A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1934 results for "Mpro" · page 40 of 65
Fertig A, Hartman A, Iyer L et al. · 2026 · The journal of politics
Can financial incentives lead households to register land in women's names, thereby providing them with formal property rights? Can formal property ownership improve women's economic outcomes and change decision-making dynamics within the…
Gass JC, Tonkin S, Maguin E et al. · 2024 · Translational behavioral medicine
Ecological Momentary Assessment (EMA) methods are increasingly used by translational scientists to study real-world behavior and experience. The ability to draw meaningful conclusions from EMA research depends upon participant compliance…
Kumar AR, Sanford NN · 2025 · Seminars in radiation oncology
Based on available Level 1 evidence, standard dose conventional chemoradiation does not improve survival in patients with locally advanced pancreas cancer (LAPC), thus chemotherapy remains the only widely accepted therapy. Yet prognosis…
Van der Helm-van Mil AHM · 2023 · Joint bone spine
During the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved greatly, especially for patients with autoantibody-positive RA. To further improve long-term disease outcomes, the field has turned to…
Gatto L, Di Nunno V, Tosoni A et al. · 2023 · Cancers
The lack of significant improvement in the prognosis of patients with GB over the last decades highlights the need for innovative treatments aimed at fighting this malignancy and increasing survival outcomes. The results of the phase III…
Janeway KA, Chou AJ, Buxton A et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Mouse models demonstrate a role for RANK and its ligand, RANKL, in osteosarcoma. The primary objective of this single-arm, open-label phase 2 trial was to determine whether denosumab, a RANKL mAb, improved disease control in…
Andersson Y, Løvstakken E, Herud TM et al. · 2025 · Annals of surgical oncology
Background Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and…
de Zeeuw D · 2020 · Journal of nephrology
Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will…
Dijk SW, Wollny C, Barkhausen J et al. · 2025 · JAMA
Importance Given the widespread use of medical imaging, evaluating the effectiveness of interventions to improve appropriateness is crucial for optimizing health care resources and patient outcomes. Objective To assess the effects of…
Yurttas C, Horvath P, Fischer I et al. · 2024 · Journal of clinical medicine
(1) Background: Laparoscopic staging is essential in gastric cancer (GC) to rule out peritoneal metastasis (PM). Hypericin, a plant-derived fluorescent compound, has been suggested to improve laparoscopic visualization of PM from GC. This…
Wulff KC, Miller FG, Pearson SD · 2011 · Health affairs (Project Hope)
To attain the anticipated benefits of increased investments in comparative effectiveness research, the results must translate into improved medical practice and policy. In this article we present an analysis of a case study of percutaneous…
Coxon AT, Johanns TM, Dunn GP · 2020 · Missouri medicine
Glioblastoma is a devastating disease with a dismal prognosis. While recent advancements in cancer immunotherapy have led to improvements in treating other types of cancer, patients with glioblastoma have not benefited from these new…
Mitting RB, Ray S, Raffles M et al. · 2019 · PloS one
Background Methylprednisolone remains a commonly used ancillary therapy for paediatric acute respiratory distress syndrome (PARDS), despite a lack of level 1 evidence to justify its use. When planning prospective trials it is useful to…
Galloway NL, Sargeant GA, Powers JG et al. · 2026 · Journal of wildlife diseases
Effective wildlife disease management and research rely on trustworthy disease diagnostics. For chronic wasting disease (CWD), immunohistochemistry (IHC) is recognized as the gold standard, and ELISA is a reliable high-throughput screening…
Boardman-Pretty F, Kumar J, Grant C et al. · 2026 · Orphanet journal of rare diseases
BACKGROUND: Accurate and early diagnosis to optimise rare disease care is a global priority. With recent developments in artificial intelligence (AI)-based solutions, a promising area to improve rare disease diagnosis is the application of…
Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Malaria journal
Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers' (HCWs) concerns…
Atobatele S, Mpimbaza A, Ngufor C et al. · 2025 · Preprint
Abstract Background Malaria rapid diagnostic tests (RDTs) have improved case management and surveillance across sub-Saharan Africa by reducing presumptive treatment and enhancing diagnostic specificity. However, healthcare workers’ (HCWs)…
Sheybani L · 2026 · The European journal of neuroscience
A recent study by Hausdorf et al. reported that combining closed-loop acoustic stimulation with transcranial direct current stimulation during sleep does not improve memory consolidation. This contrasts with past studies that reported a…
Ngufor C, Lindblade KA, Atobatele S et al. · 2025 · Preprint
Abstract Background Rapid diagnostic tests (RDTs) have improved malaria case management by enabling point-of-care confirmation of infection, particularly in low-resource settings. In addition to clinical use, RDT results recorded in health…
Dätwyler I, Kuster H, Greiner MA et al. · 2025 · Preprint
Introduction Pneumocystis jirovecii (PJ) causes pneumonia primarily in immunocompromised individuals. Although direct immunofluorescence (IF) remains the diagnostic standard, PCR assays are increasingly used because of higher sensitivity…
Russo F, Chatterjee D, DeMaria N et al. · 2024 · Journal of community genetics
DNA-based population screening for adult-onset diseases holds promise for advancing personalized medicine and improving public health. Yet as most individuals pursuing such screening receive negative results, the return of results process…
Triantafyllidou O, Panagodimou E, Chasiakou S et al. · 2026 · Cureus
Objective To evaluate whether the addition of clomiphene citrate (CC) to a low-dose recombinant follicle-stimulating hormone (FSH) (r-FSH) gonadotropin-releasing hormone (GnRH)-antagonist protocol improves clinical outcomes in women with…
Liu Q, Liu X, Chang L et al. · 2025 · Clinica chimica acta; international journal of clinical chemistry
Introduction Accurate and early HIV detection is crucial for improving outcomes and controlling transmission. This study compares HIV marker patterns and evaluates detection assay performance in general screening and ART-treated…
Kawamura T, Koyama S, Karaushi H et al. · 2026 · Preprint
Introduction: The Gram stain is a fundamental and widely used technique in clinical microbiology for its simplicity and diagnostic value, particularly in bacterial meningitis. However, its reliability can be compromised by contamination…
Wang H, Ardura MI, Oyeniran SJ et al. · 2026 · ASM case reports
Background Cytomegalovirus (CMV) continues to be a significant cause of morbidity and mortality in immunocompromised patients. Nucleic acid amplification tests (NAATs) are the preferred method for both diagnosing CMV infection and…
Pantazis JC, Palmer AC · 2026 · Molecular cancer therapeutics
The phase III study of romidepsin plus CHOP for peripheral T-cell lymphoma (PTCL) yielded negative results in the overall analysis and showed that outcomes were only improved in the T follicular helper (TFH) subgroup of PTCL, with no…
Badelita SN, Sandu HM, Coriu D et al. · 2026 · Frontiers in oncology
Bone marrow hemodilution could compromise next generation flow cytometry based measurable residual disease evaluation in multiple myeloma and may cause false negative results. This review summarizes definitions, markers, indices,…
Hajkowicz K, Woodford J, Pillai ES et al. · 2025 · Emerging infectious diseases
Using metatranscriptomics, we identified Trubanaman virus in cerebrospinal fluid from a severely immunocompromised man who died of encephalitis in Queensland, Australia. Virus sequences were related to orthobunyaviruses previously detected…
Stewart SF, Enne VI, Pandolfo AM et al. · 2026 · Antimicrobial resistance and infection control
Background Rapid molecular diagnostics such as the BioFire FilmArray Pneumonia Panel (the Pneumonia Panel) can improve antibiotic stewardship by supporting doctors to make more targeted antibiotic prescribing decisions faster compared to…
Ceacero-Marín D, Puig-Pey Comas I, Nieto-Moragas J et al. · 2026 · Scandinavian journal of clinical and laboratory investigation
Background The direct antiglobulin test (DAT) is a key diagnostic tool in evaluating autoimmune haemolytic anaemia. However, indiscriminately ordering this test, together with certain methodological limitations, can compromise the…