEE transactions on visualization and computer graphics

Multimodal vision-language models (VLMs) continue to achieve ever-improving scores on chart understanding benchmarks. Yet, we find that this progress does not fully capture the breadth of visual reasoning capabilities essential for…

View details →DOI: 10.1109/tvcg.2025.3634249
Negative / Null Result ReportMedicine

Why the present is not the key to past or future: moving beyond restricted relict habitat conditions to improve outcomes in mountain woodland restoration

Watts SH, Barsoum N, Park KJ et al. · 2025 · Restoration Ecology

INTRODUCTION: Mountain woodland restoration can enhance upland biodiversity and contribute to nature‐based solutions mitigating climate change impacts. However, high‐altitude planting of trees and shrubs requires considerable commitment of…

Negative / Null Result ReportMedicine

Audit and feedback: effects on professional practice.

Ivers N, Yogasingam S, Lacroix M et al. · 2026 · The Cochrane database of systematic reviews

Background Audit and feedback (A&F) is a widely used strategy to improve professional practice. This is supported by prior Cochrane reviews and behavioural theories describing how healthcare professionals are prompted to modify their…

View details →DOI: 10.1002/14651858.cd000259.pub5
Negative / Null Result ReportMedicine

"Did I buy that just now?" - Investigating factors influencing the accuracy of food choice self-reports in a simulated online grocery store.

Manzke L, O'Sullivan K, Tiefenbeck V · 2025 · Appetite

Food choices profoundly impact population health and the environment. Related research often relies on self-reported data, which is prone to biases, compromising the accuracy and validity of conclusions about consumer behavior. There are…

View details →DOI: 10.1016/j.appet.2025.108032
Negative / Null Result ReportMedicine

The effect of an Iyengar yoga-based exercise programme versus a seated yoga relaxation programme on falls in people aged 60 years and older (SAGE): a pragmatic, two-arm, parallel randomised controlled trial.

Oliveira JS, Sherrington C, Lord SR et al. · 2025 · The lancet. Healthy longevity

Background Exercises targeting balance and strength are proven to prevent falls. Yoga is growing in popularity and can improve balance and mobility in older adults, but its effects on falls have not been rigorously tested. In this study,…

View details →DOI: 10.1016/j.lanhl.2025.100749
Failed Experiment ReportMedicine

Optimizing Genome Editing in Mollusks (<i>Crassostrea gigas</i>) <i>in Vitro</i> Validation of sgRNA and Identifying Key Factors Influencing Efficiency.

Li Q, Yu H, Du S et al. · 2025 · The CRISPR journal

CRISPR-Cas9 genome editing holds tremendous potential for accelerating genetic improvements in aquaculture. The success of the CRISPR-Cas9 system relies on the specificity and efficiency of engineered single-guide RNAs (sgRNAs). In this…

View details →DOI: 10.1089/crispr.2024.0086
Negative / Null Result ReportOpen accessMedicine

Burns results in profound muscle protein wasting in Sprague Dawley rats that is not resolved using the lipolysis inhibitor, acipimox.

Vardarli E, Bhattarai N, El Ayadi A et al. · 2025 · PloS one

Introduction Major burns results in the rapid and profound accumulation of lipid in peripheral tissues, but its impact on muscle metabolic function is unclear. Given previous reports demonstrating that lipid oversupply compromises…

View details →DOI: 10.1371/journal.pone.0323640
Negative / Null Result ReportMedicine

Integrating vision and somatosensation does not improve the accuracy and response time when estimating area and perimeter of rectangles in primary school.

Leukel C, Loibl K, Leuders T · 2024 · Trends in neuroscience and education

Background Problem-solving and learning in mathematics involves sensory perception and processing. Multisensory integration may contribute by enhancing sensory estimates. This study aims to assess if combining visual and somatosensory…

View details →DOI: 10.1016/j.tine.2024.100238
Negative / Null Result Report

Pembrolizumab, Temozolomide and HSPPC-96 Vaccine in Newly Diagnosed Glioblastoma Post-Chemoradiation: Results from a Multi-institutional, Phase 2, Randomized, Placebo-Controlled Trial

Ozer BH, Lindhorst SM, Merrell RT et al. · 2026 · Preprint

Background GBM is one of the most common and most aggressive brain tumors in adults, and upfront standard of care treatment has limited efficacy. Immune checkpoint inhibitor strategies have significantly improved outcomes in various solid…

View details →DOI: 10.64898/2026.06.22.26354817
Negative / Null Result ReportOpen accessMedicine

A phase II study of trifluridine/tipiracil in combination with ramucirumab in advanced, refractory gastric, or gastroesophageal junction adenocarcinomas.

Kim DW, Kim RD, Jimenez MM et al. · 2025 · The oncologist

Background Ramucirumab plus paclitaxel after progression on fluoropyrimidine/platinum in metastatic gastric (GA) and gastroesophageal junction adenocarcinoma (GEJC) has shown improvement in overall survival over paclitaxel alone. However,…

View details →DOI: 10.1093/oncolo/oyaf303
Negative / Null Result ReportOpen accessMedicine

Effect of Adjuvant Silodosin on Stone Clearance After Extracorporeal Shock Wave Lithotripsy for Renal Stones: A Randomised Controlled Trial.

Leelahawong P, Ketsuwan C · 2026 · Journal of clinical medicine

Background/Objectives : To evaluate whether adjunctive silodosin improves the stone-free rate (SFR) and clinical outcomes of extracorporeal shock wave lithotripsy (ESWL) for renal calculi. Methods : In this prospective randomised…

View details →DOI: 10.3390/jcm15072471
Negative / Null Result ReportMedicine

A Pilot Randomized Control Trial to Assess the Adjunctive Effect of Diet on Response to Advanced Therapies in Patients With Ulcerative Colitis.

Damas OM, Leo M, Colina N et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Diet may influence ulcerative colitis (UC), but its impact on medication response remains unclear. We examined whether two 5-day cycles of a low-calorie, plant-based (LC-PB), fasting-mimicking diet could improve UC…

View details →DOI: 10.1016/j.cgh.2025.03.020
Negative / Null Result ReportMedicine

Multicenter phase I/II trial of gemcitabine, oxaliplatin and nab-paclitaxel as first-line treatment for patients with advanced biliary tract cancer.

Pressiani T, Balsano R, Giordano L et al. · 2024 · European journal of cancer (Oxford, England : 1990)

Introduction The prognosis of patients with advanced biliary tract cancer (BTC) is still poor, and new strategies improving patients' outcome are needed. In our trial we investigated safety and activity of nab-paclitaxel in combination…

View details →DOI: 10.1016/j.ejca.2024.114196
Negative / Null Result ReportOpen accessMedicine

Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results.

Levy A, Morel D, Texier M et al. · 2025 · Signal transduction and targeted therapy

Immunoradiotherapy holds promise for improving outcomes in patients with advanced solid tumors, including in soft-tissue sarcoma (STS). However, the ideal combination of treatment modalities remains to be determined, and reliable…

View details →DOI: 10.1038/s41392-025-02173-3
Negative / Null Result ReportMedicine

Results from a Phase 2 Study of Induction Docetaxel and Carboplatin Followed by Maintenance Rucaparib in the Treatment of Patients with Metastatic Castration-resistant Prostate Cancer with DNA Homologous Recombination Repair Deficiency.

Raychaudhuri R, Cheng HH, Gulati R et al. · 2026 · European urology oncology

Background and objective Our aim was to determine whether induction chemotherapy followed by PARP inhibitor (PARPi) maintenance improves outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) harboring…

View details →DOI: 10.1016/j.euo.2025.04.026