e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

1761 results in Negative / Null Result Report for "Mpro" · page 39 of 59

Negative / Null Result ReportOpen accessMedicine

Therapeutic Drug Monitoring of Psychotropic Drugs in Inpatient Psychiatry: Local Practice and Improvement.

Pfeifer P, Mathys B, Alan EM et al. · 2025 · Psychiatry and clinical psychopharmacology

Background Therapeutic drug monitoring (TDM) is an important tool to personalize psychopharmacotherapy, thereby optimizing its effectiveness and tolerability. Despite consensus on medications, indications, and implementation of TDM,…

View details →DOI: 10.5152/pcp.2025.24981
Negative / Null Result ReportMedicine

Ischemic Preconditioning Does Not Improve Climbing Specific Performance in Elite Athletes.

Platzer HP, Köck A, Schobersberger W et al. · 2026 · Journal of strength and conditioning research

Abstract Platzer, H-P, Köck, A, Schobersberger, W, and Dünnwald, T. Ischemic preconditioning does not improve climbing specific performance in elite athletes. J Strength Cond Res 40(1): e69-e75, 2026-The aim of the present investigation…

View details →DOI: 10.1519/jsc.0000000000005271
Negative / Null Result ReportOpen accessMedicine

Design characteristics of studies evaluating the effect of non-surgical periodontal treatment on systemic health outcomes.

Treat T, Jones D, Lorenzano N et al. · 2026 · Journal of periodontology

Background Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this…

View details →DOI: 10.1002/jper.24-0847
Negative / Null Result ReportOpen accessMedicine

The effect of citicoline administration on visual function improvement in stroke patients at Prof. Dr. Chairuddin Panusunan Lubis Hospital, University of Sumatera Utara, and affiliated network hospitals.

Fransisca S, Sitepu BRE, Delfi · 2026 · Frontiers in medicine

Background Visual disturbances are a common and often debilitating complication following stroke, significantly impairing patients' functional independence and quality of life. Among various neuroprotective agents, Citicoline…

View details →DOI: 10.3389/fmed.2026.1769632
Negative / Null Result ReportMedicine

The effect of far infrared radiation on maturation in arteriovenous fistulas in patients on hemodialysis: A randomized controlled, multicenter trial.

Lindhard K, Hansen HP, Gliese K et al. · 2026 · The journal of vascular access

Introduction Improved arteriovenous fistula (AVF) maturation is crucial for reducing the dependency on central venous catheters in patients undergoing hemodialysis (HD). Far-infrared radiation (FIR) is a treatment modality that may enhance…

View details →DOI: 10.1177/11297298251385043
Negative / Null Result ReportOpen accessMedicine

Nocturnal Cardiac Arrhythmias in Sleep Apnoea After Acute Myocardial Infarction and the Effect of Adaptive Servo-Ventilation: An Ancillary Study of the TEAM-ASV I Trial.

Pec J, Nigl M, Fox H et al. · 2026 · Journal of cardiovascular development and disease

(1) Background: Early treatment of sleep-disordered breathing (SDB) with adaptive servo-ventilation (ASV) after acute myocardial infarction (AMI) has been shown to improve myocardial salvage. This analysis evaluates nocturnal…

View details →DOI: 10.3390/jcdd13040157
Negative / Null Result ReportMedicine

The Role of Circulating Tumor DNA in Patients Treated with Adjuvant Immune Checkpoint Inhibitors: Clinical Reality or Distant Horizon?

Maffezzoli M, Nagpal R, Elewaily M et al. · 2025 · Current oncology reports

PURPOSE OF REVIEW: Adjuvant immunotherapy has improved outcomes in several cancers, although patient selection and toxicity remain challenges. Circulating tumor DNA (ctDNA) has emerged as a biomarker for minimal residual disease (MRD)…

View details →DOI: 10.1007/s11912-025-01701-2
Negative / Null Result ReportOpen accessMedicine

Improving Non-Invasive Prediction of Thyroid Nodule Malignancy: A Machine Learning-Based Clinical Approach.

Reiner M, Drobińska H, Miciak M et al. · 2026 · Cancer management and research

Background Thyroid cancer (TC) is the most commonly diagnosed endocrine malignancy, with rising global incidence. Current diagnostic techniques, including ultrasound and fine-needle aspiration biopsy (FNAB), often yield inconclusive…

View details →DOI: 10.2147/cmar.s571308
Negative / Null Result ReportMedicine

Sharpening the lens to evaluate interprofessional education and interprofessional collaboration by improving the conceptual framework: a critical discussion.

Neubauer FB, Wagner FL, Lörwald A et al. · 2024 · BMC medical education

It has been difficult to demonstrate that interprofessional education (IPE) and interprofessional collaboration (IPC) have positive effects on patient care quality, cost effectiveness of patient care, and healthcare provider satisfaction.…

View details →DOI: 10.1186/s12909-024-05590-0
Negative / Null Result ReportOpen accessMedicine

Three-dimensional Bovine Collagen-Elastin Matrix in Soft Tissue Reconstruction: No Detectable Bovine DNA After 1 Year.

Nicklas A, Rudari M, Reidow N et al. · 2026 · Plastic and reconstructive surgery. Global open

Background Postoperative wound healing remains a critical challenge, particularly in complex reconstructions such as free flap surgeries. Despite technical improvements, perfusion-related complications may cause partial flap loss.…

View details →DOI: 10.1097/gox.0000000000007662
Negative / Null Result ReportMedicine

Prospective Study of Cytomegalovirus Reactivation in Patients With Multiple Myeloma Receiving Anti-CD38 and BCMA Therapies.

Baneman E, Jacobs SE, Rana M et al. · 2026 · Clinical lymphoma, myeloma & leukemia

Background Cytomegalovirus (CMV) is an opportunistic pathogen that causes infection in certain immunocompromised hosts, but the risk of clinically significant CMV infection in patients with multiple myeloma (MM) is not well understood.…

View details →DOI: 10.1016/j.clml.2026.05.008
Negative / Null Result ReportOpen accessMedicine

Baseline Data on Viral Suppression, Treatment Adherence and Mental Health in Peripartum Girls and Young Women With HIV in Zimbabwe.

Chawana-Mutingwende TD, Ngara B, Mudadi LS et al. · 2026 · Journal of the International AIDS Society

Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir-based regimens and psychosocial peer motivation may improve viral…

View details →DOI: 10.1002/jia2.70117
Negative / Null Result ReportMedicine

Combination of color-Doppler ultrasound and MRI to improve lacrimal gland lesion characterization: A machine learning approach.

Riehm A, Senicourt L, O'Shaughnessy E et al. · 2026 · Diagnostic and interventional imaging

Purpose The purpose of this study was to develop a machine learning-based algorithm based on a combination of magnetic resonance imaging (MRI) and color-Doppler ultrasound (CDUS) to characterize lacrimal gland lesions. Materials and…

View details →DOI: 10.1016/j.diii.2026.06.001
Negative / Null Result ReportMedicine

Assessment of improvements in exercise tolerance following pulmonary valve replacement using physical accelerometry.

Joy N, Soslow JH, Crum K et al. · 2026 · Cardiology in the young

Background Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom…

View details →DOI: 10.1017/s1047951126113493
Negative / Null Result ReportMedicine

Estimating differences in life satisfaction as a function of health-related behaviours: cross-sectional evidence from the Health Survey for England.

Ng Fat, West, E Jackson · 2026 · BMJ public health

Stopping tobacco smoking, reducing alcohol consumption from high-risk levels, increasing physical activity and improving diet can improve mental well-being. To gain a preliminary estimate of the potential benefits of healthy lifestyle…

View details →DOI: 10.1136/bmjph-2025-004301
Negative / Null Result ReportMedicine

Is surgery always warranted for high-grade acromioclavicular dislocations?

Jamei-Martel, Garibaldi, Castroviejo Fernández et al. · 2026 · JSES international

The optimal management of high-grade acromioclavicular (AC) joint dislocations remains controversial. While surgical treatment improves radiographic alignment, its impact on functional outcomes remains debated. This study prospectively…

View details →DOI: 10.1016/j.jseint.2026.101722
Negative / Null Result ReportMedicine

Preperitoneal analgesia under direct visualization: laparoscopic-guided deep rectus sheath block improves postoperative pain control after laparoscopic cholecystectomy: a randomized controlled trial.

Kavakli, Bozkurt, Diri et al. · 2026 · Surgical endoscopy

Conventional abdominal wall blocks primarily target somatic afferent nerves and may therefore provide limited relief for the peritoneal component of postoperative pain. This study aimed to investigate whether a laparoscopic-guided deep…

View details →DOI: 10.1007/s00464-026-12973-5
Negative / Null Result ReportMedicine

A polypill strategy for lipid lowering and anti-platelet therapy after acute coronary syndrome: A pilot randomized controlled trial.

Coellar, Keshvani, Jain et al. · 2026 · American journal of preventive cardiology

Medication non-adherence following acute coronary syndrome (ACS) is common, especially among underserved populations. The use of fixed-dose combination pills (polypills) may improve both adherence and prescription practices. This…

View details →DOI: 10.1016/j.ajpc.2026.101499
Negative / Null Result ReportMedicine

Primary High-Grade Spinal Sarcomas: A Retrospective Review of 10 Cases.

Fukushi, Emori, Tsuchie et al. · 2026 · Cureus

Aggressive surgical resection with adequate margins is associated with improved local control and survival in selected patients with primary spinal sarcomas. However, anatomical constraints often preclude complete resection, and outcomes…

View details →DOI: 10.7759/cureus.108569
Negative / Null Result ReportMedicine

Effectiveness of the Anatomage Table Vet Prior to Cadaveric Dissection of Dog's Thoracic Limb Muscles: A Preliminary Assessment and Student Learning Outcomes.

Merluzzi, Lepri, Lidano et al. · 2026 · Animals : an open access journal from MDPI

The Anatomage Table Vet (ATV) is a digital tool that may facilitate the understanding of complex structures and improve visuospatial skills. This study evaluated the effectiveness of the ATV as a review method prior to cadaveric dissection…

View details →DOI: 10.3390/ani16111695